References
- Krachmer JH, Eagle RC, Belin MD. Keratoconus and related non-inflammatory corneal thinning disorders. Surv Ophthalmol. 1984;28:293–322. doi:https://doi.org/10.1016/0039-6257(84)90094-8.
- Rabinowitz YS. Keratoconus. Surv Ophthalmol. 1998;42:297–319. doi:https://doi.org/10.1016/S0039-6257(97)00119-7.
- Godefrooij DA, de Wit GA, Uiterwaal CS, Imhof SM, Wisse RP, Incidence A-S. Prevalence of Keratoconus: A nationwide registration study. Am J Ophthalmol. 2017;175:169–172. doi:https://doi.org/10.1016/j.ajo.2016.12.015.
- Lema I, Duran JA. Inflammatory molecules in the tears of patients with keratoconus. Ophthalmology. 2005;112:654–659. doi:https://doi.org/10.1016/j.ophtha.2004.11.050.
- Lema I, Sobrino T, Duran JA, Brea D, Diez-Feijoo E. Subclinical keratoconus and inflammatory molecules from tears. British J Ophthalmol. 2009;93:820–824. doi:https://doi.org/10.1136/bjo.2008.144253.
- Ionescu C, Corbu CG, Tanase C, et al. Inflammatory biomarkers profile as microenvironmental expression in Keratoconus. Dis Markers. 2016;2016:1243819. doi:https://doi.org/10.1155/2016/1243819.
- Kenney MC, Chwa M, Atilano SR, et al. Increased levels of catalase and cathepsin V/L2 but decreased TIMP-1 in keratoconus corneas: evidence that oxidative stress plays a role in this disorder. Invest Ophthalmol Vis Sci. 2015;46:823–832. doi:https://doi.org/10.1167/iovs.04-0549.
- Balasubramanian SA, Wasinger VC, Pye DC, Willcox MD. Preliminary identification of differentially expressed tear proteins in keratoconus. Mol Vis. 2013;19:e2124–34.
- Gordon-Shaag A, Millodot M, Shneor E, Liu Y. The genetic and environmental factors for keratoconus. Biomed Res Int. 2015;2015:795738. doi:https://doi.org/10.1155/2015/795738.
- Galvis V, Sherwin T, Tello A, Merayo J, Barrera R, Acera A. Keratoconus: an inflammatory disorder? Eye. 2015;29:843–885. doi:https://doi.org/10.1038/eye.2015.63.
- Yenihayat F, Ö A, Kasap M, Akpınar G, Güzel N, Çelik OS. Comparative proteome analysis of the tear samples in patients with low-grade keratoconus. Int Ophthalmol. 2018;38(5):1895–1905. doi:https://doi.org/10.1007/s10792-017-0672-6.
- McKay TB, Hjortdal J, Priyadarsini S, Karamichos D. Acute hypoxia influences collagen and matrix metalloproteinase expression by human keratoconus cells in vitro. PLoS One. 2017;2017:e0176017. doi:https://doi.org/10.1371/journal.pone.0176017.
- McKay TB, Hjortdal J, Sejersen H, Karamichos D. Differential effects of hormones on cellular metabolism in Keratoconus in vitro. Sci Rep. 2017;17:42896. doi:https://doi.org/10.1038/srep42896.
- Wisse RP, Kuiper JJ, Gans R, Imhof S, Radstake TR, Van der Lelij A. Cytokine expression in keratoconus and its corneal microenvironment: A systematic review. Ocul Surf. 2015;13:272–283. doi:https://doi.org/10.1016/j.jtos.2015.04.006.
- Yuksel E, Yalinbas D, Aydin B, Bilgihan K. Keratoconus progression induced by in vitro fertilization treatment. J Refract Surg. 2016;32:60–63. doi:https://doi.org/10.3928/1081597X-20151207-10.
- Shen Y, Han T, Jhanji V, et al. Correlation between corneal topographic, densitometry, and biomechanical parameters in Keratoconus eyes. Transl Vis Sci Technol. 2019;6;8:12. doi:https://doi.org/10.1167/tvst.8.3.12.
- Collier SA. Is the corneal degradation in keratoconus caused by matrix-metalloproteinases? Clin Exp Ophthalmol. 2001;29:340–344. doi:https://doi.org/10.1046/j.1442-9071.2001.d01-17.x.
- Saghizadeh M, Chwa M, Aoki A, et al. Altered expression of growth factors and cytokines in Keratoconus, bullous keratopathy and diabetic corneas. Exp Eye Res. 2001;73:179–189. doi:https://doi.org/10.1006/exer.2001.1028.
- Mackiewicz Z, Määttä M, Stenman M, Konttinen L, Tervo T, Konttinen YT. Collagenolytic proteinases in keratoconus. Cornea. 2006;25:603–610. doi:https://doi.org/10.1097/01.ico.0000208820.32614.00.
- Matthews FJ, Cook SD, Majid MA, Dick AD, Smith VA. Changes in the balance of the tissue inhibitor of matrix metalloproteinases (TIMPs)-1 and −3 may promote keratocyte apoptosis in keratoconus. Exp Eye Res. 2007;84:1125–1134. doi:https://doi.org/10.1016/j.exer.2007.02.013.
- Lema I, Brea D, Rodríguez-González R, Díez-Feijoo E, Sobrino T. Proteomic analysis of the tear film in patients with keratoconus. Mol Vis. 2010;16:2055–2061.
- Pannebaker C, Chandler HL, Nichols JJ. Tear proteomics in keratoconus. Mol Vis. 2010;16:1949–1957.
- Jun AS, Cope L, Speck C, et al. Subnormal cytokine profile in the tear fluid of keratoconus patients. PLoS One. 2011;6:e16437. doi:https://doi.org/10.1371/journal.pone.0016437.
- Acera A, Vecino E, Rodríguez-Agirretxe I, et al. Changes in tear protein profile in keratoconus disease. Eye. 2011;25:1225–1233. doi:https://doi.org/10.1038/eye.2011.105.
- Sakimoto T, Sawa M. Metalloproteinases in corneal diseases: degradation and processing. Cornea. 2012;31(Suppl1):S50–6. doi:https://doi.org/10.1097/ICO.0b013e318269ccd0.
- Balasubramanian SA, Mohan S, Pye DC, Willcox MD. Proteases, proteolysis and inflammatory molecules in the tears of people with keratoconus. Acta Ophthalmol. 2012;90:e303–e309. doi:https://doi.org/10.1111/j.1755-3768.2011.02369.x.
- Balasubramanian SA, Pye DC, Willcox MD. Levels of lactoferrin, secretory IgA and serum albumin in the tear film of people with keratoconus. Exp Eye Res. 2012;96:132–137. doi:https://doi.org/10.1016/j.exer.2011.12.010.
- Kolozsvári BL, Petrovski G, Gogolák P, et al. Association between mediators in the tear fluid and the severity of keratoconus. Ophthalmic Res. 2014;51:46–51. doi:https://doi.org/10.1159/000351626.
- Sorkhabi R, Ghorbanihaghjo A, Taheri N, Ahoor MH. Tear film inflammatory mediators in patients with keratoconus. Int Ophthalmol. 2015;35:467–472. doi:https://doi.org/10.1007/s10792-014-9971-3.
- Shetty R, Ghosh A, Lim RR, et al. Elevated expression of matrix metalloproteinase-9 and inflammatory cytokines in keratoconus patients is inhibited by cyclosporine A. Invest Ophthalmol Vis Sci. 2015;56:738–750. doi:https://doi.org/10.1167/iovs.14-14831.
- Pásztor D, Kolozsvári BL, Csutak A, et al. Scheimpflug imaging parameters associated with tear mediators and bronchial asthma in Keratoconus. J Ophthalmol. 2016;2016:e9392640.
- Nishtala K, Pahuja N, Shetty R, Nuijts RM, Ghosh A. Tear biomarkers for keratoconus. Eye Vis (Lond). 2016;3:e19. 4. doi:https://doi.org/10.1186/s40662-016-0051-9.
- Shetty R, Deshmukh R, Ghosh A, Sethu S, Jayadev C. Altered tear inflammatory profile in Indian keratoconus patients - the 2015 col rangachari award paper. Indian J Ophthalmol. 2017;65:1105–1108. doi:https://doi.org/10.1016/j.jcrs.2011.08.041.
- Sharif R, Bak-Nielsen S, Hjortdal J, Karamichos D. Pathogenesis of Keratoconus: The intriguing therapeutic potential of Prolactin-inducible protein. Prog Retin Eye Res. 2018;67:150–167. doi:https://doi.org/10.1016/j.preteyeres.2018.05.002.
- Sharif R, Bak-Nielsen S, Sejersen H, Ding K, Hjortdal J, Karamichos D. Prolactin-Induced Protein is a novel biomarker for Keratoconus. Exp Eye Res. 2019;179:55–63. doi:https://doi.org/10.1016/j.exer.2018.10.015.
- Wollensak G, Spoerl E, Seiler T. Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol. 2003;135:620–627. doi:https://doi.org/10.1016/S0002-9394(02)02220-1.
- Raiskup-Wolf F, Hoyer A, Spoerl E, Pillunat LE. Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: long-term results. J Cataract Refract Surg. 2008;34:796–801. doi:https://doi.org/10.1016/j.jcrs.2007.12.039.
- Vinciguerra P, Albè E, Trazza S, Seiler T, Epstein D. Intraoperative and postoperative effects of corneal collagen cross-linking on progressive keratoconus. Arch Ophthalmol. 2009;127:1258–1265. doi:https://doi.org/10.1001/archophthalmol.2009.205.
- Greenstein SA, Fry KL, Hersh MJ, Hersh PS. Higher-order aberrations after corneal collagen crosslinking for keratoconus and corneal ectasia. J Cataract Refract Surg. 2012;38:292–302. doi:https://doi.org/10.1016/j.jcrs.2011.08.041.
- Arora R, Jain P, Goyal JL, Gupta D. Comparative analysis of refractive and topographic changes in early and advanced Keratoconic eyes undergoing corneal collagen crosslinking. Cornea. 2013;32:1359–1364. doi:https://doi.org/10.1097/ICO.0b013e3182a02ddb.
- Rabinowitz YS. Videokeratographic indices to aid in screening for keratoconus. J Refract Surg. 1995;11:371–379.
- De Bernardo M, Capasso L, Lanza M, et al. Long-term results of corneal collagen crosslinking for progressive keratoconus. J Optom. 2015;8:180–186. doi:https://doi.org/10.1016/j.optom.2014.05.006.
- Spadea L, Salvatore S, Verboschi F, Vingolo EM. Corneal collagen cross-linking followed by phacoemulsification with IOL implantation for progressive keratoconus associated with high myopia and cataract. Int Ophthalmol. 2015;35:727–731. doi:https://doi.org/10.1007/s10792-015-0107-1.
- Waszczykowska A, Jurowski P. Two-year accelerated corneal cross-linking outcome in patients with progressive keratoconus. Biomed Res Int. 2015;2015:325157.
- Fodor M, Kolozsvári BL, Petrovski G, et al. Effect of contact lens wear on the release of tear mediators in keratoconus. Eye Contact Lens. 2013;39:147–152. doi:https://doi.org/10.1097/ICL.0b013e318273b35f.
- Wei Y, Gadaria-Rathod N, Epstein S, Asbell P. Tear cytokine profile as a noninvasive biomarker of inflammation for ocular surface diseases: standard operating procedures. Invest Ophthalmol Vis Sci. 2013;54:8327–8336. doi:https://doi.org/10.1167/iovs.13-12132.
- Martínez-Abad A, Piñero DP, Chorro E, Bataille L, Alió JL. Development of a reference model for Keratoconus progression prediction based on characterization of the course of nonsurgically treated cases. Cornea. 2018;37:1497–1505. doi:https://doi.org/10.1097/ICO.0000000000001673.
- Karaca EE, Özmen MC, Ekici F, Yüksel E, Türkoğlu Z. Neutrophil-to-lymphocyte ratio may predict progression in patients with keratoconus. Cornea. 2014;33:1168–1173. doi:https://doi.org/10.1097/ICO.0000000000000260.
- Lee HK, Lee KS, Kim HC, Lee SH, Kim EK. Nerve growth factor concentration and implications in photorefractive keratectomy vs laser in situ keratomileusis. Am J Ophthalmol. 2005;139:965–971. doi:https://doi.org/10.1016/j.ajo.2004.12.051.
- Nguyen DH, Beuerman RW, Thompson HW, DiLoreto DA. Growth factor and neurotrophic factor mRNA in human lacrimal gland. Cornea. 1997;16:192–199.
- Lambiase A, Micera A, Sacchetti M, Cortes M, Mantelli F, Bonini S. Alterations of tear neuromediators in dry eye disease. Arch Ophthalmol. 2011;129:981–986. doi:https://doi.org/10.1001/archophthalmol.2011.200.
- Lambiase A, Manni L, Bonini S, Rama P, Micera A, Aloe L. Nerve growth factor promotes corneal healing: structural, biochemical, and molecular analyses of rat and human corneas. Invest Ophthalmol Vis Sci. 2000;41:1063–1069.
- Pouliquen Y, Bureau J, Mirshahi M, Mirshahi SS, Assouline M, Lorens G. Keratoconus and inflammatory processes. Bull Soc Belge Ophtalmol. 1996;262:25–28.