References
- Aguirre , J I , Plotkin , L I , Stewart , S A , Weinstein , R S , Parfitt , A M , Manolagas , S C and Bellido , T . 2006 . Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss . J Bone Miner Res , 21 : 605 – 615 .
- Bellido , T . 2009 . Why to keep osteocytes alive and how? . J Korean Endocr Soc , 24 : 223 – 226 .
- Bentley , V A , Sample , S J , Livesey , M A , Scollay , M C , Radtke , C L , Frank , J D , Kalscheur , V L and Muir , P . 2007 . Morphologic changes associated with functional adaptation of the navicular bone of horses . J Anat , 211 : 662 – 672 .
- Biggi , M and Dyson , S . 2011 . High-field magnetic resonance imaging investigation of distal border fragments of the navicular bone in horses with foot pain . Equine Vet J , 43 : 302 – 308 .
- Blunden , A , Dyson , S , Murray , R and Schramme , M . 2006 . Histopathology in horses with chronic palmar foot pain and age-matched controls. Part 1: Navicular bone and related structures . Equine Vet J , 38 : 15 – 22 .
- Bonucci , E . 2009 . The osteocyte: the underestimated conductor of the bone orchestra . Rend Fis Acc Lincei , 20 : 237 – 254 .
- Burger , E H and Klein-Nulend , J . 1999 . Mechanotransduction in bone – role of lacunocanalicular network . FASEB J , 13 : 101 – 112 .
- Claerhoudt , S , Bergman , E HJ , Van Der Veen , H , Vanderperren , K , Raes , E V and Saunders , J H . 2011 . Computed tomographic morphology of the synovial invaginations of the distal sesamoid bone of the horse . Anat Histol Embryol , 40 : 55 – 60 .
- Cruz , A M , Pharr , J W , Bailey , J V , Barber , S M and Fretz , P B . 2001 . Podotrochlear bursa endoscopy in the horse: a cadaver study . Vet Surg , 30 : 639 – 545 .
- Currey , J D . 2005 . Bone architecture and fracture . Curr Osteoporos Rep , 3 : 52 – 56 .
- Denoix , J M , Thibaud , D and Riccio , B . 2003 . Tiludronate as a new theraupeutic agent in the treatment of navicular disease: a double-blind placebo-controlled clinical trial . Equine Vet J , 35 : 407 – 413 .
- Diesterbeck , U S and Distl , O . 2007 . Review of genetic aspects of radiological alterations in the navicular bone of the horse . Dtsch Tierarztl Wochenschr , 114 : 404 – 411 .
- Diesterbeck , U S , Hertsch , B and Distl , O . 2007 . Genome-wide search for microsatellite markers associated with radiologic alterations in the navicular bone of Hanoverian warmblood horses . Mamm Genome , 18 : 373 – 381 .
- Doige , C E and Hoffer , M A . 1983 . Pathological changes in the navicular bone and associated structures of the horse . Can J Vet Res , 47 : 387 – 395 .
- Donahue , H J . 2000 . Gap junctions and biophysical regulation of bone cell differentiation . Bone , 26 : 417 – 422 .
- Dyson , S and Murray , R . 2007 . Magnetic resonance imaging evaluation of 264 horses with foot pain: the podotrochlear apparatus, deep digital flexor tendon and collateral ligaments of the distal interphalangeal joint . Equine Vet J , 39 : 340 – 343 .
- Dyson , S , Murray , R , Schramme , M and Blunden , T . 2011a . Current concepts of navicular disease . Equine Vet Educ , 23 : 27 – 39 .
- Dyson , S , Tranquille , C A , Collins , S N , Parkin , T DH and Murray , R C . 2011b . An investigation of the relationships between angles and shapes of the hoof capsule and the distal phalanx . Equine Vet J , 43 : 295 – 301 .
- Eliashar , E , Mcguigan , M and Wilson , A . 2004 . Relationship of conformation and force applied to the navicular bone of sound horses at the trot . Equine Vet J , 36 : 431 – 435 .
- Eriksen , E F . 1986 . Normal and pathological remodeling of human trabecular bone – 3-dimensional reconstruction of the remodeling sequence in normal and in metabolic bone disease . Endocr Rev , 7 : 379 – 408 .
- Ficker , C , Riek , W and Hugelshofer , J . 1982 . Occlusion of the digital arteries. A model of pathogenesis of navicular disease . Equine Vet J , 14 : 203 – 207 .
- Firth , E C . 2006 . The response of bone, articular cartilage and tendon to exercise in the horse . J Anat , 208 : 513 – 526 .
- Firth , E C , Rogers , C W , Perkins , N R , Anderson , B H and Grace , N D . 2004 . Musculoskeletal response of 2-year-old thoroughbred horses to early training. 1. Study design, and clinical, nutritional, radiological and histological observations . New Zeal Vet J , 52 : 261 – 271 .
- Frost , H M . 1960 . Micropetrosis . J Bone Joint Surg Am , 42 : 144 – 150 .
- Frost , H M . 1990a . Skeletal structural adaptations to mechanical usage (SATMU): 2 Redefining Wolff's Law: the modeling problem . Anat Rec , 226 : 403 – 413 .
- Frost , H M . 1990b . Skeletal structural adaptations to mechanical usage (SATMU): 2 Redefining Wolff's Law: the remodeling problem . Anat Rec , 226 : 414 – 422 .
- Gabriel , A , Detilleux , J , Jolly , S , Reginster , J Y , Collin , B and Dessy-Doize , C . 1999 . Morphometric study of the navicular bone: age-related changes and influence of exercise . Vet Res Commun , 23 : 15 – 40 .
- Gabriel , A , Jolly , S , Detilleux , J , Dessy-Doize , C , Collin , B and Reginster , J Y . 1998 . Morphometric study of the navicular bone: variations with breeds and types of horse and influence of exercise . J Anat , 193 : 535 – 549 .
- Haapasalo , H , Kontulainen , S , Sievanen , H , Kannus , P , Jarvinen , M and Vuori , I . 2000 . Exercise-induced bone gain is due to enlargement in bone size without a change in volumetric bone density: a peripheral quantitative computed tomography study of the upper arms of male tennis players . Bone , 27 : 351 – 357 .
- Hunt , R J . 2006 . Clinical evaluation and diagnosis of palmar foot pain . Proc AAEP , 52 : 198 – 202 .
- Jann , H , Henry , G , Berry , A and Cash , L . 1991 . Arthrographic observations of the equine distal interphalangeal joint and navicular bursa . Anat Histol Embryol , 20 : 30 – 36 .
- Jenner , F and Kirker-Head , C . 2011 . Core decompression of the equine navicular bone: an in vitro biomechanical study . Vet Surg , 40 : 163 – 170 .
- Kamiya , N , Ye , L , Kobayashi , T , Mochida , Y , Yamauchi , M , Kronenberg , H M , Feng , J Q and Mishina , Y . 2008 . BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway . Development , 135 : 3801 – 3811 .
- Kanczler , J M and Oreffo , R OC . 2008 . Osteogenesis and angiogenesis: the potential for engineering bone . Eur Cells Mater , 15 : 100 – 114 .
- Kaneps , A J and Turner , T A . 2004 . “ Diseases of the foot ” . In Equine sports medicine and surgery , Edited by: Hinchcliff , K W , Geor , R J and Kaneps , A J . 260 – 288 . Philadelphia (PA) : Elsevier Health Sciences. Chapter 15 .
- Kawcak , C E , Mcilwraith , C W , Norrdin , R W , Park , R D and Steyn , P S . 2000 . Clinical effects of exercise on subchondral bone of carpal and meta carpophalangeal joints in horses . Am J Vet Res , 61 : 1252 – 1258 .
- Lopes , M S , Diesterbeck , U , Da Câmara Machado , A and Distl , O . 2009 . Fine mapping a quantitative trait locus on horse chromosome 2 associated with radiological signs of navicular disease in Hanoverian warmblood horses . Anim Genet , 40 : 955 – 957 .
- Murray , R C , Schramme , M C , Dyson , S J , Branch , M V and Blunden , T S . 2006 . Magnetic resonance imaging characteristics of the foot in horses with palmar foot pain and control horses . Vet Radiol Ultrasoun , 47 : 1 – 16 .
- Ostblom , L , Lund , C and Melsen , F . 1989 . Navicular bone disease: a comparative histomorphometric study . Equine Vet J , 21 : 431 – 433 .
- Parks , A . 2006 . Structure and function of the equine digit in relation to palmar foot pain . Proc AAEP , 52 : 188 – 197 .
- Poole , K ES , Van Bezooijen , RL , Loveridge , N , Hamersma , H , Papapoulos , S E , Löwik , C W and Reeve , J . 2005 . Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation . FASEB J , 19 : 1842 – 1844 .
- Purzyc , H . 2009 . Focus on Hucul horses during postnatal development in view of chosen morphometric traits . Rev Med Vet – Toulouse , 160 : 500 – 506 .
- Rauch , F . 2005 . Bone growth in length and width: the Yin and Yang of bone stability . J Musculoskelet Neuronal Interact , 5 : 194 – 201 .
- Rijkenhuizen , A BM . 2006 . Navicular disease: a review of what's new . Equine Vet J , 38 : 82 – 88 .
- Rijkenhuizen , A BM , Nemeth , F , Dik , K J and Geodegebuure , S A . 1989 . The arterial supply of the navicular bone in adult horses with navicular disease . Equine Vet J , 21 : 418 – 424 .
- Rubin , J , Rubin , C and Jacobs , C R . 2006 . Molecular pathways mediating mechanical signaling in bone . Gene , 367 : 1 – 16 .
- Ruimerman , R , Hilbers , P , Van Rietbergen , B and Huiskes , R . 2005 . A theoretical framework for strain-related trabecular bone maintenance and adaptation . J Biomech , 38 : 931 – 941 .
- Ruimerman , R , Huiskes , R , Van Lenthe , GH and Janssen , J D . 2001 . A computer-simulation model relating bone-cell metabolism, to mechanical adaptation of trabecular bone . Comput Method Biomech , 4 : 433 – 448 .
- Sandler , E A , Kawcak , C E , Mcilwraith , C and Norrdin , R W . 2000 . Remodeling of the navicular bone in response to exercise – a controlled study . Proc AAEP , 46 : 46 – 50 .
- Shapiro , F . 2008 . Bone development and its relation to fracture repair. The role of mesenchymal osteoblasts and surface of osteoblasts . Eur Cells Mater , 15 : 53 – 76 .
- Sherlock , C , Mair , T and Blunden , T . 2008 . Deep erosions of the palmar aspect of the navicular bone diagnosed by standing magnetic resonance imaging . Equine Vet J , 40 : 684 – 692 .
- Steck , A , Niederer , P and Knothe , Tate ML . 2003 . A finite element analysis for the prediction of load induced fluid flow and mechanochemical transduction in bone . J Theor Biol , 220 : 249 – 259 .
- Turner , C H and Robling , A G . 2005 . Mechanisms by which exercise improves bone strength . J Bone Miner Metab , 23 : 16 – 22 .
- Turner , T A . 1996 . Differentiation of navicular region pain from other forms of palmar heel pain . Pferdeheilkunde , 12 : 603 – 606 .
- Van Wulfen , KK and Bowker , R M . 2002 . Microanatomic characteristics of the insertion of the distal sesamoidean impar ligament and the deep digital flexor tendon on the distal phalanx in healthy feet obtained from horses . Am J Vet Res , 63 : 215 – 221 .
- Vezeridis , P S , Semeins , C M , Chen , Q and Klein-Nulend , J . 2006 . Osteocytes subjected to pulsating fluid flow regulate osteoblast proliferation and differentiation . Biochem Bioph Res Co , 348 : 1082 – 1088 .
- Viitanen , M . 2003 . Navicular disease: biochemical studies of synovial fluids and tissues involved [PhD thesis] , Helsinki , , Finland) : University of Helsinki, Department of Farm Animal and Equine Medicine and Surgery .
- Viitanen , M , Bird , J , Makela , O , Schramme , M , Smith , M , Tulamo , R M and May , S . 2001 . Synovial fluid studies in navicular disease . Res Vet Sci , 71 : 201 – 206 .
- Winkler , D G , Sutherland , M K , Geoghegan , J C , Yu , C , Hayes , T , Skonier , J E , Shpektor , D , Jonas , M , Kovacevich , B R Staehling-Hampton , K . 2003 . Osteocyte control of bone formation via sclerostin, a novel BMP antagonist . EMBO J , 22 : 6267 – 6276 .
- Wolff , J . 1892 . Das Gesetz der Transformation der Knochen , Berlin : Hirschwald .
- Wright , I M . 1993 . A study of 118 cases of navicular disease: radiological features . Equine Vet J , 25 : 493 – 500 .