Association of Central Retinal Arteriolar and Venular Equivalents with Brain-aging and Macular Ganglion Cell-inner Plexiform Layer Thickness

References

• Debette S, Seshadri S, Beiser A, et al. Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline. Neurology. 2011;77:461–468. doi:10.1212/WNL.0b013e318227b227.
   PubMed Web of Science ®Google Scholar
• Gottesman RF, Albert MS, Alonso A, et al. Associations between midlife vascular risk factors and 25-year incident dementia in the atherosclerosis risk in communities (ARIC) cohort. JAMA Neurol. 2017;74(10):1246–1254. doi:10.1001/jamaneurol.2017.1658.
   PubMed Web of Science ®Google Scholar
• Bendlin BB, Carlsson CM, Gleason CE, et al. Midlife predictors of Alzheimer’s disease. Maturitas. 2010;65(2):131–137. doi:10.1016/j.maturitas.2009.12.014.
   PubMed Web of Science ®Google Scholar
• Schubert CR, Fischer ME, Pinto A, et al. Brain aging in midlife: the beaver dam offspring study. J Am Geriatr Soc. 2019;67(8):1610–1616. doi:10.1111/jgs.15886.
   PubMed Web of Science ®Google Scholar
• London A, Benhar I, Schwartz M. The retina as a window to the brain – from eye research to CNS disorders. Nat Rev Neurol. 2013;9:44–53. doi:10.1038/nrneurol.2012.227.
   PubMed Web of Science ®Google Scholar
• Patton N, Aslam T, MacGillivray T, Pattie A, Dreary IJ, Dhillon B. Retinal vascular image analysis as a potential screening tool for cerebrovascular disease: a rationale based on homology between cerebral and retinal microvasculatures. J Anat. 2005;206:319–348. doi:10.1111/j.1469-7580.2005.00395.x.
   PubMed Web of Science ®Google Scholar
• Yoon SP, Grewal DS, Thompson AC, et al. Retinal microvascular and neurodegenerative changes in Alzheimer’s disease and mild cognitive impairment compared to controls. Ophthalmol Retina. 2019;3(6):489–499. doi:10.1016/j.oret.2019.02.002.
   PubMedGoogle Scholar
• Wong TY, Klein R, Sharrett AR, et al. Retinal microvascular abnormalities and cognitive impairment in middle-aged persons: the atherosclerosis risk in communities study. Stroke. 2002;33:1487–1492. doi:10.1161/01.STR.0000016789.56668.43.
   PubMed Web of Science ®Google Scholar
• Lesage SR, Mosley TH, Wong TY, et al. Retinal microvascular abnormalities and cognitive decline: the ARIC 14-year follow-up study. Neurology. 2009;73:862–868. doi:10.1212/WNL.0b013e3181b78436.
   PubMed Web of Science ®Google Scholar
• Deal JA, Sharrett AR, Rawlings AM, et al. Retinal signs and 20-year cognitive decline in the atherosclerosis risk in communities study. Neurology. 2018;90:e1158–e1166. doi:10.1212/WNL.0000000000005205.
   PubMed Web of Science ®Google Scholar
• Deal JA, Sharrett AR, Albert M, et al. Retinal signs and risk of incident dementia in the atherosclerosis risk in communities study. Alzheimers Dement. 2019;15(3):477–486. doi:10.1016/j.jalz.2018.10.002.
   PubMed Web of Science ®Google Scholar
• Liew G, Mitchell P, Wong TY, et al. Retinal microvascular signs and cognitive impairment. J Am Geriatr Soc. 2009;57:1892–1896. doi:10.1111/j.1532-5415.2009.02459.x.
   PubMed Web of Science ®Google Scholar
• Kim DH, Newman AB, Hajjar I, et al. Retinal microvascular signs and functional loss in older persons: the cardiovascular health study. Stroke. 2011;42(6):1589–1595. doi:10.1161/STROKEAHA.110.605261.
   PubMed Web of Science ®Google Scholar
• Gatto NM, Varma R, Torres M, et al. Retinal microvascular abnormalities and cognitive function in Latino adults in Los Angeles. Ophthalmic Epidemiol. 2012;19(3):127–136. doi:10.3109/09286586.2011.615452.
   PubMed Web of Science ®Google Scholar
• Patton N, Pattie A, MacGillivray T, et al. The association between retinal vascular network geometry and cognitive ability in an elderly population. Invest Ophthalmol Vis Sci. 2007;48(5):1995–2000. doi:10.1167/iovs.06-1123.
   PubMed Web of Science ®Google Scholar
• Ding J, Patton N, Deary IJ, et al. Retinal microvascular abnormalities and cognitive dysfunction: a systematic review. Br J Ophthalmol. 2008;92:1017–1025. doi:10.1136/bjo.2008.141994.
   PubMed Web of Science ®Google Scholar
• Heringa SM, Bouvy WH, van den Berg E, Moll AC, Kappelle LJ, Biessels GJ. Associations between retinal microvascular changes and dementia, cognitive functioning, and brain imaging abnormalities: a systematic review. J Cereb Blood Flow Metab. 2013;33(7):983–995. doi:10.1038/jcbfm.2013.58.
   PubMed Web of Science ®Google Scholar
• Jung N, Han JC, Ong YT, et al. Retinal microvasculature changes in amyloid-negative subcortical vascular cognitive impairment compared to amyloid-positive Alzheimer’s disease. J Neurol Sci. 2019;396:94–101. doi:10.1016/j.jns.2018.10.025.
   PubMed Web of Science ®Google Scholar
• Cheung CY, Ong YT, Ikram MK, et al. Microvascular network alterations in the retina of patients with Alzheimer’s disease. Alzehimers Dement. 2014;10(2):135–142. doi:10.1016/j.jalz.2013.06.009.
   PubMed Web of Science ®Google Scholar
• Szegedi S, Dal-Bianco P, Stögmann E, et al. Anatomical and functional changes in the retina in patients with Alzheimer’s disease and mild cognitive impairment. Acta Ophthalmol. 2020;98:e914–e921. doi:10.1111/aos.14419.
   PubMed Web of Science ®Google Scholar
• Geneid MI, Uusitalo JJ, Leiviskä IL, Saarela VO, Liinamaa MJ. Relation between retinal vessel diameter and posterior segment optical coherence tomography variables in middle-aged caucasisans: the Northern Finland Birth Cohort Eye Study. Br J Ophthalmol. 2020;104:1435–1442. doi:10.1136/bjophthalmol-2019-314803.
   PubMed Web of Science ®Google Scholar
• Merten N, Paulsen AJ, Pinto A, et al. Macular ganglion cell-inner plexiform layer as a marker of cognitive and sensory function in midlife. J Gerontol A Biol Sci Med Sci. 2020;75(9):e42–e48. doi:10.1093/gerona/glaa135.
   PubMed Web of Science ®Google Scholar
• Koronyo Y, Biggs D, Barron E, et al. Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer’s disease. JCI Insight. 2017;2(16):e93621. doi:10.1172/jci.insight.93621.
   PubMed Web of Science ®Google Scholar
• Czakó C, Kovács T, Ungvari Z, et al. Retinal biomarkers for Alzheimer’s disease and vascular cognitive impairment and dementia (VCID): implication for early diagnosis and prognosis. Geroscience. 2020;42:1499–1525. doi:10.1007/s11357-020-00252-7.
   PubMed Web of Science ®Google Scholar
• Lee MJ, Abraham AG, Swenor BK, Sharrett AR, Ramulu PY. Application of optical coherence tomography in the detection and classification of cognitive decline. J Curr Glaucoma Pract. 2018;12(1):10–18. doi:10.5005/jp-journals-10028-1238.
   PubMedGoogle Scholar
• Nash SD, Cruickshanks KJ, Klein R, et al. The prevalence of hearing impairment and associated risk factors: the Beaver Dam Offspring Study. Arch Otolaryngol Head Neck Surg. 2011;137(5):432–439. doi:10.1001/archoto.2011.15.
   PubMed Web of Science ®Google Scholar
• Paulsen AJ, Pinto A, Merten N, et al. Factors associated with the macular ganglion cell-inner plexiform layer thickness in a cohort of middle-aged U.S. adults. Optom Vis Sci. 2021;98:295–305. doi:10.1097/OPX.0000000000001650.
   PubMed Web of Science ®Google Scholar
• Parr JC, Spears GF. General caliber of the retinal arteries expressed as the equivalent width of the central retinal artery. Am J Ophthalmol. 1974;77:472–477. doi:10.1016/0002-9394(74)90457-7.
   PubMed Web of Science ®Google Scholar
• Hubbard LD, Brothers RJ, King WN, et al. Methods for evaluation of retinal microvascular abnormalities associated with hypertension/sclerosis in the atherosclerosis risk in communities study. Ophthalmology. 1999;106:2269–2280. doi:10.1016/S0161-6420(99)90525-0.
   PubMed Web of Science ®Google Scholar
• Knudtson MD, Lee KE, Hubbard LD, et al. Revised formulas for summarizing retinal vessel diameters. Curr Eye Res. 2003;27:143–149. doi:10.1076/ceyr.27.3.143.16049.
   PubMed Web of Science ®Google Scholar
• Klein R, Meuer SM, Moss SE, et al. Detection of age-related macular degeneration using a nonmydriatic digital camera and a standard film fundus camera. Arch Ophthalmol. 2004;122:1642–1646. doi:10.1001/archopht.122.11.1642.
   PubMedGoogle Scholar
• Klein R, Cruickshanks KJ, Nash SD, et al. The prevalence of age-related macular degeneration and associated risk factors: the beaver dam offspring study. Arch Ophthalmol. 2010;128:750–758. doi:10.1001/archophthalmol.2010.92.
   PubMed Web of Science ®Google Scholar
• Klein BEK, Klein R, Linton KL, et al. Assessment of cataracts from photographs in the beaver dam eye study. Ophthalmology. 1990;97:1428–1433. doi:10.1016/S0161-6420(90)32391-6.
   PubMed Web of Science ®Google Scholar
• Radloff LS. The CES-D scale: a self-report depression scale for research in the general population. Appl Psychol Meas. 1977;1(3):385–401. doi:10.1177/014662167700100306.
   Web of Science ®Google Scholar
• Jolliffe IT. Principal Component Analysis. 2nd ed. New York, NY: Springer; 2002.
   Google Scholar
• Wong TY, Shankar A, Klein R, Klein BEK, Hubbard LD. Retinal arteriolar narrowing, hypertension, and subsequent risk of diabetes mellitus. Arch Intern Med. 2005;165(9):1060–1065. doi:10.1001/archinte.165.9.1060.
   PubMedGoogle Scholar
• Klein R, Klein BEK, Tomany SC, Wong TY. The relation of retinal microvascular characteristics to age-related eye disease: the beaver dam eye study. Am J Ophthalmol. 2004;137(3):435–444. doi:10.1016/j.ajo.2003.10.020.
   PubMed Web of Science ®Google Scholar
• Wang JJ, Mitchell P, Rochtchina E, Tan AG, Wong TY, Klein R. Retinal vessel wall signs and the 5 year incidence of age related maculopathy: the Blue Mountains Eye Study. Br J Ophthalmol. 2004;88:104–109. doi:10.1136/bjo.88.1.104.
   PubMed Web of Science ®Google Scholar
• Moghimi S, Zangwill LM, Penteado RC, et al. Macular and optic nerve head vessel density and progressive retinal nerve fiber layer loss in glaucoma. Ophthalmology. 2018;125(11):1720–1728. doi:10.1016/j.ophtha.2018.05.006.
   PubMed Web of Science ®Google Scholar
• Richter GM, Madi I, Chu Z, et al. Structural and functional associations of macular microcirculation in the ganglion cell-inner plexiform layer in glaucoma using optical coherence tomography angiography. J Glaucoma. 2018;27(3):281–290. doi:10.1097/IJG.0000000000000888.
   PubMed Web of Science ®Google Scholar
• Cesareo M, Giannini C, Martucci A, et al. Chapter 2 – links between obstructive sleep apnea and glaucoma neurodegeneration. In: Bagetta G, Nucci C, eds. Progress in Brain Research. Vol. 257. Amsterdam, Netherlands; Oxford, UK; Cambridge, MA, USA: Elsevier. 2020: 19–36. doi:10.1016/bs.pbr.2020.07.010.
   Google Scholar
• Zhaba W, Deji Q, Deng H, et al. Retinal hypoxia after experimental subarachnoid hemorrhage. Neurosci Lett. 2021;742:135554. doi:10.1016/j.neulet.2020.135554.
   PubMed Web of Science ®Google Scholar
• Meyer ML, Klein BEK, Klein R, et al. Central arterial stiffness and retinal vessel calibers: the atherosclerosis risk in communities study-neurocognitive study. J Hypertens. 2020;38(2):266–273. doi:10.1097/HJH.0000000000002252.
   PubMed Web of Science ®Google Scholar
• Triantafyllou A, Anyfanti P, Gavriilaki E, et al. Association between retinal vessel caliber and arterial stiffness in a population comprised of normotensive to early-stage hypertensive individuals. Am J Hypertens. 2014;27(12):1472–1478. doi:10.1093/ajh/hpu074.
   PubMed Web of Science ®Google Scholar
• Wei Y, Jiang H, Shi Y, et al. Age-related alterations in the retinal microvasculature, microcirculation, and microstructure. IOVS. 2017;58(9):3804–3817.
   PubMed Web of Science ®Google Scholar