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Ocular Immunology and Inflammation Volume 30, 2022 - Issue 6
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Letters to the Editor

Pembrolizumab-induced Stevens–Johnson Syndrome with Severe Ocular Complications

Soyoung RyuThe Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Republic of KoreaView further author information
, MD,
Ikhyun JunThe Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Republic of KoreaCorrespondence[email protected]
View further author information
, MD, PhD,
Tae-Im KimThe Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Republic of KoreaView further author information
, MD, PhD,
Kyoung Yul SeoThe Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Republic of KoreaView further author information
, MD, PhD &
Eung Kweon KimThe Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Republic of KoreaView further author information
, MD, PhD
Pages 1533-1535 | Received 08 Apr 2020, Accepted 22 Feb 2021, Published online: 07 Apr 2021

References

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  • Ueta M, Tokunaga K, Sotozono C, et al. HLA class I and II gene polymorphisms in Stevens-Johnson syndrome with ocular complications in Japanese. Mol Vis. 2008;14:550–555.
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  • Navarro-Perea C, Garcia-Gonzalez J, Perez-Blazquez E. Case report: bilateral uveitis and papillitis secondary to treatment with pembrolizumab. Indian J Ophthalmol. 2019;67:2075–2077. doi:10.4103/ijo.IJO_1161_19.
  • Fessas P, Possamai LA, Clark J, et al. Immunotoxicity from checkpoint inhibitor therapy: clinical features and underlying mechanisms. Immunology. 2020;159:167–177. doi:10.1111/imm.13141.
  • Antoun J, Titah C, Cochereau I. Ocular and orbital side-effects of checkpoint inhibitors: a review article. Curr Opin Oncol. 2016;28:288–294. doi:10.1097/CCO.0000000000000296.
  • Della Vittoria Scarpati G, Fusciello C, Perri F, et al. Ipilimumab in the treatment of metastatic melanoma: management of adverse events. Onco Targets Ther. 2014;7:203–209. doi:10.2147/OTT.S57335.
  • Fang T, Maberley DA, Etminan M. Ocular adverse events with immune checkpoint inhibitors. J Curr Ophthalmol. 2019;31:319–322. doi:10.1016/j.joco.2019.05.002.
  • Saeed HN, Chodosh J. Ocular manifestations of Stevens-Johnson syndrome and their management. Curr Opin Ophthalmol. 2016;27:522–529. doi:10.1097/ICU.0000000000000312.

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