Proteomic and bioinformatic analysis of human endometrium from polycystic ovarian syndrome with and without insulin resistance

References

• Hoeger KM, Dokras A, Piltonen T. Update on PCOS: consequences, challenges, and guiding treatment. J Clin Endocrinol Metab. 2021;106(3):1–7.
   PubMed Web of Science ®Google Scholar
• Escobar-Morreale HF. Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nat Rev Endocrinol. 2018;14(5):270–284.
   PubMed Web of Science ®Google Scholar
• Lewandowski KC, Skowrońska-Jóźwiak E, Łukasiak K, et al. How much insulin resistance in polycystic ovary syndrome? Comparison of HOMA-IR and insulin resistance (belfiore) index models. Arch Med Sci. 2019;15(3):613–618.
   PubMed Web of Science ®Google Scholar
• Diamanti-Kandarakis E, Papavassiliou AG. Molecular mechanisms of insulin resistance in polycystic ovary syndrome. Trends Mol Med. 2006;12(7):324–332.
   PubMed Web of Science ®Google Scholar
• Wang J, Wu D, Guo H, et al. Hyperandrogenemia and insulin resistance: the chief culprit of polycystic ovary syndrome. Life Sci. 2019;236:116940.
   PubMed Web of Science ®Google Scholar
• Rosen MW, Tasset J, Kobernik EK, et al. Risk Factors for endometrial cancer or hyperplasia in adolescents and women 25 years old or younger. J Pediatr Adolesc Gynecol. 2019;32(5):546–549.
   PubMed Web of Science ®Google Scholar
• Hanson B, Johnstone E, Dorais J, et al. Female infertility, infertility-associated diagnoses, and comorbidities: a review. J Assist Reprod Genet. 2017;34(2):167–177.
   PubMed Web of Science ®Google Scholar
• Chang EM, Han JE, Seok HH, et al. Insulin resistance does not affect early embryo development but lowers implantation rate in in vitro maturation-in vitro fertilization-embryo transfer cycle. Clin Endocrinol (Oxf). 2013;79(1):93–99.
   PubMed Web of Science ®Google Scholar
• Cho HJ, Baek MO, Khaliq SA, et al. Microgravity inhibits decidualization via decreasing akt activity and FOXO3a expression in human endometrial stromal cells. Sci Rep. 2019;9(1):12094.
   PubMedGoogle Scholar
• Hatami H, Montazeri SA, Hashemi N, et al. Optimal cutoff points for anthropometric variables to predict insulin resistance in polycystic ovary syndrome. Int J Endocrinol Metab. 2017;15(4):e12353.
   PubMedGoogle Scholar
• Cardenas EI, Breaux K, Da Q, et al. Platelet Munc13-4 regulates hemostasis, thrombosis and airway inflammation. Haematologica. 2018;103(7):1235–1244.
   PubMed Web of Science ®Google Scholar
• Targher G, Zoppini G, Bonora E, et al. Hemostatic and fibrinolytic abnormalities in polycystic ovary syndrome. Semin Thromb Hemost. 2014;40(5):600–618.
   PubMed Web of Science ®Google Scholar
• Dereli D, Ozgen G, Buyukkececi F, et al. Platelet dysfunction in lean women with polycystic ovary syndrome and association with insulin sensitivity. J Clin Endocrinol Metab. 2003;88(5):2263–2268.
   PubMed Web of Science ®Google Scholar
• Gursoy A, Ertugrul DT, Pamuk B, et al. Mean platelet volume in patients with polycystic ovary disease. Platelets. 2006;17(7):505–506.
   PubMed Web of Science ®Google Scholar
• Kebapcilar L, Taner CE, Kebapcilar AG, et al. High mean platelet volume, low-grade systemic coagulation and fibrinolytic activation are associated with androgen and insulin levels in polycystic ovary syndrome. Arch Gynecol Obstet. 2009;280(2):187–193.
   PubMed Web of Science ®Google Scholar
• Singh A, Bisht P, Bhattacharya S, et al. Role of platelet cytokines in dengue virus infection. Front Cell Infect Microbiol. 2020;10:561366.
   PubMed Web of Science ®Google Scholar
• Rudnicka E, Suchta K, Grymowicz M, et al. Chronic low grade inflammation in pathogenesis of PCOS. Int J Mol Sci. 2021;22(7):3789.
   Web of Science ®Google Scholar
• Tersigni C, Vatish M, D’ippolito S, et al. Abnormal uterine inflammation in obstetric syndromes: molecular insights into the role of chemokine decoy receptor D6 and inflammasome NLRP3. Mol Hum Reprod. 2020;26(2):111–121.
   PubMed Web of Science ®Google Scholar
• Erdbrügger P, Fröhlich F. The role of very long chain fatty acids in yeast physiology and human diseases. Biol Chem. 2020;402(1):25–38.
   PubMed Web of Science ®Google Scholar
• Li S, Chu Q, Ma J, et al. Discovery of novel lipid profiles in PCOS: do insulin and androgen oppositely regulate bioactive lipid production? J Clin Endocrinol Metab. 2017;102(3):810–821.
   PubMed Web of Science ®Google Scholar
• Thimgan MS, Seugnet L, Turk J, et al. Identification of genes associated with resilience/vulnerability to sleep deprivation and starvation in drosophila. Sleep. 2015;38(5):801–814.
   PubMed Web of Science ®Google Scholar
• González F, Considine RV, Abdelhadi OA, et al. Saturated fat ingestion promotes lipopolysaccharide-mediated inflammation and insulin resistance in polycystic ovary syndrome. J Clin Endocrinol Metab. 2019;104(3):934–946.
   PubMed Web of Science ®Google Scholar
• Szczuko M, Kikut J, Szczuko U, et al. Nutrition strategy and life style in polycystic ovary syndrome-narrative review. Nutrients. 2021;13(7):2452.
   PubMed Web of Science ®Google Scholar
• Mohammadi M. Oxidative stress and polycystic ovary syndrome: a brief review. Int J Prev Med. 2019;10:86.
   PubMed Web of Science ®Google Scholar
• Ferreira SR, Motta AB. Uterine function: from normal to polycystic ovarian syndrome alterations. Curr Med Chem. 2018;25(15):1792–1804.
   PubMed Web of Science ®Google Scholar
• Parisi LR, Li N, Atilla-Gokcumen GE. Very long chain fatty acids are functionally involved in necroptosis. Cell Chem Biol. 2017;24(12):1445–1454.e8.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Hu M, Jia W, et al. Hyperandrogenism and insulin resistance modulate gravid uterine and placental ferroptosis in PCOS-like rats. J Endocrinol. 2020;246(3):247–263.
   PubMed Web of Science ®Google Scholar
• Kamal AHM, Aloor JJ, Fessler MB, et al. Cross-linking proteomics indicates effects of simvastatin on the TLR2 interactome and reveals ACTR1A as a novel regulator of the TLR2 signal cascade. Mol Cell Proteomics. 2019;18(9):1732–1744.
   PubMed Web of Science ®Google Scholar
• Hu M, Zhang Y, Li X, et al. TLR4-Associated IRF-7 and NFκB signaling act as a molecular link between androgen and metformin activities and cytokine synthesis in the PCOS endometrium. J Clin Endocrinol Metab. 2021;106(4):1022–1040.
   PubMed Web of Science ®Google Scholar
• Chen Q, Zhang A, Yu F, et al. Label-free proteomics uncovers energy metabolism and focal adhesion regulations responsive for endometrium receptivity. J Proteome Res. 2015;14(4):1831–1842.
   PubMed Web of Science ®Google Scholar
• Li XH, Chen XJ, Ou WB, et al. Knockdown of creatine kinase B inhibits ovarian cancer progression by decreasing glycolysis. Int J Biochem Cell Biol. 2013;45(5):979–986.
   PubMed Web of Science ®Google Scholar
• Narang P, Chen M, Sharma AA, et al. The neoepitope landscape of breast cancer: implications for immunotherapy. BMC Cancer. 2019;19(1):200.
   PubMed Web of Science ®Google Scholar