Construction of a decellularized spinal cord matrix/GelMA composite scaffold and its effects on neuronal differentiation of neural stem cells

References

• Murray M, Fischer I. Transplantation and gene therapy: combined approaches for repair of spinal cord injury. Neuroscientist. 2001;7(1):28–41.
   PubMed Web of Science ®Google Scholar
• Chen MS, Huber AB, van der Haar ME, et al. Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody in-1. Nature. 2000;403(6768):434–439.
   PubMed Web of Science ®Google Scholar
• Kim HM, Hwang DH, Choi JY, et al. Differential and cooperative actions of Olig1 and Olig2 transcription factors on immature proliferating cells after contusive spinal cord injury. Glia. 2011;59(7):1094–1106.
   PubMed Web of Science ®Google Scholar
• Cofano F, Boido M, Monticelli M, et al. Mesenchymal stem cells for spinal cord injury: current options, limitations, and future of cell therapy. Int J Mol Sci. 2019;20(11):2698.
   PubMed Web of Science ®Google Scholar
• Cao Q, Benton RL, Whittemore SR. Stem cell repair of Central nervous system injury. J Neurosci Res. 2002;68(5):501–510.
   PubMed Web of Science ®Google Scholar
• Grochowski C, Radzikowska E, Maciejewski R. Neural stem cell therapy - brief review. Clin Neurol Neurosurg. 2018;173:8–14.
   PubMed Web of Science ®Google Scholar
• Zhu Y, Uezono N, Yasui T, et al. Neural stem cell therapy aiming at better functional recovery after spinal cord injury. Dev Dyn. 2018;247(1):75–84.
   PubMed Web of Science ®Google Scholar
• Liu X, Hao M, Chen Z, et al. 3D bioprinted neural tissue constructs for spinal cord injury repair. Biomaterials. 2021;272:120771.
   PubMed Web of Science ®Google Scholar
• Yang Y, Fan Y, Zhang H, et al. Small molecules combined with collagen hydrogel direct neurogenesis and migration of neural stem cells after spinal cord injury. Biomaterials. 2021;269:120479. (
   PubMed Web of Science ®Google Scholar
• Sun Y, Liu X, George MN, et al. Enhanced nerve cell proliferation and differentiation on electrically conductive scaffolds embedded with graphene and carbon nanotubes. J Biomed Mater Res A. 2021;109(2):193–206.
   PubMed Web of Science ®Google Scholar
• Koffler J, Zhu W, Qu X, et al. Biomimetic 3D-printed scaffolds for spinal cord injury repair. Nat Med. 2019;25(2):263–269.
   PubMed Web of Science ®Google Scholar
• Dehqan Niri A, Karimi Zarchi AA, Ghadiri Harati P, et al. Tissue engineering scaffolds in the treatment of brain disorders in geriatric patients. Artif Organs. 2019;43(10):947–960.
   PubMed Web of Science ®Google Scholar
• Crapo PM, Gilbert TW, Badylak SF. An overview of tissue and whole organ decellularization processes. Biomaterials. 2011;32(12):3233–3243.
   PubMed Web of Science ®Google Scholar
• Kong JS, Huang X, Choi YJ, et al. Promoting Long-Term cultivation of motor neurons for 3D neuromuscular junction formation of 3D in vitro using Central-Nervous-Tissue-Derived bioink. Adv Healthc Mater. 2021;10(18):e2100581.
   PubMed Web of Science ®Google Scholar
• Guo SZ, Ren XJ, Wu B, et al. Preparation of the acellular scaffold of the spinal cord and the study of biocompatibility. Spinal Cord. 2010;48(7):576–581.
   PubMed Web of Science ®Google Scholar
• Chen J, Zhang Z, Liu J, et al. Acellular spinal cord scaffold seeded with bone marrow stromal cells protects tissue and promotes functional recovery in spinal cord-injured rats. J Neurosci Res. 2014;92(3):307–317.
   PubMed Web of Science ®Google Scholar
• Xing H, Ren X, Yin H, et al. Construction of a NT-3 sustained-release system cross-linked with an acellular spinal cord scaffold and its effects on differentiation of cultured bone marrow mesenchymal stem cells. Mater Sci Eng C Mater Biol Appl. 2019;104:109902.
   PubMed Web of Science ®Google Scholar
• Xu HL, Tian FR, Lu CT, et al. Thermo-sensitive hydrogels combined with decellularised matrix deliver bFGF for the functional recovery of rats after a spinal cord injury. Sci Rep. 2016;6:38332.
   PubMed Web of Science ®Google Scholar
• Taylor DA, Sampaio LC, Ferdous Z, et al. Decellularized matrices in regenerative medicine. Acta Biomater. 2018;74:74–89.
   PubMed Web of Science ®Google Scholar
• Parmaksiz M, Dogan A, Odabas S, et al. Clinical applications of decellularized extracellular matrices for tissue engineering and regenerative medicine. Biomed Mater. 2016;11(2):022003.
   PubMed Web of Science ®Google Scholar
• Cornelison RC, Gonzalez-Rothi EJ, Porvasnik SL, et al. Injectable hydrogels of optimized acellular nerve for injection in the injured spinal cord. Biomed Mater. 2018;13(3):034110.
   PubMed Web of Science ®Google Scholar
• Xu Y, Zhou J, Liu C, et al. Understanding the role of tissue-specific decellularized spinal cord matrix hydrogel for neural stem/progenitor cell microenvironment reconstruction and spinal cord injury. Biomaterials. 2021;268:120596.
   PubMed Web of Science ®Google Scholar
• Tukmachev D, Forostyak S, Koci Z, et al. Injectable extracellular matrix hydrogels as scaffolds for spinal cord injury repair. Tissue Eng A. 2016;22(3–4):306–317.
   PubMed Web of Science ®Google Scholar
• Ramis JM, Blasco-Ferrer M, Calvo J, et al. Improved physical and osteoinductive properties of demineralized bone matrix by gelatin methacryloyl formulation. J Tissue Eng Regen Med. 2020;14(3):475–485.
   PubMed Web of Science ®Google Scholar
• Fischer I, Dulin JN, Lane MA. Transplanting neural progenitor cells to restore connectivity after spinal cord injury. Nat Rev Neurosci. 2020;21(7):366–383.
   PubMed Web of Science ®Google Scholar
• Man K, Barroso IA, Brunet MY, et al. Controlled release of epigenetically-enhanced extracellular vesicles from a GelMA/nanoclay composite hydrogel to promote bone repair. Int J Mol Sci. 2022;23(2):832.
   PubMed Web of Science ®Google Scholar
• Zou J-L, Liu S, Sun J-H, et al. Peripheral nerve-derived matrix hydrogel promotes remyelination and inhibits synapse formation. Adv Funct Mater. 2018;28(13):1705739.
   Web of Science ®Google Scholar
• Jiankang H, Dichen L, Yaxiong L, et al. Fabrication and characterization of chitosan/gelatin porous scaffolds with predefined internal microstructures. Polymer. 2007;48(15):4578–4588.
   Web of Science ®Google Scholar
• Nayak KK, Gupta P. In vitro biocompatibility study of keratin/agar scaffold for tissue engineering. Int J Biol Macromol. 2015;81:1–10.
   PubMed Web of Science ®Google Scholar
• Johe KK, Hazel TG, Muller T, et al. Single factors direct the differentiation of stem cells from the fetal and adult Central nervous system. Genes Dev. 1996;10(24):3129–3140.
   PubMed Web of Science ®Google Scholar
• Ahuja CS, Wilson JR, Nori S, et al. Traumatic spinal cord injury. Nat Rev Dis Primers. 2017;3:17018.
   PubMed Web of Science ®Google Scholar
• Fang Y, Shi B, Liu X, et al. Xiaoyao pills attenuate inflammation and nerve injury induced by lipopolysaccharide in hippocampal neurons in vitro. Neural Plast. 2020;2020:8841332.
   PubMed Web of Science ®Google Scholar
• Gong Z, Xia K, Xu A, et al. Stem cell transplantation: a promising therapy for spinal cord injury. Curr Stem Cell Res Ther. 2020;15(4):321–331.
   PubMed Web of Science ®Google Scholar
• Ceto S, Sekiguchi KJ, Takashima Y, et al. Neural stem cell grafts form extensive synaptic networks that integrate with host circuits after spinal cord injury. Cell Stem Cell. 2020;27(3):430–440.e5.
   PubMed Web of Science ®Google Scholar
• Li X, Peng Z, Long L, et al. Transplantation of Wnt5a-modified NSCs promotes tissue repair and locomotor functional recovery after spinal cord injury. Exp Mol Med. 2020;52(12):2020–2033.
   PubMed Web of Science ®Google Scholar
• Bedir T, Ulag S, Ustundag CB, et al. 3D bioprinting applications in neural tissue engineering for spinal cord injury repair. Mater Sci Eng C Mater Biol Appl. 2020;110:110741.
   PubMed Web of Science ®Google Scholar
• Abbas WA, Ibrahim ME, El-Naggar M, et al. Recent advances in the regenerative approaches for traumatic spinal cord injury: materials perspective. ACS Biomater Sci Eng. 2020;6(12):6490–6509.
   PubMed Web of Science ®Google Scholar
• Kumar H, Sakthivel K, Mohamed MGA, et al. Designing gelatin methacryloyl (GelMA)-based bioinks for visible light stereolithographic 3D biofabrication. Macromol Biosci. 2021;21(1):e2000317.
   PubMed Web of Science ®Google Scholar
• Goto R, Nishida E, Kobayashi S, et al. Gelatin methacryloyl-riboflavin (GelMA-RF) hydrogels for bone regeneration. Int J Mol Sci. 2021;22(4):1635.
   Web of Science ®Google Scholar
• Zheng Y, Wu G, Chen L, et al. Neuro-regenerative imidazole-functionalized GelMA hydrogel loaded with hAMSC and SDF-1α promote stem cell differentiation and repair focal brain injury. Bioact Mater. 2021;6(3):627–637.
   PubMed Web of Science ®Google Scholar
• Ozudogru E, Isik M, Eylem CC, et al. Decellularized spinal cord meninges extracellular matrix hydrogel that supports neurogenic differentiation and vascular structure formation. J Tissue Eng Regen Med. 2021;15(11):948–963.
   PubMed Web of Science ®Google Scholar
• Ma YH, Shi HJ, Wei QS, et al. Developing a mechanically matched decellularized spinal cord scaffold for the in situ matrix-based neural repair of spinal cord injury. Biomaterials. 2021;279:121192.
   PubMed Web of Science ®Google Scholar
• Fan L, Liu C, Chen X, et al. Directing induced pluripotent stem cell derived neural stem cell fate with a three-dimensional biomimetic hydrogel for spinal cord injury repair. ACS Appl Mater Interfaces. 2018;10(21):17742–17755.
   PubMed Web of Science ®Google Scholar
• Xu P, Guan J, Chen Y, et al. Stiffness of photocrosslinkable gelatin hydrogel influences nucleus pulposus cell propertiesin vitro. J Cell Mol Med. 2021;25(2):880–891.
   PubMed Web of Science ®Google Scholar
• Sun JH, Li G, Wu TT, et al. Decellularization optimizes the inhibitory microenvironment of the optic nerve to support neurite growth. Biomaterials. 2020;258:120289.
   PubMed Web of Science ®Google Scholar
• Kanie K, Kondo Y, Owaki J, et al. Focused screening of ECM-selective adhesion peptides on cellulose-bound peptide microarrays. Bioengineering (Basel). 2016;3(4):31.
   Google Scholar
• Anderson MA, O'Shea TM, Burda JE, et al. Required growth facilitators propel axon regeneration across complete spinal cord injury. Nature. 2018;561(7723):396–400.
   PubMed Web of Science ®Google Scholar
• Gloster A, El-Bizri H, Bamji SX, et al. Early induction of Talpha1 alpha-tubulin transcription in neurons of the developing nervous system. J Comp Neurol. 1999;405(1):45–60.
   PubMed Web of Science ®Google Scholar
• De Camilli P, Miller PE, Navone F, et al. Distribution of microtubule-associated protein 2 in the nervous system of the rat studied by immunofluorescence. Neuroscience. 1984;11(4):817–846.
   PubMed Web of Science ®Google Scholar
• Wang LS, Chung JE, Chan PP, et al. Injectable biodegradable hydrogels with tunable mechanical properties for the stimulation of neurogenesic differentiation of human mesenchymal stem cells in 3D culture. Biomaterials. 2010;31(6):1148–1157.
   PubMed Web of Science ®Google Scholar
• Tseng TC, Tao L, Hsieh FY, et al. An injectable, self-healing hydrogel to repair the Central nervous system. Adv Mater. 2015;27(23):3518–3524.
   PubMed Web of Science ®Google Scholar
• DeQuach JA, Yuan SH, Goldstein LS, et al. Decellularized porcine brain matrix for cell culture and tissue engineering scaffolds. Tissue Eng A. 2011;17(21–22):2583–2592.
   PubMed Web of Science ®Google Scholar
• Crapo PM, Medberry CJ, Reing JE, et al. Biologic scaffolds composed of Central nervous system extracellular matrix. Biomaterials. 2012;33(13):3539–3547.
   PubMed Web of Science ®Google Scholar
• Fan Z, Liao X, Tian Y, et al. A prevascularized nerve conduit based on a stem cell sheet effectively promotes the repair of transected spinal cord injury. Acta Biomater. 2020;101:304–313.
   PubMed Web of Science ®Google Scholar