340
Views
2
CrossRef citations to date
0
Altmetric
Biochemistry & Molecular Biology

Overexpressing of POU2F2 accelerates fracture healing via regulating HMGA1/Wnt/β-catenin signaling pathway

, , &
Pages 491-499 | Received 26 Jul 2019, Accepted 12 Nov 2019, Published online: 29 Nov 2019

References

  • Einhorn TA, Gerstenfeld LC. Fracture healing: mechanisms and interventions. Nat Rev Rheumatol. 2015;11:45–54.
  • O’Keefe RJ. Fibrinolysis as a target to enhance fracture healing. N Engl J Med. 2015;373:1776–1778.
  • Chandra A, Lan S, Zhu J, et al. Epidermal growth factor receptor (EGFR) signaling promotes proliferation and survival in osteoprogenitors by increasing early growth response 2 (EGR2) expression. J Biol Chem. 2013;288:20488–20498.
  • Berasain C, Avila MA. Amphiregulin. Semin Cell Dev Biol. 2014;28:31–41.
  • Griffin XL, Costa ML, Parsons N, et al. (2011) Electromagnetic field stimulation for treating delayed union or non-union of long bone fractures in adults, The Cochrane database of systematic reviews, CD008471.
  • Hatzopoulos AK, Stoykova AS, Erselius JR, et al. Structure and expression of the mouse Oct2a and Oct2b, two differentially spliced products of the same gene. Development. 1990;109:349–362.
  • Tang H, Sharp PA. Transcriptional regulation of the murine 3ʹ IgH enhancer by OCT-2. Immunity. 1999;11:517–526.
  • Chiefari E, Arcidiacono B, Possidente K, et al. Transcriptional regulation of the HMGA1 gene by octamer-binding proteins Oct- 1and Oct-2. PloS One. 2013;8:e83969.
  • Kang SM, Tsang W, Doll S, et al. Induction of the POU domain transcription factor Oct- 2during T-cell activation by cognate antigen. Mol Cell Biol. 1992;12:3149–3154.
  • Zhang J. Bioinformatics analysis of novel transcription factors and related differentially regulated modules in non-union skeletal fractures. J Back Musculoskelet Rehabil. 2018;31:623–628.
  • Chiappetta G, Avantaggiato V, Visconti R, et al. High level expression of the HMGI (Y) gene during embryonic development. Oncogene. 1996;13:2439–2446.
  • Fedele M, Fusco A. Role of the high mobility group A proteins in the regulation of pituitary cell cycle. J Mol Endocrinol. 2010;44:309–318.
  • Schuldenfrei A, Belton A, Kowalski J, et al. HMGA1 drives stem cell, inflammatory pathway, and cell cycle progression genes during lymphoid tumorigenesis. BMC Genomics. 2011;12:549.
  • Giannini G, Kim CJ, Di Marcotullio L, et al. Expression of the HMGI(Y) gene products in human neuroblastic tumours correlates with differentiation status. Br J Cancer. 2000;83:1503–1509.
  • Sgarra R, Diana F, Rustighi A, et al. Increase of HMGA1a protein methylation is a distinctive characteristic of leukaemic cells induced to undergo apoptosis. Cell Death Differ. 2003;10:386–389.
  • Ha TK, Her NG, Lee MG, et al. Caveolin-1 increases aerobic glycolysis in colorectal cancers by stimulating HMGA1-mediated GLUT3 transcription. Cancer Res. 2012;72:4097–4109.
  • Murata K, Ito H, Yoshitomi H, et al. Inhibition of miR-92a enhances fracture healing via promoting angiogenesis in a model of stabilized fracture in young mice. J Bone Miner Res. 2014;29:316–326.
  • Xian L, Georgess D, Huso T, et al. HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche. Nat Commun. 2017;8:15008.
  • Nelson FR, Brighton CT, Ryaby J, et al. Use of physical forces in bone healing. J Am Acad Orthop Surg. 2003;11:344–354.
  • Crockett JC, Rogers MJ, Coxon FP, et al. Bone remodelling at a glance. J Cell Sci. 2011;124:991–998.
  • Saito M, Tanaka S, Mori A, et al. Primary gastric Hodgkin’s lymphoma expressing a B-Cell profile including Oct- 2and Bob-1 proteins. Int J Hematol. 2007;85:421–425.
  • Robinson AR, Kwek SS, Kenney SC. The B-cell specific transcription factor, Oct-2, promotes Epstein-Barr virus latency by inhibiting the viral immediate-early protein, BZLF1. PLoS Pathog. 2012;8:e1002516.
  • Garcia-Cosio M, Santon A, Martin P, et al. Analysis of transcription factor OCT.1, OCT.2 and BOB.1 expression using tissue arrays in classical Hodgkin’s lymphoma. Mod Pathol. 2004;17:1531–1538.
  • Wang SM, Tie J, Wang WL, et al. POU2F2-oriented network promotes human gastric cancer metastasis. Gut. 2016;65:1427–1438.
  • Takeda S, Bonnamy JP, Owen MJ, et al. Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice. Genes Dev. 2001;15:467–481.
  • Zheng Q, Zhou G, Morello R, et al. Type X collagen gene regulation by Runx2 contributes directly to its hypertrophic chondrocyte-specific expression in vivo. J Cell Biol. 2003;162:833–842.
  • Lee CH, Huang YL, Liao JF, et al. Ugonin K promotes osteoblastic differentiation and mineralization by activation of p38 MAPK- and ERK-mediated expression of Runx2 and osterix. Eur J Pharmacol. 2011;668:383–389.
  • Gao X, Ge J, Li W, et al. LncRNA KCNQ1OT1 promotes osteogenic differentiation to relieve osteolysis via Wnt/beta-catenin activation. Cell Biosci. 2018;8:19.
  • Bustin M. Revised nomenclature for high mobility group (HMG) chromosomal proteins. Trends Biochem Sci. 2001;26:152–153.
  • Catez F, Yang H, Tracey KJ, et al. Network of dynamic interactions between histone H1 and high-mobility-group proteins in chromatin. Mol Cell Biol. 2004;24:4321–4328.
  • Pegoraro S, Ros G, Piazza S, et al. HMGA1 promotes metastatic processes in basal-like breast cancer regulating EMT and stemness. Oncotarget. 2013;4:1293–1308.
  • Thuault S, Valcourt U, Petersen M, et al. Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition. J Cell Biol. 2006;174:175–183.
  • Morishita A, Zaidi MR, Mitoro A, et al. HMGA2 is a driver of tumor metastasis. Cancer Res. 2013;73:4289–4299.
  • Sgarra R, Pegoraro S, Ros G, et al. High Mobility Group A (HMGA) proteins: molecular instigators of breast cancer onset and progression. Biochim Biophys Acta Rev Cancer. 2018;1869:216–229.
  • Vortkamp A, Pathi S, Peretti GM, et al. Recapitulation of signals regulating embryonic bone formation during postnatal growth and in fracture repair. Mech Dev. 1998;71:65–76.
  • Ellegaard M, Jørgensen NR, Schwarz P. Parathyroid hormone and bone healing. Calcif Tissue Int. 2010;87:1–13.
  • Tsuji K, Bandyopadhyay A, Harfe BD, et al. BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. Nat Genet. 2006;38:1424–1429.
  • Huang Y, Zhang X, Du K, et al. Inhibition of beta-catenin signaling in chondrocytes induces delayed fracture healing in mice. J Orthop Res. 2012;30:304–310.
  • Zhang W, Xue D, Yin H, et al. Overexpression of HSPA1A enhances the osteogenic differentiation of bone marrow mesenchymal stem cells via activation of the Wnt/beta-catenin signaling pathway. Sci Rep. 2016;6:27622.
  • Kubota T, Michigami T, Ozono K. Wnt signaling in bone. Clin Pediatr Endocrinol. 2010;19:49–56.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.