Soy hydrolysate enhances the isoproterenol-stimulated lipolytic pathway through an increase in β-adrenergic receptor expression in adipocytes

References

• Xiao CW. Health effects of soy protein and isoflavones in humans. J Nutr. 2008;138:1244S–1249S.
   PubMed Web of Science ®Google Scholar
• Setchell KD, Brown NM, Desai P, et al. Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements. J Nutr. 2001;131:1362S–1375S.
   PubMed Web of Science ®Google Scholar
• Mukund V, Mukund D, Sharma V, et al. Genistein: its role in metabolic diseases and cancer. Crit Rev Oncol Hematol. 2017;119:13–22.
   PubMed Web of Science ®Google Scholar
• Pi-Sunyer XF. Clinical guidelines on the identification, evaluation and treatment of overweight and obesity in adults-the evidence report. Obes Res. 1998;6:51S–210S.
   PubMedGoogle Scholar
• Rosen ED, Spiegelman BM. Adipocytes as regulators of energy balance and glucose homeostasis. Nature. 2006;444:847–853.
   PubMed Web of Science ®Google Scholar
• Ducharme NA, Bickel PE. Minireview: lipid droplets in lipogenesis and lipolysis. Endocrinology. 2008;149:942–949.
   PubMed Web of Science ®Google Scholar
• Arner P, Bernard S, Salehpour M, et al. Dynamics of human adipose lipid turnover in health and metabolic disease. Nature. 2011;478:110–113.
   PubMed Web of Science ®Google Scholar
• Feldmann HM, Golozoubova V, Cannon B, et al. UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab. 2009;9:203–209.
   PubMed Web of Science ®Google Scholar
• Aoyama T, Fukui K, Takamatsu K, et al. Soy protein isolate and its hydrolysate reduce body fat of dietary obese rats and genetically obese mice (yellow KK). Nutrition. 2000;16:349–354.
   PubMed Web of Science ®Google Scholar
• Allison DB, Gadbury G, Schwartz LG, et al. A novel soy-based meal replacement formula for weight loss among obese individuals: a randomized controlled clinical trial. Eur J Clin Nutr. 2003;57:514–522.
   PubMed Web of Science ®Google Scholar
• Moriyama T, Kishimoto K, Nagai K, et al. Soybean β-conglycinin diet suppresses serum triglyceride levels in normal and genetically obese mice by induction of β-oxidation, downregulation of fatty acid synthase, and inhibition of triglyceride absorption. Biosci Biotechnol Biochem. 2004;68:352–359.
   PubMed Web of Science ®Google Scholar
• Tsou MJ, Lin SB, Chao CH, et al. Enhancing the lipolysis-stimulating activity of soy protein using limited hydrolysis with Flavourzyme and ultrafiltration. Food Chem. 2012;134:1564–1570.
   PubMed Web of Science ®Google Scholar
• Maebuchi M, Samoto M, Kohno M, et al. Improvement in the intestinal absorption of soy protein by enzymatic digestion to oligopeptide in healthy adult men. Food Sci Technol Res. 2007;13:45–53.
   Web of Science ®Google Scholar
• Kohno M. Soybean protein and peptide as complementation medical food materials for treatment of dyslipidemia and inflammatory disorders. Food Sci Technol Res. 2017;23:773–782.
   Web of Science ®Google Scholar
• Goto T, Lee JY, Teraminami A, et al. Activation of peroxisome proliferator-activated receptor-alpha stimulates both differentiation and fatty acid oxidation in adipocytes. J Lipid Res. 2011;52:873–884.
   PubMed Web of Science ®Google Scholar
• Goto T, Mori A, Nagaoka S. Soluble soy protein peptic hydrolysate stimulates adipocyte differentiation in 3T3-L1 cells. Mol Nutr Food Res. 2013;57:1435–1445.
   PubMed Web of Science ®Google Scholar
• Takahashi H, Goto T, Yamazaki Y, et al. Metabolomics reveal 1-palmitoyl lysophosphatidylcholine production by peroxisome proliferator-activated receptor α. J Lipid Res. 2015;56:254–265.
   PubMed Web of Science ®Google Scholar
• Takahashi H, Sanada K, Nagai H, et al. Over-expression of PPARα in obese mice adipose tissue improves insulin sensitivity. Biochem Biophys Res Commun. 2017;493:108–114.
   PubMed Web of Science ®Google Scholar
• Anthonsen MW, Rönnstrand L, Wernstedt C, et al. Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro. J Biol Chem. 1998;273:215–221.
   PubMed Web of Science ®Google Scholar
• Carmen GY, Víctor SM. Signalling mechanisms regulating lipolysis. Cell Signal. 2006;18:401–408.
   PubMed Web of Science ®Google Scholar
• Holm C. Molecular mechanisms regulating hormone-sensitive lipase and lipolysis. Biochem Soc Trans. 2003;31:1120–1124.
   PubMed Web of Science ®Google Scholar
• Miyoshi H, Souza SC, Zhang HH, et al. Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and -independent mechanisms. J Biol Chem. 2006;281:15837–15844.
   PubMed Web of Science ®Google Scholar
• Brasaemle DL, Subramanian V, Garcia A, et al. Perilipin A and the control of triacylglycerol metabolism. Mol Cell Biochem. 2009;326:15–21.
   PubMed Web of Science ®Google Scholar
• Lu X, Gruia-Gray J, Copeland NG, et al. The murine perilipin gene: the lipid droplet-associated perilipins derive from tissue-specific, mRNA splice variants and define a gene family of ancient origin. Mamm Genome. 2001;12:741–749.
   PubMed Web of Science ®Google Scholar
• Bertholet AM, Kirichok Y. UCP1: A transporter for H+ and fatty acid anions. Biochimie. 2017;134:28–34.
   PubMed Web of Science ®Google Scholar
• Miller CN, Yang JY, England E, et al. Isoproterenol increases uncoupling, glycolysis, and markers of beiging in mature 3T3-L1 adipocytes. PLoS One. 2015;10:e0138344.
   PubMed Web of Science ®Google Scholar
• Monjo M, Pujol E, Roca P. α2- to β3-Adrenoceptor switch in 3T3-L1 preadipocytes and adipocytes: modulation by testosterone, 17β-estradiol, and progesterone. Am J Physiol Endocrinol Metab. 2005;289:E145–E150.
   PubMed Web of Science ®Google Scholar
• Guest SJ, Hadcock JR, Watkins DC, et al. β1- and β2-adrenergic receptor expression in differentiating 3T3-L1 cells. Independent regulation at the level of mRNA. J Biol Chem. 1990;265:5370–5375.
   PubMed Web of Science ®Google Scholar
• Tsou MJ, Kao FJ, Lu HC, et al. Purification and identification of lipolysis-stimulating peptides derived from enzymatic hydrolysis of soy protein. Food Chem. 2013;138:1454–1460.
   PubMed Web of Science ®Google Scholar
• Messina MJ. Legumes and soybeans: overview of their nutritional profiles and health effects. Am J Clin Nutr. 1999;70:439s–450s.
   PubMed Web of Science ®Google Scholar
• Chirumbolo S. Genistein as a nature-derived PPAR agonist in adipogenesis and weight gain. Eur J Nutr. 2015;54:489–491.
   PubMed Web of Science ®Google Scholar
• Torres N, Torre-Villalvazo I, Tovar AR. Regulation of lipid metabolism by soy protein and its implication in diseases mediated by lipid disorders. J Nutr Biochem. 2006;17:365–373.
   PubMed Web of Science ®Google Scholar
• Ahima RS, Flier JS. Adipose tissue as an endocrine organ. Trends Endocrinol Metab. 2000;11:327–332.
   PubMed Web of Science ®Google Scholar
• Bartelt A, Heeren J. Adipose tissue browning and metabolic health. Nat Rev Endocrinol. 2014;10:24–36.
   PubMed Web of Science ®Google Scholar