Oral melatonin supplementation during in vitro fertilization treatment: a systematic PRISMA review and meta-analysis of randomized controlled trials

References

• Mascarenhas NM, F. R S, Boerma T, et al. National, Regional, and Global Trends in Infertility Prevalence Since 1990: A Systematic Analysis of 277 Health Surveys, <https://journals.plos.org/plosmedicine/article?id=https://doi.org/10.1371/journal.pmed.1001356. > 2012.
   Google Scholar
• Adamson GD, de Mouzon J, Chambers GM, et al. International committee for monitoring assisted reproductive technology: world report on assisted reproductive technology, 2011. Fertil Steril. 2018;110(6):1067–1080.
   PubMed Web of Science ®Google Scholar
• Goto Y, Noda Y, Mori T, et al. Increased generation of reactive oxygen species in embryos cultured in vitro. Free Radical Biol Med. 1993;15(1):69–75.
   PubMed Web of Science ®Google Scholar
• Nakayama T, Noda Y, Goto Y, et al. Effects of visible light and other environmental factors on the production of oxygen radicals by hamster embryos. Theriogenology. 1994;41(2):499–510.
   PubMed Web of Science ®Google Scholar
• Nasr-Esfahani MH, Aitken JR, Johnson MH. Hydrogen peroxide levels in mouse oocytes and early cleavage stage embryos developed in vitro or in vivo. Development. 1990;109(2):501–507.
   PubMed Web of Science ®Google Scholar
• Bedaiwy MA, Mahfouz RZ, Goldberg JM, et al. Relationship of reactive oxygen species levels in day 3 culture media to the outcome of in vitro fertilization/intracytoplasmic sperm injection cycles. Fertil Steril. 2010;94(6):2037–2042.
   PubMed Web of Science ®Google Scholar
• Martín-Romero FJ, Miguel-Lasobras EM, Domínguez-Arroyo JA, et al. Contribution of culture media to oxidative stress and its effect on human oocytes. Reprod Biomed Online. 2008;17(5):652–661.
   PubMed Web of Science ®Google Scholar
• Tamura H, Takasaki A, Miwa I, et al. Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate. J Pineal Res. 2008;44(3):280–287.
   PubMed Web of Science ®Google Scholar
• Yang HW, Hwang KJ, Kwon HC, et al. Detection of reactive oxygen species (ROS) and apoptosis in human fragmented embryos. Hum Reprod. 1998;13(4):998–1002.
   PubMed Web of Science ®Google Scholar
• Bedaiwy MA, Falcone T, Mohamed MS, et al. Differential growth of human embryos in vitro: role of reactive oxygen species. Fertil Steril. 2004;82(3):593–600.
   PubMed Web of Science ®Google Scholar
• Zorn B, Vidmar G, Meden-Vrtovec H. Seminal reactive oxygen species as predictors of fertilization, embryo quality and pregnancy rates after conventional in vitro fertilization and intracytoplasmic sperm injection. Int J Androl. 2003;26(5):279–285.
   PubMedGoogle Scholar
• Attaran M, et al. The effect of follicular fluid reactive oxygen species on the outcome of in vitro fertilization. Int J Fertil Women's Med. 2000;45:314–320.
   PubMed Web of Science ®Google Scholar
• Gauer F, Craft CM. Circadian regulation of hydroxyindole-O-methyltransferase mRNA levels in rat pineal and retina. Brain Res. 1996;737(1-2):99–109.
   PubMed Web of Science ®Google Scholar
• Lynch HJ, Ozaki Y, Shakal D, et al. Melatonin excretion of man and rats: effect of time of day, sleep, pinealectomy and food consumption. Int J Biometeorol. 1975;19(4):267–279.
   PubMed Web of Science ®Google Scholar
• Tesoriere L, D'Arpa D, Conti S, et al. Melatonin protects human red blood cells from oxidative hemolysis: new insights into the radical-scavenging activity. J Pineal Res. 1999;27(2):95–105.
   PubMed Web of Science ®Google Scholar
• Galano A, Tan DX, Reiter RJ. On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK. J Pineal Res. 2013;54(3):245–257.
   PubMed Web of Science ®Google Scholar
• Zarazaga LA, Gatica MC, Celi I, et al. Reproductive performance is improved during seasonal anoestrus when female and male Murciano-Granadina goats receive melatonin implants and in payoya goats when females are thus treated. Reprod Domestic Anim. 2012;47(3):436–442.
   PubMed Web of Science ®Google Scholar
• Mura MC, Luridiana S, Farci F, et al. Melatonin treatment in winter and spring and reproductive recovery in sarda breed sheep. Anim Reprod Sci. 2017;185:104–108.
   PubMed Web of Science ®Google Scholar
• Han L, Wang H, Li L, et al. Melatonin protects against maternal obesity-associated oxidative stress and meiotic defects in oocytes via the SIRT3-SOD2-dependent pathway. J Pineal Res. 2017;63: e12431–32.
   Web of Science ®Google Scholar
• Song C, Peng W, Yin S, et al. Melatonin improves age-induced fertility decline and attenuates ovarian mitochondrial oxidative stress in mice. Sci Rep. 2016;6:35165
   PubMed Web of Science ®Google Scholar
• Behram Kandemir Y, Aydin C, Gorgisen G. The effects of melatonin on oxidative stress and prevention of primordial follicle loss via activation of mTOR pathway in the rat ovary. Cell Mol Biol (Noisy-le-Grand)). 2017;63(2):100–106.
   PubMed Web of Science ®Google Scholar
• Zheng M, Tong J, Li WP, et al. Melatonin concentration in follicular fluid is correlated with antral follicle count (AFC) and in vitro fertilization (IVF) outcomes in women undergoing assisted reproductive technology (ART) procedures. Gynecol Endocrinol. 2018;34(5):446–450.
   PubMed Web of Science ®Google Scholar
• Tong J, Sheng S, Sun Y, et al. Melatonin levels in follicular fluid as markers for IVF outcomes and predicting ovarian reserve. Reproduction. 2017;153(4):443–451.
   PubMed Web of Science ®Google Scholar
• Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and Meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol. 2009;62(10):e1–34.
   PubMed Web of Science ®Google Scholar
• National Institute for Health Research. PROSPERO Protocol <https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=172970.
   Google Scholar
• Borenstein M, Hedges LV, Higgins JP, et al. A basic introduction to fixed-effect and random-effects models for meta-analysis. Res Synth Methods. 2010;1(2):97–111.
   PubMed Web of Science ®Google Scholar
• Jahromi BN, Sadeghi S, Alipour S, et al. Effect of melatonin on the outcome of assisted reproductive technique cycles in women with diminished ovarian reserve: a double-blinded randomized clinical trial. Iran J Med Sci. 2017;42(1):73–78.
   PubMed Web of Science ®Google Scholar
• Batıoğlu AS, Şahin U, Gürlek B, et al. The efficacy of melatonin administration on oocyte quality. Gynecol Endocrinol. 2012;28(2):91–93.
   PubMed Web of Science ®Google Scholar
• Eryilmaz OG, Devran A, Sarikaya E, et al. Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems. J Assist Reprod Genet. 2011;28(9):815–820.
   PubMed Web of Science ®Google Scholar
• Pacchiarotti A, Carlomagno G, Antonini G, et al. Effect of myo-inositol and melatonin versus myo-inositol, in a randomized controlled trial, for improving in vitro fertilization of patients with polycystic ovarian syndrome. Gynecol Endocrinol. 2016;32(1):69–73.
   PubMed Web of Science ®Google Scholar
• Rizzo P, Raffone E, Benedetto V. Effect of the treatment with myo-inositol plus folic acid plus melatonin in comparison with a treatment with myo-inositol plus folic acid on oocyte quality and pregnancy outcome in IVF cycles. A prospective, clinical trial. Eur Rev Med Pharmacol Sci. 2010;14(6):555–561.
   PubMed Web of Science ®Google Scholar
• Espino J, Macedo M, Lozano G, et al. Impact of melatonin supplementation in women with unexplained infertility undergoing fertility treatment. Antioxidants (Basel). 2019;8(9):338.
   PubMedGoogle Scholar
• Fernando S, Wallace EM, Vollenhoven B, et al. Melatonin in assisted reproductive technology: a pilot double-blind randomized placebo-controlled clinical trial. Front Endocrinol. 2018;9.
   PubMed Web of Science ®Google Scholar
• Waldhauser F, Waldhauser M, Lieberman HR, et al. Bioavailability of oral melatonin in humans. Neuroendocrinology. 1984;39(4):307–313.
   PubMed Web of Science ®Google Scholar
• Gougeon A. Dynamics of follicular growth in the human: a model from preliminary results. Hum Reprod. 1986;1(2):81–87.
   PubMed Web of Science ®Google Scholar
• Scholtes MC, Hop WC, Alberda AT, et al. Factors influencing the outcome of successive IVF treatment cycles in attaining a follicular puncture. Hum Reprod. 1988;3(6):755–759.
   PubMed Web of Science ®Google Scholar
• Templeton A, Morris JK, Parslow W. Factors that affect outcome of in-vitro fertilisation treatment. Lancet (London, England). 1996;348(9039):1402–1406.
   PubMed Web of Science ®Google Scholar
• Fedorcsak P, et al. Impact of overweight and underweight on assisted reproduction treatment. Hum Reprod. 2004;19:2523–2528.
   PubMed Web of Science ®Google Scholar
• Maximovich A, Beyler SA. Cigarette smoking at time of in vitro fertilization cycle initiation has negative effect on in vitro fertilization-embryo transfer success rate. J Assist Reprod Genet. 1995;12(2):75–77.
   PubMed Web of Science ®Google Scholar
• Rosevear SK, Ford WCL, Wardle PG, et al. Smoking and decreased fertilisation rates in vitro. Lancet. 1992;340(8829):1195–1196.
   PubMed Web of Science ®Google Scholar
• Seko LMD, Moroni RM, Leitao VMS, et al. Melatonin supplementation during controlled ovarian stimulation for women undergoing assisted reproductive technology: systematic review and Meta-analysis of randomized controlled trials. Fertil Steril. 2014;101(1):154–161.e154.
   PubMed Web of Science ®Google Scholar
• Hu KL, Ye X, Wang S, et al. Melatonin application in assisted reproductive technology: a systematic review and Meta-Analysis of randomized Trials. Front Endocrinol. 2020;11:160.
   PubMed Web of Science ®Google Scholar