Low-dose aspirin can downregulate progesterone resistance and increase the expression of LIF in endometriosis during the implantation window

References

• Marquardt RM, Kim TH, Shin JH, et al. Progesterone and estrogen signaling in the endometrium: what goes wrong in endometriosis? Int J Mol Sci. 2019;20(15):3822.
   Web of Science ®Google Scholar
• Miller JE, Ahn SH, Monsanto SP, et al. Implications of immune dysfunction on endometriosis associated infertility. Oncotarget. 2017;8(4):7138–7147.
   PubMedGoogle Scholar
• Hauzman EE, Garcia-Velasco JA, Pellicer A. Oocyte donation and endometriosis: what are the lessons? Semin Reprod Med. 2013;31(02):173–177.
   PubMedGoogle Scholar
• Ghazal S, McKinnon B, Zhou JC, et al. H19 lnc RNA alters stromal cell growth via IGF signaling in the endometrium of women with endometriosis. EMBO Mol Med. 2015;7(8):996–1003.
   PubMed Web of Science ®Google Scholar
• Lessey BA, Lebovic DI, Taylor RN. Eutopic endometrium in women with endometriosis: ground zero for the study of implantation defects. Semin Reprod Med. 2013;31(02):109–124.
   PubMedGoogle Scholar
• Cakmak H, Taylor HS. Molecular mechanisms of treatment resistance in endometriosis: the role of progesterone-hox gene interactions. Semin Reprod Med. 2010;28(01):69–74.
   PubMedGoogle Scholar
• Gupta S, Goldberg JM, Aziz N, et al. Pathogenic mechanisms in endometriosis-associated infertility. Fertil Steril. 2008;90(2):247–257.
   PubMed Web of Science ®Google Scholar
• Wang TF, Kang XM, Zhao AM, et al. Low-dose aspirin improves endometrial receptivity in the midluteal phase in unexplained recurrent pregnancy loss. Int J Gynecol Obstet. 2020;150(1):77–82.
   PubMed Web of Science ®Google Scholar
• Chi YG, He P, Lei L, et al. Transdermal estrogen gel and oral aspirin combination therapy improves fertility prognosis via the promotion of endometrial receptivity in moderate to severe intrauterine adhesion. Mol Med Rep. 2018;17(5):6337–6344.
   PubMed Web of Science ®Google Scholar
• Zhang ZH, Li S, Deng J, et al. Aspirin inhibits endometrial fibrosis by suppressing the TGF–β1–Smad2/Smad3 pathway in intrauterine adhesions. Int J Mol Med. 2020;45(5):1351–1360.
   PubMed Web of Science ®Google Scholar
• Lessey BA, Kim JJ. Endometrial receptivity in the eutopic endometrium of women with endometriosis: it is affected, and let me show you why. Fertil Steril. 2017;108(1):19–27.
   PubMed Web of Science ®Google Scholar
• Lessey BA, Young SL. What exactly is endometrial receptivity? Fertil Steril. 2019;111(4):611–617.
   PubMed Web of Science ®Google Scholar
• Lessey BA. Implantation defects in infertile women with endometriosis. Ann NY Acad Sci. 2002;955(1):265–280.
   PubMedGoogle Scholar
• Schmitz CR, Oehninger S, Genro VK, et al. Alterations in expression of endometrial milk fat globule-EGF factor 8 (MFG-E8) and leukemia inhibitory factor (LIF) in patients with infertility and endometriosis. JBRA Assist Reprod. 2017;21(4):313–320.
   PubMed Web of Science ®Google Scholar
• Mathyk B, Adams N, Young SL. Endometrial receptivity: lessons from systems biology and candidate gene studies of endometriosis. Minerva Ginecol. 2017;69(1):41–56.
   PubMed Web of Science ®Google Scholar
• Zhao M, Chang C, Liu Z, et al. Treatment with low-dose aspirin increased the level LIF and integrin β3 expression in mice during the implantation window. Placenta. 2010;31(12):1101–1105.
   PubMed Web of Science ®Google Scholar
• Wu L, Lv CZ, Su YF, et al. Expression of programmed death-1 (PD-1) and its ligand PD-L1 is upregulated in endometriosis and promoted by 17beta-estradiol. Gynecol Endocrinol. 2019;35(3):251–256.
   PubMed Web of Science ®Google Scholar
• Garrido N, Navarro J, García-Velasco J, et al. The endometrium versus embryonic quality in endometriosis-related infertility. Hum Reprod Update. 2002;8(1):95–103.
   PubMed Web of Science ®Google Scholar
• Steiner N, Shrem G, Tannus S, et al. Effect of GnRH agonist and letrozole treatment in women with recurrent implantation failure. Fertil Steril. 2019;112(1):98–104.
   PubMed Web of Science ®Google Scholar
• Celik O, Acet M, Kucuk T, et al. Surgery for benign gynecological disorders improve endometrium receptivity. Reprod Sci. 2017;24(2):174–192.
   PubMed Web of Science ®Google Scholar
• Patel BG, Rudnicki M, Yu J, et al. Progesterone resistance in endometriosis: origins, consequences and interventions. Acta Obstet Gynecol Scand. 2017;96(6):623–632.
   PubMed Web of Science ®Google Scholar
• Arosh JA, Lee J, Balasubbramanian D, et al. Molecular and preclinical basis to inhibit PGE2 receptors EP2 and EP4 as a novel nonsteroidal therapy for endometriosis. Proc Natl Acad Sci USA. 2015;112(31):9716–9721.
   PubMed Web of Science ®Google Scholar
• Matteo M, Cicinelli E, Neri M, et al. Pro-inflammatory M1/Th1 type immune network and increased expression of TSG-6 in the eutopic endometrium from women with endometriosis. Eur J Obstet Gynecol Reprod Biol. 2017;218:99–105.
   PubMed Web of Science ®Google Scholar
• Young SL, Lessey BA. Progesterone function in human endometrium: clinical perspectives. Semin Reprod Med. 2010;28(01):5–16.
   PubMedGoogle Scholar
• Revel A. Defective endometrial receptivity. Fertil Steril. 2012;97(5):1028–1032.
   PubMed Web of Science ®Google Scholar
• Fatemi HM, Popovic-Todorovic B. Implantation in assisted reproduction: a look at endometrial receptivity. Reprod Biomed Online. 2013;27(5):30–538.
   Web of Science ®Google Scholar
• Xiao Y, Sun X, Yang X, et al. leukemia inhibitory factor is dysregulated in the endometrium and uterine flushing of patients with adenomyosis during implantation window. Fertil Steril. 2010;94(1):85–89.
   PubMed Web of Science ®Google Scholar
• Margioula-Siarkou C, Prapas Y, Petousis S, et al. LIF endometrial expression is impaired in women with unexplained infertility while LIF-R expression in all infertility sub-groups. Cytokine. 2017;96:166–172.
   PubMed Web of Science ®Google Scholar
• Rosario GX, Stewart CL. The multifaceted actions of leukaemia inhibitory factor in mediating uterine receptivity and embryo implantation. Am J Reprod Immunol. 2016;75(3):246–255.
   PubMed Web of Science ®Google Scholar