Ocular Syphilis: Experience over 11 Years at a German Ophthalmology Reference Centre

References

• WHO. Report on global sexually transmitted infection surveillance 2018. WHO. 2019. http://www.who.int/reproductivehealth/publications/stis-surveillance-2018/en/ Accessed March 6, 2021.
   Google Scholar
• Doris JP, Saha K, Jones NP, Sukthankar A. Ocular syphilis: the new epidemic. Eye. 2006;20(6):703–705. doi:10.1038/sj.eye.6701954.
   PubMed Web of Science ®Google Scholar
• Pratas AC, Goldschmidt P, Lebeaux D, et al. Clinical manifestations and ophthalmic outcomes of ocular syphilis at a time of re-emergence of the systemic infection. Ocul Immunol Inflamm. 2018;(1):1–8. doi:10.1038/s41598-018-30559-7.
   PubMedGoogle Scholar
• Koch-Institut R. Epidemiologisches Bulletin Des Robert Koch-Institut Ausgabe 50/2019. 2019. https://survstat.rki Accessed March 28, 2020.
   Google Scholar
• Peeling RW, Mabey D, Kamb ML, Chen X-S, Radolf JD, Benzaken AS. Syphilis. Nat Rev Dis Primers. 2017;3:17073. doi:10.1038/nrdp.2017.73.
   PubMed Web of Science ®Google Scholar
• Yang P, Zhang Z, Zhou H, et al. Clinical patterns and characteristics of uveitis in a tertiary center for uveitis in China. Curr Eye Res. 2005;30:943–948. doi:10.1080/02713680500263606.
   PubMed Web of Science ®Google Scholar
• Peeling RW, Hook EW. The pathogenesis of syphilis: the Great Mimicker, revisited. J Pathol. 2006;208(2):224–232. doi:10.1002/path.1903.
   PubMed Web of Science ®Google Scholar
• Neß T. Lues – Okuläre SyphilisLues – ocular syphilis. Der Ophthalmologe. 2017;114(4):381–390. doi:10.1007/s00347-017-0477-z.
   PubMed Web of Science ®Google Scholar
• Mathew RG, Goh BT, Westcott MC. British Ocular Syphilis Study (BOSS): 2-year national surveillance study of intraocular inflammation secondary to ocular syphilis. Invest Ophthalmol Vis Sci. 2014;55:5394. doi:10.1167/iovs.14-14559.
   PubMed Web of Science ®Google Scholar
• Woolston SL, Dhanireddy S, Marrazzo J. Ocular syphilis: a clinical review. Curr Infect Dis Rep. 2016;18(11):36. doi:10.1007/s11908-016-0542-9.
   PubMed Web of Science ®Google Scholar
• Brodsky JL, Samuel MC, Mohle-Boetani JC, et al. Syphilis outbreak at a California men’s prison, 2007-2008: propagation by lapses in clinical management, case management, and public health surveillance. J Correct Health Care. 2013;19(1):54–64. doi:10.1177/1078345812458088.
   PubMed Web of Science ®Google Scholar
• RKI - RKI-Ratgeber - Syphilis. https://www.rki.de/DE/Content/Infekt/EpidBull/Merkblaetter/Ratgeber_Syphilis.html#doc2382636bodyText1 Accessed April 27, 2019.
   Google Scholar
• Bibbins-Domingo K, Grossman DC, Curry SJ, et al. Screening for syphilis infection in nonpregnant adults and adolescents: US preventive services task force recommendation statement. JAMA. 2016;315(21):2321–2327. doi:10.1001/jama.2016.5824.
   PubMed Web of Science ®Google Scholar
• SurvStat@RKI 2.0. https://survstat.rki.de/Content/Query/Main.aspx Accessed December 13, 2020.
   Google Scholar
• Fonollosa A, Giralt J, Pelegrín L, et al. Ocular syphilisback again: understanding recent increases in the incidence of ocular syphilitic disease. Ocul Immunol Inflamm. 2009;17:207–212. doi:10.1080/09273940902741709.
   PubMed Web of Science ®Google Scholar
• Amaratunge BC, Camuglia JE, Hall AJ. Syphilitic uveitis: a review of clinical manifestations and treatment outcomes of syphilitic uveitis in human immunodeficiency virus-positive and negative patients. Clin Exp Ophthalmol. 2010;38:68–74. doi:10.1111/j.1442-9071.2010.02203.x.
   PubMed Web of Science ®Google Scholar
• Menard A, Meddeb L, Conrath J, Charrel RN, Colson P. Ocular syphilis, an old adversary is back in the old world too! AIDS. 2018;32(16):2433–2434. doi:10.1097/QAD.0000000000001973.
   PubMed Web of Science ®Google Scholar
• Tucker JD, Li JZ, Robbins GK, et al. Ocular syphilis among HIV-infected patients: a systematic analysis of the literature. Sex Transm Infect. 2011;87(1):4–8. doi:10.1136/sti.2010.043042.
   PubMed Web of Science ®Google Scholar
• Dersch R, Hottenrott T, Senel M, et al. The chemokine CXCL13 is elevated in the cerebrospinal fluid of patients with neurosyphilis. Fluids Barriers CNS. 2015;12(1):12. doi:10.1186/s12987-015-0008-8.
   PubMedGoogle Scholar
• Kiss S, Damico FM, Young LH. Ocular manifestations and treatment of syphilis. Semin Ophthalmol. 2005;20(3):161–167. doi:10.1080/08820530500232092.
   PubMedGoogle Scholar
• Aldave AJ, King JA, Cunningham ET. Ocular syphilis. Curr Opin Ophthalmol. 2001;12(6):433–441. doi:10.1097/00055735-200112000-00008.
   PubMed Web of Science ®Google Scholar
• Browning DJ. Posterior segment manifestations of active ocular syphilis, their response to a neurosyphilis regimen of penicillin therapy, and the influence of human immunodeficiency virus status on response. Ophthalmology. 2000;107:2015–2023. doi:10.1016/S0161-6420(00)00457-7.
   PubMed Web of Science ®Google Scholar
• Kuo IC, Kapusta MA, Rao NA. Vitritis as the primary manifestation of ocular syphilis in patients with HIV infection. Am J Ophthalmol. 1998;125:306–311. doi:10.1016/S0002-9394(99)80136-6.
   PubMed Web of Science ®Google Scholar
• Moradi A, Salek S, Daniel E, et al. Clinical features and incidence rates of ocular complications in patients with ocular syphilis. Am J Ophthalmol. 2015;159:334–343.e1. doi:10.1016/j.ajo.2014.10.030.
   PubMed Web of Science ®Google Scholar
• Furtado JM, Arantes TE, Nascimento H, et al. Clinical manifestations and ophthalmic outcomes of ocular syphilis at a time of re-emergence of the systemic infection. Sci Rep. 2018;8(1). doi:10.1038/s41598-018-30559-7.
   Google Scholar
• Salmon JF. Kanski’s clinical ophthalmology : a systematic approach. 8th edition. Philadelphia: Saunders Ltd.;26 May 2015 .
   Google Scholar
• Oliver SE, Aubin M, Atwell L, et al. Ocular syphilis - eight jurisdictions, United States, 2014-2015. MMWR. 2016;65(43):1185–1188. doi:10.15585/mmwr.mm6543a2.
   PubMed Web of Science ®Google Scholar
• Bollemeijer JG, Wieringa WG, Missotten TOAR, et al. Clinical manifestations and outcome of syphilitic uveitis. Invest Ophthalmol Vis Sci. 2016;57(2):404–411. doi:10.1167/iovs.15-17906.
   PubMed Web of Science ®Google Scholar
• Syphilis - 2015 STD treatment guidelines. https://www.cdc.gov/std/tg2015/syphilis.htm Accessed March 28, 2020.
   Google Scholar
• Deutsche STI-Gesellschaft - Gesellschaft zur Förderung der Sexuellen Gesundheit. https://www.dstig.de/was-sind-stdsti/syphilis.html Accessed March 28, 2020.
   Google Scholar
• Workowski KA, Bolan GA. Centers for disease control and prevention. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recommendations Rep. 2015;64(RR–03):1–137. http://www.ncbi.nlm.nih.gov/pubmed/26042815 Accessed April 27, 2019.
   PubMed Web of Science ®Google Scholar
• Sacco KA, Bates A, Brigham TJ, Imam JS, Burton MC. Clinical outcomes following inpatient penicillin allergy testing: a systematic review and meta-analysis. Allergy. 2017;72(9):1288–1296. doi:10.1111/all.13168.
   PubMed Web of Science ®Google Scholar