Testosterone replacement therapy in the climacteric: Benefits beyond sexuality

References

• Mazer N A. Testosterone deficiency in women: etiologies, diagnosis and emerging treatments. Int J Fertil Womens Med 2002; 47: 77–86
   PubMedGoogle Scholar
• Zumoff B, Strain G W, Miller L K, Rosner W. Twenty-four-hour mean plasma testosterone concentration declines with age in normal premenopausal women. J Clin Endocrinol Metab 1995; 80: 1429–1430
   PubMed Web of Science ®Google Scholar
• Bachmann G A, Bancroft J, Braunstein G, Burger H, Davis S, Dennerstein L, Goldstein I, Guay A, Leiblum S, Lobo R, et al. Female androgen insufficiency: the Princeton consensus statement on definition, classification and assessment. Fertil Steril 2002; 77: 660–665
   PubMed Web of Science ®Google Scholar
• Papalia M A, Davis S R. What is the rationale for androgen therapy for women. Treat Endocrinol 2003; 2: 77–84
   PubMedGoogle Scholar
• Longcope C, Baker S. Androgen and estrogen dynamics: relationships with age, weight and menopausal status. J Clin Endocrinol Metab 1993; 76: 601–604
   PubMed Web of Science ®Google Scholar
• Davis S R. When to expect androgen deficiency other than at menopause. Fertil Steril 2001; 77(Suppl 4)S68–S71
   Web of Science ®Google Scholar
• Davis S R, Tran J. Testosterone influences libido and well being in women. Trends Endocrinol Metab 2001; 12: 33–37
   PubMed Web of Science ®Google Scholar
• Wilson C M, McPhaul M J. A and B forms of the androgen receptor are expressed in a variety of human tissues. Mol Cell Endocrinol 1996; 120: 51–57
   PubMed Web of Science ®Google Scholar
• Maia H, Jr, Maltez A, Fahel P, Athayde C, Coutinho E. Detection of testosterone and estrogen receptors in the postmenopausal endometrium. Maturitas 2001; 38: 179–188
   PubMed Web of Science ®Google Scholar
• Meldrum D R, Davidson B J, Tataryn I V, Judd H L. Changes in circulating steroids with aging in postmenopausal women. Obstet Gynecol 1981; 57: 624–628
   PubMed Web of Science ®Google Scholar
• Simpson E R. Aromatization of androgens in women: current concepts and findings. Fertil Steril 2002; 77(Suppl 4)S6–S10
   PubMed Web of Science ®Google Scholar
• Purohit A, Reed M J. Regulation of estrogen synthesis in postmenopausal women. Steroids 2002; 67: 979–983
   PubMed Web of Science ®Google Scholar
• Bachman G A. The hypo-androgenic woman: pathophysiologic overview. Fertil Steril 2002; 77(Suppl 4)S72–S76
   PubMed Web of Science ®Google Scholar
• Fortunati N. Sex hormone-binding globulin: not only a transport protein. What news is around the corner?. J Endocrinol Invest 1999; 22: 223–234
   PubMed Web of Science ®Google Scholar
• Pardridge W M. Serum bioavailability of sex steroid hormones. Clin Endocrinol Metab 1986; 15: 259–278
   PubMedGoogle Scholar
• Chapurlat R D, Garnero P, Breart G, Meunier P J, Delmas P D. Serum estradiol and sex hormone-binding globulin and the risk of hip fracture in elderly women: the EPIDOS study. J Bone Miner Res 2000; 15: 1835–1841
   PubMed Web of Science ®Google Scholar
• Adams L A, Vician L, Clifton D K, Steiner R A. Testosterone regulates pro-opiomelanocortin gene expression in the primate brain. Endocrinology 1991; 128: 1881–1886
   PubMed Web of Science ®Google Scholar
• Sarrel P M. Androgen deficiency: menopause and estrogen related factors. Fertil Steril 2002; 77(Suppl 4)S63–S67
   PubMed Web of Science ®Google Scholar
• Sherwin B B. Use of combined estrogen–androgen preparations in the postmenopause: evidence from clinical studies. Int J Fertil Womens Med 1998; 43: 98–103
   PubMed Web of Science ®Google Scholar
• Guay A T. Decreased testosterone in regularly menstruating women with decreased libido: a clinical observation. J Sex Marital Ther 2001; 27: 513–519
   PubMed Web of Science ®Google Scholar
• Attar E. Aromatase and other steroidogenic genes in endometriosis: translational aspects. Hum Reprod Update 2006; 12: 49–56
   PubMed Web of Science ®Google Scholar
• Purohit A, Ghilchik M W, Leese M P, Potter B V, Reed M J. Regulation of aromatase activity by cytokines, PGE2 and 2-methoxyoestrone-3-O-sulphamate in fibroblasts derived from normal and malignant breast tissues. J Steroid Biochem Mol Biol 2005; 94: 167–172
   PubMed Web of Science ®Google Scholar
• Zeitoun K, Bulun S E. Aromatase: a key molecule in the pathophysiology of endometriosis and a therapeutic target. Fertil Steril 1999; 72: 961–969
   PubMed Web of Science ®Google Scholar
• Burger H G, Hailes J, Menelaus M, Nelson J, Hudson B, Balazs N. The management of persistent menopausal symptoms with oestradiol testosterone implants: clinical lipid and hormonal results. Maturitas 1984; 6: 351–358
   PubMed Web of Science ®Google Scholar
• Carruthers M. Androgen deficiency in the adult male. Taylor & Francis, London 2004; 179–182
   Google Scholar
• Baumann C K, Castiglione-Gertsch M. Estrogen receptor modulators and down regulators: optimal use in postmenopausal women with breast cancer. Drugs 2007; 67: 2335–2353
   PubMed Web of Science ®Google Scholar
• Sylvestre C, Buckett W. Is there a role for androgens in premenopausal women?. Androgens and reproductive aging, T Tulandi, M Gelfand. Taylor & Francis, London 2006; 93–97
   Google Scholar
• Kloosterboer H J. Tibolone: a steroid with tissue-specific mode of action. J Steroid Biochem Mol Biol 2001; 76: 231–238
   PubMed Web of Science ®Google Scholar
• Vos R M, Krebbers S, Verhoeven C, Delbressine L. The in vivo human metabolism of tibolone. Drug Metab Dispos 2002; 30: 106–112
   PubMed Web of Science ®Google Scholar
• Sherwin B B. Effects of combined estrogen androgen preparations on sexual function in postmenopausal women. Androgens and reproductive aging, T Tulandi, M Gelfand. Taylor Francis, London 2006; 57–65
   Google Scholar
• Goldstat R, Briganti E, Tran J, Wolfe R, Davis S R. Transdermal testosterone improves well-being mood, and sexual function in premenopausal patients. Menopause 2003; 10: 390–398
   PubMed Web of Science ®Google Scholar
• Sarrel P, Dobay B, Wiita B. Estrogen and estrogen–androgen replacement in postmenopausal women dissatisfied with estrogen-alone therapy. J Reprod Med 1998; 43: 847–856
   PubMed Web of Science ®Google Scholar
• Shifren J L, Braunstein G D, Simon J A, Casson P R, Buster J E, Redmond G P, Burki R E, Ginsburg E S, Rosen R C, Leiblum S R, et al. Transdermal testosterone treatment in women with impaired sexual function after oophorectomy. N Engl J Med 2000; 343: 682–688
   PubMed Web of Science ®Google Scholar
• Coutinho E M, Erdens C, Maltez A, Maia H, Jr. Long term testosterone replacement therapy with slow release silastic implants. Advances in gynecological endocrinology, A Genazzani. Parthenon Publishing Group, London 2002; 259–266
   Google Scholar
• Davis S R. The effects of tibolone on mood and libido. Menopause 2002; 9: 162–170
   PubMed Web of Science ®Google Scholar
• Odmark I S, Carlstrom K, Jonsson B, Jonasson A F. Conjugated estrogen/progestogen versus tibolone hormone replacement therapy in postmenopausal women. Effects on carbohydrate metabolism and serum sex hormone binding globulin. Maturitas 2006; 53: 89–96
   PubMed Web of Science ®Google Scholar
• Taskin O, Gokdeniz R, Yalcinoglu A, Buhur A, Burak F, Atmaca R, Ozekici U. Placebo-controlled cross-over study of effects of tibolone on premenstrual symptoms and peripheral β-endorphin concentrations in premenstrual syndrome. Hum Reprod 1998; 13: 2402–2405
   PubMed Web of Science ®Google Scholar
• Maia H, Jr, Athayde C, Coutinho E M. Effect of low dose tibolone in perimenopausal patients. Climacteric 20058, Suppl 2: 80
   Google Scholar
• Genazzani A R, Petraglia F, Facchinetti F, Grasso A, Volpe A. Steroid replacement treatment increases β-endorphin and β-lipotropin plasma levels in postmenopausal women. Gynecol Obstet Invest 1988; 26: 153–159
   PubMed Web of Science ®Google Scholar
• Hulley S, Grady D, Bush T, Furberg C, Herrington D, Riggs B, Vittinghoff E. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. JAMA 1998; 280: 605–613
   PubMed Web of Science ®Google Scholar
• Grodstein F, Lifford K, Resnick N M, Curhan G C. Postmenopausal hormone therapy and risk of developing urinary incontinence. Obstet Gynecol 2004; 103(2)254–260
   PubMed Web of Science ®Google Scholar
• Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women. JAMA 2002; 288: 321–333
   PubMed Web of Science ®Google Scholar
• Ho M H, Bhatia N N, Bhasin S. Anabolic effects of androgens on muscle of female pelvic floor and lower urinary tract. Curr Opin Obstet Gynecol 2004; 16: 405–409
   PubMed Web of Science ®Google Scholar
• Alperin M, Moale P A. Remodeling of vaginal connective tissue in patients with prolapse. Curr Opin Obstet Gynecol 2006; 18: 544–550
   PubMed Web of Science ®Google Scholar
• Chen B H, Wen Y, Li H, Polan M L. Collagen metabolism and turnover in women with stress urinary incontinence and pelvic prolapse. Int Urogynecol J Pelvic Floor Dysfunct 2002; 13: 80–87
   PubMed Web of Science ®Google Scholar
• Ishikawa T, Harada T, Kubota T, Aso T. Testosterone inhibits matrix metalloproteinase-1 production in human endometrial stroma cells in vitro. Reproduction 2007; 133: 1233–1239
   PubMed Web of Science ®Google Scholar
• Edwall L, Carlström K, Jonasson A F. Markers of collagen synthesis and degradation in urogenital tissue from women with and without stress urinary incontinence. Neurourol Urodyn 2005; 24: 319–324
   PubMed Web of Science ®Google Scholar
• Edwall L, Carlström K, Jonasson A F. Markers of collagen synthesis and degradation in urogenital tissue and serum from women with and without uterogenital prolapsed. Mol Hum Reprod 2008; 14: 193–197
   PubMed Web of Science ®Google Scholar
• Edwall L, Carlström K, Jonasson A F. Endocrine status and markers of collagen synthesis and degradation in serum and urogenital tissue from women with and without stress urinary incontinence. Neurourol Urodyn 2007; 26: 410–415
   PubMed Web of Science ®Google Scholar
• Burger H G, Hailes J, Nelson J, Menelaus M. Effects of combined implants of estradiol and testosterone on libido in postmenopausal women. Br Med J 1987; 294: 936–937
   PubMed Web of Science ®Google Scholar
• Sherwin B B, Gelfan M M. Differential symptom response to parental estrogen and/or androgen administration in the surgical menopause. Am J Obstet Gynecol 1985; 151: 153–160
   PubMed Web of Science ®Google Scholar
• Apperloo M, Midden M, van der Stege J, Wouda J, Hoek A, Schultz W W. Vaginal application of testosterone: a study on pharmacokinetics and the sexual response in healthy volunteers. J Sex Med 2006; 3: 541–549
   PubMed Web of Science ®Google Scholar
• Maia H, Jr, Pimentel K, Casoy J, Athayde C. Should tibolone be used in the perimenopause to treat androgen deficiency. Abstract book of World Congress on Controversies in Obstetrics and Gynecology. BarcelonaSpain 2007; A-86
   Google Scholar
• Berman J E, Almeida F G, Jolin J, Raz S, Chaudhuri G, Gonzalez-Cadavid N F. Correlation of androgen receptors, aromatase and 5-α reductase in the human vagina with menopausal status. Fertil Steril 2003; 79: 925–931
   PubMed Web of Science ®Google Scholar
• Naessén S, Carlström K, Byström B, Pierre Y, Hirschberg A L. Effects of an antiandrogenic oral contraceptive on appetite and eating behavior in bulimic women. Psychoneuroendocrinology 2007; 32: 548–554
   PubMed Web of Science ®Google Scholar