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Gynecological Endocrinology Volume 37, 2021 - Issue 8
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ORIGINAL ARTICLES: UTERINE FIBROIDS

The role of anti-proliferative effects of atorvastatin on uterine fibroids: findings from a clinical study

Masoumeh Ghafarzadeha Department of Obstetrics and Gynecology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, IranORCID Iconhttps://orcid.org/0000-0001-8493-1520
ORCID Icon,
Amir Shakaramib Department of Cardiology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, IranORCID Iconhttps://orcid.org/0000-0003-1056-657X
ORCID Icon,
Fatemeh Yaric Department of Reproductive Health, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, IranCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-4285-3429
ORCID Icon &
Zahra Marzban Radd Department of Obstetrics and Gynecology, School of Medicine, Aja University of Medical Sciences, Tehran, IranORCID Iconhttps://orcid.org/0000-0002-1516-7976
ORCID Icon
Pages 721-724 | Received 23 Aug 2020, Accepted 24 Apr 2021, Published online: 07 May 2021

References

  • Sparic R, Mirkovic L, Malvasi A, et al. Epidemiology of uterine myomas: a review. Int J Fertil Steril. 2016;9(4):424–435.
  • Stewart EA. Clinical practice. Uterine fibroids. N Engl J Med. 2015;372(17):1646–1655.
  • Sohn GS, Cho S, Kim YM, et al. Current medical treatment of uterine fibroids. Obstet Gynecol Sci. 2018;61(2):192–201.
  • Keltz J, Levie M, Chudnoff S. Pregnancy outcomes after direct uterine myoma thermal ablation: review of the literature. J Minim Invasive Gynecol. 2017;24(4):538–545.
  • Mohammadkhani N, Gharbi S, Rajani HF, et al. Statins: complex outcomes but increasingly helpful treatment options for patients. Eur J Pharmacol. 2019;863:172704.
  • Mas A, Tarazona M, Dasí Carrasco J, et al. Updated approaches for management of uterine fibroids. Int J Womens Health. 2017;9:607–617.
  • Ali M, Jackson-Bey T, Al-Hendy A. Simvastatin and uterine fibroids: opportunity for a novel therapeutic option. Fertil Steril. 2018;110(7):1272–1273.
  • Kang S, Brinker A, Jones SC, et al. An evaluation of postmarketing reports of serious idiosyncratic liver injury associated with ulipristal acetate for the treatment of uterine fibroids. Drug Saf. 2020;43(12):1267–1276.
  • Gatti M, Poluzzi E, De Ponti F, et al. Liver injury with ulipristal acetate: exploring the underlying pharmacological basis. Drug Saf. 2020;43(12):1277–1285.
  • Ali M, Chaudhry ZT, Al-Hendy A. Successes and failures of uterine leiomyoma drug discovery. Expert Opin Drug Discov. 2018;13(2):169–177.
  • Malik M, Britten J, Borahay M, et al. Simvastatin, at clinically relevant concentrations, affects human uterine leiomyoma growth and extracellular matrix production. Fertil Steril. 2018;110(7):1398.e1–1407.e1.
  • Moshesh M, Peddada S, Cooper T, et al. Intraobserver Variability in Fibroid Size measurements: estimated effects on assessing fibroid growth. J Ultrasound Med. 2014;33(7):1217–1224.
  • Borahay MA, Fang X, Baillargeon JG, et al. Statin use and uterine fibroid risk in hyperlipidemia patients: a nested case-control study. Am J Obstet Gynecol. 2016;215(6):750.e1–750.e8.
  • Afrin S, Borahay MA. Simvastatin inhibits RhoA activation, collagen expression and gel contraction in human leiomyoma cells. Fertil Steril. 2019;112(3):e347.
  • Afrin S, Islam S, Su S-C, et al. Effect of simvastatin on integrin-β1 and its downstream mediators in human leiomyoma cells. Fertil Steril. 2019;112(3):e346.
  • Malik M, Catherino WH, Laknaur A, et al. Synergistic effects of simvastatin and ulipristal acetate on uterine leiomyoma. Fertil Steril. 2017;108(3):e65.
  • Montaseri A, Khazaei M, Ghorbani R, et al. Evaluating the effects of Atorvastatin on cultured human endometrium in a three-dimensional fibrin matrix. J Reprod Infertil. 2007;7(4):358–366.
  • Yilmaz B, Ozat M, Kilic S, et al. Atorvastatin causes regression of endometriotic implants in a rat model. Reprod Biomed Online. 2010;20(2):291–299.
  • Li J, Sun YM, Wang LF, et al. Comparison of effects of simvastatin versus atorvastatin on oxidative stress in patients with coronary heart disease. Clin Cardiol. 2010;33(4):222–227.
  • Jose MA, Anandkumar S, Narmadha MP, et al. A comparative effect of atorvastatin with other statins in patients of hyperlipidemia. Indian J Pharmacol. 2012;44(2):261–263.
  • Shachaf CM, Perez OD, Youssef S, et al. Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesis. Blood. 2007;110(7):2674–2684.
  • Tal R, Segars JH. The role of angiogenic factors in fibroid pathogenesis: potential implications for future therapy. Hum Reprod Update. 2014;20(2):194–216.
  • Konarska M, Wrona AN, Aleksandrovych V, et al. Angiogenesis and pro-angiogenic factors in uterine fibroids – facts and myths. Folia Med Cracov. 2016;56(2):37–43.
  • Gentry CC, Okolo SO, Fong LF, et al. Quantification of vascular endothelial growth factor-A in leiomyomas and adjacent myometrium. Clin Sci (Lond). 2001;101(6):691–695.
  • Ruiz-Velasco N, Domínguez A, Vega MA. Statins upregulate CD36 expression in human monocytes, an effect strengthened when combined with PPAR-gamma ligands putative contribution of Rho GTPases in statin-induced CD36 expression. Biochem Pharmacol. 2004;67(2):303–313.
  • Laufs U. Beyond lipid-lowering: effects of statins on endothelial nitric oxide. Eur J Clin Pharmacol. 2003;58(11):719–731.
  • Schooling CM, Au Yeung SL, Freeman G, et al. The effect of statins on testosterone in men and women, a systematic review and meta-analysis of randomized controlled trials. BMC Med. 2013;11(1):57.

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