Role of postmenopausal hormone replacement therapy on body fat gain and leptin levels

References

• Grant C, Gray A, Paolettti R, Thornton H, von Kleist S. Clinical synthesis panel on HRT. Lancet 1999;354:152–5.
   Google Scholar
• Poehlman ET, Toth MJ, Gardner AW. Changes in energy balance and body composition at menopause: a controlled longitudinal study. Ann Intern Med 1995;123:673–5.
   Google Scholar
• Pi-Sunyer FX. The epidemiology of central fat distribution in relation to disease. Nutr Rev 2004;62:5120–6.
   Google Scholar
• Calle EE, Thun MJ. Obesity and cancer. Oncogene 2004;23 (38) : 6365–78.
   PubMed Web of Science ®Google Scholar
• Ahima RS, Flier JS. Leptin. Annu Rev Physiol 2000;62:413–37.
   PubMed Web of Science ®Google Scholar
• Mastorakos G, Zapanti E. The hypothalamic-pituitary-adre-nal axis in the neuroendocrine regulation of food intake and obesity: the role of corticotropin releasing hormone. Nutr Neurosci. (in press).
   Google Scholar
• Espeland MA, Stefanick ML, Kritz-Silvestein D, Fineberg SE, Waclawiw MA, James MK, Greendale GA. Effect of post-menopausal hormone therapy on body weight and waist and hip girths. Postmenopausal Estrogen-Progestin Interventions Study Investigators. J Chin Endocrinol Metab 1997;82:1549–56.
   Google Scholar
• Colditz GA, Hankinson SE, Hunter DJ, Willett WC, Manson JE, Stampfer MJ, Hennekens C, Rosner B, Speizer FE. The use of estrogens and progestins and the risk of breast cancer in postmenopausal women. N Engl J Med 1995;332:1589–93.
   Google Scholar
• Weiss NS, Voigt LF, Knight MC. Risk of endometrial cancer in relation to use of estrogen combined with cyclic progestagen therapy in postmenopausal women. Lancet 1997; 349:458–61.
   Google Scholar
• Paech K, Webb P, Kupfer GG, Nilsson S, Gustafsson J, Kushner PJ, Scanlan TS. Differential ligand activation of estrogen receptors Era and MO at AP1 sites. Science 1997;277: 1508–10.
   Google Scholar
• Kloosterboer L. The tissue-specific mechanism of action of tibolone. Climacteric 2002;5 (Suppl I):214–215.
   Google Scholar
• Ettinger B, Black DM, Mitlak BH, Knickerbocker RK, Nickelsen T, Genant HK, Christiansen C, Delmas PD, Zanchetta Jr, Stakkestad J, et al. Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators. J Am Med Assoc 1999;282:637–45.
   Google Scholar
• de Valk-de Roo GW, Stehouwer CD, Meijer P, Mijatovic V, Kluft C, Kenemans P, Cohen F, Watts S, Netelenbos C. Both raloxifene and estrogen reduce major cardiovascular risk factors in healthy postmenopausal women: a 2-year, placebo-controlled study. Arterioscler Thromb Vasc Biol 1999;19:2993–3000.
   PubMed Web of Science ®Google Scholar
• Lovejoy JC. The menopause and obesity. Prim Care 2003;30:317–25.
   PubMed Web of Science ®Google Scholar
• Tchernof A, Poehlman ET, Despres JP. Body fat distribution, the menopause transition, and hormone replacement therapy. Diabetes Metab 2000;26:12–20.
   Google Scholar
• Reaven GM. Banting Lecture: role of insulin resistance in human disease. Diabetes 1988;37:1595–607.
   PubMed Web of Science ®Google Scholar
• Alberti KG, Zimmet PZ. Definition, diagnosis and classifica-tion of diabetes mellitus and its complications. Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998;15:539–53.
   Google Scholar
• Kissebah AH, Vydelingum N, Murray R, Evans FDJ, Hartz AJ, Kalkhoff RK, Adams PW. Relation of body fat distribution to metabolic complications of obesity. J Chin Endocrinol Metab 1982;54:254–60.
   PubMed Web of Science ®Google Scholar
• Vague J. The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout and uric calculous disease. Am J Chin Nutr 1956;4:20–34.
   PubMedGoogle Scholar
• Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S, et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1995;1:1155–61.
   PubMed Web of Science ®Google Scholar
• Dua A, Hennes MI, Hoffmann RG, Maas DL, Krakower GR, Sonnenberg GE, Kissebah AH. Leptin: a significant indicator of total body fat but not of visceral fat and insulin insensitivity in African-American women. Diabetes 1996; 45:1635–7.
   Google Scholar
• Havel PJ, Kasim-Karakas S, Dubuc GR, Mueller W, Phinney SD. Gender differences in plasma leptin concentrations. Nat Med 1996;2:949–50.
   PubMed Web of Science ®Google Scholar
• Di Carlo C, Tommaselli G, Nappi C. Effects of sex steroid hormones and menopause on serum leptin concentrations. Gynecol Endocrinol 2002;16:479–91.
   Google Scholar
• Hassink SG, Sheslow DV, de Lancey E, Opentanova I, Considine RV, Caro JF. Serum leptin in children with obesity: relationship to gender and development. Pediatrics 1997;98:201–3.
   Google Scholar
• Kristensen K, Pedersen SB, Richelsen B. Interactions between sex steroid hormones and leptin in women. Studies in vivo and in vitro. hit J Obes Relat Metab Disord 2000;24:1438–44.
   Google Scholar
• Messinis IE, Milingos SD, Alexandris E, Kariotis I, Kollios G, Seferiadis K. Leptin concentrations in normal women follow-ing bilateral ovariectomy. Hum Reprod 1999;14:913–18.
   Google Scholar
• Ghizzoni L, Barreca A, Mastorakos G, Furlini M, Vottero A, Ferrari B, Chrousos GP, Bernasconi S Leptin inhibits steriod biosynthesis by human granulosa-lutein cells. Horm Metab Res 2001;6:323–8.
   Google Scholar
• Machinal-Quelin F, Dieudonne MN, Pecquery R, Leneveu MC, Giu Y. Direct in vitro effects of androgens and estrogens on ob gene expression and leptin secretion in human adipose tissue. Endocrinology 2002;18:179–84.
   Google Scholar
• Shimomura K, Shimizu H, Tsuchiya T, Abe Y, Uehara Y, Mori M. Is leptin a key factor which develops obesity by ovariectomy? Endocr J 2002;49:417–23.
   Google Scholar
• Ainslie DA, Morris MJ, Witten G, Turnbull H, Proietto J, Thorburn AW. Estrogen deficiency causes central leptin insensitivity and increased hypothalamic neuropeptide Y. hit J Obes Relat Metab Disord 2001;25:1680–8.
   PubMed Web of Science ®Google Scholar
• Gower BA, Nagy TR, Goran MI, Smith A, Kent E. Leptin in postmenopausal women: influence of hormone therapy, insulin, and fat distribution. J Chin Endocrinol Metab 2000;85:1770–5.
   Google Scholar
• Messinis IE, Kariotis I, Milingos S, Kollios G, Seferiadis K. Treatment of normal women with oestradiol plus progester-one prevents the decrease of leptin concentrations induced by ovariectomy. Hum Reprod 2000;15:2383–7.
   Google Scholar
• Nijhuis J, van Dielen FM, Buurman WA, Greve JW. Ghrelin, leptin and insulin levels after restrictive surgery: a 2-year follow-up study. Obes Surg 2004;14:783–7.
   PubMed Web of Science ®Google Scholar
• Ghigo E, Broglio F, Me E, Prodam F, Ragazzoni F. Ghrelin: more than a new frontier in neuroendocrinology. J Endocrinol Invest 2004;27 (Suppl 6):101–4.
   Google Scholar
• Ambrogi M, Volpe S, Tamanini C. Ghrelin: central and peripheral effects of a novel peptydil hormone. Med Sci Monit 2003;9:RA217–24.
   Google Scholar
• Matsubara M, Sakata I, Wada R, Yamazaki M, Inoue K, Sakai T. Estrogen modulates ghrelin expression in the female rat stomach. Peptides 2004;25:289–97.
   Google Scholar
• Nikander E, Tiitinen A, Laitinen K, Tikkanen M, Ylikorkala O. Effects of isolated isoflavonoids on lipids, lipoproteins, insulin sensitivity, and ghrelin in postmenopausal women. J Chin Endocrinol Metab 2004;89:3567–72.
   Google Scholar
• Gambacciani M, Ciaponi M, Cappagli B, Benussi C, De Simone L, Genazzani AR. Climacteric modifications in body weight and fat tissue distribution. Climacteric 1999;2:37–44.
   PubMedGoogle Scholar
• Hadji P, Gorke K, Hars O, Bauer T, Emons G, Schulz KD. The influence of hormone replacement therapy (HRT) on serum leptin concentration in postmenopausal women. Maturitas 2000;29:105–11.
   Google Scholar
• Arabi A, Garner° P, Porcher R, Pelissier C, Benhamou CL, Roux C. Changes in body composition during post-meno-pausal hormone therapy: a 2 year prospective study. Hum Reprod 2003;18:1747–52.
   PubMed Web of Science ®Google Scholar
• Davies KM, Heaney RP, Recker RR, Barger-Lux MJ, Lappe JM. Hormones, weight change and menopause. hit J Obes Relat Metab Disord 2001;25:874–9.
   PubMed Web of Science ®Google Scholar
• Sorensen MB. Changes in body composition at menopause - age, lifestyle or hormone deficiency? J Br Menopause Soc 2002;8:137–40.
   PubMedGoogle Scholar
• Jensen LB, Vestergaard P, Hermann AP, Gram J, Eiken P, Abrahan B, Brot C, Kolthoff N, Sorensen OH, Beck-Nielsen H, et al. Hormone replacement therapy dissociates fat mass and bone mass, and tends to reduce weight gain in early postmenopausal women: a randomized controlled 5-year clinical trial of the Danish Osteoporosis Prevention Study. J Bone Miner Res 2003;18: 333–42.
   Google Scholar
• Norman RJ, Flight IH, Rees MC. Oestrogen and progestogen hormone replacement therapy for perimenopausal and post-menopausal women: weight and body fat distribution. Cochrane Database Syst Rev 2000(2):CD001018.
   Google Scholar
• Meeuwsen IB, Samson MM, Duursma SA, Verhaar HJ. The effect of tibolone on fat mass, fat-free mass, and total body water in postmenopausal women. Endocrinology 2001; 142:4813–17.
   PubMed Web of Science ®Google Scholar
• Shadoan MK, Anthony MS, Rankin SE, Clarkson TB, Wagner JD. Effects of tibolone and conjugated equine estrogens with or without medroxyprogesterone acetate on body composition and fasting carbohydrate measures in surgically postmenopausal monkeys. Metabolism 2003; 52:1085–91.
   Google Scholar
• Hanggi W, Lippuner K, Jaeger P, Birkhauser MH, Horber FF. Differential impact of conventional oral or transdermal hormone replacement therapy or tibolone on body composi-tion in postmenopausal women. Chin Endocrinol (Oxf) 1998;48:691–9.
   Google Scholar
• Meli R, Pacilio M, Raso GM, Esposito E, Coppola A, Nasti A, Di Carlo C, Nappi C, Di Carlo R. Estrogen and raloxifene modulate leptin and its receptor in hypothalamus and adipose tissue from ovariectomised rats. Endocrinology 2004;145:3115–21.
   Google Scholar
• Lee CC, Kasa-Vubu JZ, Supiano MA. Differential effects of raloxifene and estrogen on insulin sensitivity in postmeno-pausal women. J Am Geriatr Soc 2003;51:683–8.
   PubMedGoogle Scholar
• Brann DW, De Sevilla L, Zamorano PL, Mahesh VB. Regulation of leptin gene expression and secretion by steroid hormones. Steroids 1999;64:659–63.
   PubMed Web of Science ®Google Scholar
• Lavoie HB, Taylor AE, Sharpless JL, Anderson EJ, Strauss CC, Hall JE. Effects of short- term hormone replacement on serum leptin levels in postmenopausal women. Chin Endocri-nol (Oxf) 1999;51:415–22.
   PubMed Web of Science ®Google Scholar
• Konukoglu D, Serin O, Ercan M. Plasma leptin levels in obese and non-obese postmenopausal women before and after hormone replacement therapy. Maturitas 2000;36:203–7.
   Google Scholar
• Thomas T, Burguera B, Melton ij 3rd, Atkinson EJ, O'Fallon WM, Riggs BL, Khosla S. Relationship of serum leptin levels with body composition and sex steroid and insulin levels in men and women. Metabolism 2000;49:1278–84.
   Google Scholar
• Lambrinoudaki I, Christodoulakos G, Panoulis C, Rizos D, Dendrinos S, Liakakos T, Augoulea A, Creatsas G. Effect of hormone replacement therapy and tibolone on serum leptin levels in postmenopausal women. Maturitas 2004;48:107–13.
   PubMed Web of Science ®Google Scholar
• Perera M, Sattar N, Petrie Jr, Hillier C, Small M, Connell JM, Lowe GD, Lumsden MA. The effects of transdermal estradiol in combination with oral norethisterone on lipoproteins, coagulation, and endothelial markers in postmenopausal women with type 2 diabetes: a randomized, placebo-con-trolled study. J Chin Endocrinol Metab 2001;86:1140–3.
   PubMed Web of Science ®Google Scholar
• Salbach B, Nawroth PP, Kubler W, von Holst T, Salbach PB. Serum leptin levels and body weight in postmenopausal women under transdermal hormone replacement therapy. Eur J Med Res 2000;28:63–6.
   Google Scholar
• Cagnacci A, Malmusi S, Arangino S, Zanni A, Rovati L, Volpe A. Influence of transdermal estradiol in the regulation of leptin levels of postmenopausal women: a double-blind, placebo-controlled study. Menopause 2000;9:65–71.
   Google Scholar
• Laivuori H, Koistinen HA, Karonen SL, Cacciatore B, Ylikorkala O. Comparison between 1 year oral and transder-mal oestradiol and sequential norethisterone acetate on circulating concentrations of leptin in postmenopausal wo-men. Hum Reprod 2001;16: 1632–5.
   Google Scholar
• Di Carlo C, Tommaselli G, Pisano G, Nasti A, Rossi V, Palomba S, Nappi C. Serum leptin levels in postmenopausal women: effects of transdermal hormone replacement therapy. Menopause 2000;7:36–41.
   Google Scholar
• Di Carlo C, Tommaselli GA, Sammartino A, Bifulco G, Nasti A, Nappi C. Serum leptin levels and body composition in post menopausal women: effects of hormone therapy. Menopause 2004;11:466–73.
   PubMed Web of Science ®Google Scholar
• Lambrinoudaki I, Christodoulakos G, Panoulis C, Botsis D, RiZOS D, Augoulea A, Creatsas G. Determinants of serum leptin levels in healthy postmenopausal women. J Endocrinol Invest 2003;26:1225–30.
   Google Scholar
• Panidis DK, Rousso DH, Kourtis Al, Stergiopoulos KN, Mavromatidis GA, Katsikis IK. The influence of tibolone upon serum leptin levels in post-menopausal women. Eur J Obstet Gynecol Reprod Biol 2001;96:85–7.
   PubMed Web of Science ®Google Scholar