317
Views
1
CrossRef citations to date
0
Altmetric
Low M.W. Heparin In Ivf/Icsi

Administration of low-molecular-weight heparin in patients with two or more unsuccessful IVF/ICSI cycles: a multicenter cohort study

, , , , , , , , & show all
Pages 747-751 | Received 07 Oct 2017, Accepted 15 Feb 2018, Published online: 21 Feb 2018

References

  • European IVF-Monitoring Consortium (EIM); European Society of Human Reproduction and Embryology (ESHRE), Kupka MS, D’Hooghe T, Ferraretti AP, et al. Assisted reproductive technology in Europe, 2011: results generated from European registers by ESHRE. Hum Reprod 2016;31:233–48.
  • Bohlmann MK. Effects and effectiveness of heparin in assisted reproduction. J Reprod Immunol 2011;90:82–90.
  • Tan BK, Vandekerckhove P, Kennedy R, Keay SD. Investigation and current management of recurrent IVF treatment failure in the UK. Bjog: Int J O&G 2005;112:73–80.
  • Fatemi HM, Popovic-Todorovic B. Implantation in assisted reproduction: a look at endometrial receptivity. Reprod Biomed Online 2013;27:530–8.
  • Coughlan C, Ledger W, Wang Q, et al. Recurrent implantation failure: definition and management. Reprod Biomed Online 2014;28:14–38.
  • Nelson SM, Greer IA. The potential role of heparin in assisted conception. Hum Reprod Update 2008;14:623–45.
  • Fiedler K, Würfel W. Effectivity of heparin in assisted reproduction. Eur J Med Res 2004;30:207–14.
  • Simon A, Laufer N. Assessment and treatment of repeated implantation failure (RIF). J Assist Reprod Genet 2012;29:1227–39.
  • Oduah EI, Linhardt RJ, Sharfstein ST. Heparin: past, present, and future. Pharmaceuticals (Basel) 2016;9:pii: E38.
  • Bick RL, Frenkel EP, Walenga J, et al. Unfractionated heparin, low molecular weight heparins, and pentasaccharide: basic mechanism of actions, pharmacology and clinical use. Hematol Oncol Clin North Am 2005;19:1–51.
  • Akhtar MA, Sur S, Raine-Fenning N, et al. Heparin for assisted reproduction. Cochrane Database Syst Rev 2013;17:CD009452.
  • Erden O, Imir A, Guvenal T, et al. Investigation of the effects of heparin and low molecular weight heparin on E-cadherin and laminin expression in rat pregnancy by immunohistochemistry. Hum Reprod 2006;21:3014–18.
  • Fluhr H, Spratte J, Ehrhardt J, et al. Heparin and low-molecular-weight heparins modulate the decidualization of human endometrial stromal cells. Fertil Steril 2010;93:2581–7.
  • Tamada H, Higashiyama C, Takano H, et al. The effects of heparin-binding epidermal growth factor-like growth factor on preimplantation-embryo development and implantation in the rat. Life Sci 1999;64:1967–73.
  • Hossain N, Schatz F, Paidas MJ. Heparin and maternal fetal interface: why should it work to prevent pregnancy complications?. Thromb Res 2009;124:653–5.
  • Urman B, Ata B, Yakin K, et al. Luteal phase empirical low molecular weight heparin administration in patients with failed ICSI embryo transfer cycles: a randomized open-labeled pilot trial. Hum Reprod 2009;24:1640.
  • Berker B, Taşkin S, Kahraman K, et al. The role of low-molecular-weight heparin in recurrent implantation failure: a prospective, quasi-randomized, controlled study. Fertil Steril 2011;95:2499–502.
  • Siristatidis C, Chrelias C, Creatsa M, et al. Addition of prednisolone and heparin in patients with failed IVF/ICSI cycles: a preliminary report of a clinical trial. Hum Fertil (Camb) 2013;16:207–10.
  • Lodigiani C, Di Micco P, Ferrazzi P, et al. Low-molecular-weight heparin in women with repeated implantation failure. Womens Health (Lond) 2011;7:425–31.
  • Dentali F, Grandone E, Rezoagli E, Ageno W. Efficacy of low molecular weight heparin in patients undergoing in vitro fertilization or intracytoplasmic sperm injection. J Thromb Haemost 2011;9:2503–6.
  • Seshadri S, Sunkara SK, Khalaf Y, et al. Effect of heparin on the outcome of IVF treatment: a systematic review and meta-analysis. Reprod Biomed Online 2012;25:572–84.
  • Ferraretti AP, La Marca A, Fauser BC, et al. ESHRE consensus on the definition of ’poor response’ to ovarian stimulation for in vitro fertilization: the Bologna criteria. Hum Reprod 2011;26:1616–24.
  • Siristatidis C, Askoxylaki M, Varounis C, et al. E-selectin, resistin and reactive oxygen species levels in GnRH -agonist and -antagonist protocols in IVF/ICSI: a prospective cohort study. J Assist Reprod Genet 2015;32:959–67.
  • Ziebe S, Petersen K, Lindenberg S, et al. Embryo morphology or cleavage stage: how to select the best embryos for transfer after in-vitro fertilization. Hum Reprod 1997;12:1545–9.
  • Potdar N, Gelbaya TA, Konje JC, Nardo LG. Adjunct low-molecular-weight heparin to improve live birth rate after recurrent implantation failure: a systematic review and meta-analysis. Hum Reprod Update 2013;19:674–84.
  • Royal College of Obstetricians and Gynecologists. The Investigation and Treatment of Couples with Recurrent First-trimester and Second-trimester Miscarriage. London: RCOG; April 2011 [Green-top Guideline No. 17].
  • Jauniaux E, Farquharson RG, Christiansen OB, Exalto N. Evidence-based guidelines for the investigation and medical treatment of recurrent miscarriage. Hum Reprod 2006;21:2216–22.
  • Nardo LG, El-Toukhy T, Stewart J, et al. British fertility society policy and practice committee: adjuvants in IVF: evidence for good clinical practice. Hum Fertil (Camb) 2015;18:2–15.
  • Horcajadas JA, Riesewijk A, Polman J, et al. Effect of controlled ovarian hyperstimulation in IVF on endometrial gene expression profiles. Mol Hum Reprod 2005;11:195–205.
  • Strowitzki T, Germeyer A, Popovici R, von Wolff M. The human endometrium as a fertility-determining factor. Hum Reprod Update 2006;12:617–30.
  • Polanski LT, Baumgarten MN, Quenby S, et al. What exactly do we mean by ’recurrent implantation failure’? A systematic review and opinion. Reprod Biomed Online 2014;28:409–23.
  • Vlachadis N, Vrachnis N, Economou E, Siristatidis C. Zooming in on the definition of ’recurrent implantation failure’. Reprod Biomed Online 2014;29:144–5.
  • Fishel S, Baker DJ, Greer IA. LMWH in IVF - Biomarkers and benefits. Thromb Res 2017;151(Suppl 1):S65–S9.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.