525
Views
2
CrossRef citations to date
0
Altmetric
Biochemistry & Molecular Biology (Note)

Tumor cell-derived secretory factor downregulates Semaphorin-3a in osteoblasts by activating mammalian target of rapamycin pathway

, , &
Pages 942-944 | Received 26 Oct 2015, Accepted 18 Dec 2015, Published online: 11 Feb 2016

References

  • Neufeld G, Kessler O. The semaphorins: versatile regulators of tumour progression and tumour angiogenesis. Nat. Rev. Cancer. 2008;8:632–645.10.1038/nrc2404
  • Bielenberg DR, Klagsbrun M. Targeting endothelial and tumor cells with semaphorins. Cancer Metastasis Rev. 2007;26:421–431.10.1007/s10555-007-9097-4
  • Zhou H, Wu A, Fu W, et al. Significance of semaphorin-3A and MMP-14 protein expression in non-small cell lung cancer. Oncol. Lett. 2014;7:1395–1400.
  • Maione F, Molla F, Meda C, et al. Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models. J. Clin. Invest. 2009;119:3356–3372.
  • Chakraborty G, Kumar S, Mishra R, et al. Semaphorin 3A suppresses tumor growth and metastasis in mice melanoma model. PLoS ONE. 2012;7:e33633.10.1371/journal.pone.0033633
  • Sabag AD, Bode J, Fink D, et al. Semaphorin-3D and semaphorin-3E inhibit the development of tumors from glioblastoma cells implanted in the cortex of the brain. PLoS ONE. 2012;7:e42912.10.1371/journal.pone.0042912
  • Nasarre P, Gemmill RM, Drabkin HA. The emerging role of class-3 semaphorins and their neuropilin receptors in oncology. Onco. Targets Ther. 2014;7:1663–1687.
  • Bagci T, Wu JK, Pfannl R, et al. Autocrine semaphorin 3A signaling promotes glioblastoma dispersal. Oncogene. 2009;28:3537–3550.10.1038/onc.2009.204
  • Casazza A, Laoui D, Wenes M, et al. Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity. Cancer Cell. 2013;24:695–709.10.1016/j.ccr.2013.11.007
  • Takayanagi H. Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Nat. Rev. Immunol. 2007;7:292–304.10.1038/nri2062
  • Weilbaecher KN, Guise TA, McCauley LK. Cancer to bone: a fatal attraction. Nat. Rev. Cancer. 2011;11:411–425.10.1038/nrc3055
  • Hayashi M, Nakashima T, Taniguchi M, et al. Osteoprotection by semaphorin 3A. Nature. 2012;485:69–74.10.1038/nature11000
  • Fukuda T, Takeda S, Xu R, et al. Sema3A regulates bone-mass accrual through sensory innervations. Nature. 2013;497:490–493.10.1038/nature12115

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.