Advanced search
Publication Cover
Gynecological Endocrinology Volume 25, 2009 - Issue 7
Submit an article Journal homepage
216
Views
22
CrossRef citations to date
0
Altmetric
PCOS

Metformin administration was associated with a modification of LH, prolactin and insulin secretion dynamics in women with polycystic ovarian syndrome

Evangelia Billa Endocrine Department, Elena Venizelou Hospital, Athens, Greece
,
Niki Kapolla Endocrine Department, Elena Venizelou Hospital, Athens, Greece
,
Stamatina C. Nicopoulou Endocrine Department, Elena Venizelou Hospital, Athens, Greece
,
Eftychia Koukkou Endocrine Department, Elena Venizelou Hospital, Athens, Greece
,
Evangelia Venaki Endocrine Department, Elena Venizelou Hospital, Athens, Greece
,
Spyros Milingos Department of Obstetrics and Gynaecology, Athens University Medical School, Athens, Greece
,
Aristides Antsaklis Department of Obstetrics and Gynaecology, Athens University Medical School, Athens, Greece
&
Prof. Dimitrios A. Adamopoulos Endocrine Department, Elena Venizelou Hospital, Athens, GreeceCorrespondence[email protected]
 show all
Pages 427-434 | Received 06 Jan 2009, Accepted 22 Jan 2009, Published online: 21 Jul 2009

References

  • Nestler J E, Jakubowicz D J, Evans W S, Pasquali R. Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome. N Engl J Med 1998; 338: 1876–1880
  • Glueck C J, Wang P, Fontaine T, Tracy T, Sieve-Smith L. Metformin- induced resumption of normal menses in 39 of 43 (91%) previously amenorrhoeic women with the polycystic ovary syndrome. Metabolism 1999; 48: 511–519
  • Legro R, Barnhart H, Scklaff W, Carr B, Diamond M, Carson S, Steinkamp M, Coutifaris C, Mc Govern P, Cataldo N, et al. Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome. N Engl J Med 2007; 356: 551–566
  • Barbieri R L. Metformin for the treatment of polycystic ovary syndrome. Obstet Gynecol 2003; 101: 785–793
  • Harborne L, Fleming R, Lyall H, Norman J, Sattar N. Descriptive review of the evidence for the use of metformin in polycystic ovary syndrome. Lancet 2003; 361: 1894–1901
  • Pasquali R, Grambineri A. Insulin-sensitizing agents in polycystic ovary syndrome. Eur J Endocrinol 2006; 154: 763–775
  • Lord J M, Flight I HK, Norman R J. Insulin-sensitising drugs (metformin, troglitazone, rosiglitazone, pioglitazone, d-chiro-inositol) for polycystic ovary syndrome. Cochrane Database Syst Rev 2003; 3: CD003053
  • Genazzani A D, Lanzoni C, Ricchieri F, Baraldi E, Casarosa E, Jasonni V. Metformin administration is more effective when non-obese patients with polycystic ovary syndrome show both hyperandrogenism and hyperinsulinemia. Gynecol Endocrinol 2007; 23: 146–152
  • Ulloa-Aguirre A, Portocarrero L, Zarinan T, Olivares A, Carranza-Lira S, Veldhuis J D, Lopez-Alvarenga J C. Effects of metformin on inappropriate LH release in women with polycystic ovarian syndrome and insulin resistance. Reprod Biomed Online 2006; 12: 669–683
  • Genazzani A D, Battaglia C, Malavasi B, Strucchi C, Tortonali F, Gamba O. Metformin administration modulates and restores luteinizing hormone spontaneous episodic secretion and ovarian function in nonobese patients with polycystic ovary syndrome. Fertil Steril 2004; 81: 114–119
  • Genazzani A D, Strucchi C, Luisi M, Casarosa E, Lanzoni C, Baraldi E, Ricchieri F, Mehmeti H, Genazzani A R. Metformin administration modulates neurosteroids secretion in non-obese amenorrhoic patients with polycystic ovary syndrome. Gynecol Endocrinol 2006; 22: 36–43
  • Zawadzki J K, Dunaif A. Diagnostic criteria for polycystic ovary syndrome: towards a rational approach. Polycystic ovary syndrome, A Dunaif, J R Givens, F R Haseltine, G R Merriam. Boston: Blackwell Scientific. 1992; 377–384
  • The Rotterdam ESHRE/ASRM – Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004; 81: 19–25
  • Ferimman D M, Gallwey J D. Clinical assessment of body hair growth in women. J Clin Endocrinol Metab 1961; 21: 1440–1447
  • Hatch R, Rosenfield R N, Kim M H, Tredway D. Hirsutism: implications, etiology and management. Am J Obstet Gynecol 1981; 140: 815–830
  • Attiomo W U, Pearson S, Shaw S, Prentice A, Dubbin P. Ultrasound criteria in the diagnosis of polycystic ovarian syndrome (PCOS). Ultras Med Biol 2000; 26: 977–980
  • Vermeulen A, Verdonck L, Kaufman J M. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 1999; 84: 3666–3672
  • Tai M M. A mathematical model for the determination of total area under glucose tolerance and other metabolic curves. Diab Care 1994; 17: 152–154
  • Katz A, Nambi S S, Mather K, Baron A D, Follmann D A, Sullivan G, Quon M J. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 2000; 85: 2402–2410
  • Shoupe D, Lobo R A. Evidence for altered catecholamine metabolism in polycystic ovary syndrome. Am J Obstets Gynecol 1984; 150: 566–571
  • Hernandez I, Parra A, Mendez I, Cabrela V, Cravioto M C, Mercado M, Diaz Sanchez V, Larrea F. Hypothalamic dopaminergic tone and prolactin bioactivity in women with polycystic ovary syndrome. Arch Med Res 2000; 31: 216–222
  • Ortega-Gonzalez C, Cardoza I, Coutino B, Hidalgo R, Arteaga-Troncoso G, Parra A. Insulin sensitizing drugs increase the endogenous dopaminergic tone in obese insulin-resistant women with polycystic ovary syndrome. J Endocrinol 2005; 184: 233–239
  • Falaschi P, Del Pozo E, Rocco A, Toscano V, Petrangeu E, Pompei P, Frajese G. Prolactin release in polycystic ovary. Obstet Gynaecol 1980; 55: 579–582
  • Vigersky R A, Filmore-Nassar A, Class A R. Thyrotropin suppression by metformin. J Clin Endocrinol Metab 2006; 91: 225–227

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.