Methacrylated gelatin hydrogels as corneal stroma substitutes: in vivo study

References

• Ludwig PE, Dulebohn SC. Anatomy, head, eye, cornea. Treasure Island (FL): StatPearls Publishing; 2017.
   Google Scholar
• Eghrari AO, Riazuddin SA, Gottsch JD. Overview of the cornea: structure, function, and development. Prog Mol Biol Transl Sci. 2015;134:7–23.
   PubMed Web of Science ®Google Scholar
• Ambati BK, Nozaki M, Singh N, et al. Corneal avascularity is due to soluble VEGF receptor-1. Nature. 2006;443(7114):993–997.
   PubMed Web of Science ®Google Scholar
• Chirila TV, Hicks CR, Dalton PD, et al. Artificial cornea. Prog Polym Sci. 1998;23(3):447–473.
   Web of Science ®Google Scholar
• Connon CJ. Approaches to corneal tissue engineering: top-down or bottom-up? Proc Eng. 2015;110:15–20.
   Google Scholar
• Gain P, Jullienne R, He Z, et al. Global survey of corneal transplantation and eye banking. JAMA Ophthalmol. 2016;134(2):167–173.
   PubMed Web of Science ®Google Scholar
• Viitala R, Franklin V, Green D, et al. Towards a synthetic osteo-odonto-keratoprosthesis. Acta Biomater. 2009;5(1):438–452.
   PubMed Web of Science ®Google Scholar
• Ghezzi CE, Rnjak-Kovacina J, Kaplan DL. Corneal tissue engineering: recent advances and future perspectives. Tissue Eng Part B Rev. 2015;21(3):278–287.
   PubMed Web of Science ®Google Scholar
• Laattala K, Huhtinen R, Puska M, et al. Bioactive composite for keratoprosthesis skirt. J Mech Behav Biomed Mater. 2011;4(8):1700–1708.
   PubMed Web of Science ®Google Scholar
• Yang S, Leong K-F, Du Z, et al. The design of scaffolds for use in tissue engineering. Part I. Traditional factors. Tissue Eng. 2001;7(6):679–689.
   PubMedGoogle Scholar
• Stock UA, Vacanti JP. Tissue engineering: current state and prospects. Annu Rev Med. 2001;52:443–451.
   PubMed Web of Science ®Google Scholar
• Zorlutuna P, Tezcaner A, Kiyat I, et al. Cornea engineering on polyester carriers. J Biomed Mater Res A. 2006;79(1):104–113.
   PubMedGoogle Scholar
• Mirazul Islam M, Cėpla V, He C, et al. Functional fabrication of recombinant human collagen–phosphorylcholine hydrogels for regenerative medicine applications. Acta Biomater. 2015;12:70–80.
   PubMed Web of Science ®Google Scholar
• Vrana NE, Builles N, Justin V, et al. Development of a Reconstructed Cornea from collagen-chondroitin sulfate foams and human cell cultures. Invest Ophthalmol Vis Sci. 2008;49(12):5325–5331.
   PubMed Web of Science ®Google Scholar
• Tang Q, Luo C, Lu B, et al. Thermosensitive chitosan-based hydrogels releasing stromal cell derived factor-1 alpha recruit MSC for corneal epithelium regeneration. Acta Biomater. 2017;61:103–113.
   Web of Science ®Google Scholar
• Tonsomboon K, Oyen ML. Composite electrospun gelatin fiber-alginate gel scaffolds for mechanically robust tissue engineered cornea. J Mech Behav Biomed Mater. 2013;21:185–194.
   PubMed Web of Science ®Google Scholar
• Phu D, Wray LS, Warren RV, et al. Effect of substrate composition and alignment on corneal cell phenotype. Tissue Eng Part A. 2011;17(5-6):799–807.
   PubMed Web of Science ®Google Scholar
• Vrana NE, Elsheikh A, Builles N, et al. Effect of human corneal keratocytes and retinal pigment epithelial cells on the mechanical properties of micropatterned collagen films. Biomaterials. 2007;28(29):4303–4310.
   PubMed Web of Science ®Google Scholar
• Kilic C, Girotti A, Rodriguez-Cabello JC, et al. A collagen-based corneal stroma substitute with micro-designed architecture. Biomater Sci. 2014;2(3):318–329.
   PubMed Web of Science ®Google Scholar
• Acun A, Hasirci V. Construction of a collagen-based, split-thickness cornea substitute. J Biomater Sci Polym Ed. 2014;25(11):1110–1132.
   PubMed Web of Science ®Google Scholar
• Hong S, Yun JH, Kim E-S, et al. Human conjunctival epithelial sheets grown on poly(lactic-co-glycolic) acid membranes and cocultured with human tenon’s fibroblasts for corneal repair. Invest Ophthalmol Vis Sci. 2018;59(3):1475–1485.
   PubMed Web of Science ®Google Scholar
• Fagerholm P, Lagali NS, Merrett K, et al. A biosynthetic alternative to human donor tissue for inducing corneal regeneration: 24-month follow-up of a phase 1 clinical study. Sci Transl Med. 2010;2(46):46ra61.
   PubMed Web of Science ®Google Scholar
• Hasirci N, Kilic C, Kömez A, et al. Hydrogels in regenerative medicine. In: Demirci U, Khademhosseini A, editors. Gels Handbook. Singapore: World Scientific; 2016. p. 1–52.
   Google Scholar
• Liu Y, Ren L, Wang Y. Crosslinked collagen-gelatin-hyaluronic acid biomimetic film for cornea tissue engineering applications. Mater Sci Eng C. 2013;33(1):196–201.
   PubMed Web of Science ®Google Scholar
• Kawakita T, Higa K, Shimmura S, et al. A gelatin hydrogel for corneal stromal transplantation in rabbit. Invest Ophthalmol Vis Sci. 2014;55:5156.
   Web of Science ®Google Scholar
• Ozcelik B, Brown KD, Blencowe A, et al. Ultrathin chitosan-poly(ethylene glycol) hydrogel films for corneal tissue engineering. Acta Biomater. 2013;9(5):6594–6605.
   PubMed Web of Science ®Google Scholar
• Rafat M, Li F, Fagerholm P, et al. PEG-stabilized carbodiimide crosslinked collagen-chitosan hydrogels for corneal tissue engineering. Biomaterials. 2008;29(29):3960–3972.
   PubMed Web of Science ®Google Scholar
• Van Den Bulcke AI, Bogdanov B, De Rooze N, et al. Structural and rheological properties of methacrylamide modified gelatin hydrogels. Biomacromolecules. 2000;1(1):31–38.
   PubMed Web of Science ®Google Scholar
• Kilic Bektas C, Hasirci V. Mimicking corneal stroma using keratocyte-loaded photopolymerizable methacrylated gelatin hydrogels. J Tissue Eng Regen Med. 2018;12(4):e1899–e1910.
   PubMed Web of Science ®Google Scholar
• Bahcecioglu G, Hasirci N, Bilgen B, et al. A 3D printed PCL/hydrogel construct with zone-specific biochemical composition mimicking that of the meniscus. Biofabrication. 2019;11(2):025002.
   PubMed Web of Science ®Google Scholar
• Harley BA, Leung JH, Silva E, et al. Mechanical characterization of collagen-glycosaminoglycan scaffolds. Acta Biomater. 2007;3(4):463–474.
   PubMed Web of Science ®Google Scholar
• McLaughlin CR, Fagerholm P, Muzakare L, et al. Regeneration of corneal cells and nerves in an implanted collagen corneal substitute. Cornea. 2008;27:580–589
   PubMed Web of Science ®Google Scholar
• Shin H, Olsen BD, Khademhosseini A. The mechanical properties and cytotoxicity of cell-laden double-network hydrogels based on photocrosslinkable gelatin and gellan gum biomacromolecules. Biomaterials. 2012;33(11):3143–3152.
   PubMed Web of Science ®Google Scholar
• Lobo AO, Afewerki S, de Paula MMM, et al. Electrospun nanofiber blend with improved mechanical and biological performance. Int J Nanomed. 2018;13:7891–7903.
   PubMed Web of Science ®Google Scholar
• Mallet JD, Rochette PJ. Wavelength-dependent ultraviolet induction of cyclobutane pyrimidine dimers in the human cornea. Photochem Photobiol Sci. 2013;12(8):1310–1318.
   PubMed Web of Science ®Google Scholar
• Peppas NA, Hilt JZ, Khademhosseini A, et al. Hydrogels in biology and medicine: from molecular principles to bionanotechnology. Adv Mater. 2006;18(11):1345–1360.
   Web of Science ®Google Scholar
• Liang Y, Liu W, Han B, et al. Fabrication and characters of a corneal endothelial cells scaffold based on chitosan. J Mater Sci: Mater Med. 2011;22(1):175–183.
   PubMed Web of Science ®Google Scholar
• Petsche SJ, Chernyak D, Martiz J, et al. Depth-dependent transverse shear properties of the human corneal stroma. Invest Ophthalmol Vis Sci. 2012;53(2):873–880.
   PubMed Web of Science ®Google Scholar
• Battaglioli JL, Kamm RD. Measurements of the compressive properties of scleral tissue. Invest Ophthalmol Vis Sci. 1984;25:59–65.
   PubMed Web of Science ®Google Scholar
• Ethier CR, Johnson M, Ruberti J. Ocular biomechanics and biotransport. Annu Rev Biomed Eng. 2004;6:249–273.
   PubMed Web of Science ®Google Scholar
• Ruberti JW, Zieske JD, Trinkaus-Randall V. Chapter sixty-eight - corneal-tissue replacement. In: Langer R, Vacanti, editors. Principles of Tissue Engineering. Burlington: Academic Press; 2007. p. 1025–1047.
   Google Scholar
• Pianini V, Passani A, Rossi GCM, et al. Efficacy and safety of netilmycin/dexamethasone preservative-free and tobramycin/dexamethasone-preserved fixed combination in patients after cataract surgery. J Ocul Pharmacol Ther. 2010;26(6):617–621.
   PubMed Web of Science ®Google Scholar
• Loftsson T, Stefánsson E. Cyclodextrins in eye drop formulations: enhanced topical delivery of corticosteroids to the eye. Acta Ophthalmol. Scand. 2002;80(2):144–150.
   PubMedGoogle Scholar
• Chang J-H, Garg NK, Lunde E, et al. Corneal neovascularization: an anti-VEGF therapy review. Surv Ophthalmol. 2012;57(5):415–429.
   PubMed Web of Science ®Google Scholar
• Brown DM, Regillo CD. Anti-VEGF agents in the treatment of neovascular age-related macular degeneration: applying clinical trial results to the treatment of everyday patients. Am J Ophthalmol. 2007;144(4):627–637.e2.
   PubMed Web of Science ®Google Scholar
• Amadio M, Govoni S, Pascale A. Targeting VEGF in eye neovascularization: what’s new? A comprehensive review on current therapies and oligonucleotide-based interventions under development. Pharmacol Res. 2016;103:253–269.
   PubMed Web of Science ®Google Scholar
• Chan T, Payor S, Holden BA. Corneal thickness profiles in rabbits using an ultrasonic pachometer. Invest Ophthalmol Vis Sci. 1983;24(10):1408–1410.
   PubMed Web of Science ®Google Scholar
• Kaye GI, Pappas GD. Studies on the Cornea. I. The fine structure of the rabbit cornea and the uptake and transport of colloidal particles by the cornea in vivoJ Cell Biol. 1962;12:457–479.
   PubMed Web of Science ®Google Scholar
• Mimura T, Amano S, Yokoo S, et al. Tissue engineering of corneal stroma with rabbit fibroblast precursors and gelatin hydrogels. Mol Vis. 2008;14:1819–1828.
   PubMed Web of Science ®Google Scholar
• Long Y, Zhao X, Liu S, et al. Collagen–hydroxypropyl methylcellulose membranes for corneal regeneration. ACS Omega. 2018;3(1):1269–1275.
   PubMed Web of Science ®Google Scholar
• Cui Z, Zeng Q, Liu S, et al. Cell-laden and orthogonal-multilayer tissue-engineered corneal stroma induced by a mechanical collagen microenvironment and transplantation in a rabbit model. Acta Biomater. 2018;75:183–199.
   PubMed Web of Science ®Google Scholar
• Xiao J, Duan H, Liu Z, et al. Construction of the recellularized corneal stroma using porous acellular corneal scaffold. Biomaterials. 2011;32(29):6962–6971.
   PubMed Web of Science ®Google Scholar
• Du L, Wu X. Development and characterization of a full-thickness acellular porcine cornea matrix for tissue engineering. Artif Organs. 2011;35(7):691–705.
   PubMed Web of Science ®Google Scholar
• Hashimoto Y, Funamoto S, Sasaki S, et al. Preparation and characterization of decellularized cornea using high-hydrostatic pressurization for corneal tissue engineering. Biomaterials. 2010;31(14):3941–3948.
   PubMed Web of Science ®Google Scholar
• Chung L, Maestas DR, Housseau F, et al. Key players in the immune response to biomaterial scaffolds for regenerative medicine. Adv Drug Deliv Rev. 2017;114:184–192.
   PubMed Web of Science ®Google Scholar
• Hu W-J, Eaton JW, Ugarova TP, et al. Molecular basis of biomaterial-mediated foreign body reactions. Blood. 2001;98(4):1231–1238.
   PubMed Web of Science ®Google Scholar
• Franz S, Rammelt S, Scharnweber D, et al. Immune responses to implants – A review of the implications for the design of immunomodulatory biomaterials. Biomaterials. 2011;32(28):6692–6709.
   PubMed Web of Science ®Google Scholar
• Trindade R, Albrektsson T, Tengvall P, et al. Foreign body reaction to biomaterials: on mechanisms for buildup and breakdown of osseointegration. Clin Implant Dent Relat Res. 2016;18(1):192–203.
   PubMed Web of Science ®Google Scholar