Homocysteinemia is inversely correlated with platelet count and directly correlated with sE- and sP-selectin levels in females homozygous for C677T methylenetetrahydrofolate reductase

References

• Cotter AM, Molloy AM, Scott JM, Daly SF. Elevated plasma homocysteine in early pregnancy: a risk factor for the development of nonsevere preeclampsia. Am J Obstet Gynecol 2003;189:391–4.
   PubMed Web of Science ®Google Scholar
• Macy PA. Homocysteine: predictor of thrombotic disease. Clin Lab Sci 2001;14:272–5.
   PubMedGoogle Scholar
• Pereira AC, Schettert IT, Morandini Filho AA, Guerra- Shinohara EM, Krieger JE. Methyltetrahydrofolate reductase C677T gene variant modulates the homocysteyne folate correlation in a mild folate-deficient population. Clin Chim Acta 2004;340:99–105.
   PubMed Web of Science ®Google Scholar
• Geisel J, Hubner U, Bodis M, Schorr H, Knapp JP, Obeid R et al. The role of genetic factors in the development of hyperhomocysteinemia. Clin Chem Lab Med 2003;41:1427–34.
   PubMedGoogle Scholar
• Davi G, Di Minno G, Coppola A, Andria G, Cerbone AM, Madonna P, et al. Oxidative stress and platelet activation in homozygous homocystinuria. Circulation 2001;104:1124–8.
   PubMed Web of Science ®Google Scholar
• Leoncini G, Pascale L, Signorello MG. Effects of homocysteine on l-arginine transport and nitric oxide formation in human platelets. Eur J Clin Invest 2003;33:713–9.
   PubMed Web of Science ®Google Scholar
• Li J, Zhang X, Zhang B, Du J, Tang C. Effect of homocysteine on the L-arginine/nitric oxide synthase/nitric oxide pathway in human platelets. Heart Vessels 2002;16:46–50.
   PubMedGoogle Scholar
• Browns KS, Kluijtsmans La, Young IS, Woodside J, Yarnell JW, McMaster D, et al. Genetic evidence that nitric oxide modulates homocysteine: the NOS3 894TT genotype is a risk factor for hyperhomocysteinemia. Arterioscler Thromb Vasc Biol 2003;23:1014–20.
   PubMedGoogle Scholar
• Stamler JS, Osborne JA, Jaraki O, Rabbani LE, Mullins M, Singel D, et al. Adverse vascular effects of homocysteine are modulated by endothelium-derved relaxing factor and related oxides of nitrogen. J Clin Invest 1993;91:308–18.
   PubMed Web of Science ®Google Scholar
• Stabler SP, Marcell PD, Podell ER, Allen RH, Savage DG, Lindenbaum J. Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry. J Clin Invest 1988;81:466–74.
   PubMed Web of Science ®Google Scholar
• Wang J, Dudman NPB, Wilken DE. Effects of homocysteine and related compounds on prostacyclin production by cul- tured human vascular endothelial cells. Thromb Haemostasis 1993;6:1047–52.
   Google Scholar
• Blann AD. Endothelial cell damage and homocysteine. Atherosclerosis 1992;94:89–91.
   PubMed Web of Science ®Google Scholar
• Kim KN, Kim YJ, Chang N. Effects of the interaction between C677T 5,10 methylene-tetrahydrofolate reductase polymorphism and serum B vitamins on homocysteine levels in pregnant women. Eur J Clin Nutri 2004;58:10–6.
   PubMed Web of Science ®Google Scholar
• Riksen NP, Rongen GA, Blom HJ, Russel FG, Boers GH, Smits P. Potential role for adenosine in the pathogenesis of the vascular complications of hyperhomocysteinemia. Cardiovasc Res 2003;59:271–6.
   PubMed Web of Science ®Google Scholar
• Durand P, Prost M, Blache D. Pro-thrombotic effects of a folic acid deficient diet in rat platelets and macrophages related to elevated homocysteine and n-3 polyunsaturated fatty acids. Atherosclerosis 1996;121:231–43.
   PubMed Web of Science ®Google Scholar
• Graeber JE, Slott JH, Ulane RE, Shulman JD, Stuart MJ. Effect of homocysteine and homocystine on platelet and vascular arachidonic acid metabolism. Pediatr Res 1982;16:490–3.
   PubMed Web of Science ®Google Scholar
• Signorello MG, Pascale R, Leoncini G. Effects of homo- cysteine on arachidonic acid release in human platelets. Eur J Clin Invest 2002;32:279–84.
   PubMed Web of Science ®Google Scholar
• Fryer RH, Wilson BD, Gubler DB, Fitzgerald La, Rodgers GM. Homocysteine, a risk factor for premature vascular disease and thrombosis, induces tissue factors activity in endothelial cells. Artherioscler Thromb 1993;13:1327–33.
   PubMedGoogle Scholar
• Fuglsang J, Stender M, Zhou J, Moller J, Falk E, Ravn HB. 2002. Platelet activity and in vivo arterial trombus formation in rats with mild hyperhomocysteinemia. Blood Coagul Fibrinolysis 13:683–9.
   PubMed Web of Science ®Google Scholar
• Toffoli G, Russo A, Innocenti F, Corona G, Tumolo S, Sartor F, et al. Effect of methylenetetrahydrofolate reductase 677C-T polymorphism on toxicity and homocysteine plasma level after chronic methotrexate treatment of ovarian cancer patients. Int J Cancer 2003;103:294–9.
   PubMed Web of Science ®Google Scholar
• Di Minno G, Davi’ G, Margaglione M, Cirillo F, Grandone E, Ciabattoni G, et al. Abnormally high thromboxane biosynthesis in homozygous homocystinuria. Evidence for platelet involvement and probucol-sensitive mechanisms. J Clin Invest 1993;92:1400–6.
   PubMed Web of Science ®Google Scholar
• De Stefano V, Chiusolo P, Paciaroni K, Serra FG, Voso MT, Casorelli I, et al. Prevalence of the 677C to T mutation in the methylenetetrahydrofolate reductase gene in Italian Patients with venous. Thrombotic Disease Tromb Haemost 1998;79:686–7.
   PubMedGoogle Scholar
• Esfahani St, Cogger EA, Caudill MA. Heterogeneity in the presence of methylene-tetrahydrofolate reductase gene polymorphisms in women of different ethnic groups. J Am Diet Assoc 2003;103:200–7.
   PubMed Web of Science ®Google Scholar
• Kupferminc MJ, Eldor A, Steinman N, Many A, Bar-Am A, Jaffa A, et al. Increased frequency of genetic thrombophilia in women with complications of pregnancy. NEJM 1999;340:9–13.
   PubMed Web of Science ®Google Scholar
• Abbate R, Sofi F, Gensini F, Fatini C, Sticchi E, Fedi S. Thrombophilias as risk factors for disorders of pregnancy and fetal damage. Pathophysiol Haemost Thromb 2002; 32:318–21.
   PubMedGoogle Scholar
• Shmeleva VM, Kapustin SI, Papayan LP, Sobczynska- Malefora A, Harrington DJ, Savidge GF. Prevalence of hyperomocysteinemia and the MTHFR C677T polymorph- ism in patients with arterial and venous thrombosis from north western Russia. Thromb Res 2003;111:351–6.
   PubMed Web of Science ®Google Scholar
• Chaiworapongsa T, Romero R, Yoshimatsu J, Espinoza J, Kim YM, Park K, et al. Soluble adhesion molecule profile in normal pregnancy and pre-eclampsia. J Matern Fetal Neonatal Med 2002;12:19–27.
   PubMedGoogle Scholar
• Mansoor MA, Seljeflot I, Arnesen H, Knudsen A, Bates CJ, Mishra G, et al. Endothelial cell adhesion molecules in healthy adults during acute hyperomo- cysteinemia and mild hypertriglyceridemia. Clin Biochem 2004;37:408–14.
   PubMed Web of Science ®Google Scholar
• Riba R, Nicolau A, Troxler M, Homer-Vaniasinkam S, Naseem KM. Altered platelet reactivity in peripheral vascular disease complicated with elevated plasma homocysteine levels. Atherosclerosis 2004;175:69–75.
   PubMed Web of Science ®Google Scholar