State of the art, new treatment strategies, and emerging drugs for non-hormonal treatment of endometriosis: a systematic review of randomized control trials

References

• Giudice LC, Kao LC. Endometriosis. Lancet. 2004;364(9447):1789–1799.
   PubMed Web of Science ®Google Scholar
• Alio L, Angioni S, Arena S, et al. Endometriosis: seeking optimal management in women approaching menopause. Climacteric. 2019;22(4):329–338.
   PubMed Web of Science ®Google Scholar
• Angioni S. New insights on endometriosis. Minerva Obstet Gynecol. 2017;69(5):438–439.
   Google Scholar
• Angioni S, Cela V, Sedda F, et al. Focusing on surgery results in infertile patients with deep endometriosis. Gynecol Endocrinol. 2015;31(8):595–598.
   PubMed Web of Science ®Google Scholar
• Škegro B, Bjedov S, Mikuš M, et al. Endometriosis, pain and mental health. Psychiatr Danub. 2021;33(Suppl 4):632–636.
   PubMedGoogle Scholar
• Troìa L, Luisi S. Sexual function and quality of life in women with endometriosis. Minerva Obstet Gynecol. 2022;74(3):203–221.
   PubMedGoogle Scholar
• Angioni S, D’Alterio MN, Coiana A, et al. Genetic characterization of endometriosis patients: review of the literature and a prospective cohort study on a mediterranean population. IJMS. 2020;21(5):1765.
   Google Scholar
• Barbara G, Buggio L, Facchin F, et al. Medical treatment for endometriosis: tolerability, quality of life and adherence. Front Glob Womens Health. 2021;2:729601.
   PubMedGoogle Scholar
• Dunselman GaJ, Vermeulen N, Becker C, et al.., European Society of Human Reproduction and Embryology. ESHRE guideline: management of women with endometriosis. Hum Reprod. 2014;29(3):400–412.
   PubMed Web of Science ®Google Scholar
• Mehedintu C, Plotogea MN, Ionescu S, et al. Endometriosis still a challenge. J Med Life. 2014;7:349–357.
   PubMedGoogle Scholar
• Angioni S, Nappi L, Sorrentino F, et al. Laparoscopic treatment of deep endometriosis with a diode laser: our experience. Arch Gynecol Obstet. 2021;304(5):1221–1231.
   PubMed Web of Science ®Google Scholar
• Martone S, Troìa L, Marcolongo P, et al. Role of medical treatment of endometriosis. Minerva Obstet Gynecol. 2021;73(3):304–316.
   PubMedGoogle Scholar
• Ercan CM, Kayaalp O, Cengiz M, et al. Comparison of efficacy of bromocriptine and cabergoline to GnRH agonist in a rat endometriosis model. Arch Gynecol Obstet. 2015;291(5):1103–1111.
   PubMed Web of Science ®Google Scholar
• Hussein M, Chai DC, Kyama CM, et al. c-Jun NH 2 -terminal kinase inhibitor bentamapimod reduces induced endometriosis in baboons: an assessor-blind placebo-controlled randomized study. Fertil Steril. 2016;105(3):815–824.e5.
   PubMed Web of Science ®Google Scholar
• Karslıoglu T, Karasu AFG, Yildiz P. The effects of micronized progesterone and cabergoline on a rat autotransplantation endometriosis model: a placebo controlled randomized trial. J Invest Surg. 2021;34(8):897–901.
   PubMed Web of Science ®Google Scholar
• Almassinokiani F, Mehdizadeh A, Sariri E, et al. Effects of simvastatin in prevention of pain recurrences after surgery for endometriosis. Med Sci Monit. 2013;19:534–539.
   PubMed Web of Science ®Google Scholar
• Hamid AMSA, Madkour WAI, Moawad A, et al. Does cabergoline help in decreasing endometrioma size compared to LHRH agonist? A prospective randomized study. Arch Gynecol Obstet. 2014;290(4):677–682.
   PubMed Web of Science ®Google Scholar
• Mendes da Silva D, Gross LA, Neto E de PG, et al. The use of resveratrol as an adjuvant treatment of pain in endometriosis: a randomized clinical trial. J Endocr Soc. 2017;1(4):359–369.
   PubMed Web of Science ®Google Scholar
• Trummer D, Walzer A, Groettrup-Wolfers E, et al. Efficacy, safety and tolerability of the CCR1 antagonist Bay 86-5047 for the treatment of endometriosis-associated pelvic pain: a randomized controlled trial. Acta Obstet Gynecol Scand. 2017;96(6):694–701.
   PubMed Web of Science ®Google Scholar
• Laganà AS, Garzon S, Götte M, et al. The pathogenesis of endometriosis: molecular and cell biology insights. Int J Mol Sci. 2019;20(22):5615.
   PubMed Web of Science ®Google Scholar
• Stochino-Loi E, Pontis A, Cofelice V, et al. Effect of ultramicronized-palmitoylethanolamide and co-micronized palmitoylethanolamide/polydatin on chronic pelvic pain and quality of life in endometriosis patients: an open-label pilot study. Int J Womens Health. 2019;11:443–449.
   PubMed Web of Science ®Google Scholar
• Chen F-Y, Wang X, Tang R-Y, et al. New therapeutic approaches for endometriosis besides hormonal therapy. Chin Med J (Engl). 2019;132(24):2984–2993.
   PubMed Web of Science ®Google Scholar
• Laschke MW, Menger MD. Anti-angiogenic treatment strategies for the therapy of endometriosis. Hum Reprod Update. 2012;18(6):682–702.
   PubMed Web of Science ®Google Scholar
• Hull ML, Charnock-Jones DS, Chan CLK, et al. Antiangiogenic agents are effective inhibitors of endometriosis. J Clin Endocrinol Metab. 2003;88(6):2889–2899.
   PubMed Web of Science ®Google Scholar
• Basu S, Nagy JA, Pal S, et al. The neurotransmitter dopamine inhibits angiogenesis induced by vascular permeability factor/vascular endothelial growth factor. Nat Med. 2001;7(5):569–574.
   PubMed Web of Science ®Google Scholar
• Novella-Maestre E, Carda C, Noguera I, et al. Dopamine agonist administration causes a reduction in endometrial implants through modulation of angiogenesis in experimentally induced endometriosis. Hum Reprod. 2009;24(5):1025–1035.
   PubMed Web of Science ®Google Scholar
• Pellicer N, Galliano D, Herraiz S, et al. Use of dopamine agonists to target angiogenesis in women with endometriosis. Hum Reprod. 2021;36(4):850–858.
   PubMed Web of Science ®Google Scholar
• Category – adolescent gynaecology. BJOG: Int J Obstet Gynecol. 2021;128:4–7.
   Web of Science ®Google Scholar
• Bagger Y, Arce J-C. Quinagolide vaginal ring for endometriosis: results from the clinical phase 1 program. Fertil Steril. 2020;114(3):e78.
   Web of Science ®Google Scholar
• Jiao XF, Li HL, Jiao XY, et al. Ovary and uterus related adverse events associated with statin use: an analysis of the FDA adverse event reporting system. Sci Rep. 2020;10(1):11955.
   PubMed Web of Science ®Google Scholar
• Kotlyar A, Taylor HS, D’Hooghe TM. Use of immunomodulators to treat endometriosis. Best Pract Res Clin Obstet Gynaecol. 2019;60:56–65.
   PubMed Web of Science ®Google Scholar
• Maia H, Haddad C, Pinheiro N, et al. Advantages of the association of resveratrol with oral contraceptives for management of endometriosis-related pain. Int J Womens Health. 2012;4:543–549.
   PubMedGoogle Scholar