64
Views
34
CrossRef citations to date
0
Altmetric
Original Article

Endocrine ,neuroendocrine and behavioral effects of oral dehydroepiandrosterone sulfate supplementation in postmenopausal women

, , , , , , & show all
Pages 15-25 | Published online: 28 Aug 2009

References

  • Parker L N ,Odell W D. Control of adrenal androgen secretion. Endocr Rev 1980; 4: 392–410
  • Yamaji T ,Ibayashi H. Serum dehydroepiandrosterone sulphate in normal and pathological conditions. J Clin Endocrinol Metab 1969; 29: 273–8
  • Orienteich L ,Brind J L ,Rizer R L ,et al. Age changes and sex differences in serum dehydro-epiandrosterone sulphate concentration through-out adulthood. J Clin Endocrinol Metab 1984; 59: 551–5
  • Berr C ,Lafont S ,Debuire B ,et al. Relationship of dehydroepiandrosterone sulphate in the elderly functional ,and mental status ,and short-term mortality: a French community-based study. Proc Natl Acad Sci USA 1996; 93: 13410–15
  • Liu C H ,Laughlin G A ,Fischer U G ,et al. Marked attenuation of ultradian and circadian rhythms of dehydroepiandrosterone in postmenopausal women: evidence for a reduced 17,20- desmolase enzymatic activity. J Clin Endocrinol Metab 1990; 71: 900–6
  • Couch R M ,Muller J ,Winter JSD. Regulation of the activities of 17-hydroxylase and 17,20-desmolase in the human adrenal cortex: kinetic analysis and inhibition by endogenous steroids. J Clin Endocrinol Metab 1986; 63: 613–18
  • Mortola J F ,Yen SSC. The effects of oral dehydroepiandrosterone on endocrine—metabolic parameters in postmenopausal women. J Clin Endocrinol Metab 1990; 71: 696–704
  • Morales A J ,Nolan J J ,Nelson J C ,et al. Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age. J Clin Endocrinol Metab 1994; 78: 1360–71
  • Coleman D L ,Leiter E H ,Schwizer R W. Therapeutic effects of dehydroepiandrosterone in diabetic mice. Diabetes 1982; 31: 830–3
  • Coleman D L ,Schwizer R W ,Leiter E H. Effect of genetic background on the therapeutic effects of dehydroepiandrosterone (DHEA) in diabetes-obesity mutans and aged normal mice. Diabetes 1984; 33: 26–33
  • Yen T Y ,Allan J A ,Pearson D V ,et al. Prevention of obesity in Avy/a mice by dehydroepiandrosterone. Lipids 1977; 12: 409–13
  • Gordon G B ,Bush D E ,Weisman H F. Reduction of atherosclerosis by administration of dehydroepiandrosterone. A study in hypercholesterolemic New Zealand White rabbit with aortic intimal injury. J Clin Invest 1988; 82: 712–20
  • Schwartz A G. Inhibition of spontaneous breast cancer formation in female C3H (Avy/a) mice by long-term treatment with dehydroepiandrosterone. Cancer Res 1979; 39: 1129–31
  • Shantz L M ,Talav P ,Gordon G B. Mechanism of inhibition of growth of 3T3-L1 fibroblast and their differentiation to adipocytes by dehydroepiandrosterone and related steroids: role of glucose-6-phosphate dehydrogenase. Proc Natl Acad Sci USA 1989; 86: 3852–6
  • Blauer K I ,Rogers W M ,Benton E W (1989) Dehydroepiandrosterone antagonizes the suppressive effects of glucocorticoids on lymphocyte proliferation. Presented at the 71st Annual Meeting of The Endocrine Society. 1989
  • Rogers W M ,Blauer K L ,Bernton W (1989) Dehydroepiandrosterone protection against dexamethasone induced thymic involution: flow cytometric and mechanism studies. Presented at the 71st Annual Meeting of The Endocrine Society. 1989 ,780–801
  • Barret-Connor E ,Khaw K ,Yen SSC. A prospective study of DS mortality and cardiovascular disease. N Engl J Med 1986; 315: 1519–24
  • Helzlsouer K J ,Gordon G B ,Alberg A ,et al. Relationship of prediagnostic serum levels of DHEA and DS to the risk of developing premenopausal breast cancer. Cancer Res 1992; 52: 1–4
  • Bulbrook R D ,Hayward J L ,Spicer C C. Relation between urinary androgen and corticoid secretion and subsequent breast cancer. Lancet 1975; 2: 395–8
  • Thoman M L ,Weigle W O. The cellular and subcellular bases of immunosenescene. Adv Immunol 1989; 46: 221–61
  • Nestler J E ,Barlascini C O ,Clore J N ,et al. Dehydroepiandrosterone reduces serum low density lipoprotein levels and body fat but does not alter insulin sensitivity in normal men. J Clin Endocrinol Metab 1988; 66: 57–61
  • Usiskin K S ,Butterworth S ,Clore J N ,et al. Lack of effect of DHEA in obese men. Int J Obesity 1990; 14: 457–63
  • Welle S ,Jozefowicz R ,Statt M. Failure of DHEA to influence energy and protein metabolism in humans. J Clin Endocrinol Metab 1990; 71: 1259–64
  • Labire F ,Diamond P ,Cusan L ,et al. Effects of 12-month dehydroepiandrosterone replacement therapy on bone ,vagina ,and endometrium in postmenopausal women. J Clin Endocrinol Metab 1997; 82: 3498–505
  • Genazzani A R ,Petraglia F ,Cleva M ,et al. Norgestimate increases pituitary and hypothalamic concentrations of immunoreactive beta-endorphin. Contraception 1989; 5: 605–13
  • Genazzani A R ,Petraglia F ,Mercuri N ,et al. Effect of steroid hormones and antihormones on hypothalamic beta-endorphin concentrations in intact and castrated female rats. J Endocrinol Invest 1990; 13: 91–6
  • Stomati M ,Bersi C ,Rubino S ,et al. Neuroendocrine effects of different oestradiol-progestin regimens in postmenopausal women. Maturitas 1997; 28: 127–35
  • Wiklund I ,Heist J ,Korlberg J. A new methodology for evaluating quality of life in postmenopausal women during transdermal estrogen replacement therapy. Maturitas 1992; 14: 211–24
  • Young J ,Couzinet B ,Brailly S ,et al. Panhypopituitarism as a model to study the metabolism of dehydroepiandrosterone (DHEA) in humans. J Clin Endocrinol Metab 1997; 82: 2578–85
  • Rubino S ,Stomati M ,Bersi C ,et al. Neuroendocrine effect of a short-term treatment with DHEA in postmenopausal women. Maturitas 1998; 28: 251–7
  • Naber D. Opioids in the etiology and treatment of psychiatric disorders. Opioids. II ,A Herz. Springer-Verlag ,Berlin 1993; 780–801
  • Genazzani A R ,Petraglia F ,Facchinetti F ,et al. Increase of proopiomelanocortin-related peptides during subjective menopausal flushes. Am J Obstet Gynecol 1984; 149: 775–9
  • McLoughin L ,Grossman A ,Tomlin S ,et al. CRF-41 stimulates the release of beta-lipotropin and beta-endorphin in normal human subjects. Neuroendocrinology 1984; 38: 282–4
  • Petraglia F ,Comitini G ,Genazzani A R ,. β-Endorphin in human reproduction. Opioids. II ,A Herz ,et al. Springer-Verlag ,Berlin 1993; 763–80
  • Mellon S H. Neurosteroids: biochemistry ,modes of action ,and clinical relevance. J Clin Endocrinol Metab 1994; 78: 1003–8
  • Majewska M D. Neurosteroids: endogenous bimodal modulators of the GABA-A receptor. Mechanism of action and physiological significance. Prog Neurobiol 1992; 38: 379–95
  • Corpechot C ,Young J ,Calvel M ,et al. Neurosteroids: 3α-hydroxy-5α-pregnan-20-one and its precursors in the brain ,plasma ,and steroidogenic glands of male and female rats. Endocrinology 1993; 133: 1003–9
  • Majewska M D ,Demirgoren S ,Spivak C E ,et al. The neurosteroid DHEA is an allosteric antagonist of the GABAA receptor. Brain Res 1990; 526: 143–6
  • Flood J F ,Morley J E ,Roberts E. Memory-enhancing effects in male mice of pregnenolone and steroid metabolically derived from it. Proc Natl Acad Sci USA 1992; 89: 1567–71
  • McEwen B. Non-genomic and genomic effects of steroid on neural plasticity. Trends Pharmacol Sci 1991; 12: 141–7
  • Wolf O T ,Neumenn O ,Helhammer D H ,et al. Effects of a two-week physiological dehydroepiandrosterone substitution on cognitive performance and well-being in healthy elderly women and men. J Clin Endocrinol Metab 1997; 82: 2363–7
  • Wolkowitz O M ,Reus V I ,Roberts E ,et al. Dehydroepiandrosterone (DHEA) treatment of depression. Biol Psychiatry 1997; 41: 311–18

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.