Effects of Subcutaneous Repository Corticotropin Gel Injection on Regulatory T Cell Population in Noninfectious Retinal Vasculitis

References

• Paovic J, Paovic P, Vukosavljevic M. Clinical and Immunological features of retinal vasculitis in systemic diseases. Vojnosanit Pregl Mil-Med Pharmv Rev. 2009; 66(12):9615.
   Google Scholar
• Rosenbaum JT, Ku J, Ali A, Choi D, Suhler EB. Patients with retinal vasculitis rarely suffer from systemic vasculitis. Semin Arthritis Rheum. 2012;41(6):859–865. doi:10.1016/j.semarthrit.2011.10.006.
   PubMed Web of Science ®Google Scholar
• Rosenbaum JT, Sibley CH, Lin P. Retinal vasculitis. Curr Opin Rheumatol. 2016;28(3):228–235. doi:10.1097/BOR.0000000000000271.
   PubMed Web of Science ®Google Scholar
• Hatemi G, Silman A, Bang D, et al., EULAR Expert Committee. EULAR recommendations for the management of the Behcet disease. Ann Rheum Dis. 2008;67(12):1656–1662. doi:10.1136/ard.2007.080432.
   PubMed Web of Science ®Google Scholar
• Jaffe GJ, Dick AD, Brézin AP, et al. Adalimumab in patients with active noninfectious uveitis. N Engl J Med. 2016;375(10):932–943. doi:10.1056/NEJMoa1509852.
   PubMed Web of Science ®Google Scholar
• Nguyen QD, Merrill PT, Jaffe GJ, et al. Adalimumab for prevention of uveitic flare in patients with inactive non-infectious uveitis controlled by corticosteroids (VISUAL II): a multicentre, double-masked, randomised, placebo-controlled phase 3 trial. Lancet. 2016;388(10050):1183–1192. doi:10.1016/S0140-6736(16)31339-3.
   PubMed Web of Science ®Google Scholar
• Atienza-Mateo B, Calvo-Río V, Beltrán E, et al. Anti-interleukin 6 receptor tocilizumab in refractory uveitis associated with Behçet’s disease: multicentre retrospective study. Rheumatology (Oxford). 2018;57(5):856–864. doi:10.1093/rheumatology/kex480.
   PubMed Web of Science ®Google Scholar
• Wang W, Guo DY, Lin YJ, Tao YX. Melanocortin regulation of inflammation. Front Endocrinol (Lausanne). 2019;10:683. doi:10.3389/fendo.2019.00683.
   PubMed Web of Science ®Google Scholar
• Sharon Y, Chu DS. Adrenocorticotropic hormone gel for patients with non-infectious uveitis. Am J Ophthalmol Case Rep. 2019;15:100502. doi:10.1016/j.ajoc.2019.100502.
   PubMedGoogle Scholar
• Anesi SD, Chang PY, Maleki A, et al. Treatment of noninfectious retinal vasculitis using subcutaneous repository corticotropin injection. J Ophthalmic Vis Res. 2021;16(2):219–233. doi:10.18502/jovr.v16i2.9086.
   PubMedGoogle Scholar
• Agarwal A, Hassan M, Sepah YJ, Do DV, Nguyen QD. Subcutaneous repository corticotropin gel for non-infectious panuveitis: reappraisal of an old pharmacologic agent. Am J Ophthalmol Case Rep. 2016;4:78–82. doi:10.1016/j.ajoc.2016.09.004.
   PubMedGoogle Scholar
• Oh DJ, Singh A, Kanu LN, Lobo-Chan AM, MacIntosh PW, Bhat P. Outcomes of repository corticotropin gel for ocular sarcoidosis. Ocul Immunol Inflamm. 2021;7:1–5. doi:10.1080/09273948.2021.1884887.
   Google Scholar
• Taylor AW, Lee DJ. The alpha-melanocyte stimulating hormone induces conversion of effector T cells into treg cells. J Transplant. 2011;2011:246856. doi:10.1155/2011/246856.
   PubMedGoogle Scholar
• Mandrika I, Muceniece R, Wikberg JE. Effects of melanocortin peptides on lipopolysaccharide/interferon-gamma-induced NF-kappaB DNA binding and nitric oxide production in macrophage-like RAW 264.7 cells: evidence for dual mechanisms of action. Biochem Pharmacol. 2001;61(5):613–621. doi:10.1016/S0006-2952(00)00583-9.
   PubMed Web of Science ®Google Scholar
• Namba K, Kitaichi N, Nishida T, Taylor AW. Induction of regulatory T cells by the immunomodulating cytokines alpha-melanocyte-stimulating hormone and transforming growth factor-beta2. J Leukoc Biol. 2002;72:946–952.
   PubMed Web of Science ®Google Scholar
• Taylor A, Namba K. In vitro induction of CD25+ CD4+ regulatory T cells by the neuropeptide alpha-melanocyte stimulating hormone (alpha-MSH). Immunol Cell Biol. 2001;79(4):358–367. doi:10.1046/j.1440-1711.2001.01022.x.
   PubMed Web of Science ®Google Scholar
• Jabs DA, Nussenblatt RB, Rosenbaum JT, et al. Standardization of Uveitis Nomenclature (SUN) Working Group. Standardization of uveitis nomenclature for reporting clinical data. Results of the first international workshop. Am J Ophthalmol. 2005;140(3):509–516.
   PubMed Web of Science ®Google Scholar
• Deschenes J, Murray PI, Rao NA, et al., International Uveitis Study Group. International Uveitis Study Group (IUSG): clinical classification of uveitis. Ocul Immunol Inflamm. 2008;16(1):1–2. doi:10.1080/09273940801899822.
   PubMed Web of Science ®Google Scholar
• Wright D, Zweifel B, Sharma P, Galen K, Fitch R. Reduced streoidogenic activity of repository corticotropin injection (RCI) induces a distinct cytokine response following T cell activation in Vivo. 2021. https://ard.bmj.com/content/78/Suppl_2/1504.1
   Google Scholar
• Huang YJ, Galen K, Zweifel B, Brooks LR, Wright AD. Distinct binding and signaling activity of Acthar Gel compared to other melanocortin receptor agonists. J Recept Signal Transduct Res. 2021;41(5):425–433. doi:10.1080/10799893.2020.1818094.
   PubMed Web of Science ®Google Scholar
• Gordon D, Mclean J. Effects of pituitary adrenocortictropine hormone (ACTH) therapy in ophthalmologic conditions. J Am Med Assoc. 1950;142:1271–1276. doi:10.1001/jama.1950.02910340017005.
   Web of Science ®Google Scholar
• Olson J, Steffensen E, Smith R. Use of adenocorticotropin hormone and cortisone in ocular disease. AMA Arc Ophthalmol. 1951;45:274–300. doi:10.1001/archopht.1951.01700010280004.
   PubMedGoogle Scholar
• Fitzgerald J, Bellows J, Donegan J, et al. Clinical results of ACTH and cortisone treatment of ocular disease. AMA Arch Ophthalmol. 1951;45:320–333. doi:10.1001/archopht.1951.01700010326007.
   PubMedGoogle Scholar
• Wolfson W, Quinn J, Spearman W. Corticoid therapy in eye diseases: sustained restoration of vision in certain eye diseases considered corticoid-refractory or clinically irreversible. AMA Am Arch Intern Med. 1955;95:400–410. doi:10.1001/archinte.1955.00250090038006.
   PubMedGoogle Scholar
• Nelson WW, Lima AF, Kranyak J, et al. Retrospective medical record review to describe use of repository corticotropin injection among patients with uveitis in the United States. J Ocul Pharmacol Ther. 2019 Apr;35(3):182–188. doi:10.1089/jop.2018.0090.
   PubMed Web of Science ®Google Scholar
• An ongoing, open-label Phase 4 study of up to 36 patients with severe or recalcitrant keratitis despite previous treatment. Open-label keratitis study: ongoing Phase 4 study. Data on file: REF-MNK14084113. Mallinckrodt ARD LLC. accessed 1 october 2021. https://actharhcp.com/clinical-experience/keratitis/phase4/
   Google Scholar
• Sakaguchi S, Yamaguchi T, Nomura T, Ono M. Regulatory T cells and immune tolerance. Cell. 2008;133(5):775–787. doi:10.1016/j.cell.2008.05.009.
   PubMed Web of Science ®Google Scholar
• Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol. 2003;4(4):330–336. doi:10.1038/ni904.
   PubMed Web of Science ®Google Scholar
• de Latour R P, Dujardin HC, Mishellany F, et al. Ontogeny, function, and peripheral homeostasis of regulatory T cells in the absence of interleukin-7. Blood. 2006;108(7):2300–2306.doi:10.1182/blood-2006-04-017947.
   PubMedGoogle Scholar
• Liu HY, Ma LP, Wei J, et al. Analysis of CD4(+)CD25(+)CD127(low/-) Treg cells in mice. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012;20(6):1469–1473.
   PubMedGoogle Scholar
• Klein S, Kretz CC, Krammer PH, Kuhn A. CD127(low/-) and FoxP3(+) expression levels characterize different regulatory T-cell populations in human peripheral blood. J Invest Dermatol. 2010;130(2):492–499. doi:10.1038/jid.2009.313.
   PubMedGoogle Scholar
• Hartzell S, Sanchez-Russo L, Pecchio IP, et al. Repository corticotropin injections promote clinical remission and regulatory T cell expansion in membranous nephropathy. Kidney Int Rep. 2021;6(9):2491–2495.doi:10.1016/j.ekir.2021.06.010.
   PubMedGoogle Scholar
• Madan A, Mijovic-Das S, Stankovic A, Teehan G, Milward AS, Khastgir A. Acthar gel in the treatment of nephrotic syndrome: a multicenter retrospective case series. BMC Nephrol. 2016 Mar 31;17:37. doi:10.1186/s12882-016-0241-7.
   PubMed Web of Science ®Google Scholar