220
Views
10
CrossRef citations to date
0
Altmetric
DHEA Supplementation Effects on Cumulus Cells

Protection of cumulus cells following dehydroepiandrosterone supplementation

, , , , , & show all
Pages 100-104 | Received 04 Jun 2016, Accepted 14 Jul 2016, Published online: 12 Aug 2016

References

  • Lin LT, Tsui KH, Wang PH. Clinical application of dehydroepiandrosterone in reproduction: a review of the evidence. J Chin Med Assoc 2015;78:446–53
  • Labrie F. All sex steroids are made intracellularly in peripheral tissues by the mechanisms of intracrinology after menopause. J Steroid Biochem Mol Biol 2015;145:133–8
  • Casson PR, Lindsay MS, Pisarska MD, et al. Dehydroepiandrosterone supplementation augments ovarian stimulation in poor responders: a case series. Human Reprod 2000;15:2129–32
  • Gleicher N, Barad DH. Dehydroepiandrosterone (DHEA) supplementation in diminished ovarian reserve (DOR). Reprod Biol Endocrinol 2011;9:67
  • Fusi FM, Ferrario M, Bosisio C, et al. DHEA supplementation positively affects spontaneous pregnancies in women with diminished ovarian function. Gynecol Endocrinol 2013;29:940–3
  • Xu B, Li Z, Yue J, et al. Effect of dehydroepiandrosterone administration in patients with poor ovarian response according to the Bologna criteria. PLoS One 2014;9:e99858
  • Li J, Yuan H, Chen Y, et al. A meta-analysis of dehydroepiandrosterone supplementation among women with diminished ovarian reserve undergoing in vitro fertilization or intracytoplasmic sperm injection. Int J Gynaecol Obstet 2015;131:240–5
  • Yilmaz N, Uygur D, Inal H, et al. Dehydroepiandrosterone supplementation improves predictive markers for diminished ovarian reserve: serum AMH, inhibin B and antral follicle count. Eur J Obstet Gynecol Reprod Biol 2013;169:257–60
  • Hyman JH, Margalioth EJ, Rabinowitz R, et al. DHEA supplementation may improve IVF outcome in poor responders: a proposed mechanism. Eur J Obstet Gynecol Reprod Biol 2013;168:49–53
  • Barad D, Gleicher N. Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF. Human Reprod 2006;21:2845–9
  • Sonmezer M, Ozmen B, Cil AP, et al. Dehydroepiandrosterone supplementation improves ovarian response and cycle outcome in poor responders. Reprod Biomed Online 2009;19:508–13
  • Barad D, Brill H, Gleicher N. Update on the use of dehydroepiandrosterone supplementation among women with diminished ovarian function. J Assist Reprod Genet 2007;24:629–34
  • Gleicher N, Ryan E, Weghofer A, et al. Miscarriage rates after dehydroepiandrosterone (DHEA) supplementation in women with diminished ovarian reserve: a case control study. Reprod Biol Endocrinol 2009;7:108
  • Wiser A, Gonen O, Ghetler Y, et al. Addition of dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: a randomized prospective study. Human Reprod 2010;25:2496–500
  • Nagels HE, Rishworth JR, Siristatidis CS, Kroon B. Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction. Cochrane Database Syst Rev 2015;11:CD009749
  • Fragouli E, Lalioti MD, Wells D. The transcriptome of follicular cells: biological insights and clinical implications for the treatment of infertility. Human Reprod Update 2014;20:1–11
  • Albertini DF, Combelles CM, Benecchi E, Carabatsos MJ. Cellular basis for paracrine regulation of ovarian follicle development. Reproduction 2001;121:647–53
  • Cillo F, Brevini TA, Antonini S, et al. Association between human oocyte developmental competence and expression levels of some cumulus genes. Reproduction 2007;134:645–50
  • Adriaenssens T, Wathlet S, Segers I, et al. Cumulus cell gene expression is associated with oocyte developmental quality and influenced by patient and treatment characteristics. Human Reprod 2010;25:1259–70
  • Wathlet S, Adriaenssens T, Segers I, et al. Cumulus cell gene expression predicts better cleavage-stage embryo or blastocyst development and pregnancy for ICSI patients. Human Reprod 2011;26:1035–51
  • Li SH, Lin MH, Hwu YM, et al. Correlation of cumulus gene expression of GJA1, PRSS35, PTX3, and SERPINE2 with oocyte maturation, fertilization, and embryo development. Reprod Biol Endocrinol 2015;13:93
  • Iager AE, Kocabas AM, Otu HH, et al. Identification of a novel gene set in human cumulus cells predictive of an oocyte’s pregnancy potential. Fertil Steril 2013;99:745–52. e746
  • Tsui KH, Lin LT, Horng HC, et al. Gene expression of cumulus cells in women with poor ovarian response after dehydroepiandrosterone supplementation. Taiwan J Obstet Gynecol 2014;53:559–65
  • Hussein MR. Apoptosis in the ovary: molecular mechanisms. Human Reprod Update 2005;11:162–77
  • Host E, Gabrielsen A, Lindenberg S, Smidt-Jensen S. Apoptosis in human cumulus cells in relation to zona pellucida thickness variation, maturation stage, and cleavage of the corresponding oocyte after intracytoplasmic sperm injection. Fertil Steril 2002;77:511–15
  • Corn CM, Hauser-Kronberger C, Moser M, et al. Predictive value of cumulus cell apoptosis with regard to blastocyst development of corresponding gametes. Fertil Steril 2005;84:627–33
  • Xiong S, Mu T, Wang G, Jiang X. Mitochondria-mediated apoptosis in mammals. Protein Cell 2014;5:737–49
  • Santos TA, El Shourbagy S, St John JC. Mitochondrial content reflects oocyte variability and fertilization outcome. Fertil Steril 2006;85:584–91
  • Zeng HT, Ren Z, Yeung WS, et al. Low mitochondrial DNA and ATP contents contribute to the absence of birefringent spindle imaged with PolScope in in vitro matured human oocytes. Human Reprod 2007;22:1681–6
  • Lee SK, Zhao MH, Kwon JW, et al. The association of mitochondrial potential and copy number with pig oocyte maturation and developmental potential. J Reprod Dev 2014;60:128–35
  • Ferraretti AP, La Marca A, Fauser BC, et al. ESHRE consensus on the definition of ‘poor response’ to ovarian stimulation for in vitro fertilization: the Bologna criteria. Human Reprod 2011;26:1616–24
  • The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Human Reprod 2011;26:1270–83
  • Zangmo R, Singh N, Kumar S, et al. Role of dehydroepiandrosterone in improving oocyte and embryo quality in IVF cycles. Reprod Biomed Online 2014;28:743–7
  • Vlahos N, Papalouka M, Triantafyllidou O, et al. Dehydroepiandrosterone administration before IVF in poor responders: a prospective cohort study. Reprod Biomed Online 2015;30:191–6
  • Van Blerkom J. Mitochondrial function in the human oocyte and embryo and their role in developmental competence. Mitochondrion 2011;11:797–813
  • Tsai HD, Hsieh YY, Hsieh JN, et al. Mitochondria DNA deletion and copy numbers of cumulus cells associated with in vitro fertilization outcomes. J Reprod Med 2010;55:491–7
  • Roy MJ, Vom A, Czabotar PE, Lessene G. Cell death and the mitochondria: therapeutic targeting of the BCL-2 family-driven pathway. Br J Pharmacol 2014;171:1973–87
  • Ramalho-Santos J, Varum S, Amaral S, et al. Mitochondrial functionality in reproduction: from gonads and gametes to embryos and embryonic stem cells. Human Reprod Update 2009;15:553–72
  • Lee KS, Joo BS, Na YJ, et al. Cumulus cells apoptosis as an indicator to predict the quality of oocytes and the outcome of IVF-ET. J Assist Reprod Genet 2001;18:490–8

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.