121
Views
0
CrossRef citations to date
0
Altmetric
Pregnancy loss

Circulating levels of Elabela in pregnant women with missed abortion

, , , &
Pages 693-696 | Received 18 Mar 2022, Accepted 13 Jun 2022, Published online: 27 Jun 2022

References

  • Sebire NJ, Thornton S, Hughes K, et al. The prevalence and consequences of missed abortion in twin pregnancies at 10 to 14 weeks of gestation. Br J Obstet Gynaecol. 1997;104(7):847–848.
  • O’Connell RM, Rao DS, Chaudhuri AA, et al. Physiological and pathological roles for microRNAs in the immune system. Nat Rev Immunol. 2010;10(2):111–122.
  • Chen H, Deng X, Yang Y, et al. Expression of GRIM-19 in missed abortion and possible pathogenesis. Fertil Steril. 2015;103(1):138–146.e3.
  • Xia S, Zhen Y, Ma H, et al. Abnormal expression of microRNA-575 leads to missed abortion through regulating apoptosis and angiogenesis. Exp Ther Med. 2017;14:3993–4000.
  • Ozçakir T, Thran MA, Simşek F, et al. A comparison of the molecular distribution of proangiogenic factors in endometrium of missed abortions and of voluntary first trimester termination cases. Clin Exp Obstet Gynecol. 2015;42:40–48.
  • Zhi Z, Yang W, Liu L, et al. Early missed abortion is associated with villous angiogenesis via the HIF-1α/VEGF signaling pathway. Arch Gynecol Obstet. 2018;298(3):537–543.
  • Fang Y, Yu S, Ma Y, et al. Association of Dll4/notch and HIF-1a-VEGF signaling in the angiogenesis of missed abortion. PLoS One. 2013;8(8):e70667.
  • Xiao Q, Zeng FL, Tang GY, et al. Expression of galectin-3 and apoptosis in placental villi from patients with missed abortion during early pregnancy. Exp Ther Med. 2019;17:2623–2631.
  • Mercé LT, Barco MJ, Alcázar JL, et al. Intervillous and uteroplacental circulation in normal early pregnancy and early pregnancy loss assessed by 3-dimensional power doppler angiography. Am J Obstet Gynecol. 2009;200(3):315.e1-8–315.e8.
  • Xu J, Chen L, Jiang Z, et al. Biological functions of elabela, a novel endogenous ligand of APJ receptor. J Cell Physiol. 2018;233(9):6472–6482.
  • Wang L, Zhang Y, Qu H, et al. Reduced ELABELA expression attenuates trophoblast invasion through the PI3K/AKT/mTOR pathway in early onset preeclampsia. Placenta. 2019;87:38–45.
  • Georgiadou D, Afink GB, van Dijk M. The apelinergic-axis in human preeclamptic pregnancies: a systematic review. Pregnancy Hypertens. 2019;17:148–157.
  • Eberlé D, Marousez L, Hanssens S, et al. Elabela and apelin actions in healthy and pathological pregnancies. Cytokine Growth Factor Rev. 2019;46:45–53.
  • Sağraç D, Şişli HB, Doğan A. Apelin receptor signaling during mesoderm development. Adv Exp Med Biol. 2020;1298:1–15.
  • Liu W, Yan J, Pan W, et al. Apelin/Elabela-APJ: a novel therapeutic target in the cardiovascular system. Ann Transl Med. 2020;8(5):243.
  • Zhou S, Wang J, Wang Q, et al. Essential role of the ELABELA-APJ signaling pathway in cardiovascular system development and diseases. J Cardiovasc Pharmacol. 2020;75:284–291.
  • Georgiadou D, Boussata S, Ranzijn WHM, et al. Peptide hormone ELABELA enhances extravillous trophoblast differentiation, but placenta is not the major source of circulating ELABELA in pregnancy. Sci Rep. 2019;9(1):19077.
  • Ho L, van Dijk M, Chye STJ, et al. ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice. Science. 2017;357(6352):707–713.
  • Charo DN, Ho M, Fajardo G, et al. Endogenous regulation of cardiovascular function by apelin-APJ. Am J Physiol Heart Circ Physiol. 2009;297(5):H1904–1913.
  • Kuba K, Sato T, Imai Y, et al. Apelin and elabela/toddler; double ligands for APJ/apelin receptor in heart development, physiology, and pathology. Peptides. 2019;111:62–70.
  • Chng SC, Ho L, Tian J, et al. ELABELA: a hormone essential for heart development signals via the apelin receptor. Dev Cell. 2013;27(6):672–680.
  • Pauli A, Norris ML, Valen E, et al. Toddler: an embryonic signal that promotes cell movement via apelin receptors. Science. 2014;343(6172):1248636.
  • Freyer L, Hsu CW, Nowotschin S, et al. Loss of apela peptide in mice causes low penetrance embryonic lethality and defects in early mesodermal derivatives. Cell Rep. 2017;20(9):2116–2130.
  • Sato T, Sato C, Kadowaki A, et al. ELABELA-APJ axis protects from pressure overload heart failure and angiotensin II-induced cardiac damage. Cardiovasc Res. 2017;113(7):760–769.
  • Morin L, Cargill YM, Glanc P. Ultrasound evaluation of first trimester complications of pregnancy. J Obstet Gynaecol Can. 2016;38(10):982–988.
  • Doubilet P, Benson C, Bourne T, et al. Diagnostic criteria for nonviable pregnancy early in the first trimester. N Engl J Med. 2013;369(15):1443–1451.
  • Miyagami S, Koide K, Sekizawa A, et al. Physiological changes in the pattern of placental gene expression early in the first trimester. Reprod Sci. 2013;20(6):710–714.
  • Zhou L, Sun H, Cheng R, et al. ELABELA, as a potential diagnostic biomarker of preeclampsia, regulates abnormally shallow placentation via APJ. Am J Physiol Endocrinol Metab. 2019;316(5):E773–781.
  • Fournier T, Guibourdenche J, Evain-Brion D. Review: hCGs: different sources of production, different glycoforms and functions. Placenta. 2015;36(Suppl. 1):S60–S65.
  • Panaitescu B, Romero R, Gomez-Lopez N, et al. ELABELA plasma concentrations are increased in women with late-onset preeclampsia. J Matern Fetal Neonatal Med. 2020;33(1):5–15.
  • Behram M, Oğlak SC, Dağ İ. Circulating levels of elabela in pregnant women complicated with intrauterine growth restriction. J Gynecol Obstetric Hum Reprod. 2021;50(8):102127.
  • Huang R, Zhu J, Zhang L, et al. Is ELABELA a reliable biomarker for hypertensive disorders of pregnancy? Pregnancy Hypertens. 2019;17:226–232.
  • Pritchard N, Kaitu’u-Lino TJ, Gong S, et al. ELABELA/APELA levels are not decreased in the maternal circulation or placenta among women with preeclampsia. Am J Pathol. 2018;188(8):1749–1753.
  • Hao S, You J, Chen L, et al. Changes in pregnancy-related serum biomarkers early in gestation are associated with later development of preeclampsia. PLoS One. 2020;15(3):e0230000.
  • Guo YY, Li T, Liu H, et al. Circulating levels of elabela and apelin in the second and third trimesters of pregnancies with gestational diabetes mellitus. Gynecol Endocrinol. 2020;36(10):890–894.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.