Serum kisspeptin levels along reproductive period in women: is it a marker for aging?

References

• Roseweir A, Millar R. The role of kisspeptin in the control of gonadotrophin secretion. Hum Reprod Update. 2009;15(2):203–212.
   PubMed Web of Science ®Google Scholar
• Clarke SA, Dhillo WS. Kisspeptin across the human lifespan: evidence from animal studies and beyond. J Endocrinol. 2016;229(3):R83–R98.
   PubMed Web of Science ®Google Scholar
• Lee J-H, Miele ME, Hicks DJ, et al. KiSS-1, a novel human malignant melanoma metastasis-suppressor gene. J Natl Cancer Inst. 1996;88(23):1731–1737.
   PubMedGoogle Scholar
• Wang T, Han S, Tian W, et al. Effects of kisspeptin on pathogenesis and energy metabolism in polycystic ovarian syndrome (PCOS). Gynecol Endocrinol. 2019;35(9):807–810.
   PubMed Web of Science ®Google Scholar
• Szeliga A, Podfigurna A, Bala G, et al. Kisspeptin and neurokinin B analogs use in gynecological endocrinology: where do we stand? J Endocrinol Invest. 2020;43(5):555–561.
   PubMed Web of Science ®Google Scholar
• Navarro VM. Metabolic regulation of kisspeptin – the link between energy balance and reproduction. Nat Rev Endocrinol. 2020;16(8):407–420.
   PubMed Web of Science ®Google Scholar
• Smith JT, Popa SM, Clifton DK, et al. Kiss1 neurons in the forebrain as central processors for generating the preovulatory luteinizing hormone surge. J Neurosci. 2006;26(25):6687–6694.
   PubMed Web of Science ®Google Scholar
• Lippincott MF, Chan Y-M, Rivera Morales D, et al. Continuous kisspeptin administration in postmenopausal women: impact of estradiol on luteinizing hormone secretion. J Clin Endocrinol Metab. 2017;102(6):2091–2099.
   PubMed Web of Science ®Google Scholar
• Roberts RE, Farahani L, Webber L, et al. Current understanding of hypothalamic amenorrhoea. Ther Adv Endocrinol Metab. 2020;11:2042018820945854.
   Web of Science ®Google Scholar
• Araújo BS, Baracat MCP, dos Santos Simões R, et al. Kisspeptin influence on polycystic ovary syndrome – a mini review. Reprod Sci. 2020;27(2):455–460.
   PubMed Web of Science ®Google Scholar
• Coutinho EA, Kauffman AS. The role of the brain in the pathogenesis and physiology of polycystic ovary syndrome (PCOS). Med Sci. 2019;7(8):84.
   Google Scholar
• Modi M, Dhillo WS. Neurokinin 3 receptor antagonism: a novel treatment for menopausal hot flushes. Neuroendocrinology. 2019;109(3):242–248.
   PubMed Web of Science ®Google Scholar
• Hunjan T, Abbara A, editors. Clinical translational studies of kisspeptin and neurokinin B. Seminars in reproductive medicine. New York, NY: Thieme Medical Publishers; 2019.
   Google Scholar
• Seminara SB, Messager S, Chatzidaki EE, et al. The GPR54 gene as a regulator of puberty. N Engl J Med. 2003;349(17):1614–1627.
   PubMed Web of Science ®Google Scholar
• De Roux N, Genin E, Carel J-C, et al. Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proc Natl Acad Sci USA. 2003;100(19):10972–10976.
   PubMed Web of Science ®Google Scholar
• Mut A, Erel CT, Inan D, et al. Serum kisspeptin levels correlated with anti-Mullerian hormone levels in women with and without polycystic ovarian syndrome. Gynecol Endocrinol. 2021;37(5):462–466.
   PubMed Web of Science ®Google Scholar
• Hu K-L, Zhao H, Chang H-M, et al. Kisspeptin/kisspeptin receptor system in the ovary. Front Endocrinol. 2017;8:365.
   PubMed Web of Science ®Google Scholar
• Hu K-L, Zhao H, Min Z, et al. Increased expression of KISS1 and KISS1 receptor in human granulosa lutein cells-potential pathogenesis of polycystic ovary syndrome. Reprod Sci. 2019;26(11):1429–1438.
   PubMed Web of Science ®Google Scholar
• Hu K-L, Chang H-M, Zhao H-C, et al. Potential roles for the kisspeptin/kisspeptin receptor system in implantation and placentation. Hum Reprod Update. 2019;25(3):326–343.
   PubMed Web of Science ®Google Scholar
• Zeydabadi Nejad S, Ramezani Tehrani F, Zadeh-Vakili A. The role of kisspeptin in female reproduction. Int J Endocrinol Metab. 2017;15(3):e44337–e44337.
   PubMed Web of Science ®Google Scholar
• Narayanaswamy S, Jayasena CN, Ng N, et al. Subcutaneous infusion of kisspeptin‐54 stimulates gonadotrophin release in women and the response correlates with basal oestradiol levels. Clin Endocrinol. 2016;84(6):939–945.
   PubMed Web of Science ®Google Scholar
• Meczekalski B, Katulski K, Podfigurna-Stopa A, et al. Spontaneous endogenous pulsatile release of kisspeptin is temporally coupled with luteinizing hormone in healthy women. Fertil Steril. 2016;105(5):1345–1350.
   PubMed Web of Science ®Google Scholar
• Barbakadze L, Kristesashvili J, Khonelidze N, et al. The correlations of anti-Mullerian hormone, follicle-stimulating hormone and antral follicle count in different age groups of infertile women. Int J Fertil Steril. 2015;8(4):393.
   PubMed Web of Science ®Google Scholar
• Spaziani M, Tarantino C, Tahani N, et al. Hypothalamo-pituitary axis and puberty. Mol Cell Endocrinol. 2021;520:111094.
   PubMed Web of Science ®Google Scholar
• Jayasena CN, Nijher GM, Narayanaswamy S, et al. Age-dependent elevations in plasma kisspeptin are observed in boys and girls when compared with adults. Ann Clin Biochem. 2014;51(Pt 1):89–96.
   PubMed Web of Science ®Google Scholar
• Fang P, She Y, Zhao J, et al. Emerging roles of kisspeptin/galanin in age-related metabolic disease. Mech Ageing Dev. 2021;199:111571.
   PubMed Web of Science ®Google Scholar
• Kruszyńska A, Słowińska-Srzednicka J. Anti-Müllerian hormone (AMH) as a good predictor of time of menopause. Prz Menopauzalny. 2017;16(2):47–50.
   PubMedGoogle Scholar
• Randolph JF Jr, Zheng H, Sowers MR, et al. Change in follicle-stimulating hormone and estradiol across the menopausal transition: effect of age at the final menstrual period. J Clin Endocrinol Metab. 2011;96(3):746–754.
   PubMed Web of Science ®Google Scholar
• Moolhuijsen LM, Visser JA. Anti-Müllerian hormone and ovarian reserve: update on assessing ovarian function. J Clin Endocrinol Metab. 2020;105(11):3361–3373.
   PubMed Web of Science ®Google Scholar
• Erel CT, Ozcivit IB. Anti-Müllerian hormone and ovarian aging. New York, NY: Taylor & Francis; 2021.
   Google Scholar
• Pérez-López FR, Ornat L, López-Baena MT, et al. Circulating kisspeptin and anti-müllerian hormone levels, and insulin resistance in women with polycystic ovary syndrome: a systematic review, meta-analysis, and meta-regression. Eur J Obstet Gynecol Reprod Biol. 2021;260:85–98.
   PubMed Web of Science ®Google Scholar
• Katagiri F, Kotani M, Hirai T, et al. The relationship between circulating kisspeptin and sexual hormones levels in healthy females. Biochem Biophys Res Commun. 2015;458(3):663–666.
   PubMed Web of Science ®Google Scholar
• Peng J, Xu H, Yang B, et al. Plasma levels of kisspeptins in postmenopausal Chinese women do not show substantial elevation. Peptides. 2010;31(12):2255–2258.
   PubMed Web of Science ®Google Scholar
• Rometo AM, Krajewski SJ, Lou Voytko M, et al. Hypertrophy and increased kisspeptin gene expression in the hypothalamic infundibular nucleus of postmenopausal women and ovariectomized monkeys. J Clin Endocrinol Metab. 2007;92(7):2744–2750.
   PubMed Web of Science ®Google Scholar
• Rance NE. Menopause and the human hypothalamus: evidence for the role of kisspeptin/neurokinin B neurons in the regulation of estrogen negative feedback. Peptides. 2009;30(1):111–122.
   PubMed Web of Science ®Google Scholar
• Dubois SL, Acosta-Martínez M, DeJoseph MR, et al. Positive, but not negative feedback actions of estradiol in adult female mice require estrogen receptor α in kisspeptin neurons. Endocrinology. 2015;156(3):1111–1120.
   PubMed Web of Science ®Google Scholar