Does progesterone to oocyte index have a predictive value for IVF outcome? A retrospective cohort and review of the literature

References

• Fanchin R, de Ziegler D, Taieb J, et al. Premature elevation of plasma progesterone alters pregnancy rates of in vitro fertilization and embryo transfer. Fertil Steril 1993;59:1090–4.
   PubMed Web of Science ®Google Scholar
• Papanikolaou EG, Kolibianakis EM, Pozzobon C, et al. Progesterone rise on the day of human chorionic gonadotropin administration impairs pregnancy outcome in day 3 single-embryo transfer, while has no effect on day 5 single blastocyst transfer. Fertil Steril 2009;91:949–52.
   PubMed Web of Science ®Google Scholar
• Bosch E, Labarta E, Crespo J, et al. Circulating progesterone levels and ongoing pregnancy rates in controlled ovarian stimulation cycles for in vitro fertilization: analysis of over 4000 cycles. Hum Reprod 2010;25:2092–100.
   PubMed Web of Science ®Google Scholar
• Kilicdag EB, Haydardedeoglu B, Cok T, et al. Premature progesterone elevation impairs implantation and live birth rates in GnRH-agonist IVF/ICSI cycles. Arch Gynecol Obstet 2010;281:747–52.
   PubMed Web of Science ®Google Scholar
• Elgindy EA. Progesterone level and progesterone/estradiol ratio on the day of hCG administration: detrimental cutoff levels and new treatment strategy. Fertil Steril 2011;95:1639–44.
   PubMed Web of Science ®Google Scholar
• Xu B, Li Z, Zhang H, et al. Serum progesterone level effects on the outcome of in vitro fertilization in patients with different ovarian response: an analysis of more than 10,000 cycles. Fertil Steril 2012;97:1321–7.e1–4.
   PubMed Web of Science ®Google Scholar
• Ochsenkuhn R, Arzberger A, von Schonfeldt V, et al. Subtle progesterone rise on the day of human chorionic gonadotropin administration is associated with lower live birth rates in women undergoing assisted reproductive technology: a retrospective study with 2,555 fresh embryo transfers. Fertil Steril 2012;98:347–54.
   PubMed Web of Science ®Google Scholar
• Venetis CA, Kolibianakis EM, Bosdou JK, Tarlatzis BC. Progesterone elevation and probability of pregnancy after IVF: a systematic review and meta-analysis of over 60 000 cycles. Hum Reprod Update 2013;19:433–57.
   PubMed Web of Science ®Google Scholar
• Nayak S, Ochalski ME, Fu B, et al. Progesterone level at oocyte retrieval predicts in vitro fertilization success in a short-antagonist protocol: a prospective cohort study. Fertil Steril 2014;101:676–82.
   PubMed Web of Science ®Google Scholar
• Edelstein MC, Seltman HJ, Cox BJ, et al. Progesterone levels on the day of human chorionic gonadotropin administration in cycles with gonadotropin-releasing hormone agonist suppression are not predictive of pregnancy outcome. Fertil Steril 1990;54:853–7.
   PubMed Web of Science ®Google Scholar
• Silverberg KM, Burns WN, Olive DL, et al. Serum progesterone levels predict success of in vitro fertilization/embryo transfer in patients stimulated with leuprolide acetate and human menopausal gonadotropins. J Clin Endocrinol Metab 1991;73:797–803.
   PubMed Web of Science ®Google Scholar
• Check JH. Predictive value of serum progesterone levels for pregnancy outcome? Fertil Steril 1994;62:1090–1.
   PubMed Web of Science ®Google Scholar
• Givens CR, Schriock ED, Dandekar PV, Martin MC. Elevated serum progesterone levels on the day of human chorionic gonadotropin administration do not predict outcome in assisted reproduction cycles. Fertil Steril 1994;62:1011–7.
   PubMed Web of Science ®Google Scholar
• Shechter A, Lunenfeld E, Potashnik G, Glezerman M. The significance of serum progesterone levels on the day of hCG administration on IVF pregnancy rates. Gynecol Endocrinol 1994;8:89–94.
   PubMed Web of Science ®Google Scholar
• Levy MJ, Smotrich DB, Widra EA, et al. The predictive value of serum progesterone and 17-OH progesterone levels on in vitro fertilization outcome. J Assist Reprod Genet 1995;12:161–6.
   PubMed Web of Science ®Google Scholar
• Ubaldi F, Smitz J, Wisanto A, et al. Oocyte and embryo quality as well as pregnancy rate in intracytoplasmic sperm injection are not affected by high follicular phase serum progesterone. Hum Reprod 1995;10:3091–6.
   PubMed Web of Science ®Google Scholar
• Abuzeid MI, Sasy MA. Elevated progesterone levels in the late follicular phase do not predict success of in vitro fertilization-embryo transfer. Fertil Steril 1996;65:981–5.
   PubMed Web of Science ®Google Scholar
• Miller KF, Behnke EJ, Arciaga RL, et al. The significance of elevated progesterone at the time of administration of human chorionic gonadotropin may be related to luteal support. J Assist Reprod Genet 1996;13:698–701.
   PubMed Web of Science ®Google Scholar
• Moffitt DV, Queenan JT Jr, Shaw R, Muasher SJ. Progesterone levels on the day of human chorionic gonadotropin do not predict pregnancy outcome from the transfer of fresh or cryopreserved embryos from the same cohort. Fertil Steril 1997;67:296–301.
   PubMed Web of Science ®Google Scholar
• Urman B, Alatas C, Aksoy S, et al. Elevated serum progesterone level on the day of human chorionic gonadotropin administration does not adversely affect implantation rates after intracytoplasmic sperm injection and embryo transfer. Fertil Steril 1999;72:975–9.
   PubMed Web of Science ®Google Scholar
• Martinez F, Coroleu B, Clua E, et al. Serum progesterone concentrations on the day of HCG administration cannot predict pregnancy in assisted reproduction cycles. Reprod Biomed Online 2004;8:183–90.
   PubMed Web of Science ®Google Scholar
• Venetis CA, Kolibianakis EM, Papanikolaou E, et al. Is progesterone elevation on the day of human chorionic gonadotrophin administration associated with the probability of pregnancy in in vitro fertilization? A systematic review and meta-analysis. Hum Reprod Update 2007;13:343–55.
   PubMed Web of Science ®Google Scholar
• Martinez F, Rodriguez I, Devesa M, et al. Should progesterone on the human chorionic gonadotropin day still be measured?. Fertil Steril 2016;105:86–92.
   PubMed Web of Science ®Google Scholar
• Van Vaerenbergh I, Fatemi HM, Bourgain C. Premature progesterone rise and gene expression. Hum Reprod 2011;26:2913.author reply 194.
   PubMed Web of Science ®Google Scholar
• Li R, Qiao J, Wang L, et al. MicroRNA array and microarray evaluation of endometrial receptivity in patients with high serum progesterone levels on the day of hCG administration. Reprod Biol Endocrinol 2011;9:29.
   PubMed Web of Science ®Google Scholar
• Griesinger G, Mannaerts B, Andersen CY, et al. Progesterone elevation does not compromise pregnancy rates in high responders: a pooled analysis of in vitro fertilization patients treated with recombinant follicle-stimulating hormone/gonadotropin-releasing hormone antagonist in six trials. Fertil Steril 2013;100:1622–8.e1–3.
   PubMed Web of Science ®Google Scholar
• Shufaro Y, Sapir O, Oron G, et al. Progesterone-to-follicle index is better correlated with in vitro fertilization cycle outcome than blood progesterone level. Fertil Steril 2015;103:669–74.e3.
   PubMed Web of Science ®Google Scholar
• Roque M, Valle M, Sampaio M, et al. Ratio of progesterone-to-number of follicles as a prognostic tool for in vitro fertilization cycles. J Assist Reprod Genet 2015;32:951–7.
   PubMed Web of Science ®Google Scholar
• Singh N, Malik N, Malhotra N, et al. Impact of progesterone (on hCG day)/oocyte ratio on pregnancy outcome in long agonist non donor fresh IVF/ICSI cycles. Taiwan J Obstetr Gynecol 2016;55:503–6.
   PubMed Web of Science ®Google Scholar
• Aflatoonian A, Davar R, Hojjat F. Elevated serum progesterone/MII oocyte ratio on the day of human chorionic gonadotropin administration can predict impaired endometrial receptivity. Iran J Reproduct Med 2014;12:427–34.
   PubMedGoogle Scholar
• Hill MJ, Royster GDt, Healy MW, et al. Are good patient and embryo characteristics protective against the negative effect of elevated progesterone level on the day of oocyte maturation?. Fertil Steril 2015;103:1477–84.e1–5.
   PubMed Web of Science ®Google Scholar
• Venetis CA, Kolibianakis EM, Bosdou JK, et al. Estimating the net effect of progesterone elevation on the day of hCG on live birth rates after IVF: a cohort analysis of 3296 IVF cycles. Hum Reprod 2015;30:684–91.
   PubMed Web of Science ®Google Scholar
• Huang Y, Wang EY, Du QY, et al. Progesterone elevation on the day of human chorionic gonadotropin administration adversely affects the outcome of IVF with transferred embryos at different developmental stages. Reprod Biol Endocrinol 2015;13:82.
   PubMed Web of Science ®Google Scholar
• Bosch E, Valencia I, Escudero E, et al. Premature luteinization during gonadotropin-releasing hormone antagonist cycles and its relationship with in vitro fertilization outcome. Fertil Steril 2003;80:1444–9.
   PubMed Web of Science ®Google Scholar
• Patton PE, Lim JY, Hickok LR, et al. Precision of progesterone measurements with the use of automated immunoassay analyzers and the impact on clinical decisions for in vitro fertilization. Fertil Steril 2014;101:1629–36.
   PubMed Web of Science ®Google Scholar
• Oktem O, Akin N, Bildik G, et al. FSH Stimulation promotes progesterone synthesis and output from human granulosa cells without luteinization. Hum Reprod 2017;32:643–52.
   PubMed Web of Science ®Google Scholar
• Vanni VS, Somigliana E, Reschini M, et al. Top quality blastocyst formation rates in relation to progesterone levels on the day of oocyte maturation in GnRH antagonist IVF/ICSI cycles. PloS One 2017;12:e0176482.
   PubMed Web of Science ®Google Scholar
• Hill MJ, Healy MW, Richter KS, et al. Revisiting the progesterone to oocyte ratio. Fertil Steril 2017;107:671–6.e2.
   PubMed Web of Science ®Google Scholar
• Burns WN, Witz CA, Klein NA, et al. Serum progesterone concentrations on the day after human chorionic gonadotropin administration and progesterone/oocyte ratios predict in vitro fertilization/embryo transfer outcome. J Assist Reprod Genet 1994;11:17–23.
   PubMed Web of Science ®Google Scholar