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Original

Platelets possess functional TGF-β receptors and Smad2 protein

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Pages 35-42 | Received 08 Apr 2006, Accepted 20 Apr 2006, Published online: 07 Jul 2009

References

  • Assoian RK, Komoriya A, Meyers CA, Miller DM, Sporn MB. Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization. J Biol Chem 1983; 258: 7155–7160
  • Grainger DJ, Wakefield L, Bethell HW, Farndale RW, Metcalfe JC. Release and activation of platelet latent TGF-β in blood clots during dissolution with plasmin. Nat Med 1995; 1: 932–937
  • O’Kane S, Ferguson MWJ. Transforming growth factor βs and wound healing. Int J Biochem Cell Biol 1997; 29: 63–78
  • Clark RAF, McCoy GA, Folkvord JM, McPherson JM. TGF-β1 stimulates cultured human fibroblasts to proliferate and produce tissue-like fibroplasia: A fibronectin matrix-dependent event. J Cell Physiol 1997; 170: 69–80
  • Roberts AB, Sporn MB, Assoian RK, Smith JM, Roche NS, Wakefield LM, Heine VI, Liotta LA, Falanga V, Kehrl JH, et al. Transforming growth factor type β: Rapid induction of fibrosis and angiogenesis in vivo stimulation of collagen formation in vitro. Proc Nat Acad Sci USA 1986; 83: 4167–4171
  • Messadi DV, Berg S, Shung-Cho K, Lesavoy M, Bertolami CN. Autocrine TGF-β1 activity and glycosaminoglycan synthesis by human cutaneous scar fibroblasts. Wound Rep Regul 1994; 2: 284–291
  • Yang L, Qiu CX, Ludlow A, Ferguson MWJ, Brunner G. Active transforming growth factor-β in wound repair. Determination using a new assay. Am J Pathol 1999; 154: 105–111
  • Hoying JB, Yin M, Diebold R, Ormsby I, Becker A. Doetschman T. Transforming Growth factor b1 enhances platelet aggregation through a non-transcriptional effect on the fibrinogen receptor. J Biol Chem 1999; 274: 31008–1013
  • Soslau G, Morgan DA, Jaffe JS, Brodsky I, Wang Y. Cytokine mRNA expression in human platelets and a megakaryocytic cell line and cytokine modulation of platelet function. Cytokine 1997; 9(6)405–411
  • Derynck R, Feng XH. TGF-β receptor signaling. Biochim Biophys Acta 1997; 133: F105–F150
  • Heldin CH, Miyazono K, Ten Dijke. TGF-β signalling from cell membrane to nucleus through SMAD proteins. Nature 1997; 390: 465–471
  • Yue J, Mulder K. Transforming growth factor-b signal transduction in epithelial cells. Pharmacol Ther 2001; 91: 1–34
  • Massague J. How cells read TGF-β signals. Nat Rev Mol Cell Biol 2000; 1: 169–178
  • Segreto HRC, Ferreira AT, Kimura ET, Franco M, Egami MI, Silva MRR. Segreto RA. Amifostine does not prevent activation of TGF-β1 but induces smad 7 activation in megakaryocytes irradiated in vivo. Am J Hematol 2002; 71: 143–151
  • Davis RJ. Signal transduction by c-Jun N-terminal kinase. Biochem Soc Symp 1998; 64: 1–12
  • Kyriakis JM. Making the connection: Coupling of stress-activated ERK/MAPK (extracellular-signal-regulated kinase/mitogen-activated protein kinase) core signaling modules to extracellular stimuli and biological responses. Biochem Soc Symp 1998; 64: 29–48
  • Lenormand P, Sardet C, Pages G, L’Allemain G, Brunet A, Pouyssegur J. Growth factors induce nuclear translocation of MAP Kinases (p42MAPK and p44MAPK) but not their activator MAP Kinase Kinase (p54MAPKK) in fibroblast. J Cell Biol 1993; 122: 1079–1088
  • Ravanti L, Hakkinen L, Larjava H, Saarialho-Kere U, Foschi M, Han J, Kahari VM. Transforming growth factor-b induces collagenase-3 espression by human gingival fibroblast via p38 mitogen-activated protein kinase. J Biol Chem 1999; 274: 37292–37300
  • Hartsough MT, Mulder KM. Transforming growth factor-β signaling in epithelial cells. Pharmacol Ther 1997; 75: 21–41
  • Li Z, Zhang G, Feil R, Han J, Du X. Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin αIIbβ3. Blood 2006; 107: 965–972
  • Heller PG, Glembotsky AC, Gandhi MJ, Cummings CL, Pirola CJ, Marta RF, Kornblihtt LI, Drachman JG, Molinas FC. Low Mpl receptor expression in a pedigree with familial platelet disorder with predisposition to acute myelogenous leukemia and a novel AML1 mutation. Blood 2005; 105: 4664–4670
  • Levy-Toledano S, Bredoux R, Rendu F, Jenneaux C, Savarian E, Dassin E. Isolement et fonction de plaquettes. I. A partir du plasma rich en plaquettes, compareison de deux methods: Filtration sur gradient de metrizamide. Nouv Rev Fr Hematol 1976; 16: 367–374
  • Pelletier AJ, Kunicki T, Ouaranta V. Activation of the integrin alpha v beta 3 involves a discrete cation-binding site that regulates conformation. J Biol Chem 1996; 271(19)1364–1370
  • Lin HY, Wang XF, Ng-Eanton E, Weinberg RA, Lodish HF. Expression cloning of TGF-β type-II receptor, a functional transmembrane serine/threonine kinase. Cell 1992; 68: 775–785
  • Sakamaki S, Hirayama Y, Matsunaga T, Kuroda H, Kusakabe T, Akiyama T, Konuma Y, Sasaki K, Tsuji N, Okamoto T, et al. Transforming growth factor-β induces thrombopoietin from bone marrow stromal cells, which stimulates the expression of TGF-β receptor on megakaryocytes and, in turn, renders them susceptible to suppression by TGF-β itself with high specificity. Blood 1999; 64: 1961–1970
  • Martyre MC, Magdelenat H, Bryckaert H, Laine-Bidron C, Calvo F. Increased intraplatelet levels of platelet-derived growth factor and transforming growth factor-b in patients with myelofibrosis with myeloid metaplasia. Br J Haematol 1991; 77: 80–86
  • Lev PR, Marta RF, Vassallu P, Molinas FC. Variation of PDGF, TGF-β, and bFGF levels in essential thrombocythemia patients treated with anagrelide. Am J Hematol 2002; 70: 85–91
  • Rocca B, Ciabattoni G, Tartaglione R, Cortelazzo S, Barbui T, Patrono C, Landolfi R. Increased tromboxane biosynthesis in essential thrombocythemia. Throm Haemost 1995; 74: 1225–1230
  • Laguna MS, Kornblihtt LI, Marta RF, Molinas FC. Tromboxano B2 y factor de crecimiento derivado de las plaquetas en la trombocitemia esencial tratada con anagrelide. Medicina 2000; 60: 448–452
  • Taylor LM, Khachigan LM. Induction of platelet-derived growth factor B-chain expression by transforming growth factor-β involves transactivation by Smads. J Biol Chem 2000; 22: 16709–16716
  • Kang Y, He W, Tulley S, Gupta GP, Serganova I, Chen CR, Manova-Todorova K, Blasberg R, Gerald WL, Massague J. Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway. Proc Natl Acad Sci USA 2005; 102(39)13909–13914
  • Bachelot C, Cano E, Grelac F, Saleun S, Druker BJ, Levy-Toledano S, Fischer S, Rendu F. Functional implications of tyrosine protein phosphorylation in platelets. Biochem J 1992; 284: 923–928
  • Levy-Toledano S, Maclouf J, Rosa JP, Gallet C, Valles G, Nurden P, Nurden A. Abnormal tyrosine phosphorylation linked to a defective interaction between ADP and its receptor on platelets. Thromb Haemost 1998; 80: 463–468
  • Rosa JP, Artcanuthurry V, Grelac F, Maclouf J, Caen JP, Levy-Toledano S. Reassessment of protein tyrosine phosphorylation in thrombasthenic platelets: Evidence that phosphorylation of cortactin and a 64-kD protein is dependent on thrombin activation and integrin alphaIIb beta3. Blood 1997; 89(12)4385–4392
  • Cacciola RR, Cipolla A, Di Francesco E, Giustolisi R, Cacciola E. Treatment of symptomatic patients with essential thrombocythemia: Effectiveness of anagrelide. Am J Hematol 2005; 80(1)81–83
  • Kong FM, Anscher MS, Murase T, Abbott BD, Iglehart JD, Jirtle RL. Elevated plasma transforming growth factor-beta 1 levels in breast cancer patients decrease after surgical removal of the tumor. Ann Surg 1995; 222(2)155–162
  • Hegele A, Varga Z, von Knobloch R, Heidenreich A, Kropf J, Hofmann R. TGF-β1 in patients with renal cell carcinoma. Urol Res 2002; 30(2)126–129
  • Anitua E, Andia I, Ardanza B, Nurden P, Nurden AT. Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb Haemost 2004; 91: 4–15

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