References
- Hulme SE, Whitesides GM. Chemistry and the worm: Caenorhabditis elegans as a platform for integrating chemical and biological research. Angew. Chem. Int. Ed. Engl. 2011;50:4774–4807.10.1002/anie.v50.21
- Rodriguez M, Snoek LB, De Bono M, et al. Worms under stress: C. elegans stress response and its relevance to complex human disease and aging. Trends Genet. 2013;29:367–374.10.1016/j.tig.2013.01.010
- Aitlhadj L, Stürzenbaum SR. Caenorhabditis elegans in regenerative medicine: a simple model for a complex discipline. Drug Discov. Today. 2014;19:730–734.10.1016/j.drudis.2014.01.014
- Kaletta T, Hengartner MO. Finding function in novel targets: C. elegans as a model organism. Nat. Rev. Drug Discov. 2006;5:387–399.10.1038/nrd2031
- Epstein HF, Benian GM. Paradigm shifts in cardiovascular research from Caenorhabditis elegans muscle. Trends Cardiovasc. Med. 2012;22:201–209.10.1016/j.tcm.2012.07.021
- Lublin AL, Link CD. Alzheimer’s disease drug discovery: in vivo screening using Caenorhabditis elegans as a model for β-amyloid peptide-induced toxicity. Drug Discov. Today Technol. 2013;10:e115–e119.10.1016/j.ddtec.2012.02.002
- Arvanitis M, Glavis-Bloom J, Mylonakis E. C. elegans for anti-infective discovery. Curr. Opin. Pharmacol. 2013;13:769–774.10.1016/j.coph.2013.08.002
- Sin O, Michels H, Nollen EA. Genetic screens in Caenorhabditis elegans models for neurodegenerative diseases. Biochim. Biophys. Acta. 2014;1842:1951–1959.10.1016/j.bbadis.2014.01.015
- Leung CK, Wang Y, Malany S, et al. An ultra high-throughput, whole-animal screen for small molecule modulators of a specific genetic pathway in Caenorhabditis elegans. PLoS One. 2013;8:e62166.10.1371/journal.pone.0062166
- O’Reilly LP, Luke CJ, Perlmutter DH, et al. C. elegans in high-throughput drug discovery. Adv. Drug. Deliv. Rev. 2014;69–70:247–253.10.1016/j.addr.2013.12.001
- Schulz TJ, Zarse K, Voigt A, et al. Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab. 2007;6:280–293.10.1016/j.cmet.2007.08.011
- Lee SJ, Murphy CT, Kenyon C. Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression. Cell Metab. 2009;10:379–391.10.1016/j.cmet.2009.10.003
- Schlotterer A, Kukudov G, Bozorgmehr F, et al. C. elegans as model for the study of high glucose- mediated life span reduction. Diabetes. 2009;58:2450–2456.10.2337/db09-0567
- Mondoux MA, Love DC, Ghosh SK, et al. O-linked-N-acetylglucosamine cycling and insulin signaling are required for the glucose stress response in Caenorhabditis elegans. Genetics. 2011;188:369–382.10.1534/genetics.111.126490
- Choi SS. High glucose diets shorten lifespan of Caenorhabditis elegans via ectopic apoptosis induction. Nutr. Res. Pract. 2011;5:214–218.10.4162/nrp.2011.5.3.214
- Stiernagle T. Maintenance of C. elegans. In: Hope IA, editor. C. elegans: a practical approach. London: Oxford University Press; 1999. p. 51–67.
- Tanis JE, Moresco JJ, Lindquist RA, et al. Regulation of serotonin biosynthesis by the G proteins Galphao and Galphaq controls serotonin signaling in Caenorhabditis elegans. Genetics. 2008;178:157–169.10.1534/genetics.107.079780
- Sze JY, Victor M, Loer C, et al. Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant. Nature. 2000;403:560–564.10.1038/35000609
- Dempsey CM, Mackenzie SM, Gargus A, et al. Serotonin (5HT), fluoxetine, imipramine and dopamine target distinct 5HT receptor signaling to modulate Caenorhabditis elegans egg-laying behavior. Genetics. 2005;169:1425–1436.
- Carnell L, Illi J, Hong SW, et al. The G-protein-coupled serotonin receptor SER-1 regulates egg laying and male mating behaviors in Caenorhabditis elegans. J. Neurosci. 2005;25:10671–10681.10.1523/JNEUROSCI.3399-05.2005
- Hapiak VM, Hobson RJ, Hughes L, et al. Dual excitatory and inhibitory serotonergic inputs modulate egg laying in Caenorhabditis elegans. Genetics. 2009;181:153–163.
- Xiao H, Hapiak VM, Smith KA, et al. SER-1, a Caenorhabditis elegans 5-HT2-like receptor, and a multi-PDZ domain containing protein (MPZ-1) interact in vulval muscle to facilitate serotonin-stimulated egg-laying. Dev. Biol. 2006;298:379–391.10.1016/j.ydbio.2006.06.044
- Nowotny K, Jung T, Höhn A, et al. Advanced glycation end products and oxidative stress in type 2 diabetes mellitus. Biomolecules. 2015;5:194–222.10.3390/biom5010194
- Cunningham KA, Bouagnon AD, Barros AG, et al. Loss of a neural AMP-activated kinase mimics the effects of elevated serotonin on fat, movement, and hormonal secretions. PLoS Genet. 2014;10:e1004394.10.1371/journal.pgen.1004394
- Laporta J, Peters TL, Merriman KE, et al. Serotonin (5-HT) affects expression of liver metabolic enzymes and mammary gland glucose transporters during the transition from pregnancy to lactation. PLoS One. 2013;8:e57847.10.1371/journal.pone.0057847
- Cunningham KA, Hua Z, Srinivasan S, et al. AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegans. Cell Metab. 2012;16:113–121.10.1016/j.cmet.2012.05.014