Synergistic effect of PEGylation and pentoxifylline addition on immunoprotection of pancreatic islets

References

• Lakey JR, Mirbolooki M, Shapiro AM. Current status of clinical islet cell transplantation. Methods Mol Biol. 2006;333:47–104.
   PubMedGoogle Scholar
• O’Sullivan ES, Vegas A, Anderson DG, et al. Islets transplanted in immunoisolation devices: a review of the progress and the challenges that remain. Endocr Rev. 2011;32:827–844.10.1210/er.2010-0026
   PubMed Web of Science ®Google Scholar
• Meier RP, Sert I, Morel P, et al. Islet of Langerhans isolation from pediatric and juvenile donor pancreases. Transpl Int. 2014;27:949–955.10.1111/tri.2014.27.issue-9
   PubMed Web of Science ®Google Scholar
• Wang P, Schuetz C, Ross A, et al. Immune rejection after pancreatic islet cell transplantation: in vivo dual contrast-enhanced MR imaging in a mouse model. Radiology. 2013;266:822–830.10.1148/radiol.12121129
   PubMed Web of Science ®Google Scholar
• Sarhane KA, Ibrahim Z, Leto Barone AA, et al. Minimization of immunosuppression and tolerance induction in reconstructive transplantation. Curr Surg Rep. 2013;1:40–46.10.1007/s40137-012-0008-4
   Google Scholar
• Danielson KK, Hatipoglu B, Kinzer K, et al. Reduction in carotid intima-media thickness after pancreatic islet transplantation in patients with type 1 diabetes. Diabetes Care. 2013;36:450–456.10.2337/dc12-0679
   PubMed Web of Science ®Google Scholar
• Aghajani-Lazarjani H, Vasheghani-Farahani E, Shojaosadati SA, et al. The effect of two different polyethylene glycol (PEG) derivatives on the immunological response of PEG grafted pancreatic islets. J Artif Organs. 2010;13:218–224.10.1007/s10047-010-0525-9
   PubMed Web of Science ®Google Scholar
• Liu M, Xu M, Loh XJ, et al. PEGylated antibody in organic media. J Biosci Bioeng. 2011;111:564–568.10.1016/j.jbiosc.2011.01.001
   PubMed Web of Science ®Google Scholar
• Jevsevar S, Kunstelj M, Porekar VG. PEGylation of therapeutic proteins. Biotechnol J. 2010;5:113–128.10.1002/biot.v5:1
   PubMed Web of Science ®Google Scholar
• Lee DY, Park SJ, Nam JH, et al. A new strategy toward improving immunoprotection in cell therapy for diabetes mellitus: long-functioning PEGylated islets in vivo. Tissue Eng. 2006;12:615–623.10.1089/ten.2006.12.615
   PubMedGoogle Scholar
• Chen X, Liu Y, Wang L, et al. Enhanced humoral and cell-mediated immune responses generated by cationic polymer-coated PLA microspheres with adsorbed HBsAg. Mol Pharm. 2014;11:1772–1784.10.1021/mp400597z
   PubMed Web of Science ®Google Scholar
• Carlin LM, Yanagi K, Verhoef A, et al. Secretion of IFN-g and not IL-2 by anergic human T cells correlates with assembly of an immature immune synapse. Blood. 2005;106:3874–3879.10.1182/blood-2005-03-0996
   PubMed Web of Science ®Google Scholar
• Lotze MT, Line BR, Mathisen DJ, et al. The in vivo distribution of autologous human and murine lymphoid cells grown in T cell growth factor (TCGF): implications for the adoptive immunotherapy of tumors. J Immunol. 1980;125:1487–1493.
   PubMed Web of Science ®Google Scholar
• Yron I, Wood Jr TA, Spiess PJ, et al. In vitro growth of murine T cells. V. The isolation and growth of lymphoid cells infiltrating syngeneic solid tumors. J Immunol. 1980;125:238–245.
   PubMed Web of Science ®Google Scholar
• Erickson L, Wynn C, Pan F, et al. Microarray gene expression profiling of chronic allograft nephropathy in the rat kidney transplant model. Transpl Immunol. 2012;27:75–82.10.1016/j.trim.2012.06.007
   PubMed Web of Science ®Google Scholar
• Corrales-Tellez E, Vu D, Shah T, et al. Association between granzyme B and perforin I polymorphisms and allograft outcomes in Hispanic kidney transplant recipients. Clin Transplant. 2013;27:E308–E315.10.1111/ctr.2013.27.issue-3
   Google Scholar
• Lacotte S, Berney T, Shapiro AJ, et al. Immune monitoring of pancreatic islet graft: towards a better understanding, detection and treatment of harmful events. Expert Opin Biol Ther. 2011;11:55–66.10.1517/14712598.2011.536530
   PubMed Web of Science ®Google Scholar
• Janas ML, Groves P, Kienzle N, et al. IL-2 regulates perforin and granzyme gene expression in CD8+ T cells independently of its effects on survival and proliferation. J Immunol. 2005;175:8003–8010.10.4049/jimmunol.175.12.8003
   PubMed Web of Science ®Google Scholar
• McCormick BB, Sydor A, Akbari A, et al. The effect of pentoxifylline on proteinuria in diabetic kidney disease: a meta-analysis. Am J Kidney Dis. 2008;52:454–463.10.1053/j.ajkd.2008.01.025
   PubMed Web of Science ®Google Scholar
• Liang L, Beshay E, Prud’homme GJ. The phosphodiesterase inhibitors pentoxifylline and rolipram prevent diabetes in NOD mice. Diabetes. 1998;47:570–575.10.2337/diabetes.47.4.570
   PubMed Web of Science ®Google Scholar
• Hoskin DW, Phu T, Makrigiannis AP. Pentoxifylline inhibits granzyme B and perforin expression following T-lymphocyte activation by anti-CD3 antibody. Int J Immunopharmacol. 1996;18:623–631.10.1016/S0192-0561(96)00069-0
   PubMed Web of Science ®Google Scholar
• Mensah-Brown EP, Stosic Grujicic S, Maksimovic D, et al. Downregulation of apoptosis in the target tissue prevents low-dose streptozotocin-induced autoimmune diabetes. Mol Immunol. 2002;38:941–946.10.1016/S0161-5890(02)00021-4
   PubMed Web of Science ®Google Scholar
• Hsu CY, Norris JW, Hogan EL, et al. Pentoxifylline in acute nonhemorrhagic stroke. A randomized, placebo-controlled double-blind trial. Stroke. 1988;19:716–722.10.1161/01.STR.19.6.716
   PubMed Web of Science ®Google Scholar
• Shaw SM, Shah MK, Williams SG, et al. Immunological mechanisms of pentoxifylline in chronic heart failure. Eur J Heart Fail. 2009;11:113–118.10.1093/eurjhf/hfn040
   PubMed Web of Science ®Google Scholar
• Dong H, Fahmy TM, Metcalfe SM, et al. Immuno-isolation of pancreatic islet allografts using PEGylated nanotherapy leads to long-term normoglycemia in full MHC mismatch recipient mice. PLoS One. 2012;7:1–7.
   Web of Science ®Google Scholar
• Le Y, Scott MD. Immunocamouflage: the biophysical basis of immunoprotection by grafted methoxy poly(ethlyne glycol) (mPEG). Acta Biomater. 2010;6:2631–2641.10.1016/j.actbio.2010.01.031
   PubMed Web of Science ®Google Scholar
• Lacy PE, Kostianovsky M. Method for the isolation of intact islets of Langerhans from the rat pancreas. Diabetes. 1967;16:35–39.10.2337/diab.16.1.35
   PubMed Web of Science ®Google Scholar
• Lazarjani HA, Vasheghani-Farahani E, Barani L, et al. Effect of polymer concentration on camouflaging of pancreatic islets with mPEG-succinimidyl carbonate. Artif Cells Blood Substit Immobil Biotechnol. 2010;38:250–258.10.3109/10731199.2010.488634
   PubMed Web of Science ®Google Scholar
• Bank HL. Rapid assessment of islet viability with acridine orange and propidium iodide. In Vitro Cell Dev Biol. 1988;24:266–273.10.1007/BF02628826
   PubMed Web of Science ®Google Scholar
• Kruisbeek AM. Isolation and fractionation of mononuclear cell populations, isolation of mouse mononuclear cells. Curr Protoc Immunol. 2000;39:3.1.1–3.1.5.
   Google Scholar
• Barani L, Vasheghani‑Farahani E, Lazarjani HA, et al. Effect of molecular mass of methoxypoly(ethylene glycol) activated with succinimidyl carbonate on camouflaging pancreatic islets. Biotechnol Appl Biochem. 2010;57:25–30.10.1042/BA20100145
   PubMed Web of Science ®Google Scholar
• Le Y, Scott MD. Immunocamouflage: the biophysical basis of immunoprotection by grafted methoxypoly(ethylene glycol) (mPEG). Acta Biomater. 2010;6:2631–2641.10.1016/j.actbio.2010.01.031
   PubMed Web of Science ®Google Scholar
• Lee DY, Park SJ, Nam JH, et al. A combination therapy of PEGylation and immunosuppressive agent for successful islet transplantation. J Control Release. 2006;110:290–295.
   PubMed Web of Science ®Google Scholar
• Dibelius A, Königsberger H, Walter P, et al. Prolonged reversal of diabetes in the rat by transplantation of allogeneic islets from a single donor and cyclosporine treatment. Transplantation. 1986;41:426–431.
   PubMed Web of Science ®Google Scholar
• Gotoh M, Maki T, Satomi S, et al. Immunological characteristics of purified pancreatic islet grafts. Transplantation. 1986;42:387–389.10.1097/00007890-198610000-00011
   PubMed Web of Science ®Google Scholar
• Scandling JD, Busque S, Shizuru JA, et al. Chimerism, graft survival, and withdrawal of immunosuppressive drugs in HLA matched and mismatched patients after living donor kidney and hematopoietic cell transplantation. Am J Transplant. 2015;15:695–704.10.1111/ajt.13091
   PubMed Web of Science ®Google Scholar