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Original Article

Effect of Rapamycin Microspheres in Sjögren Syndrome Dry Eye: Preparation and Outcomes

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Pages 1357-1364 | Received 08 Dec 2017, Accepted 19 Sep 2018, Published online: 01 Oct 2018

REFERENCES

  • K. F-L, H. I, Manthorpe R ea. Sjogren’s syndrome. Ann Ophthalmol. 1980;12:836–846.
  • London NJ, Chiang A, Haller JA. The dexamethasone drug delivery system: indications and evidence. Adv Ther. 2011;28:351–366. doi:10.1007/s12325-011-0019-z.
  • Li J, Kim SG, Blenis J. Rapamycin: one drug, many effects. Cell Metab. 2014;19:373–379. doi:10.1016/j.cmet.2014.01.001.
  • Wyzgal J, Paczek L, Senatorski G, et al. Sirolimus rescue treatment in calcineurin-inhibitor nephrotoxicity after kidney transplantation. Transplant Proc. 2002;34:3185–3187.
  • Markiewicz M, Kalicinski P, Teisseyre J, Ismail H, Kaminski A, Teisseyre M. Rapamycin in children after liver transplantation. Transplant Proc. 2003;35:2284–2286.
  • W. ZXY. Effect of rapamycin applied locally in corneal neova secularization of rabbit after alkali burning. Chin J Ocul Trauma Occup Eye Dis. 2009;31:401–404.
  • Chueh SC, Kahan BD. Clinical application of sirolimus in renal transplantation: an update. Transplant Int. 2005;18:261–277. doi:10.1111/j.1432-2277.2004.00039.x.
  • Anisimov VN, Zabezhinski MA, Popovich IG, et al. Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice. Cell Cycle. 2011;10:4230–4236. doi:10.4161/cc.10.24.18486.
  • Shirouzu Y, Ryschich E, Salnikova O, Kerkadze V, Schmidt J, Engelmann G. Rapamycin inhibits proliferation and migration of hepatoma cells in vitro. J Surg Res. 2010;159:705–713. doi:10.1016/j.jss.2008.07.035.
  • Yao C, Liu J, Shao L. Rapamycin inhibits the proliferation and apoptosis of gastric cancer cells by down regulating the expression of survivin. Hepato-gastroenterology. 2011;58:1075–1080.
  • Yoshizaki A, Yanaba K, Yoshizaki A, et al. Treatment with rapamycin prevents fibrosis in tight-skin and bleomycin-induced mouse models of systemic sclerosis. Arthritis Rheum. 2010;62:2476–2487. doi:10.1002/art.27498.
  • Bridle KR, Popa C, Morgan ML, et al. Rapamycin inhibits hepatic fibrosis in rats by attenuating multiple profibrogenic pathways. Liver Transpl. 2009;15:1315–1324. doi:10.1002/lt.21804.
  • Shah M, Edman MC, Reddy Janga S, et al. Rapamycin eye drops suppress lacrimal gland inflammation in a murine model of Sjogren’s syndrome. Invest Ophthalmol Vis Sci. 2017;58:372–385. doi:10.1167/iovs.16-19159.
  • Zhang Z, Wu X, Duan J, et al. Low dose rapamycin exacerbates autoimmune experimental uveitis. PLoS One. 2012;7:e36589. doi:10.1371/journal.pone.0036589.
  • Bertelmann E, Pleyer U. Immunomodulatory therapy in ophthalmology - is there a place for topical application? Ophthalmologica Journal International D’ophtalmologie International Journal of Ophthalmology Zeitschrift Fur Augenheilkunde. 2004;218:359–367. doi:10.1159/000080937.
  • Benjamin D, Colombi M, Moroni C, Hall MN. Rapamycin passes the torch: a new generation of mTOR inhibitors. Nat Rev Drug Discov. 2011;10:868–880. doi:10.1038/nrd3531.
  • Sehgal SN, Baker H, Vezina C. Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization. J Antibiot. 1975;28:727–732.
  • Yuan XB, Yuan YB, Jiang W, et al. Preparation of rapamycin-loaded chitosan/PLA nanoparticles for immunosuppression in corneal transplantation. Int J Pharm. 2008;349:241–248. doi:10.1016/j.ijpharm.2007.07.045.
  • Hu C, Feng H, Zhu C. Preparation and characterization of rifampicin-PLGA microspheres/sodium alginate in situ gel combination delivery system. Colloids Surf B Biointerfaces. 2012;95:162–169. doi:10.1016/j.colsurfb.2012.02.030.
  • Khoee S, Hossainzadeh MT. Effect of O/S/W process parameters on 17beta-EV loaded nanoparticles properties. Colloids Surf B Biointerfaces. 2010;75:133–140. doi:10.1016/j.colsurfb.2009.08.021.
  • Kawashima M, Nakamura S, Izuta Y, Inoue S, Tsubota K. Dietary supplementation with a combination of lactoferrin, fish oil, and enterococcus faecium WB2000 for treating dry eye: A rat model and human clinical study. Ocul Surf. 2016. doi:10.1016/j.jtos.2015.12.005.
  • Vashisht S, Singh S. Evaluation of phenol red thread test versus schirmer test in dry eyes: A comparative study. Int J Appl Basic Med Res. 2011;1:40–42. doi:10.4103/2229-516X.81979.
  • Senchyna M, Wax MB. Quantitative assessment of tear production: A review of methods and utility in dry eye drug discovery. J Ocul Biol Dis Infor. 2008;1:1–6. doi:10.1007/s12177-008-9006-2.
  • Nakamura S, Shibuya M, Nakashima H, Imagawa T, Uehara M, Tsubota K. D-beta-hydroxybutyrate protects against corneal epithelial disorders in a rat dry eye model with jogging board. Invest Ophthalmol Vis Sci. 2005;46:2379–2387. doi:10.1167/iovs.04-1344.
  • van Bijsterveld OP. Diagnostic tests in the Sicca syndrome. Arch Ophthalmol. 1969;82:10–14.
  • Nelson JD. Impression cytology. Cornea. 1988;7:71–81.
  • Veroux M, Tallarita T, Corona D, D’Assoro A, Gurrieri C, Veroux P. Sirolimus in solid organ transplantation: current therapies and new frontiers. Immunotherapy. 2011;3:1487–1497. doi:10.2217/imt.11.143.
  • Kitagawa H, Hotta Y, Fujiki K, Kanai A. Cloning and high expression of rabbit FKBP25 in cornea. Jpn J Ophthalmol. 1996;40:133–141.
  • Kang CB, Hong Y, Dhe-Paganon S, Yoon HS. FKBP family proteins: immunophilins with versatile biological functions. Neuro-Signals. 2008;16:318–325. doi:10.1159/000123041.
  • Krishnadev N, Forooghian F, Cukras C, et al. Subconjunctival sirolimus in the treatment of diabetic macular edema. Graefe’s Arch Clin Exp Ophthalmol= Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. 2011;249:1627–1633. doi:10.1007/s00417-011-1694-9.
  • Nguyen QD, Ibrahim MA, Watters A, et al. Ocular tolerability and efficacy of intravitreal and subconjunctival injections of sirolimus in patients with non-infectious uveitis: primary 6-month results of the SAVE study. J Ophthalmic Inflamm Infect. 2013;3:32. doi:10.1186/1869-5760-3-32.
  • Zandstra J, van Beuge MM, Zuidema J, et al. Microsphere-based rapamycin delivery, systemic versus local administration in a rat model of renal ischemia/reperfusion injury. Pharm Res. 2015;32:3238–3247. doi:10.1007/s11095-015-1700-8.
  • Falke LL, van Vuuren SH, Kazazi-Hyseni F, et al. Local therapeutic efficacy with reduced systemic side effects by rapamycin-loaded subcapsular microspheres. Biomaterials. 2015;42:151–160. doi:10.1016/j.biomaterials.2014.11.042.

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