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Menopause

Effect of androgens combined with hormone therapy on quality of life in post-menopausal women with sexual dysfunction

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Pages 691-695 | Received 21 Jul 2008, Accepted 05 Sep 2008, Published online: 07 Jul 2009

References

  • Blumel J E, Castelo-Branco C, Binfa L, Gramegna G, Tacla X, Aracena B, Cumsille M A, Sanjuan A L. Quality of life after the menopause: a population study. Maturitas 2000; 34: 17–23
  • Zweifel J E, O'Brien W H. A meta-analysis of the effect of hormone replacement therapy upon depressed mood. Psychoneuroendocrinology 1997; 22: 189–212
  • Davis S R, McCloud P, Strauss B J, Burger H. Testosterone enhances estradiol's effects on postmenopausal bone density and sexuality. Maturitas 1995; 21: 227–236
  • Davis S R, Davison S L, Donath S, Bell R J. Circulating androgen levels and self-reported sexual function in women. JAMA 2005; 294: 91–96
  • Bell R J, Donath S, Davison S L, Davis S R. Endogenous androgen levels and well-being: differences between premenopausal and postmenopausal women. Menopause 2006; 13: 65–71
  • Rosen R, Brown C, Heiman J, Leiblum S, Meston C, Shabsigh R, Ferguson D, D'agostino R. The female sexual function index (FSFI): a multidimensional self-report instrument for the assessment of female sexual function. J Sex Marital Ther 2000; 26: 191–208
  • Hilditch J R, Lewis J, Peter A. A menopause-specific quality of life questionnaire: development and psychometric properties. Maturitas 1996; 24: 161–175
  • Brett K M, Chong Y. Hormone Replacement Therapy: Knowledge and Use in the States Unites. National Center for Health Statistics, Hyattsville, Maryland 2001
  • Wiegel M, Meston C, Rosen R. The female sexual function index (FSFI): cross-validation and development of clinical cutoff scores. J Sex Marital Ther 2005; 31: 1–20
  • Blumel J E, Binfa L, Caltaldo L, Carrasco A, Izaguirre H, Sarra S. Indice de función sexual femenina: un test para evaluar la sexualidad de la mujer. Rev Chil Obstet Ginecol 2004; 69: 118–125
  • Blumel J E, Castelo-Branco C, Binfa L, Gramegna G, Tacla X, Aracena B, Cumsille M A, Sanjuan A. Quality of life after the menopause: a population study. Maturitas 2000; 34: 17–23
  • Word Medical Association. Declaration of Helsinki. JAMA 1997; 277: 925–926
  • Castelo-Branco C, Blumel J E, Araya H, Riquelme R, Castro G, Haya J, Gramegna G. Prevalence of sexual dysfunction in a cohort of middle-aged women: influences of menopause and hormone replacement therapy. J Obstet Gynaecol 2003; 23: 426–430
  • Studd J. A comparison of 19th century and current attitudes to female sexuality. Gynecol Endocrinol 2007; 23: 673–681
  • Turna B, Apaydin E, Semerci B, Altay B, Cikili N, Nazli O. Women with low libido: correlation of decreased androgen levels with female sexual function index. Int J Impot Res 2005; 17: 148–153
  • Gracia C R, Freeman E W, Sammel M D, Lin H, Mogul M. Hormones and sexuality during transition to menopause. Obstet Gynecol 2007; 109: 831–840
  • Carney A, Bancroft J, Mathews A. Combination of hormonal and psychological treatment for female sexual unresponsiveness: a comparative study. Br J Psychiatry 1978; 133: 339–346
  • Kingsberg S, Shifren J, Wekselman K, Rodenberg C, Koochaki P, Derogatis L. Evaluation of the clinical relevance of benefits associated with transdermal testosterone treatment in postmenopausal women with hypoactive sexual desire disorder. J Sex Med 2007; 4(4 Part 1)1001–1008
  • Shifren J L, Davis S R, Moreau M, Waldbaum A, Bouchard C, DeRogatis L, et al. Testosterone patch for the treatment of hypoactive sexual desire disorder in naturally menopausal women: results from the INTIMATE NM1 Study. Menopause 2006; 13: 770–779
  • Davis S R, van der Mooren M J, van Lunsen R H, Lopes P, Ribot C, Rees M, et al. Efficacy and safety of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: a randomized, placebo-controlled trial. Menopause 2006; 13: 387–396
  • Braunstein G D, Sundwall D A, Katz M, Shifren J L, Buster J E, Simon J A, et al. Safety and efficacy of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: a randomized, placebo-controlled trial. Arch Intern Med 2005; 165: 1582–1589
  • Phillips E H, Ryan S, Ferrari R, Green C. Estratest and estratest HS (esterified estrogens and methyltestosterone) therapy: a summary of safety surveillance data, January 1989 to August 2002. Clin Ther 2003; 25: 3027–3043
  • Simon J, Klaiber E, Wiita B, Bowen A, Yang H M. Differential effects of estrogen-androgen and estrogen-only therapy on vasomotor symptoms, gonadotropin secretion, and endogenous androgen bioavailability in postmenopausal women. Menopause 1999; 6: 138–134
  • Adamson D L, Webb C M, Collins P. Esterified estrogens combined with methyltestosterone improve emotional well-being in postmenopausal women with chest pain and normal coronary angiograms. Menopause 2001; 8: 233–238
  • Dias R S, Kerr-Corrêa F, Moreno R A, Trinca L A, Pontes A, Halbe H W, et al. Efficacy of hormone therapy with and without methyltestosterone augmentation of venlafaxine in the treatment of postmenopausal depression: a double-blind controlled pilot study. Menopause 2006; 13: 202–211
  • Somboonporn W, Davis S, Seif M W, Bell R. Testosterone for peri- and postmenopausal women. Cochrane Database Syst Rev 2005; 4: CD004509
  • de Paula F J, Soares J M, Jr, Haidar M A, de Lima G R, Baracat E C. The benefits of androgens combined with hormone replacement therapy regarding to patients with postmenopausal sexual symptoms. Maturitas 2007; 56: 69–77
  • Lobo R A, Rosen R C, Yang H M, Block B, Van Der Hoop R G. Comparative effects of oral esterified estrogens with and without methyltestosterone on endocrine profiles and dimensions of sexual function in postmenopausal women with hypoactive sexual desire. Fertil Steril 2003; 79: 1341–1352
  • Sarrel P, Dobay B, Wiita B. Estrogen and estrogen-androgen replacement in postmenopausal women dissatisfied with estrogen-only therapy. Sexual behavior and neuroendocrine responses. J Reprod Med 1998; 43: 847–856
  • Barrett-Connor E, Young R, Notelovitz M, Sullivan J, Wiita B, Yang H M, Nolan J. A two-year, double-blind comparison of estrogen-androgen and conjugated estrogens in surgically menopausal women. Effects on bone mineral density, symptoms and lipid profiles. J Reprod Med 1999; 44: 1012–1020
  • Zang H, Sahlin L, Masironi B, Eriksson E, Lindén Hirschberg A. Effects of testosterone treatment on endometrial proliferation in postmenopausal women. J Clin Endocrinol Metab 2007; 92: 2169–2175
  • Braunstein G D. Safety of testosterone treatment in postmenopausal women. Fertil Steril 2007; 88: 1–17
  • Basaria S, Nguyen T, Rosenson R S, Dobs A S. Effect of methyl testosterone administration on plasma viscosity in postmenopausal women. Clin Endocrinol (Oxf) 2002; 57: 209–214
  • Gitlin N, Korner P, Yang H M. Liver function in postmenopausal women on estrogen-androgen hormone replacement therapy: a meta-analysis of eight clinical trials. Menopause 1999; 6: 216–224
  • Female sexual dissatisfaction: hormone therapy inappropriate. Prescrire Int 2007; 16: 202–205
  • Price P. Education, psychology and ‘compliance’. Diabetes Metab Res Rev 2008; 24(Suppl 1)S101–S105

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