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Gynecological Endocrinology Volume 36, 2020 - Issue 9
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POLYCYSTIC OVARY SYNDROME

Galectin-3 is a potential biomarker to insulin resistance and obesity in women with polycystic ovary syndrome

Michelle T. AlvesFaculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; View further author information
,
Isabella D. P. de SouzaFaculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; View further author information
,
Cláudia N. FerreiraColégio Técnico, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; View further author information
,
Ana Lúcia CândidoFaculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; View further author information
,
Mariana F. BizziFaculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; View further author information
,
Flávia R. OliveiraFaculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; ;Maternidade Odete Valadares – Fundação Hospitalar do Estado de Minas Gerais, Belo Horizonte, BrazilView further author information
,
Fernando M. ReisFaculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; View further author information
&
Karina B. GomesFaculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-6870-2063View further author information
ORCID Icon show all
Pages 760-763 | Received 12 Jul 2019, Accepted 03 Mar 2020, Published online: 11 Mar 2020

References

  • Randeva HS, Tan BK, Weickert MO, et al. Cardiometabolic aspects of the polycystic ovary syndrome. Endocr Rev. 2012;33(5):812–841.
  • McCartney CR, Marshall JC. Polycystic ovary syndrome. N Engl J Med. 2016;375(1):54–64.
  • Jayasena CN, Franks S. The management of patients with polycystic ovary syndrome. Nat Rev Endocrinol. 2014;10(10):624–636.
  • Barondes SH, Cooper DN, Gitt MA, et al. Galectins. Structure and function of a large family of animal lectins. J Biol Chem. 1994;269(33):20807–20810.
  • Bobronnikova L. Galectin-3 as a potential biomarker of metabolic disorders and cardiovascular remodeling in patients with hypertension and type 2 diabetes. VP. 2017;1(2):61–67.
  • Yilmaz H, Cakmak M, Inan O, et al. Increased levels of galectin-3 were associated with prediabetes and diabetes: new risk factor? J Endocrinol Invest. 2015;38(5):527–533.
  • Rabinovich GA, Baum LG, Tinari N, et al. Galectins and their ligands: amplifiers, silencers or tuners of the inflammatory response? Trends Immunol. 2002;23(6):313–320.
  • Siwicki M, Engblom C, Pittet MJ. Gal 3 links inflammation and insulin resistance. Cell Metab. 2016;8:655–656.
  • Sharma UC, Pokharel S, van Brakel TJ, et al. Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunction. Circulation. 2004;110(19):3121–3128.
  • de Boer RA, Lok DJ, Jaarsma T, et al. Predictive value of plasma galectin-3 levels in heart failure with reduced and preserved ejection fraction. Ann Med. 2011;43(1):60–68.
  • Yilmaz H, Celik HT, Ozdemir O, et al. Serum galectin-3 levels in women with PCOS. J Endocrinol Invest. 2014;37(2):181–187.
  • Anik Ilhan G, Kanlioglu C, Arslan G, et al. Galectin-3 as a novel biomarker in women with PCOS. Arch Gynecol Obstet. 2018;298(4):821–825.
  • Rotterdam ESHRE/ASRM Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnosis criteria and long term health risks related to polycystic ovary syndrome. Fertil Steril. 2004;81:19–25.
  • Baek JH, Kim SJ, Kang HG, et al. Galectin-3 activates PPAR and supports white adipose tissue formation and high-fat diet-induced obesity. Endocrinol. 2015;156(1):147–156.
  • de Boer RA, van Veldhuisen DJ, Gansevoort RT, et al. The fibrosis marker galectin-3 and outcome in the general population. J Inter Med. 2012;272(1):55–64.
  • Sartor BM, Dickey RP. Polycystic ovarian syndrome and the metabolic syndrome. Am J Med Sci. 2005;330(6):336–342.
  • Stepto NK, Cassar S, Joham AE, et al. Women with polycystic ovary syndrome have intrinsic insulin resistance on euglycaemic-hyperinsulaemic clamp. Hum Reprod. 2013;28(3):777–784.
  • Weigert J, Neumeier M, Wanninger J, et al. Serum galectin-3 is elevated in obesity and negatively correlates with glycosylated hemoglobin in type 2 diabetes. J Clin Endocrinol Metabol. 2010;95(3):1404–1411.
  • Li P, Liu S, Lu M, et al. Hematopoietic-derived galectin-3 causes cellular and systemic insulin resistance. Cell. 2016;167(4):973–984.
  • Ohkura T, Fujioka Y, Nakanishi R, et al. Low serum galectin-3 concentrations are associated with insulin resistance in patients with type 2 diabetes mellitus. Diabetol Metab Syndr. 2014;6(1):106.

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