Design of a RADA16-based self-assembling peptide nanofiber scaffold for biomedical applications

References

• Zhang S, Holmes T, Lockshin C, et al. Spontaneous assembly of a self-complementary oligopeptide to form a stable macroscopic membrane. Proc Natl Acad Sci U S A. 1993;90:3334–3338.
   PubMed Web of Science ®Google Scholar
• Paradís-Bas M, Tulla-Puche J, Zompra AA, et al. RADA-16: a tough peptide – strategies for synthesis and purification. Eur J Org Chem. 2013;2013:5871–5878.
   Web of Science ®Google Scholar
• Wu X, He L, Li W, et al. Functional self-assembling peptide nanofiber hydrogel for peripheral nerve regeneration. Regen Biomater. 2017;4:21–30.
   PubMed Web of Science ®Google Scholar
• Wang X, Wang J, Guo L, et al. Self-assembling peptide hydrogel scaffolds support stem cell-based hair follicle regeneration. Nanomedicine. 2016;12:2115–2125.
   PubMed Web of Science ®Google Scholar
• Lee MS, Kim S, Kim BG, et al. Snail1 induced in breast cancer cells in 3D collagen I gel environment suppresses cortactin and impairs effective invadopodia formation. Biochim Biophys Acta. 2014;1843:2037–2054.
   PubMed Web of Science ®Google Scholar
• Cormier AR, Pang X, Zimmerman MI, et al. Molecular structure of RADA16-I designer self-assembling peptide nanofibers. ACS Nano. 2013;7:7562–7572.
   PubMed Web of Science ®Google Scholar
• Susanna P, Alexandros L, Jennifer P. Novel polyethylene glycol hydrogels incorporating RADA16 peptides as in vitro tissue mimetics. Front Bioeng Biotechnol. 2016;2016:4.
   Google Scholar
• Nune M, Krishnan UM, Sethuraman S. PLGA nanofibers blended with designer self-assembling peptides for peripheral neural regeneration. Mater Sci Eng C. 2016;62:329–337.
   PubMed Web of Science ®Google Scholar
• Liu J, Song H, Zhang L, et al. Self-assembly-peptide hydrogels as tissue-engineering scaffolds for three-dimensional culture of chondrocytes in vitro. Macromol Biosci. 2010;10:1164–1170.
   PubMed Web of Science ®Google Scholar
• Yang G, Huang T, Wang Y, et al. Sustained release of antimicrobial peptide from self-assembling hydrogel enhanced osteogenesis. J Biomater Sci Polym Ed. 2018;29:1812–1824.
   PubMed Web of Science ®Google Scholar
• Ellis-Behnke RG, Liang YX, Tay DK, et al. Nano hemostat solution: immediate hemostasis at the nanoscale. Nanomedicine. 2006;2:207–215.
   PubMed Web of Science ®Google Scholar
• Yu Z, Xu Q, Dong C, et al. Self-assembling peptide nanofibrous hydrogel as a versatile drug delivery platform. Curr Pharm Des. 2015;21:4342–4354.
   PubMed Web of Science ®Google Scholar
• Hoffman AS. Hydrogels for biomedical applications. Ann N Y Acad Sci. 2012;64:18–23.
   Google Scholar
• Yu Z, Cai Z, Chen Q, et al. Engineering β-sheet peptide assemblies for biomedical applications. Biomater Sci. 2016;4:365–374.
   PubMed Web of Science ®Google Scholar
• Ho D, Fitzgerald M, Bartlett CA, et al. The effects of concentration-dependent morphology of self-assembling RADA16 nanoscaffolds on mixed retinal cultures. Nanoscale. 2011;3:907–910.
   PubMed Web of Science ®Google Scholar
• Monreal J, Hyde R. Spheroidal and nanocrystal structures created from carbodiimide crosslinking reaction with RADA16. J Sci Adv Mater Devices. 2017;2:178–182.
   Google Scholar
• Cormier AR, Ruiz-Orta C, Alamo RG, et al. Solid state self-assembly mechanism of RADA16-I designer peptide. Biomacromolecules. 2012;13:1794–1804.
   PubMed Web of Science ®Google Scholar
• Chen Y, Hua Y, Zhang W, et al. Amyloid-like staining property of RADA16-I nanofibers and its potential application in detecting and imaging the nanomaterial. Int J Nanomedicine. 2018;13:2477–2489.
   PubMed Web of Science ®Google Scholar
• Zarei H, Aramvash A, Seyedkarimi MS. Investigating the stability of RADA16 peptide nanofibers using CD spectra. Int J Pept Res Ther. 2019;25:2477–2489.
   Web of Science ®Google Scholar
• Wu D, Zhang S, Zhao Y, et al. The effects of motif net charge and amphiphilicity on the self-assembly of functionally designer RADA16-I peptides. Biomed Mater. 2018;13:35011.
   PubMed Web of Science ®Google Scholar
• Yang S, Wei S, Mao Y, et al. Novel hemostatic biomolecules based on elastin-like polypeptides and the self-assembling peptide RADA-16. BMC Biotechnol. 2018;18:12.
   PubMed Web of Science ®Google Scholar
• Sun Y, Zhang Y, Tian L, et al. Self-assembly behaviors of molecular designer functional RADA16-I peptides: influence of motifs, pH, and assembly time. Biomed Mater. 2016;12:15007.
   PubMed Web of Science ®Google Scholar
• Sun L, Zhao X. A self-assembling peptide RADA16-I integrated with spider fibroin uncrystalline motifs. Int J Nanomedicine. 2011;7:571–580.
   Web of Science ®Google Scholar
• Shi W, Huang CJ, Xu XD, et al. Transplantation of RADA16-BDNF peptide scaffold with human umbilical cord mesenchymal stem cells forced with CXCR4 and activated astrocytes for repair of traumatic brain injury. Acta Biomaterialia. 2016;45:247–261.
   PubMed Web of Science ®Google Scholar
• Lu J, Sun X, Yin H, et al. A neurotrophic peptide-functionalized self-assembling peptide nanofiber hydrogel enhances rat sciatic nerve regeneration. Nano Res. 2018;11:4599–4613.
   Web of Science ®Google Scholar
• Sun Y, Li W, Wu X, et al. Functional self-assembling peptide nanofiber hydrogels designed for nerve degeneration. ACS Appl Mater Interfaces. 2015;8:2348–2359.
   Web of Science ®Google Scholar
• Cheng TY, Chen MH, Chang WH, et al. Neural stem cells encapsulated in a functionalized self-assembling peptide hydrogel for brain tissue engineering. Biomaterials. 2013;34:2005–2016.
   PubMed Web of Science ®Google Scholar
• Zhang ZX, Zheng QX, Wu YC, et al. Compatibility of neural stem cells with functionalized self-assembling peptide scaffold in vitro. Biotechnol Bioproc E. 2010;15:545–551.
   Web of Science ®Google Scholar
• Wu Y, Jia Z, Liu L, et al. Functional self-assembled peptide nanofibers for bone marrow mesenchymal stem cell encapsulation and regeneration in nucleus pulposus. Art Organs. 2016;40:E112–E119.
   PubMed Web of Science ®Google Scholar
• Li XC, Wu YH, Bai XD, et al. BMP7-based functionalized self-assembling peptides protect nucleus pulposus-derived stem cells from apoptosis in vitro. Tissue Eng Part A. 2016;22:1218–1228.
   PubMed Web of Science ®Google Scholar
• Tao H, Zhang Y, Wang CF, et al. Biological evaluation of human degenerated nucleus pulposus cells in functionalized self-assembling peptide nanofiber hydrogel scaffold. Tissue Eng Part A. 2014;20:1621–1631.
   PubMed Web of Science ®Google Scholar
• Tao H, Wu Y, Li H, et al. BMP7-based functionalized self-assembling peptides for nucleus pulposus tissue engineering. ACS Appl Mater Interfaces. 2015;7:17076–17087.
   PubMed Web of Science ®Google Scholar
• Wang TW, Chang KC, Chen LH, et al. Effects of an injectable functionalized self-assembling nanopeptide hydrogel on angiogenesis and neurogenesis for regeneration of the central nervous system. Nanoscale. 2017;9:16281–16292.
   PubMed Web of Science ®Google Scholar
• Gao XR, Xu HJ, Wang LF, et al. Mesenchymal stem cell transplantation carried in SVVYGLR modified self-assembling peptide promoted cardiac repair and angiogenesis after myocardial infarction. Biochem Biophys Res Commun. 2017;491:112–118.
   PubMed Web of Science ®Google Scholar
• Horii A, Wang X, Gelain F, et al. Biological designer self-assembling peptide nanofiber scaffolds significantly enhance osteoblast proliferation, differentiation and 3-D migration. PLoS One. 2007;2:e190.
   PubMed Web of Science ®Google Scholar
• He B, Ou Y, Chen S, et al. Designer bFGF-incorporated D-form self-assembly peptide nanofiber scaffolds to promote bone repair. Mater Sci Eng C Mater Biol Appl. 2017;74:451–458.
   PubMed Web of Science ®Google Scholar
• He B, Ou Y, Ao Z, et al. Functionalizedd-form self-assembling peptide hydrogels for bone regeneration. Drug Des Devel Ther. 2016;10:1379–1388.
   PubMed Web of Science ®Google Scholar
• Bradshaw M, Ho D, Fear MW, et al. Designer Self-Assembling Hydrogel Scaffolds Can Impact Skin Cell Proliferation and Migration. Sci Rep. 2014;4:6903.
   PubMed Web of Science ®Google Scholar
• Luo H, Changsheng XU, Liu Z, et al. Neural differentiation of bone marrow mesenchymal stem cells with human brain-derived neurotrophic factor gene-modified in functionalized self-assembling peptide hydrogel in vitro. J Cell Biochem. 2019;120:2828–2835.
   PubMed Web of Science ®Google Scholar
• Zhou A, Chen S, He B, et al. Controlled release of TGF-beta 1 from RADA self-assembling peptide hydrogel scaffolds. Drug Des Devel Ther. 2016;10:3043–3051.
   PubMed Web of Science ®Google Scholar
• Cheng TY, Wu HC, Huang MY, et al. Self-assembling functionalized nanopeptides for immediate hemostasis and accelerative liver tissue regeneration. Nanoscale. 2013;5:2734–2744.
   PubMed Web of Science ®Google Scholar
• Kumada Y, Zhang S. Significant type I and type III collagen production from human periodontal ligament fibroblasts in 3D peptide scaffolds without extra growth factors. PLoS One. 2010;5:e10305.
   PubMed Web of Science ®Google Scholar
• Wang XM, Qiao L, Horii A. Screening of functionalized self-assembling peptide nanofiber scaffolds with angiogenic activity for endothelial cell growth. Prog Nat Sci Mater. 2011;21:111–116.
   Web of Science ®Google Scholar
• Pan H, Hao S, Zheng Q, et al. Bone induction by biomimetic PLGA copolymer loaded with a novel synthetic RADA16-P24 peptide in vivo. Mater Sci Eng C. 2013;33:3336–3345.
   PubMed Web of Science ®Google Scholar
• Guo HD, Cui GH, Yang JJ, et al. Sustained delivery of VEGF from designer self-assembling peptides improves cardiac function after myocardial infarction. Biochem Biophys Res Commun. 2012;424:105–111.
   PubMed Web of Science ®Google Scholar
• Ma K, Wu Y, Wang B, et al. Effect of a synthetic link N peptide nanofiber scaffold on the matrix deposition of aggrecan and type II collagen in rabbit notochordal cells. J Mater Sci: Mater Med. 2013;24:405–415.
   PubMed Web of Science ®Google Scholar
• Wang B, Sun C, Shao Z, et al. Designer self-assembling peptide nanofiber scaffolds containing link protein N-terminal peptide induce chondrogenesis of rabbit bone marrow stem cells. Biomed Res Int. 2014;2014:1.
   Google Scholar
• Wang B, Wu Y, Shao Z, et al. Functionalized self-assembling peptide nanofiber hydrogel as a scaffold for rabbit nucleus pulposus cells. J Biomed Mater Res. 2012;100A:646–653.
   Web of Science ®Google Scholar
• Im H, Kim SH, Kim SH, et al. Skin regeneration with a scaffold of predefined shape and bioactive peptide hydrogels. Tissue Eng Part A. 2018;24:1518–1530.
   PubMed Web of Science ®Google Scholar
• Mie M, Oomuro M, Kobatake E. Hydrogel scaffolds composed of genetically synthesized self-assembling peptides for three-dimensional cell culture. Polym J. 2013;45:504–508.
   Web of Science ®Google Scholar
• Guo HD, Wang HJ, Tan YZ, et al. Transplantation of marrow-derived cardiac stem cells carried in fibrin improves cardiac function after myocardial infarction. Tissue Eng Part A. 2011;17:45–58.
   PubMed Web of Science ®Google Scholar
• Ni N, Hu Y, Ren H, et al. Self-assembling peptide nanofiber scaffolds enhance dopaminergic differentiation of mouse pluripotent stem cells in 3-dimensional culture. PLoS One. 2013;8:e84504.
   PubMed Web of Science ®Google Scholar
• Li R, Liang J, He Y, et al. Sustained release of immunosuppressant by nanoparticle-anchoring hydrogel scaffold improved the survival of transplanted stem cells and tissue regeneration. Theranostics. 2018;8:878–893.
   PubMed Web of Science ®Google Scholar
• Shamsi F. Investigation of human cell response to covalently attached RADA16-I peptide on silicon surfaces. Colloids Surf B Biointerfaces. 2016;145:470–478.
   PubMed Web of Science ®Google Scholar
• Kakiuchi Y, Hirohashi N, Murakami-Murofushi K. The macroscopic structure of RADA16 peptide hydrogel stimulates monocyte/macrophage differentiation in HL60 cells via cholesterol synthesis. Biochem Biophys Res Commun. 2013;433:298–304.
   PubMed Web of Science ®Google Scholar
• Francis NL, Bennett NK, Halikere A, et al. Self-assembling peptide nanofiber scaffolds for 3-D reprogramming and transplantation of human pluripotent stem cell-derived neurons. ACS Biomater Sci Eng. 2016;2:1030–1038.
   PubMed Web of Science ®Google Scholar
• Gao M, Tao H, Wang T, et al. Functionalized self-assembly polypeptide hydrogel scaffold applied in modulation of neural progenitor cell behavior. J Bioactive Compat Polym Biomed Appl. 2017;32:45–60.
   Web of Science ®Google Scholar
• Nune M, Krishnan UM, Sethuraman S. Decoration of PLGA electrospun nanofibers with designer self-assembling peptides: a “nano-on-nano” concept. RSC Adv. 2015;5:88748–88757.
   Web of Science ®Google Scholar
• Cigognini D, Satta A, Colleoni B, et al. Evaluation of early and late effects into the acute spinal cord injury of an injectable functionalized self-assembling scaffold. PLoS One. 2011;6:78–83.
   Web of Science ®Google Scholar
• Sieminski AL, Semino CE, Gong H, et al. Primary sequence of ionic self-assembling peptide gels affects endothelial cell adhesion and capillary morphogenesis. J Biomed Mater Res. 2008;87A:494–504.
   Web of Science ®Google Scholar
• Pan Q, Li W, Yuan X, et al. Chondrogenic effect of cell-based scaffold of self-assembling peptides/PLGA-PLL loading the hTGFβ3 plasmid DNA. J Mater Sci Mater Med. 2016;27:19.
   PubMed Web of Science ®Google Scholar
• Yang H, Hong N, Liu H, et al. Differentiated adipose-derived stem cell cocultures for bone regeneration in RADA16-I in vitro. J Cell Physiol. 2018;233:9458–9472.
   PubMed Web of Science ®Google Scholar
• Wu M, Yang Z, Liu Y, et al. The 3-D culture and in vivo growth of the human hepatocellular carcinoma cell line HepG2 in a self-assembling peptide nanofiber scaffold. J Nanomater. 2010;2010:1.
   Google Scholar
• Yang Z, Zhao X. A 3D model of ovarian cancer cell lines on peptide nanofiber scaffold to explore the cell–scaffold interaction and chemotherapeutic resistance of anticancer drugs. Int J Nanomed. 2011;2011:303–310.
   Google Scholar
• Barnabas N, Cohen D. Phenotypic and molecular characterization of MCF10DCIS and SUM breast cancer cell lines. Int J Breast Cancer. 2013;2013:1.
   Google Scholar
• Song H, Han YZ, Cai GH, et al. Self-assembling peptide RADA16 Hydrogel on malignant phenotype of human hepatocellular carcinoma cell. Int J Clin Exp Med. 2015;8:14906–14915.
   PubMed Web of Science ®Google Scholar
• Jin H, Zhao G, Hu J, et al. Melittin-containing hybrid peptide hydrogels for enhanced photothermal therapy of glioblastoma. ACS Appl Mater Interfaces. 2017;9:25755–25766.
   PubMed Web of Science ®Google Scholar
• Li R, Pang Z, He H, et al. Drug depot-anchoring hydrogel: a self-assembling scaffold for localized drug release and enhanced stem cell differentiation. J Control Release. 2017;261:234–245.
   PubMed Web of Science ®Google Scholar
• Wu H, Zhou T, Tian L, et al. Self-assembling RADA16-I peptide hydrogel scaffold loaded with tamoxifen for breast reconstruction. Biomed Res Int. 2017;2017:1.
   Web of Science ®Google Scholar
• Moradi F, Bahktiari M, Joghataei MT, et al. BD PuraMatrix peptide hydrogel as a culture system for human fetal Schwann cells in spinal cord regeneration. J Neurosci Res. 2012;90:2335–2348.
   PubMed Web of Science ®Google Scholar
• Wang J, Zheng J, Zheng Q, et al. FGL-functionalized self-assembling nanofiber hydrogel as a scaffold for spinal cord-derived neural stem cells. Mater Sci Eng C Mater Biol Appl. 2015;46:140–147.
   PubMed Web of Science ®Google Scholar
• Na Z, Luo Y, He L, et al. A self-assembly peptide nanofibrous scaffold reduces inflammatory response and promotes functional recovery in a mouse model of intracerebral hemorrhage. Nanomedicine. 2016;12:1205–1217.
   PubMed Web of Science ®Google Scholar
• Sang LY, Liang YX, Li Y, et al. A self-assembling nanomaterial reduces acute brain injury and enhances functional recovery in a rat model of intracerebral hemorrhage. Nanomedicine. 2015;11:611–620.
   PubMed Web of Science ®Google Scholar
• Li Z, Hou T, Luo F, et al. Bone marrow enriched graft, modified by self-assembly peptide, repairs critically-sized femur defects in goats. Int Orthop. 2014;38:2391–2398.
   PubMed Web of Science ®Google Scholar
• Ren LF, Shi GS, Tong YQ, et al. Effects of rhBMP-2/7 heterodimer and RADA16 hydrogel scaffold on bone formation during rabbit mandibular distraction. J Oral Maxillofac Surg. 2018;76:1091–1092.
   PubMed Web of Science ®Google Scholar
• Yu H, Zeng X, Deng C, et al. Exogenous VEGF introduced by bioceramic composite materials promotes the restoration of bone defect in rabbits. Biomedicine. 2017;98:325–332.
   Google Scholar
• Chen K, Sahoo S, He P, et al. A hybrid silk/RADA-based fibrous scaffold with triple hierarchy for ligament regeneration. Tissue Eng Part A. 2012;18:1399–1409.
   PubMed Web of Science ®Google Scholar
• Rambhia K, Ma P. Controlled drug release for tissue engineering. J Control Release. 2015;219:119–128.
   PubMed Web of Science ®Google Scholar
• Takeuchi T, Bizenjima T, Ishii Y, et al. Enhanced healing of surgical periodontal defects in rats following application of a self-assembling peptide nanofibre hydrogel. J Clin Periodontol. 2016;43:279–288.
   PubMed Web of Science ®Google Scholar
• Liu X, Wang X, Horii A, et al. In vivo studies on angiogenic activity of two designer self-assembling peptide scaffold hydrogels in the chicken embryo chorioallantoic membrane. Nanoscale. 2012;4:2720–2727.
   PubMed Web of Science ®Google Scholar
• Johnson D, Bates S, Nukalo S, et al. The effects of QuikClot combat gauze on hemorrhage control in the presence of hemodilution and hypothermia. Ann Med Surg. 2014;3:21–25.
   PubMedGoogle Scholar
• Park DH, Kim SB, Ahn KD, et al. In vitro degradation and cytotoxicity of alkyl 2-cyanoacrylate polymers for application to tissue adhesives. J Appl Polym Sci. 2003;89:3272–3278.
   Web of Science ®Google Scholar
• Wen J, Weinhart M, Lai B, et al. Reversible hemostatic properties of sulfabetaine/quaternary ammonium modified hyperbranched polyglycerol. Biomaterials. 2016;86:42–55.
   PubMed Web of Science ®Google Scholar
• Ellis-Behnke RG, Schneider GE. Peptide amphiphiles and porous biodegradable scaffolds for tissue regeneration in the brain and spinal cord. Methods Mol Biol. 2011;726:259–281.
   PubMedGoogle Scholar
• Song H, Zhang L, Zhao X. Hemostatic efficacy of biological self-assembling peptide nanofibers in a rat kidney model. Macromol Biosci. 2010;10:33–39.
   PubMed Web of Science ®Google Scholar
• Wang T, Zhong X, Wang S, et al. Molecular mechanisms of RADA16-1 peptide on fast stop bleeding in rat models. Int J Mol Sci. 2012;13:15279–15290.
   PubMed Web of Science ®Google Scholar
• Xu FF, Wang YC, Sun S, et al. Comparison between self-assembling peptide nanofiber scaffold (SAPNS) and fibrin sealant in neurosurgical hemostasis. Clin Trans Sci. 2015;8:490–494.
   PubMed Web of Science ®Google Scholar
• Wu M, Ye Z, Zhu H, et al. Self-assembling peptide nanofibrous hydrogel on immediate hemostasis and accelerative osteosis. Biomacromolecules. 2015;16:3112–3118.
   PubMed Web of Science ®Google Scholar
• Leung GKK, Wang YC, Wu W. Chapter nine: Peptide nanofiber scaffold for brain tissue reconstruction. Methods Enzymol. 2012;508:177–190.
   PubMed Web of Science ®Google Scholar
• Komatsu S, Nagai Y, Naruse K, et al. The neutral self-assembling peptide hydrogel SPG-178 as a topical hemostatic agent. PLoS One. 2014;9:e102778.
   PubMed Web of Science ®Google Scholar
• Liu J, Zhang L, Yang Z, et al. Controlled release of paclitaxel from a self-assembling peptide hydrogel formed in situ and antitumor study in vitro. Int J Nanomed. 2011;6:2143–2153.
   PubMed Web of Science ®Google Scholar
• Jasty S, Suriyanarayanan S, Krishnakumar S. Influence of self-assembling peptide nanofibre scaffolds on retinal differentiation potential of stem/progenitor cells derived from ciliary pigment epithelial cells. J Tissue Eng Regen Med. 2017;11:509–518.
   PubMed Web of Science ®Google Scholar
• Briuglia ML, Urquhart AJ, Lamprou DA. Sustained and controlled release of lipophilic drugs from a self-assembling amphiphilic peptide hydrogel. Int J Pharma. 2014;474:103–111.
   PubMed Web of Science ®Google Scholar
• Koss K, Tsui C, Unsworth LD. Induced neural differentiation of MMP-2 cleaved (RADA)4 drug delivery systems. J Control Release. 2016;243:204–213.
   PubMed Web of Science ®Google Scholar
• Phipps MC, Monte F, Mehta M, et al. Intraosseous delivery of bone morphogenic protein-2 using a self-assembling peptide hydrogel. Biomacromolecules. 2016;17:2329–2336.
   PubMed Web of Science ®Google Scholar
• Gelain F, Unsworth LD, Zhang S. Slow and sustained release of active cytokines from self-assembling peptide scaffolds. J Control Release. 2010;145:231–239.
   PubMed Web of Science ®Google Scholar
• Baumann B, Wittig R, Lindén M. Mesoporous silica nanoparticles in injectable hydrogels: factors Influencing cellular uptake and viability. Nanoscale. 2017;9:12379–12390.
   PubMed Web of Science ®Google Scholar