112
Views
0
CrossRef citations to date
0
Altmetric
Original Articles

Analysis of Nuclear Receptor Coactivator 5 (NCOA5) Messenger RNA Expression and rs2903908 Single Nucleotide Polymorphism of NCOA5 in an Egyptian Cohort with Behçet’s Disease: A Single-Center Case-control Study

, MDORCID Icon, , MD, , MSc, , MD, FRCS GlasgowORCID Icon, , MDORCID Icon, , MDORCID Icon & , MDORCID Icon show all
Pages 1436-1446 | Received 01 Jun 2020, Accepted 08 Feb 2021, Published online: 13 Jul 2021

References

  • Mazzoccoli G, Matarangolo A, Rubino R, Inglese M, De Cata A. Behcet syndrome: from pathogenesis to novel therapies. Clin Exp Med. 2016;16(1):1–12. doi:10.1007/s10238-014-0328-z.
  • Gheita TA, Abd El-Latif EM, El-Gazzar II, et al.; on behalf of Egyptian College of Rheumatology – Behçet’s Disease Study Group (ECR-BDSG). Prevalence, gender-predominance and clinical presentation of Behçet’s disease in Egypt: preliminary findings from a multicenter nationwide study. Ann Rheum Dis. 2018;77(2):1762–1763.
  • Leccese P, Alpsoy E. Behçet’s disease: an overview of etiopathogenesis. Front Immunol. 2019;10:1067. doi:10.3389/fimmu.2019.01067.
  • Van Kooten C, Banchereau J. CD40‐CD40 ligand. J Leukoc Biol. 2000;67(1):2–17. doi:10.1002/jlb.67.1.2.
  • Mousa TG, Omar HH, Emad R, et al. The association of CD40 polymorphism (rs1883832C/T) and soluble CD40 with the risk of systemic lupus erythematosus among Egyptian patients. Clin Rheumatol. 2019;38(3):777–784. doi:10.1007/s10067-018-4349-y.
  • Raychaudhuri S, Ef R, At L, et al. Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Nat Genet. 2008;40(10):1216–1223. doi:10.1038/ng.233.
  • Inal EE, Rüstemoğlu A, Inanır A, et al. Associations of rs4810485 and rs1883832 polymorphisms of CD40 gene with susceptibility and clinical findings of Behçet’s disease. Rheumatol Int. 2015;35(5):837–843. doi:10.1007/s00296-014-3171-3.
  • Jiang C, Ito M, Piening V, Bruck K, Roeder RG, Xiao H. TIP30 interacts with an estrogen receptor-interacting coactivator CIA and regulates C-Myc transcription. J Biol Chem. 2004;279(26):27781–27789. doi:10.1074/jbc.M401809200.
  • Yates AD, Achuthan P, Akanni W, et al. Ensembl 2020. Nucleic Acids Res. 2020;48(D1):D682- D688. doi:10.1093/nar/gkz966.
  • UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Res. 2019;47(D1):D506- D515. doi:10.1093/nar/gky1049.
  • Gillespie MA, Gold ES, Ramsey SA, Podolsky I, Aderem A, Ranish JA. An LXR-NCOA5 gene regulatory complex directs inflammatory crosstalk-dependent repression of macrophage cholesterol efflux. Embo J. 2015;34(9):1244–1258. doi:10.15252/embj.201489819.
  • Bensinger SJ, Bradley MN, Joseph SB, et al. LXR signaling couples sterol metabolism to proliferation in the acquired immune response. Cell. 2008;134(1):97–111. doi:10.1016/j.cell.2008.04.052.
  • He P, Sun L, Zhu D, et al. Knock-down of endogenous bornavirus-like nucleoprotein 1 inhibits cell growth and induces apoptosis in human oligodendroglia cells. Int J Mol Sci. 2016;17(4):435. doi:10.3390/ijms17040435.
  • Liu X, Liu F, Gao S, et al. A single non-synonymous NCOA5 variation in type 2 diabetic patients with hepatocellular carcinoma impairs the function of NCOA5 in cell cycle regulation. Cancer Lett. 2017;391:152–161. doi:10.1016/j.canlet.2017.01.028.
  • Böser A, Drexler HC, Reuter H, et al. SILAC proteomics of planarians identifies Ncoa5 as a conserved component of pluripotent stem. cells. 2013;Cell5(4:1142–1155.
  • Jubb AW, Boyle S, Hume DA, Bickmore WA. Glucocorticoid receptor binding induces rapid and prolonged large-scale chromatin decompaction at multiple target Loci. Cell Rep. 2017;21(11):3022–3031. doi:10.1016/j.celrep.2017.11.053.
  • Yang Y, Zhang BH, Gong JP. Genes and molecular mechanisms affecting the correlation between liver cancer and diabetes mellitus. Zhonghua Gan Zang Bing Za Zhi. 2018;26(9):718–720. doi:10.3760/cma.j.1007-3418.2018.09.020.
  • Gao S, Li A, Liu F, et al. NCOA5 haploinsufficiency results in glucose intolerance and subsequent hepatocellular carcinoma. Cancer Cell. 2013;24(6):725–737. doi:10.1016/j.ccr.2013.11.005.
  • Liang Y, Zhang T, Shi M, et al. Low expression of NCOA5 predicts poor prognosis in human cervical cancer and promotes proliferation, migration, and invasion of cervical cancer cell lines by regulating notch3 signaling pathway. J Cell Biochem. 2019;120(4):6237–6249. doi:10.1002/jcb.27911.
  • Naugler WE, Sakurai T, Kim S, et al. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science. 2007;317(5834):121–124. doi:10.1126/science.1140485.
  • Wu Y, Wu J, Dong QR, Guo NZ. Association between expression of nuclear receptor co-activator 5 protein and prognosis in postoperative patients with osteosarcoma. Oncol Lett. 2018;15(2):1888–1892. doi:10.3892/ol.2017.7513.
  • Ye X, Huang D, Luo R. NCOA5 is correlated with progression and prognosis in luminal breast cancer. Biochem Biophys Res Commun. 2017;482(2):253–256. doi:10.1016/j.bbrc.2016.11.051.
  • Lewis JP, Palmer ND, Ellington JB, et al. Analysis of candidate genes on chromosome 20q12‐13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans. Genomics. 2010;96(4):211‐ 219. doi:10.1016/j.ygeno.2010.07.006.
  • Vilariño-Güell C, Zimprich A, Martinelli-Boneschi F, et al. Exome sequencing in multiple sclerosis families identifies 12 candidate genes and nominates biological pathways for the genesis of disease. PloS Genet. 2019;15(6):e1008180. Erratum in: PloS Genet. 2020 Apr 9;16(4):e1008737. doi:10.1371/journal.pgen.1008180.
  • Zervou MI, Goulielmos GN, Castro-Giner F, Boumpas DT, Tosca AD, Krueger-Krasagakis S. A CD40 and an NCOA5 gene polymorphism confer susceptibility to psoriasis in a Southern European population: a case–control study. Hum Immunol. 2011;72(9):761–765. doi:10.1016/j.humimm.2011.05.014.
  • Den Dunnen JT, Dalgleish R, Maglott DR, et al. HGVS recommendations for the description of sequence variants: 2016 update. Hum Mutat. 2016;37(6):564–569. doi:10.1002/humu.22981.
  • Rustemoglu A, Inal EE, Inanir A, et al. Clinical significance of NCOA5 gene rs2903908 polymorphism in Behçet’s disease. Excli J. 2017;16:609–617. doi:10.17179/excli2017-189.
  • Villarreal-Martínez A, Gallardo-Blanco H, Cerda-Flores R, et al. Candidate gene polymorphisms and risk of psoriasis: a pilot study. Exp Ther Med. 2016;11(4):1217–1222. doi:10.3892/etm.2016.3066.
  • Davatchi F, Assaad-Khalil S, Calamia KT, et al. the international criteria for Behçet’s Disease (ICBD): a collaborative study of 27 countries on the sensitivity and specificity of the new criteria. J Eur Acad Dermatol Venereol. 2014;28(3):338–347. doi:10.1111/jdv.12107.
  • Bhakta BB, Brennan P, James TE, Chamberlain MA, Noble BA, Silman AJ. Behçet’s disease: evaluation of a new instrument to measure clinical activity. Rheumatol. 1999;38(8):728–733. doi:10.1093/rheumatology/38.8.728.
  • Krause I, Molad Y, Weinberger A. Association of HLA-B5 with clinical expression and severity of Behcet’s disease in Israel. J Clin Rheumatol. 1999a;5(3):137–140. doi:10.1097/00124743-199906000-00005.
  • Maberley DA, Hollands H, Chuo J, et al. The prevalence of low vision and blindness in Canada. Eye (Lond). 2006;20(3):341–346. doi:10.1038/sj.eye.6701879.
  • Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C T method. Nat Protoc. 2008;3(6):1101–1108. doi:10.1038/nprot.2008.73.
  • Deng Y, Zhu W, Zhou X. Immune regulatory genes are major genetic factors to behcet disease: systematic review. Open Rheumatol J. 2018;12(1):70–85. doi:10.2174/1874312901812010070.
  • Kim JH, Bachmann RA, Chen J. Interleukin-6 and insulin resistance. Vitam Horm. 2009;80:613–633.
  • Liu K, Zou C, Qin B. The association between nuclear receptors and ocular diseases. Oncotarget. 2017;8(16):27603–27615. doi:10.18632/oncotarget.15178.
  • Velez G, Machlab DA, Tang PH, et al. Proteomic analysis of the human retina reveals region-specific susceptibilities to metabolic-and oxidative stress-related diseases. PloS One. 2018;13(2):e0193250. doi:10.1371/journal.pone.0193250.
  • Wishart DS, Knox C, Guo AC, et al. Drugbank: a comprehensive resource for in silico drug discovery and exploration. Nucleic Acids Res. 2006;34:D668–672. doi:10.1093/nar/gkj067.
  • Wilk JB, Walter RE, Laramie JM, Gottlieb DJ, O’Connor GT. Framingham heart study genome-wide association: results for pulmonary function measures. BMC Med Genet. 2007;8(Suppl 1 (Suppl1)):S8. doi:10.1186/1471-2350-8-S1-S8.
  • Kopanos C, Tsiolkas V, Kouris A, et al. VarSome: the human genomic variant search engine. Bioinformatics. 2019;35(11):1978–1980. doi:10.1093/bioinformatics/bty897.
  • Ward LD, Kellis M. HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants. Nucleic Acids Res. 2012;40:D930–934. doi:10.1093/nar/gkr917.
  • Crunkhorn S. Autoimmune disease: aryl hydrocarbon receptor suppresses inflammation. Nat Rev Drug Discov. 2018;17(7):470. doi:10.1038/nrd.2018.107.
  • Palizgir MT, Akhtari M, Mahmoudi M, et al. Macrophages from Behcet’s disease patients express decreased level of aryl hydrocarbon receptor (AHR) mRNA. Iran J Allergy Asthma Immunol. 2017;16:418–424.
  • Wang C, Ye Z, Kijlstra A, Zhou Y, Yang P. Decreased expression of the aryl hydrocarbon receptor in ocular Behcet’s disease. Mediators Inflamm. 2014;(2014):195094. doi:10.1155/2014/195094.
  • Di Meglio P, Duarte JH, Ahlfors H, et al. Activation of the aryl hydrocarbon receptor dampens the severity of inflammatory skin conditions. Immunity. 2014;40(6):989–1001. doi:10.1016/j.immuni.2014.04.019.
  • Zhang F, Xu Y, Cao H, et al. Mapsnp: an R package to plot a genomic map for single nucleotide polymorphisms. PloS One. 2015;10(4):e0123609. doi:10.1371/journal.pone.0123609.
  • Machiela MJ, Chanock SJ. Ldlink: a web-based application for exploring population-specific haplotype structure and linking correlated alleles of possible functional variants. Bioinformatics. 2015;31(21):3555–3557. doi:10.1093/bioinformatics/btv402.
  • Berman HM, Westbrook J, Feng Z, et al. The Protein Data Bank. Nucleic Acids Res. 2000;28(1):235–242. doi:10.1093/nar/28.1.235.
  • Kim S, Chen J, Cheng T, et al. PubChem 2019 update: improved access to chemical data. Nucleic Acids Res. 2019;47(D1):D1102–D1109. doi:10.1093/nar/gky1033.
  • BIOvIA DS. Discovery Studio Modeling Environment. San Diego: Dassault Systemes, Release; 2015:4.
  • Auton A, Brooks LD, Durbin RM, et al.; 1000 Genomes Project Consortium. A global reference for human genetic variation. Nature. 2015;526(7571):68–74.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.