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Original Article

Corneal Microstructural Changes by Confocal Microscopy in Vernal Keratoconjunctivitis Patients Treated with Topical Cyclosporine

, MD, , MD, , MD, , PhD & , MDORCID Icon
Pages 1599-1605 | Received 30 Jul 2019, Accepted 17 Mar 2020, Published online: 10 Apr 2020

References

  • Leonardi A, Bogacka E, Fauquert JL, et al. Ocular allergy: recognizing and diagnosing hypersensitivity disorders of the ocular surface. Allergy. 2012;67:1327–1337.
  • Leonardi A, Motterle L, Bortolotti M. Allergy and the eye. Clin Exp Immunol. 2008;153:17–21.
  • Leonardi A. Vernal keratoconjunctivitis: pathogenesis and treatment. Prog Retin Eye Res. 2002;21:319–339.
  • Tabbara KF. Ocular complications of vernal keratoconjunctivitis. Can J Ophthalmol. 1999;34:88–92.
  • Bonini S, Bonini S, Lambiase A, et al. Vernal keratoconjunctivitis revisited: a case series of 195 patients with long-term followup. Ophthalmology. 2000;107:1157–1163.
  • Bacon AS, Tuft SJ, Metz DM, et al. The origin of keratopathy in chronic allergic eye disease: a histopathological study. Eye (Lond). 1993;7(Pt 3 Suppl):21–25.
  • Leonardi A, Lazzarini D, Bortolotti M, Piliego F, Midena E, Fregona I. Corneal confocal microscopy in patients with vernal keratoconjunctivitis. Ophthalmology. 2012;119:509–515.
  • Matsuda S, Koyasu S. Mechanisms of action of cyclosporine. Immunopharmacology. 2000;47:119–125.
  • Utine CA, Stern M, Akpek EK. Clinical Review: topical Ophthalmic Use of Cyclosporin A. Ocul Immunol Inflamm. 2010;18:352–361.
  • Pucci N, Novembre E, Cianferoni A, et al. Efficacy and safety of cyclosporine eyedrops in vernal keratoconjunctivitis. Ann Allergy Asthma Immunol. 2002;89:298–303.
  • Kaçmaz RO, Kempen JH, Newcomb C, et al. Cyclosporine for Ocular Inflammatory Diseases. Ophthalmology. 2010;117:576–584.
  • Tatlipinar S, Akpek EK. Topical ciclosporin in the treatment of ocular surface disorders. Br J Ophthalmol. 2005;89:1363–1367.
  • Leonardi A, Doan S, Amrane M, et al. A randomized, controlled trial of cyclosporine a cationic emulsion in pediatric vernal keratoconjunctivitis: the VEKTIS study. Ophthalmology. 2019;126:671–681.
  • Sacchetti M, Baiardini I, Lambiase A, et al. Development and testing of the quality of life in children with vernal keratoconjunctivitis questionnaire. Am J Ophthalmol. 2007;144:557–563.e2.
  • Meijering E, Jacob M, Sarria JC, et al. Design and validation of a tool for neurite tracing and analysis in fluorescence microscopy images. Cytom A. 2004;58:167–176
  • Midena E, Cortese M, Miotto S, Gambato C, Cavarzeran F, Ghirlando A. Confocal microscopy of corneal sub-basal nerve plexus: a quantitative and qualitative analysis in healthy and pathologic eyes. J Refract Surg. 2009;25:S125–30.
  • Oliveira-Soto L, Efron N. Morphology of corneal nerves using confocal microscopy. Cornea. 2001;20:374–384.
  • Liu M, Gao H, Wang T, Wang S, Li S, Shi W. An essential role for dendritic cells in vernal keratoconjunctivitis: analysis by laser scanning confocal microscopy. Clin Exp Allergy. 2014;44:362–370.
  • Midena E, Brugin E, Ghirlando A, Sommavilla M, Avogaro A. Corneal diabetic neuropathy: a confocal microscopy study. J Refract Surg. 2006;22:S1047–52.
  • Rosenberg ME, Tervo TM, Immonen IJ, Müller LJ, Grönhagen-Riska C, Vesaluoma MH. Corneal structure and sensitivity in type 1 diabetes mellitus. Invest Ophthalmol Vis Sci. 2000;41:2915–2921.
  • Patel DV, McGhee CNJ. Mapping the corneal sub-basal nerve plexus in keratoconus by in vivo laser scanning confocal microscopy. Invest Ophthalmol Vis Sci. 2006;47:1348–1351.
  • Benítez Del Castillo JM, Wasfy MAS, Fernandez C, Garcia-Sanchez J. An in vivo confocal masked study on corneal epithelium and subbasal nerves in patients with dry eye. Invest Ophthalmol Vis Sci. 2004;45:3030–3035.
  • Pfister DR, Cameron JD, Krachmer JH, Holland EJ. Confocal microscopy findings of Acanthamoeba keratitis. Am J Ophthalmol. 1996;121:119–128.
  • Rosenberg ME, Tervo TMT, Müller LJ, Moilanen JAO, Vesaluoma MH. In vivo confocal microscopy after herpes keratitis. Cornea. 2002;21:265–269.
  • Leonardi A, Carraro G, Modugno RL, et al. Cornea verticillata in Fabry disease: A comparative study between slit-lamp examination and in vivo corneal confocal microscopy. Br J Ophthalmol. 2019;1–5. doi:https://doi.org/10.1136/bjophthalmol-2019-314249
  • Kheirkhah A, Dohlman TH, Amparo F, et al. Effects of corneal nerve density on the response to treatment in dry eye disease. Ophthalmology. 2015;122:662–668.
  • Winchester K, Mathers WD, Sutphin JE, Daley TE. Diagnosis of Acanthamoeba keratitis in vivo with confocal microscopy. Cornea. 1995;14:10–17.
  • Florakis GJ, Moazami G, Schubert H, Koester CJ, Auran JD. Scanning slit confocal microscopy of fungal keratitis. Arch Ophthalmol (Chicago, Ill 1960). 1997;115:1461–1463.
  • Brines M, Culver DA, Ferdousi M, et al. Corneal nerve fiber size adds utility to the diagnosis and assessment of therapeutic response in patients with small fiber neuropathy. Sci Rep. 2018;8:1–11.
  • Shaheen BS, Bakir M, Jain S. Corneal nerves in health and disease. Surv Ophthalmol. 2014;59:263–285.
  • Iaccheri B, Torroni G, Cagini C, et al. Corneal confocal scanning laser microscopy in patients with dry eye disease treated with topical cyclosporine. Eye. 2017;31:788–794.
  • Jester JV, Petroll WM, Cavanagh HD. Corneal stromal wound healing in refractive surgery: the role of myofibroblasts. Prog Retin Eye Res. 1999;18:311–356.
  • Dogru M, Asano-Kato N, Tanaka M, et al. Ocular surface and MUC5AC alterations in atopic patients with corneal shield ulcers. Curr Eye Res. 2005;30:897–908.
  • Hu Y, Matsumoto Y, Adan ES, et al. Corneal In Vivo confocal scanning laser microscopy in patients with atopic keratoconjunctivitis. Ophthalmology. 2008;115:2004–2012.
  • Garcia-Hirschfeld J, Lopez-Briones LG, Belmonte C. Neurotrophic influences on corneal epithelial cells. Exp Eye Res. 1994;59:597–605.
  • Reid TW, Murphy CJ, Iwahashi CK, Foster BA, Mannis MJ. Stimulation of epithelial cell growth by the neuropeptide substance P. J Cell Biochem. 1993;52:476–485.
  • Bremond-Gignac D, Donadieu J, Leonardi A, et al. Prevalence of vernal keratoconjunctivitis: A rare disease? Br J Ophthalmol. 2008;92:1097–1102.
  • Patel DV, McGhee CNJ. In vivo confocal microscopy of human corneal nerves in health, in ocular and systemic disease, and following corneal surgery: A review. Br J Ophthalmol. 2009;93:853–860.
  • Cruzat A, Qazi Y, Hamrah P. In Vivo confocal microscopy of corneal nerves in health and disease. Ocul Surf. 2017;15:15–47.
  • Mocan MC, Durukan I, Irkec M, Orhan M. Morphologic alterations of both the stromal and subbasal nerves in the corneas of patients with diabetes. Cornea. 2006;25:769–773.
  • Allgeier S, Bartschat A, Bohn S, et al. 3D confocal laser-scanning microscopy for large-area imaging of the corneal subbasal nerve plexus. Sci Rep. 2018 10;8(1):7468.

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