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Biochemistry & Molecular Biology

Flavone of Hippophae (H-flavone) lowers atherosclerotic risk factors via upregulation of the adipokine C1q/tumor necrosis factor-related protein 6 (CTRP6) in macrophages

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Pages 2000-2007 | Received 14 Dec 2018, Accepted 05 Mar 2019, Published online: 28 Jun 2019

References

  • Hansson GK, Libby P. The immune response in atherosclerosis: a double-edged sword. Nat Rev Immunol. 2006;6(7):508–519.
  • Weber C, Zernecke A, Libby P. The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models. Nat Rev Immunol. 2008;8(10):802–815.
  • Mcgettrick AF, O’Neill LA. How metabolism generates signals during innate immunity and inflammation. J Biol Chem. 2013;288(32):22893–22898.
  • Bensinger SJ, Tontonoz P. Integration of metabolism and inflammation by lipid-activated nuclear receptors. Nature. 2008;454(7203):470–477.
  • Schäffler A, Buechler C. CTRP family: linking immunity to metabolism. Trends Endocrinol Metab. 2012;23(4):194–204.
  • Yi W, Sun Y, Yuan Y, et al. C1q/tumor necrosis factor-related protein-3, a newly identified adipokine, is a novel antiapoptotic, proangiogenic, and cardioprotective molecule in the ischemic mouse heart. Circulation. 2012;125(25):3159–3169.
  • Wei Z, Seldin MM, Natarajan N, et al. C1q/tumor necrosis factor-related protein 11 (CTRP11), a novel adipose stroma-derived regulator of adipogenesis. J Biol Chem. 2013;288(15):10214–10229.
  • Wu WJ, Mo DL, Zhao CZ, et al. Knockdown of CTRP6 inhibits adipogenesis via lipogenic marker genes and Erk1/2 signalling pathway. Cell Biol Int. 2015;39(5):554–562.
  • Lee W, Kim MJ, Park EJ, et al. C1qTNF-related protein-6 mediates fatty acid oxidation via the activation of the AMP-activated protein kinase. FEBS Lett. 2010;584(11):2491.
  • Fan RH, Zhu XM, Sun YW, et al. CTRP6 inhibits fibrogenesis in TGF-Î21-stimulated human dermal fibroblasts. Biochem Biophys Res Commun. 2016;475(4):356–360.
  • Kim MJ, Lee W, Park EJ, et al. C1qTNF-related protein-6 increases the expression of interleukin-10 in macrophages. Mol Cells. 2010;30(1):59–64.
  • Yu X-H, Zhang D-W, Zheng X-L, et al. C1q tumor necrosis factor-related protein 9 in atherosclerosis: mechanistic insights and therapeutic potential. Atherosclerosis. 2018;276:109–116.
  • Zhang P, Huang C, Li J, et al. Globular CTRP9 inhibits oxLDL-induced inflammatory response in RAW 264.7 macrophages via AMPK activation. Mol Cell Biochem. 2016;417(1–2):67–74.
  • Guliyev VB, Gul M, Yildirim A. Hippophae rhamnoides L.: chromatographic methods to determine chemical composition, use in traditional medicine and pharmacological effects. J Chromatogr B Analyt Technol Biomed Life Sci. 2004;812(1):291–307.
  • Carl G, Cecilia WN, Patrick A, et al. Antiproliferative effects of sea buckthorn (Hippophae rhamnoides L.) extracts on human colon and liver cancer cell lines. Food Chem. 2010;120(4):1004–1010.
  • Basu M, Prasad R, Jayamurthy P, et al. Anti-atherogenic effects of seabuckthorn (Hippophaea rhamnoides) seed oil. Phytomedicine. 2007;14(11):770–777.
  • Geetha S, Sai RM, Mongia SS, et al. Evaluation of antioxidant activity of leaf extract of Seabuckthorn (Hippophae rhamnoides L.) on chromium(VI) induced oxidative stress in albino rats. J Ethnopharmacol. 2003;87(2):247–251.
  • Michel T, Destandau E, Elfakir C. Evaluation of a simple and promising method for extraction of antioxidants from sea buckthorn (Hippophaë rhamnoides L.) berries: pressurised solvent-free microwave assisted extraction. Food Chem. 2011;126(3):1380–1386.
  • Zeb A. Anticarcinogenic potential of lipids from Hippophae–evidence from the recent literature. Asian Pac J Cancer Prev Apjcp. 2006;7(1):32.
  • Chen L, He T, Han Y, et al. Pentamethylquercetin improves adiponectin expression in differentiated 3T3-L1 cells via a mechanism that implicates PPARγ together with TNF-α and IL-6. Molecules. 2011;16(7):5754.
  • Geetha S, Sai RM, Singh V, et al. Anti-oxidant and immunomodulatory properties of seabuckthorn (Hippophae rhamnoides)–an in vitro study. J Ethnopharmacol. 2002;79(3):373–378.
  • Lei X, Seldin MM, Little HC, et al. C1q/TNF-related protein 6 (CTRP6) links obesity to adipose tissue inflammation and insulin resistance. J Biol Chem. 2017;292(36):14836.
  • Yang F, Quan J, Zhang TY, et al. Multidimensional counter-current chromatographic system and its application. J Chromatogr A. 1998;803(1–2):298.
  • Li X, Kong L, Liu H. Advances on effective compositions of Seabuckthorn (Hippophae rhamnoides L.). J Jilin Agric Univ. 2007;29(2):162–167.
  • Bhaskar S, Sudhakaran PR, Helen A. Quercetin attenuates atherosclerotic inflammation and adhesion molecule expression by modulating TLR-NF-κB signaling pathway. Cell Immunol. 2016;310:131–140.
  • Kong L, Luo C, Li X, et al. The anti-inflammatory effect of kaempferol on early atherosclerosis in high cholesterol fed rabbits. Lipids Health Dis. 2013;12(1):115.
  • Luo Y, Sun G, Dong X, et al. Isorhamnetin attenuates atherosclerosis by inhibiting macrophage apoptosis via PI3K/AKT activation and HO-1 induction. Plos One. 2015;10(3):e0120259.
  • Ouchi N, Walsh K. Cardiovascular and metabolic regulation by the adiponectin/C1q/tumor necrosis factor-related protein family of proteins. Circulation. 2012;125(25):3066–3068.
  • Hou M, Liu J, Liu F, et al. C1q tumor necrosis factor-related protein-3 protects mesenchymal stem cells against hypoxia- and serum deprivation-induced apoptosis through the phosphoinositide 3-kinase/Akt pathway. Int J Mol Med. 2014;33(1):97–104.
  • Chavali VR, Sommer JR, Petters RM, et al. Identification of a promoter for the human C1Q-tumor necrosis factor-related protein-5 gene associated with late-onset retinal degeneration. Invest Ophthalmol Vis Sci. 2010;51(11):5499–5507.
  • Eyre S, Hinks A, Bowes J, et al. Overlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease. Arthritis Res Ther. 2010;12(5):R175–R175.
  • Wallis RH, Wang K, Marandi L, et al. Type 1 diabetes in the BB rat: a polygenic disease. Diabetes. 2009;58(4):1007.
  • Jin Y, Birlea SA, Fain PR, et al. Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo. N Engl J Med. 2010;362(18):1686.
  • Takeuchi T, Adachi Y, Nagayama T. Expression of a secretory protein C1qTNF6, a C1qTNF family member, in hepatocellular carcinoma. Anal Cell Pathol. 2016;34(3):113–121.
  • Wong GW, Krawczyk SA, Kitidis-Mitrokostas C, et al. Molecular, biochemical and functional characterizations of C1q/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-gamma agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions. Biochem J. 2008;416(2):161–177.
  • Lei H, Wu D, Wang JY, et al. C1q/tumor necrosis factor-related protein-6 attenuates post-infarct cardiac fibrosis by targeting RhoA/MRTF-A pathway and inhibiting myofibroblast differentiation. Basic Res Cardiol. 2015;110(4):1–17.

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