Bovine milk-derived α-lactalbumin prevents hepatic fibrosis induced by dimethylnitrosamine via nitric oxide pathway in rats

References

• Friedman SL. Mechanisms of hepatic fibrogenesis. Gastroenterology. 2008;134:1655–1669.10.1053/j.gastro.2008.03.003
   PubMed Web of Science ®Google Scholar
• Wallace K, Burt AD, Wright MC. Liver fibrosis. Biochem J. 2008;411:1–18.10.1042/BJ20071570
   PubMed Web of Science ®Google Scholar
• Friedman SL. Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. N Eng J Med. 1993;328:1828–1835.
   PubMed Web of Science ®Google Scholar
• Friedman SL. Molecular mechanisms of hepatic fibrosis and principles of therapy. J Gastroenterol. 1997;32:424–430.10.1007/BF02934504
   PubMed Web of Science ®Google Scholar
• Rockey DC, Housset CN, Friedman SL. Activation-dependent contractility of rat hepatic lipocytes in culture and in vivo. J Clin Invest. 1993;92:1795–1804.10.1172/JCI116769
   PubMed Web of Science ®Google Scholar
• Rockey DC, Chung JJ. Reduced nitric oxide production by endothelial cells in cirrhotic rat liver: endothelial dysfunction in portal hypertension. Gastroenterology. 1998;114:344–351.10.1016/S0016-5085(98)70487-1
   PubMed Web of Science ®Google Scholar
• Walzem RL, Dillard CJ, German JB. Whey components: millennia of evolution create functionalities for mammalian nutrition: what we know and what we may be overlooking. Crit Rev Food Sci Nutr. 2002;42:353–375.10.1080/10408690290825574
   PubMed Web of Science ®Google Scholar
• Gad AS, Khadrawy YA, El-Nekeety AA, et al. Antioxidant activity and hepatoprotective effects of whey protein and Spirulina in rats. Nutrition. 2011;27:582–589.10.1016/j.nut.2010.04.002
   PubMed Web of Science ®Google Scholar
• Xu R, Liu N, Xu X, et al. Antioxidative effects of whey protein on peroxide-induced cytotoxicity. J Dairy Sci. 2011;94:3739–3746.10.3168/jds.2010-3891
   PubMed Web of Science ®Google Scholar
• Iwamori T, Nukumi N, Itoh K, et al. Bacteriostatic activity of whey acidic protein (WAP). J Vet Med Sci. 2010;72:621–625.10.1292/jvms.08-0331
   PubMed Web of Science ®Google Scholar
• Elattar G, Saleh Z, EL-Shebini S, et al. The use of whey protein concentrate in management of chronic hepatitis C virus—a pilot study. Arch Med Sci. 2010;5:748–755.10.5114/aoms.2010.17091
   Google Scholar
• Hakkak R, Korourian S, Ronis MJ, et al. Dietary whey protein protects against azoxymethane-induced colon tumors in male rats. Cancer Epidemiol Biomarkers Prev. 2001;10:555–558.
   PubMed Web of Science ®Google Scholar
• Pal S, Ellis V. The chronic effects of whey proteins on blood pressure, vascular function, and inflammatory markers in overweight individuals. Obesity. 2010;18:1354–1359.10.1038/oby.2009.397
   PubMed Web of Science ®Google Scholar
• Kloek J, Mortaz E, Van Ark I, et al. A whey-based glutathione-enhancing diet decreases allergen-induced airway contraction in a guinea-pig model of asthma. Br J Nutr. 2011;105:1465–1470.10.1017/S0007114510005337
   PubMed Web of Science ®Google Scholar
• Kume H, Okazaki K, Sasaki H. Hepatoprotective effects of whey protein on d-galactosamine-induced hepatitis and liver fibrosis in rats. Biosci Biotechnol Biochem. 2006;70:1281–1285.10.1271/bbb.70.1281
   PubMed Web of Science ®Google Scholar
• Kume H, Okazaki K, Yamaji T, et al. A newly designed enteral formula containing whey peptides and fermented milk product protects mice against concanavalin A-induced hepatitis by suppressing overproduction of inflammatory cytokines. Clin Nutr. 2012;31:283–289.10.1016/j.clnu.2011.10.012
   PubMed Web of Science ®Google Scholar
• Jobara K, Kaido T, Hori T, et al. Whey-hydrolyzed peptide-enriched immunomodulating diet prevents progression of liver cirrhosis in rats. Nutrition. 2014;30:1195–1207.10.1016/j.nut.2014.02.005
   PubMed Web of Science ®Google Scholar
• Yamaguchi M, Yoshida K, Uchida M. Novel functions of bovine milk-derived α-lactalbumin: anti-nociceptive and anti-inflammatory activity caused by inhibiting cyclooxygenase-2 and phospholipase A2. Biol Pharm Bull. 2009;32:366–371.10.1248/bpb.32.366
   PubMed Web of Science ®Google Scholar
• Yamaguchi M, Takai S, Hosono A, et al. Bovine milk-derived α-lactalbumin inhibits colon inflammation and carcinogenesis in azoxymethane and dextran sodium sulfate-treated mice. Biosci Biotechnol Biochem. 2014;78:672–679.10.1080/09168451.2014.890034
   PubMed Web of Science ®Google Scholar
• Roy SS, Mukherjee S, Ballard BR, Das SK. Protection against dimethylbenz[a] anthracene-induced breast cancer in female rats by α-lactalbumin. Int J Cancer Oncol. 2016;3:1–6.
   PubMedGoogle Scholar
• Yamaguchi M, Takai S. Chronic administration of bovine milk-derived α-lactalbumin improves glucose tolerance via enhancement of adiponectin in Goto-Kakizaki rats with type 2 diabetes. Biol Pharm Bull. 2014;37:404–408.10.1248/bpb.b13-00762
   PubMed Web of Science ®Google Scholar
• Ushida Y, Shimokawa Y, Toida T, et al. Bovine α-lactalbumin stimulates mucus metabolism in gastric mucosa. J Dairy Sci. 2007;90:541–546.10.3168/jds.S0022-0302(07)71537-0
   PubMed Web of Science ®Google Scholar
• Yamaguchi M, Uchida M. α-Lactalbumin suppresses interleukin-6 release after intestinal ischemia/reperfusion via nitric oxide in rats. Inflammopharmacology. 2007;15:43–47.10.1007/s10787-006-1558-9
   PubMedGoogle Scholar
• Nakano S, Nagasawa T, Ijiro T, et al. Bezafibrate prevents hepatic stellate cell activation and fibrogenesis in a murine steatohepatitis model, and suppresses fibrogenic response induced by transforming growth factor-β1 in a cultured stellate cell line. Hepatol Res. 2008;38:1026–1039.10.1111/hep.2008.38.issue-10
   PubMed Web of Science ®Google Scholar
• Haggerty HG, Holsapple MP. Role of metabolism in dimethylnitrosamine-induced immunosuppression: a review. Toxicology. 1990;63:1–23.10.1016/0300-483X(90)90064-N
   PubMed Web of Science ®Google Scholar
• George J, Rao KR, Stern R, et al. Dimethylnitrosamine-induced liver injury in rats: the early deposition of collagen. Toxicology. 2001;156:129–138.10.1016/S0300-483X(00)00352-8
   PubMed Web of Science ®Google Scholar
• Tung YT, Tang TY, Chen HL, et al. Lactoferrin protects against chemical-induced rat liver fibrosis by inhibiting stellate cell activation. J Dairy Sci. 2014;97:3281–3291.10.3168/jds.2013-7505
   PubMed Web of Science ®Google Scholar
• Shin MO, Moon JO. Effect of dietary supplementation of grape skin and seeds on liver fibrosis induced by dimethylnitrosamine in rats. Nutr Res Pract. 2010;4:369–374.10.4162/nrp.2010.4.5.369
   PubMed Web of Science ®Google Scholar
• Shin JW, Son JY, Oh SM, et al. An herbal formula, CGX, exerts hepatotherapeutic effects on dimethylnitrosamine-induced chronic liver injury model in rats. World J Gastroenterol. 2006;12:6142–6148.10.3748/wjg.v12.i38.6142
   PubMed Web of Science ®Google Scholar
• Inami M, Fukushima A, Ueno T, et al. Reduction of dimethylnitrosamine-induced liver fibrosis by the novel gene regulator PI polyamide targeting transforming growth factor β1 gene. Biol Pharm Bull. 2015;38:1836–1842.10.1248/bpb.b15-00328
   PubMed Web of Science ®Google Scholar
• Nagase S, Isobe H, Ayukawa K, et al. Inhibition of nitric oxide production increases dimethylnitrosamine-induced liver injury in rats. J Hepatol. 1995;23:601–604.10.1016/0168-8278(95)80068-9
   PubMed Web of Science ®Google Scholar
• Lukivskaya O, Lis R, Zwierz K, et al. Effect of the nitric oxide donor and the nitric oxide synthase inhibitor on the liver of rats with chronic hepatitis induced by dimethylnitrosamine. Pol J Pharmacol. 2004;56:599–604.
   PubMedGoogle Scholar
• Amirtharaj GJ, Thangaraj KR., Kini A, et al. Acute liver injury induced by low dose dimethylnitrosamine alters mediators of hepatic vascular flow. Toxicol Rep. 2014;1:707–717.10.1016/j.toxrep.2014.09.001
   Google Scholar
• McKim SE, Gabele E, Isayama F, et al. Inducible nitric oxide synthase is required in alcohol-induced liver injury: studies with knockout mice. Gastroenterology. 2003;125:1834–1844.10.1053/j.gastro.2003.08.030
   PubMed Web of Science ®Google Scholar
• Matthews JR, Botting CH, Panico M, et al. Inhibition of NF-κB DNA binding by nitric oxide. Nucleic Acids Res. 1996;24:2236–2242.10.1093/nar/24.12.2236
   PubMed Web of Science ®Google Scholar
• Peng HB, Libby P, Liao JK. Induction and stabilization of IκBα by nitric oxide mediates inhibition of NF-κB. J Biol Chem. 1995;270:14214–14219.10.1074/jbc.270.23.14214
   PubMed Web of Science ®Google Scholar
• Wills PJ, Suresh V, Arun M, et al. Antiangiogenic effect of lygodium flexuosum against N-nitrosodiethylamine-induced hepatotoxicity in rats. Chem Biol Interact. 2006;164:25–38.10.1016/j.cbi.2006.08.021
   PubMed Web of Science ®Google Scholar
• Hong SW, Jung KH, Lee HS, et al. Suppression by fucoidan of liver fibrogenesis via the TGF-β/Smad pathway in protecting against oxidative stress. Biosci Biotechnol Biochem. 2011;75:833–840.10.1271/bbb.100599
   PubMed Web of Science ®Google Scholar
• Hernandez-Ledesma B, Davalos A, Bartolome B, et al. Preparation of antioxidant enzymatic hydrolysates from α-lactalbumin and β-lactoglobulin. Identification of active peptides by HPLC-MS/MS. J Agric Food Chem. 2005;53:588–593.10.1021/jf048626 m
   PubMed Web of Science ®Google Scholar