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Ocular Immunology and Inflammation Volume 30, 2022 - Issue 6
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Original Articles

Intrastromal Administration of Vancomycin to Maximize Its Early Effect on Methicillin-resistant Staphylococcus Aureus Keratitis: A Rabbit Study

Ahmet Yucel Ucgula Department of Ophthalmology, Bolu Abant Izzet Baysal University, Training and Research Hospital, Bolu, TurkeyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-9945-793X
, MDORCID Icon,
Rukiye Kilic Ucgula Department of Ophthalmology, Bolu Abant Izzet Baysal University, Training and Research Hospital, Bolu, TurkeyORCID Iconhttps://orcid.org/0000-0002-7356-9826
, MDORCID Icon &
Mustafa Behcetb Department of Medical Microbiology, Bolu Abant Izzet Baysal University, Training and Research Hospital, Bolu, Turkey
, MD
Pages 1430-1435 | Received 01 Aug 2020, Accepted 01 Feb 2021, Published online: 11 May 2021

References

  • Ung L, Bispo PJM, Shanbhag SS, Gilmore MS, Chodosh J. The persistent dilemma of microbial keratitis: global burden, diagnosis, and antimicrobial resistance. Surv Ophthalmol. 2019;64(3):255–271. doi:10.1016/j.survophthal.2018.12.003.
  • Egrilmez S, Yildirim-Theveny S. Treatment-resistant bacterial keratitis: challenges and solutions. Clin Ophthalmol. 2020;14:287–297. doi:10.2147/OPTH.S181997.
  • Durrani AF, Atta S, Bhat A, et al. Methicillin-resistant staphylococcal aureus keratitis: initial treatment, risk factors, clinical features, and treatment outcomes. Am J Ophthalmol. 2020;214:119–126. doi:10.1016/j.ajo.2020.03.017.
  • Robaei D, Carnt N, Watson S. Established and emerging ancillary techniques in management of microbial keratitis: A review. Br J Ophthalmol. 2016;100(9):1163–1170. doi:10.1136/bjophthalmol-2015-307371.
  • Mah FS, Davidson R, Holland EJ, et al. Current knowledge about and recommendations for ocular methicillin-resistant staphylococcus aureus. J Cataract Refract Surg. 2014;40(11):1894–1908. doi:10.1016/j.jcrs.2014.09.023.
  • Flynn HW, Batra NR, Schwartz SG, Grzybowski A Antimicrobial treatment: routes/dosages/preparation/adverse effects, antimicrobial resistance, and alternatives. In. Antimicrobial treatment: routes/dosages/preparation/adverse effects, antimicrobial resistance, and alternatives. Endophthalmitis in clinical practice: Springer; 2018.
  • Romanowski EG, Romanowski JE, Shanks RMQ, et al. Topical vancomycin 5% is more efficacious than 2.5% and 1.25% for reducing viable methicillin-resistant staphylococcus aureus in infectious keratitis. Cornea. 2020;39(2):250–253. doi:10.1097/ICO.0000000000002186.
  • Ong SJ, Huang YC, Tan HY, et al. Staphylococcus aureus keratitis: A review of hospital cases. PLoS One. 2013;8(11):e80119. doi:10.1371/journal.pone.0080119.
  • McLeod SD, LaBree LD, Tayyanipour R, Flowers CW, Lee PP, McDonnell PJ. The importance of initial management in the treatment of severe infectious corneal ulcers. Ophthalmology. 1995;102(12):1943–1948. doi:10.1016/S0161-6420(95)30771-3.
  • Nada WM, Al Aswad MA, El-Haig WM. Combined intrastromal injection of amphotericin b and topical fluconazole in the treatment of resistant cases of keratomycosis: A retrospective study. Clin Ophthalmol. 2017;11:871–874. doi:10.2147/OPTH.S135112.
  • Narayana S, Krishnan T, Ramakrishnan S, et al. Mycotic antimicrobial localized injection: A randomized clinical trial evaluating intrastromal injection of voriconazole. Ophthalmology. 2019;126(8):1084–1089. doi:10.1016/j.ophtha.2019.03.020.
  • Gueudry J, Le Goff L, Lamoureux F, et al. Corneal pharmacokinetics of voriconazole and posaconazole following intrastromal injection and posaconazole eye drops instillation in rats. Curr Eye Res. 2020;45(11):1369-1372. doi:10.1080/02713683.2020.1749669
  • Liang SY, Lee GA. Intrastromal injection of antibiotic agent in the management of recalcitrant bacterial keratitis. J Cataract Refract Surg. 2011;37(5):960–962. doi:10.1016/j.jcrs.2011.03.005.
  • Khan IJ, Hamada S, Rauz S. Infectious crystalline keratopathy treated with intrastromal antibiotics. Cornea. 2010;29(10):1186–1188. doi:10.1097/ICO.0b013e3181d403d4.
  • Stangogiannis-Druya E, Stangogiannis-Druya C, Naranjo-Tackman R, Vanzzini V, Villar-Kuri J. [bacterial corneal ulcer treated with intrastromal antibiotic. Experimental model in vivo]. Arch Soc Esp Oftalmol. 2009;84:123–132.
  • Torumkuney D, Tunger A, Sancak B, et al. Results from the survey of antibiotic resistance (soar) 2015-17 in turkey: data based on clsi, eucast (dose-specific) and pharmacokinetic/pharmacodynamic (pk/pd) breakpoints. J Antimicrob Chemother. 2020;75:i88–i99.
  • Parks RW, Clements WD, Smye MG, Pope C, Rowlands BJ, Diamond T. Intestinal barrier dysfunction in clinical and experimental obstructive jaundice and its reversal by internal biliary drainage. Br J Surg. 1996;83(10):1345–1349. doi:10.1002/bjs.1800831007.
  • Grzybowski A, Brona P, Zeman L, Stewart MW. Commonly used intracameral antibiotics for endophthalmitis prophylaxis: A literature review. Surv Ophthalmol. 2021;66(1):98-108. doi:10.1016/j.survophthal.2020.04.006.
  • Chang VS, Dhaliwal DK, Raju L, Kowalski RP. Antibiotic resistance in the treatment of staphylococcus aureus keratitis: A 20-year review. Cornea. 2015;34(6):698–703. doi:10.1097/ICO.0000000000000431.
  • Bhattacharjee H, Bhattacharjee K, Medhi J, Altaf A. Descemet’s membrane detachment caused by inadvertent vancomycin injection. Indian J Ophthalmol. 2008;56(3):241–243. doi:10.4103/0301-4738.40368.
  • Sharma N, Agarwal P, Sinha R, Titiyal JS, Velpandian T, Vajpayee RB. Evaluation of intrastromal voriconazole injection in recalcitrant deep fungal keratitis: case series. Br J Ophthalmol. 2011;95(12):1735–1737. doi:10.1136/bjo.2010.192815.

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