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Articles

Synthesis, characterizations, in vitro and in vivo evaluation of Etoricoxib-loaded Poly (Caprolactone) microparticles – a potential Intra-articular drug delivery system for the treatment of Osteoarthritis

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Pages 303-316 | Received 13 Sep 2015, Accepted 25 Nov 2015, Published online: 11 Jan 2016

References

  • Sarzi-Puttini P, Cimmino MA, Scarpa R, et al. Osteoarthritis: an overview of the disease and its treatment strategies. Semin. Arthritis. Rheum. 2005;35:1–10.
  • Hunter DJ, McDougall JJ, Keefe FJ. The symptoms of osteoarthritis and the genesis of pain. Rheum. Dis. Clin. N. Am. 2008;34:623–643.
  • Vonkeman HE, van de Laar MA. Nonsteroidal anti-inflammatory drugs: adverse effects and their prevention. Semin. Arthritis. Rheum. 2010;39:294–312.
  • Laine L, White WB, Rostom A, et al. COX-2 selective inhibitors in the treatment of osteoarthritis. Semin. Arthritis. Rheum. 2008;38:165–187.
  • Bingham CO, Bird SS, Smugar SS, et al. Responder analysis and correlation of outcome measures: pooled results from two identical studies comparing etoricoxib, celecoxib, and placebo in osteoarthritis. Osteoarthr. Cartil. 2008;16:1289–1293.
  • Zarraga IG, Schwarz ER. Coxibs and heart disease. What we have learned and what else we need to know. J. Am. Coll. Cardiol. 2007;49:1–14.
  • Lin JH, Cocchetto DM, Duggan DE. Protein binding as a primary determinant of the clinical pharmacokinetic properties of non-steroidal anti-inflammatory drugs. Clin. Pharmacokinet. 1987;12:402–432.
  • Gerwin N, Hops C, Lucke A. Intraarticular drug delivery in osteoarthritis. Adv. Drug Deliv. Rev. 2006;58:226–242.
  • Larsen C, Ostergaard J, Larsen SW, et al. Intra-articular depot formulation principles: role in the management of postoperative pain and arthritic disorders. J. Pharm. Sci. 2008;97:4622–4654.
  • Edwards S. Intra-articular drug delivery: the challenge to extend drug residence time within the joint. Vet. J. 2011;190:15–21.
  • Abramson S. Drug delivery in degenerative joint disease: where we are and where to go? Adv. Drug Deliv. Rev. 2006;58:125–127.
  • Saltzman WM, Weiser JR. Controlled release for local delivery of drugs: barriers and models. J. Control. Release. 2014;190:664–673.
  • Kyllonen L, D’Este M, Alini M, et al. Local drug delivery for enhancing fracture healing in osteoporotic bone. Acta Biomater. 2015;11:412–434.
  • Okada H, Toguchi H. Biodegradable microspheres in drug delivery. Crit. Rev. Ther. Drug Carrier Syst. 1995;12:1–99.
  • Prajapati VD, Jani GK, Kapadia JR. Current knowledge on biodegradable microspheres in drug delivery. Expert Opin. Drug Deliv. 2015;12:1283–1299.
  • Campos E, Branquinho J, Carreira AS, et al. Designing polymeric microparticles for biomedical and industrial applications. Eur. Polym. J. 2013;49:2005–2021.
  • Dash TK, V. Konkimalla B. Poly-є-caprolactone based formulations for drug delivery and tissue engineering: a review. J. Control Release. 2012; 158: 15–33.
  • Sinha VR, Bansal K, Kaushik R, et al. Poly–caprolactone microspheres and nanospheres: an overview. Int. J. Pharm. 2004;278:1–23.
  • Woodruff MA, Hutmacher DW. The return of a forgotten polymer – Polycaprolactone in the 21st century. Prog. Polym. Sci. 2010;35:1217–1256.
  • Aberturas MR, Molpeceres J, Guzman M, et al. Development of a new cyclosporine formulation based on poly (caprolactone) microspheres. J. Microencapsul. 2002;19:61–72.
  • Hernan D, Ossa P, Ligresti A, et al. Poly ε-caprolactone microspheres as a drug delivery system for cannabinoid administration: development, characterization and in vitro evaluation of their antitumoral efficacy. J. Control. Release. 2012;161:927–932.
  • Jeong J, Lee J, Cho K. Effects of crystalline microstructure on drug release behavior of poly (ε-caprolactone) microspheres. J. Control. Release. 2003;92:249–258.
  • Ramakrishna NVS, Vishwottam KN, Wishu S, et al. Validated liquid chromatographic ultraviolet method for the quantitation of Etoricoxib in human plasma using liquid–liquid extraction. J. Chromatogr. B. 2005;816:215–221.
  • Brautigam L, Nefflen JU, Geisslinger G. Determination of etoricoxib in human plasma by liquid chromatography–tandem mass spectrometry with electrospray ionization. J. Chromatogr. B. 2003;788:309–315.
  • Rafati H, Coombes AGA, Adler J, et al. Protein-loaded poly(DL-lactide-co-glycolide) microparticles for oral administration: formulation, structural and release characteristics. J. Control. Release. 1997;43:89–102.
  • Zidan AS, Sammour OA, Hammad MA, et al. Formulation of anastrozole microparticles as biodegradable anticancer drug carriers. AAPS Pharmscitech. 2006;7:3.
  • Vyslouzil J, Dolezel P, Kejdusova M, et al. Influence of different formulations and process parameters during the preparation of drug-loaded PLGA microspheres evaluated by multivariate data analysis. Acta Pharm. 2014;64:403–417.
  • Elzein T, Nasser-Eddine M, Delaite C, et al. FTIR study of polycaprolactone chain organization at interfaces. J. Colloid Interface Sci. 2004;273:381–387.
  • Suganya S, Senthilram T, Lakshmi BS, et al. Drug incorporated antibacterial nanofibrous mat fabricated by electrospinning: an excellent matrix for wound dressings. J. Appl. Polym. Sci. 2011;121:2893–2899.
  • Coleman MM, Zarian J. Fourier-transform infrared studies of polymer blends. Poly (Ɛ-caprolactone)–poly (vinyl chloride) system. J. Polym. Sci. Part B: Polym. Phys. 1979;17:837–850.
  • Patel HM, Bhanubhai NS, Shailesh AS, et al. Preparation and characterization of etoricoxib-β-cyclodextrin complexes prepared by the kneading method. Acta Pharm. 2007;57:351–359.
  • Gonzalez MF, Ruseckaite RA, Cuadrado TR. Structural changes of polylactic-acid (PLA) microspheres under hydrolytic degradation. J. Appl. Polym. Sci. 1999;71:1223–1230.
  • Perez MH, Zinutti C, Lamprecht A, et al. The preparation and evaluation of poly (caprolactone) microparticles containing both a lipophilic and a hydrophilic drug. J. Control. Release. 2000;65:429–438.
  • Bhaskar C, Shyam S, Anant P. Preparation and characterization of Etoricoxib solid dispersions using lipid carriers by spray drying technique. AAPS PharmSciTech. 2005;6:3.
  • Almeida MA, Jessica MN, Grassiolli S, et al. Enhanced gastric tolerability and improved anti-obesity effect of capsaicinoids-loaded PCL microparticles. Mater. Sci. Eng., C. 2014;40:345–356.
  • Korsmeyer RW, Gurny R, Doelker EM, et al. Mechanism of solute release from porous hydrophilic polymers. Int. J. Pharm. 1983;15:25–35.
  • Chen Z, Liu W, Liu D, et al. Development of brucine-loaded microsphere/thermally responsive hydrogel combination system for intra-articular administration. J. Control. Release. 2012;162:628–635.

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