Bulleyaconitine A inhibits the lung inflammation and airway remodeling through restoring Th1/Th2 balance in asthmatic model mice

References

• Papi A, Brightling C, Pedersen SE, et al. Asthma. Lancet. 2018 Feb 24;391(10122):783–800. PubMed PMID: 29273246; eng.
   PubMed Web of Science ®Google Scholar
• Svenningsen S, Nair P. Asthma endotypes and an overview of targeted therapy for asthma. Front Med (Lausanne). 2017;4:158. PubMed PMID: 29018800; PubMed Central PMCID: PMCPMC5622943.
   PubMed Web of Science ®Google Scholar
• Sethi GS, Sharma S, Naura AS. PARP inhibition by olaparib alleviates chronic asthma-associated remodeling features via modulating inflammasome signaling in mice. IUBMB Life. 2019 Jul;71(7):1003–1013. PubMed PMID: 30964965.
   PubMed Web of Science ®Google Scholar
• Cui J, Xu F, Tang Z, et al. Bu-Shen-Yi-Qi formula ameliorates airway remodeling in murine chronic asthma by modulating airway inflammation and oxidative stress in the lung. Biomed Pharmacother. 2019 Apr;112:108694. PubMed PMID: 30798140.
   PubMed Web of Science ®Google Scholar
• Lambrecht BN, Hammad H, Fahy JV. The cytokines of asthma. Immunity. 2019 Apr 16;50(4):975–991. PubMed PMID: 30995510; eng.
   PubMed Web of Science ®Google Scholar
• Fehrenbach H, Wagner C, Wegmann M. Airway remodeling in asthma: what really matters. Cell Tissue Res. 2017 Mar;367(3):551–569. PubMed PMID: 28190087; PubMed Central PMCID: PMCPMC5320023. eng.
   PubMed Web of Science ®Google Scholar
• Quirt J, Hildebrand KJ, Mazza J, et al. Asthma. Allergy Asthma Clin Immunol. 2018;14(Suppl 2):50. PubMed PMID: 30275843; PubMed Central PMCID: PMCPMC6157154. eng.
   PubMedGoogle Scholar
• Loureiro CC, Amaral L, Ferreira JA, et al. Omalizumab for severe asthma: beyond allergic asthma. Biomed Res Int. 2018;2018:3254094. PubMed PMID: 30310816; PubMed Central PMCID: PMCPMC6166383.
   PubMed Web of Science ®Google Scholar
• Zhu HQ, Xu J, Shen KF, et al. Bulleyaconitine A depresses neuropathic pain and potentiation at C-fiber synapses in spinal dorsal horn induced by paclitaxel in rats. Exp Neurol. 2015 Nov;273:263–272. PubMed PMID: 26376216; eng.
   PubMed Web of Science ®Google Scholar
• Xie MX, Zhu HQ, Pang RP, et al. Mechanisms for therapeutic effect of bulleyaconitine A on chronic pain. Mol Pain. 2018 Jan-Dec;14:1744806918797243. PubMed PMID: 30180777; PubMed Central PMCID: PMCPMC6125851.
   Web of Science ®Google Scholar
• Xie MX, Pang RP, Yang J, et al. Bulleyaconitine A preferably reduces tetrodotoxin-sensitive sodium current in uninjured dorsal root ganglion neurons of neuropathic rats probably via inhibition of protein kinase C. Pain. 2017 Nov;158(11):2169–2180. PubMed PMID: 28915149.
   PubMed Web of Science ®Google Scholar
• Li TF, Wu HY, Wang YR, et al. Molecular signaling underlying bulleyaconitine A (BAA)-induced microglial expression of prodynorphin. Sci Rep. 2017 Mar 22;7:45056. PubMed PMID: 28327597; PubMed Central PMCID: PMCPMC5361206.
   PubMed Web of Science ®Google Scholar
• Li TF, Fan H, Wang YX. Aconitum-derived bulleyaconitine a exhibits antihypersensitivity through direct stimulating dynorphin a expression in spinal microglia. J Pain. 2016 May;17(5):530–548. . PubMed PMID: 26762790; eng.
   PubMed Web of Science ®Google Scholar
• Zhan X, Zhang W, Sun T, et al. Bulleyaconitine A effectively relieves allergic lung inflammation in a murine asthmatic model. Med Sci Monit. 2019 Mar 4;25:1656–1662. PubMed PMID: 30828084; PubMed Central PMCID: PMCPMC6413559.
   PubMed Web of Science ®Google Scholar
• Huang Z, Zhou X, Zhang J, et al. Bulleyaconitine A inhibits itch and itch sensitization induced by histamine and chloroquine. Neuroscience. 2020 Mar 1;429:68–77. PubMed PMID: 31935491; eng.
   PubMed Web of Science ®Google Scholar
• Xie MX, Yang J, Pang RP, et al. Bulleyaconitine A attenuates hyperexcitability of dorsal root ganglion neurons induced by spared nerve injury: the role of preferably blocking Nav1.7 and Nav1.3 channels. Mol Pain. 2018 Jan-Dec;14:1744806918778491. PubMed PMID: 29783906; PubMed Central PMCID: PMCPMC5967161. eng.
   Web of Science ®Google Scholar
• Wang J, Diao X, Zhu H, et al. Effect of tiotropium bromide on airway inflammation and programmed cell death 5 in a mouse model of ovalbumin-induced allergic asthma. Can Respir J. 2019;2019:6462171. PubMed PMID: 31662808; PubMed Central PMCID: PMCPMC6791200. eng.
   PubMed Web of Science ®Google Scholar
• Toumpanakis D, Loverdos K, Tzouda V, et al. Tiotropium bromide exerts anti-inflammatory effects during resistive breathing, an experimental model of severe airway obstruction. Int J Chron Obstruct Pulmon Dis. 2017;12:2207–2220. PubMed PMID: 28814849; PubMed Central PMCID: PMCPMC5546183. eng.
   PubMed Web of Science ®Google Scholar
• Gon Y, Hashimoto S. Role of airway epithelial barrier dysfunction in pathogenesis of asthma. Allergol Int. 2018 Jan;67(1):12–17. . PubMed PMID: 28941636.
   PubMed Web of Science ®Google Scholar
• Fahy JV. Type 2 inflammation in asthma–present in most, absent in many. Nat Rev Immunol. 2015 Jan;15(1):57–65. PubMed PMID: 25534623; PubMed Central PMCID: PMCPMC4390063. eng.
   PubMed Web of Science ®Google Scholar
• Ano S, Panariti A, Allard B, et al. Inflammation and airway hyperresponsiveness after chlorine exposure are prolonged by Nrf2 deficiency in mice. Free Radic Biol Med. 2017 Jan;102:1–15. PubMed PMID: 27847240.
   PubMed Web of Science ®Google Scholar
• Amin K. The role of the T lymphocytes and remodeling in asthma. Inflammation. 2016 Aug;39(4):1475–1482. PubMed PMID: 27221139.
   PubMed Web of Science ®Google Scholar
• Kawayama T, Kinoshita T, Matsunaga K, et al. Role of regulatory T cells in airway inflammation in asthma. Kurume Med J. 2018 Apr 27;64(3):45–55. PubMed PMID: 29553094.
   PubMedGoogle Scholar
• Boulet LP. Airway remodeling in asthma: update on mechanisms and therapeutic approaches. Curr Opin Pulm Med. 2018 Jan;24(1):56–62. PubMed PMID: 29076828; eng.
   PubMed Web of Science ®Google Scholar
• Zhao ST, Wang CZ. Regulatory T cells and asthma. J Zhejiang Univ Sci B. 2018 Sept;19(9):663–673. PubMed PMID: 30178633; PubMed Central PMCID: PMCPMC6137416.
   PubMed Web of Science ®Google Scholar
• Robinson DS. The role of the T cell in asthma. J Allergy Clin Immunol. 2010 Dec;126(6):1081–91; quiz 1092–3. PubMed PMID: 20709383.
   Web of Science ®Google Scholar
• Deo SS, Mistry KJ, Kakade AM, et al. Role played by Th2 type cytokines in IgE mediated allergy and asthma. Lung India. 2010 Apr;27(2):66–71. PubMed PMID: 20616938; PubMed Central PMCID: PMCPMC2893428.
   PubMedGoogle Scholar
• Nakagome K, Nagata M. Involvement and possible role of eosinophils in asthma exacerbation. Front Immunol. 2018;9:2220. PubMed PMID: 30323811; PubMed Central PMCID: PMCPMC6172316.
   PubMed Web of Science ®Google Scholar
• Kay AB. TH2-type cytokines in asthma. Ann N Y Acad Sci. 1996 Oct 31;796:1–8.
   PubMed Web of Science ®Google Scholar
• Shi YH, Shi GC, Wan HY, et al. Coexistence of Th1/Th2 and Th17/Treg imbalances in patients with allergic asthma. Chin Med J (Engl). 2011 Jul 5;124(13):1951–1956. PubMed PMID: 22088452.
   PubMed Web of Science ®Google Scholar
• Chesne J, Braza F, Mahay G, et al. IL-17 in severe asthma. Where do we stand? Am J Respir Crit Care Med. 2014 Nov 15;190(10):1094–1101. PubMed PMID: 25162311; eng.
   PubMed Web of Science ®Google Scholar
• Woodfolk JA. Cytokines as a therapeutic target for allergic diseases: a complex picture. Curr Pharm Des. 2006;12(19):2349–2363. PubMed PMID: 16842183; eng.
   PubMed Web of Science ®Google Scholar
• Diao M, Min J, Guo F, et al. Effects of salbutamol aerosol combined with magnesium sulfate on T-lymphocyte subgroup and Th1/Th2 cytokines of pediatric asthma. Exp Ther Med. 2017 Jan;13(1):117–120. PubMed PMID: 28123478; PubMed Central PMCID: PMCPMC5245138.
   PubMed Web of Science ®Google Scholar
• Larche M, Robinson DS, Kay AB. The role of T lymphocytes in the pathogenesis of asthma. J Allergy Clin Immunol. 2003 Mar;111(3):450–63; quiz 464. PubMed PMID: 12642820; eng.
   PubMed Web of Science ®Google Scholar