Paeonol protects against hypertension in spontaneously hypertensive rats by restoring vascular endothelium

References

• Liu D, Huang Y, Jia C, et al. Administration of antagomir-223 inhibits apoptosis, promotes angiogenesis and functional recovery in rats with spinal cord injury. Cell Mol Neurobiol. 2015 May;35:483–491. PubMed PMID: 25416533; eng.
   PubMed Web of Science ®Google Scholar
• Antonopoulos AS, Margaritis M, Shirodaria C, et al. Translating the effects of statins: from redox regulation to suppression of vascular wall inflammation. Thromb Haemost. 2012 Nov;108:840–848. PubMed PMID: 22872079; eng.
   PubMed Web of Science ®Google Scholar
• Wu S, Han J, Li WQ, et al. Hypertension, antihypertensive medication use, and risk of psoriasis. JAMA Dermatol. 2014 Sep;150:957–963. PubMed PMID: 24990147; PubMed Central PMCID: PMCPmc4184206. eng.
   PubMed Web of Science ®Google Scholar
• Zhang FL, Guo ZN, Xing YQ, et al. Hypertension prevalence, awareness, treatment, and control in northeast China: a population-based cross-sectional survey. J Hum Hypertens. 2017 Dec;32:54–65. PubMed PMID: 29180804; eng.
   PubMed Web of Science ®Google Scholar
• Siu D. A new way of targeting to treat coronary artery disease. J Cardiovasc Med (Hagerstown). 2010 Jan;11:1–6. PubMed PMID: 19829140; eng.
   PubMed Web of Science ®Google Scholar
• Choy KW, Lau YS, Murugan D, et al. Chronic treatment with paeonol improves endothelial function in mice through inhibition of endoplasmic reticulum stress-mediated oxidative stress. PloS One. 2017;12(May):e0178365. PubMed PMID: 28562691; PubMed Central PMCID: PMCPmc5451063. eng.
   PubMedGoogle Scholar
• Fu PK, Wu CL, Tsai TH, et al. Anti-inflammatory and anticoagulative effects of paeonol on LPS-induced acute lung injury in rats. Evid Based Complement Alternat Med. 2012;2012:837513. PubMed PMID: 22454687; PubMed Central PMCID: PMCPmc3291481. eng.
   PubMed Web of Science ®Google Scholar
• Zhang LH, Xiao PG, Huang Y. Recent progresses in pharmacological and clinical studies of paeonol. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1996 Mar;16:187–190. PubMed PMID: 9208544; chi.
   PubMedGoogle Scholar
• Ding Y, Li Q, Xu Y, et al. Attenuating oxidative stress by paeonol protected against acetaminophen-induced hepatotoxicity in mice. PLoS One. 2016;11(May):e0154375. PubMed PMID: 27144271; PubMed Central PMCID: PMCPmc4856301. eng.
   PubMedGoogle Scholar
• Shi X, Chen YH, Liu H, et al. Therapeutic effects of paeonol on methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid-induced Parkinson’s disease in mice. Mol Med Rep. 2016 Sep;14:2397–2404. PubMed PMID: 27484986; PubMed Central PMCID: PMCPmc4991680. eng.
   PubMed Web of Science ®Google Scholar
• Liu J, Wang S, Feng L, et al. Hypoglycemic and antioxidant activities of paeonol and its beneficial effect on diabetic encephalopathy in streptozotocin-induced diabetic rats. J Med Food. 2013 Jul;16:577–586. PubMed PMID: 23875897; eng.
   PubMed Web of Science ®Google Scholar
• Liu J, Shen HM, Ong CN. Role of intracellular thiol depletion, mitochondrial dysfunction and reactive oxygen species in salvia miltiorrhiza-induced apoptosis in human hepatoma HepG2 cells. Life Sci. 2001 Sep 7;69:1833–1850. PubMed PMID: 11693264; eng.
   PubMed Web of Science ®Google Scholar
• Tang Y, Wang M, Le X, et al. Antioxidant and cardioprotective effects of Danshensu (3-(3, 4-dihydroxyphenyl)-2-hydroxy-propanoic acid from salvia miltiorrhiza) on isoproterenol-induced myocardial hypertrophy in rats. Phytomedicine. 2011 Sep;18:1024–1030. PubMed PMID: 21665454; eng.
   PubMed Web of Science ®Google Scholar
• Li H, Xie YH, Yang Q, et al. Cardioprotective effect of paeonol and danshensu combination on isoproterenol-induced myocardial injury in rats. PloS One. 2012;7:e48872. PubMed PMID: 23139821; PubMed Central PMCID: PMCPmc3490947. eng.
   PubMed Web of Science ®Google Scholar
• Ma L, Chuang CC, Weng W, et al. Paeonol protects rat heart by improving regional blood perfusion during no-reflow. Front Physiol. 2016 Jul;7:298. PubMed PMID: 27493631; PubMed Central PMCID: PMCPmc4954854. eng.
   PubMed Web of Science ®Google Scholar
• Zhang JY, Zhao L, Li YK, et al. Effect of paeonol on blood pressure and blood flow in artery of spontaneously hypertensive rats and its mechanisms related on vasomotion. Zhongguo Zhong Yao Za Zhi. 2015 Dec;40:4903–4907. PubMed PMID: 27245041; chi.
   PubMedGoogle Scholar
• Sandoo A, van Zanten JJ, Metsios GS, et al. The endothelium and its role in regulating vascular tone. Open Cardiovasc Med J. 2010 Dec 23;4:302–312. PubMed PMID: 21339899; PubMed Central PMCID: PMCPmc3040999. eng.
   PubMedGoogle Scholar
• Yao H, Ago T, Kitazono T, et al. NADPH oxidase-related pathophysiology in experimental models of stroke. Int J Mol Sci. 2017 Oct 11;18:2123. PubMed PMID: 29019942; PubMed Central PMCID: PMCPmc5666805. eng.
   Web of Science ®Google Scholar
• Sarkar O, Li Y, Anand-Srivastava MB. Nitric oxide attenuates overexpression of Gialpha proteins in vascular smooth muscle cells from SHR: role of ROS and ROS-mediated signaling. PloS One. 2017;12:e0179301. PubMed PMID: 28692698; PubMed Central PMCID: PMCPmc5503203. eng.
   PubMed Web of Science ®Google Scholar
• Hosoo S, Koyama M, Kato M, et al. The restorative effects of eucommia ulmoides oliver leaf extract on vascular function in spontaneously hypertensive rats. Molecules. 2015 Dec 9;20:21971–21981. PubMed PMID: 26690110; PubMed Central PMCID: PMCPmc6331908. eng.
   PubMed Web of Science ®Google Scholar
• Hu J, Li YL, Li ZL, et al. Chronic supplementation of paeonol combined with danshensu for the improvement of vascular reactivity in the cerebral basilar artery of diabetic rats. Int J Mol Sci. 2012 Nov;13:14565–14578. PubMed PMID: 23203081; PubMed Central PMCID: PMCPmc3509597. eng.
   PubMed Web of Science ®Google Scholar
• Yang Q, Wang S, Xie Y, et al. Effect of salvianolic acid B and paeonol on blood lipid metabolism and hemorrheology in myocardial ischemia rabbits induced by pituitruin. Int J Mol Sci. 2010 Sep;11:3696–3704. PubMed PMID: 21152295; PubMed Central PMCID: PMCPmc2996798. eng.
   PubMed Web of Science ®Google Scholar
• Chen Y, Liu Z, Zhou F, et al. Evaluating pharmacological effects of two major components of Shuangdan oral liquid: role of Danshensu and Paeonol in diabetic nephropathy rat. Biomol Ther (Seoul). 2016 Sep;24:536–542. PubMed PMID: 27582557; PubMed Central PMCID: PMCPmc5012880. eng.
   PubMed Web of Science ®Google Scholar
• Sechi LA, Zingaro L, Catena C, et al. Relationship of fibrinogen levels and hemostatic abnormalities with organ damage in hypertension. Hypertension. 2000 Dec;36:978–985. PubMed PMID: 11116111; eng.
   PubMed Web of Science ®Google Scholar
• Lip GY, Foster W, Blann AD. Plasma von Willebrand factor levels and surrogates of atherosclerosis. J Thromb Haemost. 2005 Apr;3:659–661. PubMed PMID: 15842350; eng.
   PubMed Web of Science ®Google Scholar
• Yatabe J, Sanada H, Midorikawa S, et al. Effects of decreased renal cortical expression of G protein-coupled receptor kinase 4 and angiotensin type 1 receptors in rats. Hypertens Res. 2008 Jul;31:1455–1464. PubMed PMID: 18957817; PubMed Central PMCID: PMCPmc3731072. eng.
   PubMed Web of Science ®Google Scholar
• Lariviere R, Thibault G, Schiffrin EL. Increased endothelin-1 content in blood vessels of deoxycorticosterone acetate-salt hypertensive but not in spontaneously hypertensive rats. Hypertension. 1993 Mar;21:294–300. PubMed PMID: 8478038; eng.
   PubMed Web of Science ®Google Scholar
• Tonelli AR, Haserodt S, Aytekin M, et al. Nitric oxide deficiency in pulmonary hypertension: pathobiology and implications for therapy. Pulm Circ. 2013 Jan;3:20–30. PubMed PMID: 23662172; PubMed Central PMCID: PMCPmc3641730. eng.
   PubMed Web of Science ®Google Scholar
• Ago T, Kitazono T, Ooboshi H, et al. Nox4 as the major catalytic component of an endothelial NAD(P)H oxidase. Circulation. 2004 Jan;109:227–233. PubMed PMID: 14718399; eng.
   PubMed Web of Science ®Google Scholar
• Bedard K, Krause KH. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev. 2007 Jan;87:245–313. PubMed PMID: 17237347; eng.
   PubMed Web of Science ®Google Scholar
• Paravicini TM, Chrissobolis S, Drummond GR, et al. Increased NADPH-oxidase activity and Nox4 expression during chronic hypertension is associated with enhanced cerebral vasodilatation to NADPH in vivo. Stroke. 2004 Feb;35:584–589. PubMed PMID: 14739416; eng.
   PubMed Web of Science ®Google Scholar
• Ono H, Ichiki T, Ohtsubo H, et al. CAMP-response element-binding protein mediates tumor necrosis factor-alpha-induced vascular cell adhesion molecule-1 expression in endothelial cells. Hypertens Res. 2006 Jan;29:39–47. PubMed PMID: 16715652; eng.
   PubMed Web of Science ®Google Scholar
• Pan LL, Dai M. Paeonol from Paeonia suffruticosa prevents TNF-alpha-induced monocytic cell adhesion to rat aortic endothelial cells by suppression of VCAM-1 expression. Phytomedicine. 2009 Nov;16:1027–1032. PubMed PMID: 19541467; eng.
   PubMed Web of Science ®Google Scholar
• Cheng YC, Sheen JM, Hu WL, et al. Polyphenols and oxidative stress in atherosclerosis-related ischemic heart disease and stroke. Oxid Med Cell Longev. 2017;2017:8526438. PubMed PMID: 29317985.
   PubMed Web of Science ®Google Scholar
• Armario P, Waeber B. Therapeutic strategies to improve control of hypertension. J Hypertens. 2013 Mar;31(Suppl 1):S9–S12. PubMed PMID: 23389085; eng.
   PubMed Web of Science ®Google Scholar
• Rubio-Guerra AF, Duran-Salgado MB. Recommendations for the treatment of hypertension in elderly people. Cardiovasc Hematol Agents Med Chem. 2015;12:146–151. PubMed PMID: 25761106; eng.
   PubMedGoogle Scholar
• Stewart MH, Lavie CJ, Ventura HO. Emerging therapy in hypertension. Current hypertension reports. Curr Hypertens Rep. 2019 Mar;21:23. PubMed PMID: 30826948; eng.
   PubMed Web of Science ®Google Scholar
• Touyz RM. Reactive oxygen species, vascular oxidative stress, and redox signaling in hypertension: what is the clinical significance? Hypertension. 2004 Sep;44:248–252. PubMed PMID: 15262903; eng.
   PubMed Web of Science ®Google Scholar
• Rincon J, Correia D, Arcaya JL, et al. Role of Angiotensin II type 1 receptor on renal NAD(P)H oxidase, oxidative stress and inflammation in nitric oxide inhibition induced-hypertension. Life Sci. 2015 Mar;124:81–90. PubMed PMID: 25623850; PubMed Central PMCID: PMCPmc6037991. eng.
   PubMed Web of Science ®Google Scholar
• Forstermann U, Munzel T. Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation. 2006 Apr;113:1708–1714. PubMed PMID: 16585403; eng.
   PubMed Web of Science ®Google Scholar
• Khattab M, Ahmad M, Al-Shabanah OA, et al. Effects of losartan on blood pressure, oxidative stress, and nitrate/nitrite levels in the nitric oxide deficient hypertensive rats. Recept Channels. 2004;10:147–157. PubMed PMID: 15989079; eng.
   PubMedGoogle Scholar