140
Views
2
CrossRef citations to date
0
Altmetric
ENDOMETRIOSIS

Elevated expressions of SHP2 and GAB2 correlated with VEGF in eutopic and ectopic endometrium of women with ovarian endometriosis

, , , , , , , , , , & show all
Pages 813-818 | Received 22 May 2020, Accepted 22 Jun 2020, Published online: 03 Jul 2020

References

  • Giudice LC. Clinical practice. Endometriosis. N Engl J Med. 2010;362(25):2389–2398.
  • Vercellini P, Vigano P, Somigliana E, et al. Endometriosis: pathogenesis and treatment. Nat Rev Endocrinol. 2014;10(5):261–275.
  • Sampson JA. Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity. Am J Obstet Gynecol. 1927;14(4):422–469.
  • Burney RO, Giudice LC. Pathogenesis and pathophysiology of endometriosis. Fertil Steril. 2012;98(3):511–519.
  • Han SJ, Jung SY, Wu SP, et al. Estrogen receptor β modulates apoptosis complexes and the inflammasome to drive the pathogenesis of endometriosis. Cell. 2015;163(4):960–974.
  • Bulun SE, Yilmaz BD, Sison C, et al. Endometriosis. Endocr Rev. 2019;40(4):1048–1079.
  • Neel BG, Gu H, Pao L. The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling. Trends Biochem. Sci. 2003;28(6):284–293.
  • Chan G, Kalaitzidis D, Neel BG. The tyrosine phosphatase Shp2 (PTPN11) in cancer. Cancer Metastasis Rev. 2008;27(2):179–192.
  • Gu H, Neel BG. The "Gab" in signal transduction. Trends Cell Biol. 2003;13(3):122–130.
  • Reiman EM, Webster JA, Myers AJ, et al. GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers. Neuron. 2007;54(5):713–720.
  • Gu H, Saito K, Klaman LD, et al. Essential role for Gab2 in the allergic response. Nature. 2001;412(6843):186–190.
  • Adams SJ, Aydin IT, Celebi JT. GAB2-a scaffolding protein in cancer. Mol Cancer Res. 2012;10(10):1265–1270.
  • Zhang X, Dong Z, Zhang C, et al. Critical role for GAB2 in neuroblastoma pathogenesis through the Promotion of SHP2/MYCN Cooperation. Cell Rep. 2017;18(12):2932–2942.
  • Liu W, Yu WM, Zhang J, et al. Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations. Leukemia. 2017;31(6):1415–1422.
  • Society AF. Revised American Fertility Society classification of endometriosis: 1985. Fertil Steril. 1985;43(3):351–352.
  • Zhang X, Qi C, Lin J. Enhanced expressions of matrix metalloproteinase (MMP)-2 and -9 and vascular endothelial growth factors (VEGF) and increased microvascular density in the endometrial hyperplasia of women with anovulatory dysfunctional uterine bleeding. Fertil Steril. 2010;93(7):2362–2367.
  • Remmele W, Stegner HE. Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER-ICA) in breast cancer tissue. Pathologe. 1987;8(3):138–140.
  • Aceto N, Sausgruber N, Brinkhaus H, et al. Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop. Nat Med. 2012;18(4):529–537.
  • Grossmann KS, Rosário M, Birchmeier C, et al. The tyrosine phosphatase Shp2 in development and cancer. Adv Cancer Res. 2010;106:53–89.
  • Yotova IY, Quan P, Leditznig N, et al. Abnormal activation of Ras/Raf/MAPK and RhoA/ROCKII signalling pathways in eutopic endometrial stromal cells of patients with endometriosis. Hum Reprod. 2011;26(4):885–897.
  • McKinnon BD, Kocbek V, Nirgianakis K, et al. Kinase signalling pathways in endometriosis: potential targets for non-hormonal therapeutics. Hum Reprod Update. 2016;22(3):382–403.
  • Ke Y, Wu D, Princen F, et al. Role of Gab2 in mammary tumorigenesis and metastasis. Oncogene. 2007;26(34):4951–4960.
  • Gu H, Pratt JC, Burakoff SJ, et al. Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation. Mol Cell. 1998;2(6):729–740.
  • Brummer T, Schramek D, Hayes VM, et al. Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein. J Biol Chem. 2006;281(1):626–637.
  • Yu WM, Hawley TS, Hawley RG, et al. Role of the docking protein Gab2 in beta(1)-integrin signaling pathway-mediated hematopoietic cell adhesion and migration. Blood. 2002;99(7):2351–2359.
  • Yu M, Luo J, Yang W, et al. The scaffolding adapter Gab2, via Shp-2, regulates kit-evoked mast cell proliferation by activating the Rac/JNK pathway. J Biol Chem. 2006;281(39):28615–28626.
  • Young VJ, Ahmad SF, Brown JK, et al. Peritoneal VEGF-A expression is regulated by TGF-beta1 through an ID1 pathway in women with endometriosis. Sci Rep. 2015;5(1):16859.
  • Shifren JL, Tseng JF, Zaloudek CJ, et al. Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis. J Clin Endocrinol Metab. 1996;81(8):3112–3118.
  • Hirota Y, Tranguch S, Daikoku T, et al. Deficiency of immunophilin FKBP52 promotes endometriosis. Am J Pathol. 2008;173(6):1747–1757.
  • Duckworth C, Zhang L, Carroll SL, et al. Overexpression of GAB2 in ovarian cancer cells promotes tumor growth and angiogenesis by upregulating chemokine expression. Oncogene. 2016;35(31):4036–4047.
  • Scotti S, Regidor PA, Schindler AE, et al. Reduced proliferation and cell adhesion in endometriosis. Mol Hum Reprod. 2000;6(7):610–617.
  • Goteri G, Altobelli E, Tossetta G, et al. High temperature requirement A1, transforming growth factor beta1, phosphoSmad2 and Ki67 in eutopic and ectopic endometrium of women with endometriosis. Eur J Histochem. 2015;59(4):2570

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.