2,419
Views
2
CrossRef citations to date
0
Altmetric
Research Article

Autophagy-dependent ferroptosis is involved in the development of endometriosis

, , , , &
Article: 2242962 | Received 18 May 2023, Accepted 26 Jul 2023, Published online: 08 Aug 2023

References

  • Xu H, Gao Y, Shu Y, et al. EPHA3 enhances macrophage autophagy and apoptosis by disrupting the mTOR signaling pathway in mice with endometriosis. Biosci Rep. 2019;39(7):1. doi: 10.1042/BSR20182274.
  • Kim SI, Yeo SG, Gen Y, et al. Differences in autophagy-associated mRNAs in peritoneal fluid of patients with endometriosis and gynecologic cancers. Eur J Obstet Gynecol Reprod Biol X. 2019;2:100016. doi: 10.1016/j.eurox.2019.100016.
  • Yang HL, Mei J, Chang KK, et al. Autophagy in endometriosis. Am J Transl Res. 2017;9(11):4707–11.
  • Zhan L, Li J, Wei B. Autophagy in endometriosis: friend or foe? Biochem Biophys Res Commun. 2018;495(1):60–63. doi: 10.1016/j.bbrc.2017.10.145.
  • Liu H, Zhang Z, Xiong W, et al. Hypoxia-inducible factor-1α promotes endometrial stromal cells migration and invasion by upregulating autophagy in endometriosis. Reproduction. 2017;153(6):809–820. doi: 10.1530/REP-16-0643.
  • Siracusa R, D’Amico R, Impellizzeri D, et al. Autophagy and mitophagy promotion in a rat model of endometriosis. Int J Mol Sci. 2021;22(10):5074. doi: 10.3390/ijms22105074.
  • Katagiri H, Nakayama K, Razia S, et al. Loss of autophagy-related protein Beclin 1 may define poor prognosis in ovarian clear cell carcinomas. Int J Oncol. 2015;47(6):2037–2044. doi: 10.3892/ijo.2015.3191.
  • Shi J, Shi S, Wu B, et al. Autophagy protein LC3 regulates the fibrosis of hypertrophic scar by controlling Bcl-xL in dermal fibroblasts. Oncotarget. 2017;8(55):93757–93770. doi: 10.18632/oncotarget.20771.
  • Zhu ML, Lu JX, Pan GP, et al. Traditional Chinese medicine Ka-Sai-Ping suppresses the growths of gastric cancers via induction of autophagy. Oncotarget. 2017;8(56):95075–95082. doi: 10.18632/oncotarget.18041.
  • Li X, He S, Ma B. Autophagy and autophagy-related proteins in cancer. Mol Cancer. 2020;19(1):12. doi: 10.1186/s12943-020-1138-4.
  • Lamark T, Johansen T. Mechanisms of selective autophagy. Annu Rev Cell Dev Biol. 2021;37:143–169. doi: 10.1146/annurev-cellbio-120219-035530.
  • Machado DE, Rodrigues-Baptista KC, Alessandra-Perini J, et al. Euterpe oleracea extract (Açaí) is a promising novel pharmacological therapeutic treatment for experimental endometriosis. PLoS One. 2016;11(11):e0166059. doi: 10.1371/journal.pone.0166059.
  • Ye H, He Y, Wang J, et al. Effect of matrix metalloproteinase promoter polymorphisms on endometriosis and adenomyosis risk: evidence from a meta-analysis. J Genet. 2016;95(3):611–619. doi: 10.1007/s12041-016-0675-5.
  • Lin SC, Chu PY, Liao WT, et al. Glycyrrhizic acid induces human MDA-MB-231 breast cancer cell death and autophagy via the ROS-mitochondrial pathway. Oncol Rep. 2018;39(2):703–710. doi: 10.3892/or.2017.6123.
  • Peng Q, Qin J, Zhang Y, et al. Autophagy maintains the stemness of ovarian cancer stem cells by FOXA2. J Exp Clin Cancer Res. 2017;36(1):171. doi: 10.1186/s13046-017-0644-8.
  • Dixon SJ, Lemberg KM, Lamprecht MR, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149(5):1060–1072. doi: 10.1016/j.cell.2012.03.042.
  • Song X, Zhu S, Chen P, et al. AMPK-Mediated BECN1 phosphorylation promotes ferroptosis by directly blocking system X(c)(-) activity. Curr Biol. 2018;28(15):2388–2399.e5. doi: 10.1016/j.cub.2018.05.094.
  • Mancias JD, Wang X, Gygi SP, et al. Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. Nature. 2014;509(7498):105–109. doi: 10.1038/nature13148.
  • Stockwell BR, Friedmann Angeli JP, Bayir H, et al. Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease. Cell. 2017;171(2):273–285. doi: 10.1016/j.cell.2017.09.021.
  • Hassannia B, Vandenabeele P, Vanden Berghe T. Targeting ferroptosis to iron out cancer. Cancer Cell. 2019;35(6):830–849. doi: 10.1016/j.ccell.2019.04.002.
  • Sanchez AM, Viganò P, Somigliana E, et al. The distinguishing cellular and molecular features of the endometriotic ovarian cyst: from pathophysiology to the potential endometrioma-mediated damage to the ovary. Hum Reprod Update. 2014;20(2):217–230. doi: 10.1093/humupd/dmt053.
  • Zhou B, Liu J, Kang R, et al. Ferroptosis is a type of autophagy-dependent cell death. Semin Cancer Biol. 2020;66:89–100. doi: 10.1016/j.semcancer.2019.03.002.
  • Li Y, Zeng X, Lu D, et al. Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis. Hum Reprod. 2021;36(4):951–964. doi: 10.1093/humrep/deaa363.
  • Alvarado-Díaz CP, Núñez MT, Devoto L, et al. Iron overload-modulated nuclear factor kappa-B activation in human endometrial stromal cells as a mechanism postulated in endometriosis pathogenesis. Fertil Steril. 2015;103(2):439–447. doi: 10.1016/j.fertnstert.2014.10.046.
  • Pirdel L, Pirdel M. Role of iron overload-induced macrophage apoptosis in the pathogenesis of peritoneal endometriosis. Reproduction. 2014;147(6):R199–207. doi: 10.1530/REP-13-0552.
  • Siracusa R, D’Amico R, Cordaro M, et al. The methyl ester of 2-Cyano-3,12-Dioxooleana-1,9-Dien-28-Oic acid reduces endometrial lesions development by modulating the NFkB and Nrf2 pathways. Int J Mol Sci. 2021;22(8):3991. doi: 10.3390/ijms22083991.
  • Jin X, Cui L, Zhao W, et al. Decidualization-derived cAMP regulates phenotypic and functional conversion of decidual NK cells from CD56(dim)CD16(-) NK cells. Cell Mol Immunol. 2021;18(6):1596–1598. doi: 10.1038/s41423-021-00675-y.
  • Lin YK, Li YY, Li Y, et al. SCM-198 prevents endometriosis by reversing low autophagy of endometrial stromal cell via balancing ERα and PR signals. Front Endocrinol (Lausanne). 2022;13:858176. doi: 10.3389/fendo.2022.858176.
  • Pei T, Huang X, Long Y, et al. Increased expression of Yap is associated with decreased cell autophagy in the eutopic endometrial stromal cells of endometriosis. Mol Cell Endocrinol. 2019;491:110432. doi: 10.1016/j.mce.2019.04.012.
  • Liang Z, Wu Q, Wang H, et al. Silencing of lncRNA MALAT1 facilitates erastin-induced ferroptosis in endometriosis through miR-145-5p/MUC1 signaling. Cell Death Discov. 2022;8(1):190. doi: 10.1038/s41420-022-00975-w.
  • Mikuš M, Goldštajn M, Brlečić I, et al. CTLA4-Linked autoimmunity in the pathogenesis of endometriosis and related infertility: a ­systematic review. Int J Mol Sci. 2022;23(18):10902. doi: 10.3390/ijms231810902.
  • Bilyk O, Coatham M, Jewer M, et al. Epithelial-to-mesenchymal transition in the female reproductive tract: from normal functioning to disease pathology. Front Oncol. 2017;7:145. doi: 10.3389/fonc.2017.00145.
  • Duan Y, He Q, Yue K, et al. Hypoxia induced bcl-2/Twist1 complex promotes tumor cell invasion in oral squamous cell carcinoma. Oncotarget. 2017;8(5):7729–7739. doi: 10.18632/oncotarget.13890.
  • Liu H, Du Y, Zhang Z, et al. Autophagy contributes to hypoxia-induced epithelial to mesenchymal transition of endometrial epithelial cells in endometriosis. Biol Reprod. 2018;99(5):968–981. doi: 10.1093/biolre/ioy128.
  • Choi J, Jo M, Lee E, et al. Differential induction of autophagy by mTOR is associated with abnormal apoptosis in ovarian endometriotic cysts. Mol Hum Reprod. 2014;20(4):309–317. doi: 10.1093/molehr/gat091.
  • Ng SW, Norwitz SG, Taylor HS, et al. Endometriosis: the role of iron overload and ferroptosis. Reprod Sci. 2020;27(7):1383–1390. doi: 10.1007/s43032-020-00164-z.
  • Ni Z, Li Y, Song D, et al. Iron-overloaded follicular fluid increases the risk of endometriosis-related infertility by triggering granulosa cell ferroptosis and oocyte dysmaturity. Cell Death Dis. 2022;13(7):579. doi: 10.1038/s41419-022-05037-8.
  • Yadav AK, Yadav PK, Chaudhary GR, et al. Autophagy in hypoxic ovary. Cell Mol Life Sci. 2019;76(17):3311–3322. doi: 10.1007/s00018-019-03122-4.
  • Li S, Zhou Y, Huang Q, et al. Iron overload in endometriosis peritoneal fluid induces early embryo ferroptosis mediated by HMOX1. Cell Death Discov. 2021;7(1):355. doi: 10.1038/s41420-021-00751-2.