REFERENCES
- Davidson AE, Hayes S, Hardcastle AJ, Tuft SJ. The pathogenesis of keratoconus. Eye. 2014;28:189–195. doi:10.1038/eye.2013.278.
- Shi Y. Strategies for improving the early diagnosis of keratoconus. Clin Optom. 2016;8:13–21. doi:10.2147/OPTO.S63486.
- Wei RH, Zhao SZ, Lim L, Tan DTH. Incidence and characteristics of unilateral keratoconus classified on corneal topography. J Refract Surg. 2011;27:745–751. doi:10.3928/1081597X-20110426-01.
- Lema I, Durán JA. Inflammatory molecules in the tears of patients with keratoconus. Ophthalmology. 2005;112:654–659. doi:10.1016/j.ophtha.2004.11.050.
- Balasubramanian SA, Mohan S, Pye DC, Willcox MDP. Proteases, proteolysis and inflammatory molecules in the tears of people with keratoconus. Acta Ophthalmol. 2012;90:e303–e309. doi:10.1111/j.1755-3768.2011.02369.x.
- Lema I, Sobrino T, Durán JA, Brea D, Diez-Feijoo E. Subclinical keratoconus and inflammatory molecules from tears. Br J Ophthalmol. 2009;93:820–824. doi:10.1136/bjo.2008.144253.
- Lema I, Brea D, Rodríguez-González R, Díez-Feijoo E, Sobrino T. Proteomic analysis of the tear film in patients with keratoconus. Mol Vis. 2010;16:2055–2061.
- Flanagan JL, Willcox MD. Role of lactoferrin in the tear film. Biochimie. 2009;91:35–43. doi:10.1016/j.biochi.2008.07.007.
- Ueta M, Kinoshita S. Ocular surface inflammation is regulated by innate immunity. Prog Retin Eye Res. 2012;31:551–575. doi:10.1016/j.preteyeres.2012.05.003.
- Akira S. TLR signaling. Curr Top MicrobiolImmunol. 2006;311:1–16.
- Lambiase A, Micera A, Sacchetti M, Mantelli F, Bonini S. Toll-like receptors in ocular surface diseases: overview and new findings. Clin Sci. 2011;120:441–450. doi:10.1042/CS20100425.
- Rabinowitz YS, Rasheed K. A quantitative videokeratography algorithm embodying minimal topographic criteria for diagnosing keratoconous. J Cataract Refrac Surg. 1999;25:1327–1335. doi:10.1016/S0886-3350(99)00195-9.
- McMahon TT, Szczotka-Flynn L, Barr JT, et al. CLEK study group. A new method for grading the severity of keratoconus: the Keratoconus Severity Score (KSS). Cornea. 2006;25:794–800. doi:10.1097/01.ico.0000226359.26678.d1.
- Rao SN, Raviv T, Majmudar PA, Epstein RJ. Role of Orbscan II in screening keratoconus suspects before refractive corneal surgery. Ophthalmology. 2002;109:1642–1646.
- Steinberg J, Katz T, Lücke K, Frings A, Druchkiv V, Linke SJ. Screening for keratoconus with new dynamic biomechanical in vivo scheimpflug analyses. Cornea. 2015;34:1404–1412. doi:10.1097/ICO.0000000000000598.
- McMonnies CW. Inflammation and keratoconus. Optom Vis Sci. 2015;92:35–41. doi:10.1097/OPX.0000000000000455.
- Galvis V, Sherwin T, Tello A, Merayo J, Barrera R, Acera A. Keratoconus: an inflammatory disorder? Eye. 2015;29:843–859. doi:10.1038/eye.2015.63.
- Ortak H, Sogut E, Tas U, Mesci C, Mendil D. The relation between keratoconus and plasma levels of MMP-2, zinc, and SOD. Cornea. 2012;31:1048–1051. doi:10.1097/ICO.0b013e318254c028.
- Kilic R, Cumurcu T, Sancaktar E, Evliyaoğlu O, Sezer H. Systemic prolidase activity and oxidative stress in keratoconus. Curr Eye Res. 2016;41:28–33. doi:10.3109/02713683.2015.1004717.
- Sobrino T, Regueiro U, Malfeito M, et al. Higher expression of toll-like receptors 2 and 4 in blood cells of Keratoconus patients. Sci Rep. 2017;7:12975. doi:10.1038/s41598-017-13525-7.
- Wisse RPL, Kuiper JJW, Gans R, Imhof S, Radstake TRDJ, van der Lelij A. Cytokine expression in keratoconus and its corneal microenvironment: a systematic review. Ocul Surf. 2015;13:272–283. doi:10.1016/j.jtos.2015.04.006.
- Choi HJ, Kim MK, Ko JH, et al. Effect of Toll-like receptors 2 and 4 of corneal fibroblasts on cytokine expression with co-culture antigen presenting cells. Cytokine. 2011;56:265–271. doi:10.1016/j.cyto.2011.07.004.
- Kücüksezer UC, Palomares O, Rückert B, et al. Triggering of specific toll-like receptors and proinflammatory cytokines breaks allergen-specific T-cell tolerance in human tonsils and peripheral blood. J Allergy Clin Immunol. 2013;131:875–885. doi:10.1016/j.jaci.2012.10.051.
- Oh JY, Choi H, Lee RH, et al. Identification of the HSPB4/TLR2/NFkB axis in macrophage as a therapeutic target for sterile inflammation of the cornea. EMBO Mol Med. 2012;4:435–448. doi:10.1002/emmm.201200221.
- Bonini S, Micera A, Iovieno A, Lambiase A, Bonini S. Expression of toll-like receptors in healthy and allergic conjunctiva. Ophthalmology. 2005;112:1528–1534. doi:10.1016/j.ophtha.2005.04.009.