Adolescent ovarian thecoma presenting as progressive hyperandrogenism: case report and review of the literature

References

• Sultan C, Gaspari L, Maïmoun L, et al. Management of adolescent hyperandrogenism: still a challenge? In: Berga SL, Genazzani AR, Naftolin F, et al. editors. Frontiers in gynecological endocrinology. Vol. 7, in press.
   Google Scholar
• Heo SH, Kim JW, Shin SS, et al. Review of ovarian tumors in children and adolescents: radiologic-pathologic correlation. Radiographics. 2014;34(7):2039–2055.
   PubMed Web of Science ®Google Scholar
• Chen H, Liu Y, Shen L-F, et al. Ovarian thecoma-fibroma groups: clinical and sonographic features with pathological comparison. J Ovarian Res. 2016;9(1):81.
   PubMedGoogle Scholar
• McGee J, Fleming NA, Senterman M, et al. Virilizing luteinized thecoma of the ovary in a 15-year-old female: a case report. J Pediatr Adolesc Gynecol. 2009;22(5):e107–e110.
   PubMedGoogle Scholar
• McElhinney MM, Gandrud LM, Miller RJ, et al. Primary amenorrhea in an adolescent secondary to a virilizing luteinized thecoma of the ovary. J Pediatr Adolesc Gynecol. 2012;25(2):e32.
   Google Scholar
• Iwasaki K, Matsushita H, Murakami H, et al. Meigs syndrome superimposed on Gorlin syndrome in a 14-year-old girl. J Pediatr Adolesc Gynecol. 2016;29(5):e75–e77.
   PubMedGoogle Scholar
• Young RH, Scully RE. Ovarian sex cord-stromal tumours: problems in di-erential diagnosis. Pathol Ann. 1988;23:237–296.
   Google Scholar
• Amin HK, Okagaki T, Richart RM, et al. Classification of fibroma and thecoma of the ovary: an ultrastructural study. Cancer. 1971;27(2):438–446.
   PubMed Web of Science ®Google Scholar
• Faber D. Meigs’ syndrome with thecomas of both ovaries in a 4-year-old girl. J Pediatr. 1962;61(5):769–773.
   Web of Science ®Google Scholar
• Johnson AD, Hebert AA, Esterly NB, et al. Nevoid basal cell carcinoma syndrome: bilateral ovarian fibromas in a 31/2-year-old girl. J Am Acad Dermatol. 1986;14(2):371–374.
   PubMed Web of Science ®Google Scholar
• Rater CJ, Selke AC, VAN Epps EF, et al. Basal cell nevus syndrome. Am J Roentgenol. 1968;103(3):589–594.
   Web of Science ®Google Scholar
• Raggio M, Kaplan AL, et al. Recurrent ovarian fibromas with basal cell nevus syndrome (Gorlin syndrome). Obstet Gynecol. 1983;61(suppl):95–96.
   PubMedGoogle Scholar
• Clement PB, Young RH, Hanna W, et al. Sclerosing peritonitis associated with luteinized thecomas of the ovary. A clinicopathological analysis of six cases. Am J Surg Pathol. 1994;18(1):1–13.
   PubMed Web of Science ®Google Scholar
• Staats PN, McCluggage WG, Clement PB, et al. Luteinized thecomas (thecomatosis) of the type typically associated with sclerosing peritonitis: a clinical, histopathologic, and immunohistochemical analysis of 27 cases. Am J Surg Pathol. 2008;32(9):1273–1290.
   PubMed Web of Science ®Google Scholar
• Nauen DW, Martin A, Katz A, et al. A case of luteinizing thecoma with sclerosing peritonitis: revisiting a link with anti-epileptic drugs. Pediatr Blood Cancer. 2010;54(3):470–472.
   PubMed Web of Science ®Google Scholar
• Noyes N, Perretta RC, Fino ME, et al. Use of hormone suppression then oocyte freezing to preserve reproductive capability in an adolescent girl with ovarian luteinized thecoma associated with sclerosing peritonitis. Fertil Steril. 2009;92(1):393.e11–393.e14.
   Web of Science ®Google Scholar
• Schweisguth O, Gerard-Marchant R, Plainfosse B, et al. Bilateral non-functioning thecoma of the ovary in epileptic children under anticonvulsant therapy. Acta Paediatr Scand. 1971;60(1):6–10.
   PubMed Web of Science ®Google Scholar
• Dudzinski M, Cohen M, Ducatman B, et al. Ovarian malignant luteinized thecoma—an unusual tumor in an adolescent. Gynecol Oncol. 1989;35(1):104–109.
   PubMed Web of Science ®Google Scholar
• Piippo S, Mustaniemi L, Lenko H, et al. Surgery for ovarian masses during childhood and adolescence: a report of 79 cases. J Pediatr Adolesc Gynecol. 1999;12(4):223–227.
   PubMedGoogle Scholar
• Burandt E, Young RH. Thecoma of the ovary: a report of 70 cases emphasizing aspects of its histopathology different from those often portrayed and its differential diagnosis. Am J Surg Pathol. 2014;38(8):1023–1032.
   PubMed Web of Science ®Google Scholar
• Dhull A, Kaushal V, Mathur S, et al. Fibrothecoma of the ovary—a rare case presentation. Int J Third World Med. 2013;9(2):10.5580/16c2.
   Google Scholar
• Chan CY, Chan SM, Liauw L, et al. A large abdominal mass in a young girl. BJR. 2000;73(872):913–914.
   Google Scholar
• Sugiyama A, Urushihara N, Fukumoto K, et al. Ovarian fibroma with marked ascites and elevated serum levels of CA-125 in a young girl. J Pediatr Surg. 2011;46(5):1001–1004.
   PubMed Web of Science ®Google Scholar
• Chen Y-J, Hsieh C-S, Eng H-L, et al. Ovarian fibroma in a 7-month-old infant: a case report and review of the literature. Ped Surgery Int. 2004;20(11–12):894–897.
   PubMed Web of Science ®Google Scholar
• Charache H. Ovarian tumours in childhood. AMA Arch Surg. 1959;79(4):573–580.
   PubMedGoogle Scholar
• Bower J, Erickson ER. Bilateral ovarian fibromas in a 5-year-old. Am J Obstet Gynecol. 1967;99(6):880–882.
   PubMed Web of Science ®Google Scholar
• Junaid TA, Nkposong EO, Kolawole TM, et al. Cutaneous meningiomas and an ovarian fibroma in a three-year-old girl. J Pathol. 1972;108(2):165–167.
   PubMed Web of Science ®Google Scholar
• Dumont-Herskowitz RA, Safaii HS, Senior B, et al. Ovarian fibromata in four successive generations. J Pediatr. 1978;93(4):621–624.
   PubMed Web of Science ®Google Scholar
• Howell CG, Rogers DA, Gable DS, et al. Bilateral ovarian fibromas in children. J Pediatr Surg. 1990;25(6):690–691.
   PubMed Web of Science ®Google Scholar
• Laufer L, Barki Y, Mordechai Y, et al. Ovarian fibroma in a prepubertal girl. Pediatr Radiol. 1996;26(1):40–42.
   PubMed Web of Science ®Google Scholar
• Mrózek K, Nedoszytko B, Babińska M, et al. Trisomy of chromosome 12 in a case of thecoma of the ovary. Gynecol Oncol. 1990;36(3):413–416.
   PubMed Web of Science ®Google Scholar
• Musani V, Sabol M, Car D, et al. PTCH1 gene polymorphisms in ovary tumors: potential protective role of c.3944T allele. Gene. 2013;517(1):55–59.
   PubMed Web of Science ®Google Scholar
• Tsuji T, Catasus L, Prat J, et al. Is loss of heterozygosity at 9q22.3 (PTCH gene) and 19p13.3 (STK11 gene) involved in the pathogenesis of ovarian stromal tumors? Hum Pathol. 2005;36(7):792–796.
   PubMed Web of Science ®Google Scholar
• Streblow RC, Dafferner AJ, Nelson M, et al. Imbalances of chromosomes 4, 9, and 12 are recurrent in the thecoma-fibroma group of ovarian stromal tumors. Cancer Genet Cytogenet. 2007;178(2):135–140.
   PubMedGoogle Scholar
• Iorio R, Castellucci A, Ventriglia G, et al. Ovarian toxicity: from environmental exposure to chemotherapy. CPD. 2014;20(34):5388–5397.
   Google Scholar
• McLachlan JA, Newbold RR, Bullock BC, et al. Long-term effects on the female mouse genital tract associated with prenatal exposure to diethylstilbestrol. Cancer Res. 1980;40(11):3988–3999.
   PubMed Web of Science ®Google Scholar
• Newbold RR, Bullock BC, Mc Lachlan JA, et al. Exposure to diethylstilbestrol during pregnancy permanently alters the ovary and oviduct. Biol Reprod. 1983;28(3):735–744.
   PubMed Web of Science ®Google Scholar
• Newbold RR, Jefferson WN, Padilla-Banks E, et al. Prenatal exposure to bisphenol a at environmentally relevant doses adversely affects the murine female reproductive tract later in life. Environ Health Perspect. 2009;117(6):879–885.
   PubMed Web of Science ®Google Scholar