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Original Article

Lipophilic statins do not affect the antiplatelet potency of clopidogrel

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Pages 225-226 | Published online: 07 Jul 2009

References

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  • Mitsios JV, Papathanasiou AI, Elisaf M, et al. The inhibitory potency of clopidogrel on ADP-induced platelet activation is not attenuated when it is co-administered with atorvastatin for five weeks in patients with acute coronary syndromes. Platelets 2005;in press.
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  • Lau WC, Waskell LA, Watkins PB, et al. Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: A new drug-drug interaction. Circulation 2003;107:32–37.
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  • Clarke TA, Waskell LA. The metabolism of clopidogrel is catalyzed by human cytochrome P450 3A and is inhibited by atorvastatin. Drug Metabolism & Disposition 2003;31:53–59.

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