1,073
Views
22
CrossRef citations to date
0
Altmetric
Obesity and IVF Outcomes

The role of female obesity on in vitro fertilization outcomes

, , , , &
Pages 184-188 | Received 24 Aug 2017, Accepted 09 Oct 2017, Published online: 16 Oct 2017

References

  • Ng M, Fleming T, Robinson M, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 2014;384:766–81.
  • Luke B. Adverse effects of female obesity and interaction with race on reproductive potential. Fertil Steril 2017;107:868–77.
  • Hruby A, Hu FB. The epidemiology of obesity: a big picture. Pharmacoeconomics 2015;33:673–89.
  • Levine JA. Poverty and obesity in the U.S. Diabetes 2011;60:2667–8.
  • Kilpeläinen TO, Qi L, Brage S, et al. Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med 2011;8:e1001116.
  • Boulangé CL, Neves AL, Chilloux J, et al. Impact of the gut microbiota on inflammation, obesity, and metabolic disease. Genome Med 2016;8:42–8.
  • Perry RJ, Peng L, Barry NA, et al. Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome. Nature 2016;534:213–7.
  • Salmon AB. Beyond diabetes: does obesity-induced oxidative stress drive the aging process? Antioxidants (Basel) 2016;18:24–8.
  • Kandimalla R, Thirumala V, Reddy PH. Is Alzheimer's disease a type 3 diabetes? A critical appraisal. Biochim Biophys Acta 2017;1863:1078–89.
  • Broughton DE, Moley KH. Obesity and female infertility: potential mediators of obesity's impact. Fertil Steril 2017;107:840–7.
  • Klenov VE, Jungheim ES. Obesity and reproductive function: a review of the evidence. Curr Opin Obstet Gynecol 2014;26:455–60.
  • Wise LA, Rothman KJ, Mikkelsen EM, et al. An internet-based prospective study of body size and time-to-pregnancy. Hum Reprod 2010;25:253–64.
  • Boots CE, Bernardi LA, Stephenson MD. Frequency of euploid miscarriage is increased in obese women with recurrent early pregnancy loss. Fertil Steril 2014;102:455–9.
  • Flenady V, Koopmans L, Middleton P, et al. Major risk factors for stillbirth in high-income countries: a systematic review and meta-analysis. Lancet 2011;377:1331–40.
  • Kitsantas P, Gallo S, Palla H, et al. Nature and nurture in the development of childhood obesity: early infant feeding practices of overweight/obese mothers differ compared to mothers of normal body mass index. J Matern Fetal Neonatal Med 2016;29:290–3.
  • ACOG Comitee on Obstetric Practice. Obesity in pregnancy. ACOG comitee opinion. No. 549. Obstet Gynecol 2013;12:213–7.
  • Provost MP, Acharya KS, Acharya CR, et al. Pregnancy outcomes decline with increasing body mass index: analysis of 239,127 fresh autologous in vitro fertilization cycles from the 2008-2010 Society for assisted reproductive technology registry. Fertil Steril 2016;105:663–9.
  • MacKenna A, Schwarze JE, Crosby JA, Zegers-Hochschild F. Outcome of assisted reproductive technology in overweight and obese women. JBRA Assist Reprod 2017;21:79–83.
  • Maheswari A, Stofberg L, Bhattachaya S. Effect of overweight and obesity on asssisted reproductive technology – a systematic review. Hum Reprod Update 2007; 13:433–44.
  • Styne-Gross A, Elkind-Hirsch K, Scott RT. Obesity does not impact implantation rates or pregnancy outcome in women attempting conception through oocyte donation. Fertil Steril 2005; 83:1629–34.
  • Dechaud H, Anahory T, Reyftmann L, et al. Obesity does not adversely affect results in patients who are undergoing in vitro fertilization and embryo transfer. Eur J Obstet Gynecol Reprod Biol 2005;127:88–93.
  • Schliep KC, Mumford SL, Ahrens KA, et al. Effect of male and female body mass index on pregnancy and live birth success after in vitro fertilization. Fertil Steril 2015;103:388–95.
  • Friedler S, Cohen O, Liberty G, et al. Should high BMI be a reason for IVF treatment denial? Gynecol Endocrinol 2017;20. [Epub ahead of print]. DOI:10.1080/09513590.2017.1327042
  • Banker M, Sorathiya D, Shah S. Effect of body mass index on the outcome of in-vitro fertilization/intracytoplasmic sperm injection in women. J Hum Reprod Sci 2017;10:37–43.
  • Bellver J, Pellicer A, García-Velasco JA, et al. Obesity reduces uterine receptivity: clinical experience from 9,587 first cycles of ovum donation with normal weight donors. Fertil Steril 2013;100:1050–8.
  • Luke B, Brown MB, Stern JE, et al. Female obesity adversely affects assisted reproductive technology (ART) pregnancy and live birth rates. Hum Reprod 2011;26:245–52.
  • Bailey AP, Hawkins LK, Missmer SA, et al. Effect of body mass index on in vitro fertilization outcomes in women with polycystic ovary syndrome. Am J Obstet Gynecol 2014;211:163.e1–6.
  • Petersen GL, Schmidt L, Pinborg A, Kamper-Jørgensen M. The influence of female and male body mass index on live births after assisted reproductive technology treatment: a nationwide register-based cohort study. Fertil Steril 2013;99:1654–62.
  • Moragianni VA, Jones SM, Ryley DA. The effect of body mass index on the outcomes of first assisted reproductive technology cycles. Fertil Steril 2012;98:102–8.
  • Rittenberg V, Seshadri S, Sunkara SK, et al. Effect of body mass index on IVF treatment outcome: an updated systematic review and meta-analysis. Reprod Biomed Online 2011;23:421–39.
  • Kawwass JF, Kulkarni AD, Hipp HS, et al. Extremities of body mass index and their association with pregnancy outcomes in women undergoing in vitro fertilization in the United States. Fertil Steril 2016;106:1742–50.
  • Luke B, Brown MB, Missmer SA, et al. The effect of increasing obesity on the response to and outcome of assisted reproductive technology: a national study. Fertil Steril 2011;96:820–5.
  • Souter I, Baltagi LM, Kuleta D, et al. Women, weight, and fertility: the effect of body mass index on the outcome of superovulation/intrauterine insemination cycles. Fertil Steril 2011;95:1042–7.
  • Atzmon Y, Shoshan-Karchovsky E, Michaeli M, et al. Obesity results with smaller oocyte in in vitro fertilization/intracytoplasmic sperm injection cycles-a prospective study. J Assist Reprod Genet 2017; [Epub ahead of print]. DOI:10.1007/s10815-017-0975-6
  • Espinós JJ, Polo A, Sánchez-Hernández J, et al. Weight decrease improves live birth rates in obese women undergoing IVF: a pilot study. Reprod Biomed Online 2017;S1472–6483:30303–6.
  • Milone M, Sosa Fernandez LM, Sosa Fernandez LV, et al. Does bariatric surgery improve assisted reproductive technology outcomes in obese infertile women?. Obes Surg 2017;27:2106–12.
  • Caillon H, Fréour T, Bach-Ngohou K, et al. Effects of female increased body mass index on in vitro fertilization cycles outcome. Obes Res Clin Pract 2015;9:382–8.
  • Zhang JJ, Feret M, Chang L, et al. Obesity adversely impacts the number and maturity of oocytes in conventional IVF not in minimal stimulation IVF. Gynecol Endocrinol 2015;31:409–13.
  • Comstock IA, Kim S, Behr B, Lathi RB. Increased body mass index negatively impacts blastocyst formation rate in normal responders undergoing in vitro fertilization. J Assist Reprod Genet 2015;32:1299–304.
  • Wei YM, Yang HX, Zhu WW, et al. Risk of adverse pregnancy outcomes stratified for pre-pregnancy body mass index. J Matern Fetal Neonatal Med 2016;29:2205–9.
  • Jungheim ES, Moley KH. Current knowledge of obesity's effects in the pre- and periconceptional periods and avenues for future research. Am J Obstet Gynecol 2010;203:525–30.
  • Machtinger R, Combelles CM, Missmer SA, et al. The association between severe obesity and characteristics of failed fertilized oocytes. Hum Reprod 2012;27:3198–207.
  • Jungheim ES, Macones GA, Odem RR, et al. Associations between free fatty acids, cumulus oocyte complex morphology and ovarian function during in vitro fertilization. Fertil Steril 2011;95:1970–4.
  • Sarais V, Pagliardini L, Rebonato G, et al. A comprehensive analysis of body mass index effect on in vitro fertilization outcomes. Nutrients 2016;8:109–13.
  • Leary C, Leese HJ, Sturmey RG. Human embryos from overweight and obese women display phenotypic and metabolic abnormalities. Hum Reprod 2015;30:122–32.
  • Robker RL, Akison LK, Bennett BD, et al. Obese women exhibit differences in ovarian metabolites, hormones, and gene expression compared with moderate-weight women. J Clin Endocrinol Metab 2009;94:1533–40.
  • Bellver J, De Los Santos MJ, Alamá P, et al. Day-3 embryo metabolomics in the spent culture media is altered in obese women undergoing in vitro fertilization. Fertil Steril 2015;103:1407–15.
  • Finger BJ, Harvey AJ, Green MP, Gardner DK. Combined parental obesity negatively impacts preimplantation mouse embryo development, kinetics, morphology and metabolism. Hum Reprod 2015;30:2084–96.
  • Rhee JS, Saben JL, Mayer AL, et al. Diet-induced obesity impairs endometrial stromal cell decidualization: a potential role for impaired autophagy. Hum Reprod 2016;31:1315–26.
  • Legro RS. Mr. fertility authority, tear down that weight wall! Hum Reprod 2016;31:2662–4.
  • Meldrum DR. Introduction: obesity and reproduction. Fertil Steril 2017;10:831–2.
  • Turner-McGrievy GM, Grant BL. Prevalence of body mass index and body weight cut-off points for in vitro fertilization treatment at U.S. clinics and current clinic weight loss strategy recommendations. Hum Fertil (Camb) 2015;18:215–9.
  • Mutsaerts MA, van Oers AM, Groen H, et al. Randomized trial of a lifestyle program in obese infertile women. N Engl J Med 2016;374:1942–53.
  • Palomba S, Falbo A, Valli B, et al. Physical activity before IVF and ICSI cycles in infertile obese women: an observational cohort study. Reprod Biomed Online 2014;29:72–9.
  • Meldrum DR, Morris MA, Gambone JC. Obesity pandemic: causes, consequences, and solutions-but do we have the will?. Fertil Steril 2017;107:833–9.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.