An investigation of the antiplatelet effects of succinobucol (AGI-1067)

References

• Meng CQ, Somers PK, Rachita CL, Holt LA, Hoong LK, Zheng XS, Simpson JE, Hill RR, Olliff LK, Kunsch C. Novel phenolic antioxidants as multifunctional inhibitors of inducible VCAM-1 expression for use in atherosclerosis. Bioorg Med Chem Lett 2002;12(18):2545–2548.
   PubMed Web of Science ®Google Scholar
• Sundell CL, Somers PK, Meng CQ, Hoong LK, Suen K-L, Hill RR, Landers LK, Chapman A, Butteiger D, Jones M. AGI-1067: a multifunctional phenolic antioxidant, lipid modulator, anti-inflammatory and antiatherosclerotic agent. J Pharmacol Exp Ther 2003;305(3):1116–1123.
   PubMed Web of Science ®Google Scholar
• Murata S, Sundell CL, Lijkwan MA, Balsam LB, Hämmäinen P, Coleman C, York C, Luchoomun J, Suen K-L, Howard R. Effects of AGI-1096, a novel antioxidant compound with anti-inflammatory and antiproliferative properties, on rodent allograft arteriosclerosis. Transplantation 2004;77(10):1494–1500.
   PubMed Web of Science ®Google Scholar
• Kunsch C, Luchoomun J, Grey JY, Olliff LK, Saint LB, Arrendale RF, Wasserman MA, Saxena U, Medford RM. Selective inhibition of endothelial and monocyte redox-sensitive genes by AGI-1067: a novel antioxidant and anti-inflammatory agent. J Pharmacol Exp Ther 2004;308(3):820–829.
   PubMed Web of Science ®Google Scholar
• Tardif J-C, McMurray JJ, Klug E, Small R, Schumi J, Choi J, Cooper J, Scott R, Lewis EF, L’Allier PL. Effects of succinobucol (AGI-1067) after an acute coronary syndrome: a randomised, double-blind, placebo-controlled trial. Lancet 2008;371(9626):1761–1768.
   PubMed Web of Science ®Google Scholar
• Watt J, Kennedy S, McCormick C, Agbani EO, McPhaden A, Mullen A, Czudaj P, Behnisch B, Wadsworth RM, Oldroyd KG. Succinobucol‐eluting stents increase neointimal thickening and peri‐strut inflammation in a porcine coronary model. Catheterization Cardiovasc Interventions 2013;81(4):698–708.
   PubMed Web of Science ®Google Scholar
• Jurček O, Ikonen S, Buřičová L, Wimmerová M, Wimmer Z, Drašar P, Horníček J, Galandáková A, Ulrichová J, Kolehmainen ET. Succinobucol’s New Coat—Conjugation with Steroids to Alter Its Drug Effect and Bioavailability. Molecules 2011;16(11):9404–9420.
   PubMed Web of Science ®Google Scholar
• Ladopoulou E, Matralis AN, Kourounakis AP. New multifunctional Di-tert-butylphenoloctahydro (pyrido/benz) oxazine derivatives with antioxidant, antihyperlipidemic, and antidiabetic action. J Med Chem 2013;56(8):3330–3338.
   PubMed Web of Science ®Google Scholar
• Serebruany V, Malinin A, Scott R. The in vitro effects of a novel vascular protectant, AGI-1067, on platelet aggregation and major receptor expression in subjects with multiple risk factors for vascular disease. J Cardiovasc Pharmacol Ther 2006;11(3):191–196.
   PubMed Web of Science ®Google Scholar
• Serebruany VL, Malinin A, Eisert C, Ong S. AGI-1067, a novel vascular protectant, anti-inflammatory drug and mild antiplatelet agent for treatment of atherosclerosis. Expert Rev Cardiovasc Ther 2007;5(4):635–641.
   PubMedGoogle Scholar
• Serebruany V, Malinin A, Qiu F-H, Xu X-C, Kunsch C, Scott R, Group AS. Selective thromboxane inhibition after vascular protectant AGI-1067: results of assessment of lipoprotein profiles (ALPS) biomarkers in vitro and in vivo substudy. J Thrombosis Thrombolysis 2009;27(4):438–446.
   PubMed Web of Science ®Google Scholar
• Delles C, Zimmerli LU, McGrane DJ, Koh-Tan CH, Pathi VL, McKay AJ, Steedman T, Dargie HJ, Hamilton CA, Dominiczak AF. Vascular stiffness is related to superoxide generation in the vessel wall. J Hypertens 2008;26(5):946–955.
   PubMed Web of Science ®Google Scholar
• Jang JY, Min JH, Wang SB, Chae YH, Baek JY, Kim M, Ryu J-S, Chang T-S. Resveratrol inhibits collagen-induced platelet stimulation through suppressing NADPH oxidase and oxidative inactivation of SH2 domain-containing protein tyrosine phosphatase-2. Free Radical Biol Med 2015;89:842–851.
   PubMed Web of Science ®Google Scholar
• de Meirelles LR, Resende AdC, Matsuura C, Salgado Â, Pereira NR, Cascarelli PG, Mendes‐Ribeiro AC, Brunini T. Platelet activation, oxidative stress and overexpression of inducible nitric oxide synthase in moderate heart failure. Clin Exp Pharmacol Physiol 2011;38(10):705–710.
   PubMed Web of Science ®Google Scholar
• Krötz F, Sohn H-Y, Pohl U. Reactive oxygen species players in the platelet game. Arteriosclerosis Thrombosis Vasc Biol 2004;24(11):1988–1996.
   PubMed Web of Science ®Google Scholar
• Wachowicz B, Olas B, Zbikowska H, Buczyński A. Generation of reactive oxygen species in blood platelets. Platelets 2002;13(3):175–182.
   PubMed Web of Science ®Google Scholar
• Li H, Horke S, Förstermann U. Vascular oxidative stress, nitric oxide and atherosclerosis. Atherosclerosis 2014;237(1):208–219.
   PubMed Web of Science ®Google Scholar
• Watt J, Ewart M-A, Greig FH, Oldroyd KG, Wadsworth RM, Kennedy S. The effect of reactive oxygen species on whole blood aggregation and the endothelial cell-platelet interaction in patients with coronary heart disease. Thrombosis Res 2012;130(2):210–215.
   PubMed Web of Science ®Google Scholar
• Muldrew KM, Franks AM. Succinobucol: review of the metabolic, antiplatelet and cardiovascular effects. Exp Opin Invest Drugs 2009;18(4):531–539.
   PubMed Web of Science ®Google Scholar
• Nomura S, Takahashi N, Inami N, Kajiura T, Yamada K, Nakamori H, Tsuda N. Probucol and ticlopidine: effect on platelet and monocyte activation markers in hyperlipidemic patients with and without type 2 diabetes. Atherosclerosis 2004;174(2):329–335.
   PubMed Web of Science ®Google Scholar
• Almeida Rezende B, Carvalho Pereira A, F Cortes S, Soares Lemos V. Vascular effects of flavonoids. Curr Med Chem 2016;23(1):87–102.
   PubMed Web of Science ®Google Scholar
• Kwon S-U, Lee H-Y, Xin M, Ji S-J, Cho H-K, Kim D-S, Kim D-K, Lee Y-M. Antithrombotic activity of Vitis labrusca extract on rat platelet aggregation. Blood Coagulation Fibrinolysis Int J Haemostasis Thrombosis 2015;27(2):141–146.
   Google Scholar
• Olas B, Hamed AI, Oleszek W, Stochmal A. Comparison of biological activity of phenolic fraction from roots of Alhagi maurorum with properties of commercial phenolic extracts and resveratrol. Platelets 2015;26(8):788–794.
   PubMed Web of Science ®Google Scholar
• Sill JC, Proper JA, Johnson ME, Uhl CB, Katusic ZS. Reactive oxygen species and human platelet GP IIb/IIIa receptor activation. Platelets 2007;18(8):613–619.
   PubMed Web of Science ®Google Scholar
• Jeng J-H, Chen S-Y, Liao C-H, Tung Y-Y, Lin B-R, Hahn L-J, Chang M-C. Modulation of platelet aggregation by areca nut and betel leaf ingredients: roles of reactive oxygen species and cyclooxygenase. Free Radical Biol Med 2002;32(9):860–871.
   PubMed Web of Science ®Google Scholar
• Iuliano L, Violi F, Pedersen JZ, Praticò D, Rotilio G, Balsano F. Free radical-mediated platelet activation by hemoglobin released from red blood cells. Arch Biochem Biophys 1992;299(2):220–224.
   PubMed Web of Science ®Google Scholar
• Ikeda H, Koga Y, Oda T, Kuwano K, Nakayama H, Ueno T, Toshima H, Michael LH, Entman ML. Free oxygen radicals contribute to platelet aggregation and cyclic flow variations in stenosed and endothelium-injured canine coronary arteries. J Am Coll Cardiol 1994;24(7):1749–1756.
   PubMed Web of Science ®Google Scholar
• Goldsmith H, Kaufer E, McIntosh F. Effect of hematocrit on adenosine diphosphate-induced aggregation of human platelets in tube flow. Biorheology 1995;32(5):537–552.
   PubMed Web of Science ®Google Scholar
• Abi-Younes SA, Ayers ML, Myers AK. Mechanism of ethanol-induced aggregation in whole blood. Thrombosis Res 1991;63(5):481–489.
   PubMed Web of Science ®Google Scholar
• Ghiselli A, Pignatelli P, Sanguigni V, Violi F. Superoxide anion and hydroxyl radical release by collagen-induced platelet aggregation-role of arachidonic acid metabolism. Thromb Haemost 2000;83:485–90.
   PubMed Web of Science ®Google Scholar
• Katusic ZS, Schugel J, Cosentino F, Vanhoutte PM. Endothelium-dependent contractions to oxygen-derived free radicals in the canine basilar artery. Am J Physiol-Heart Circulatory Physiol 1993;264(3):H859–H864.
   Web of Science ®Google Scholar
• Didion SP, Faraci FM. Effects of NADH and NADPH on superoxide levels and cerebral vascular tone. Am J Physiol-Heart Circulatory Physiol 2002;282(2):H688–H695.
   PubMed Web of Science ®Google Scholar
• Nacitarhan C, Bayram Z, Eksert B, Usta C, Golbasi I, Ozdem SS. The effect of hydrogen peroxide in human internal thoracic arteries: role of potassium channels, nitric oxide and cyclooxygenase products. Cardiovasc Drugs Ther 2007;21(4):257–262.
   PubMed Web of Science ®Google Scholar
• Zhang DX, Borbouse L, Gebremedhin D, Mendoza SA, Zinkevich NS, Li R, Gutterman DD. H2O2-induced dilation in human coronary arterioles: role of protein kinase G dimerization and large-conductance Ca2+-activated K+ channel activation. Circ Res 2012;110(3):471–480.
   PubMed Web of Science ®Google Scholar
• Lo MC, Lansang MC. Recent and emerging therapeutic medications in type 2 diabetes mellitus: incretin-based, pramlintide, colesevelam, SGLT2 inhibitors, tagatose, succinobucol. Am J Ther 2013;20(6):638–653.
   PubMed Web of Science ®Google Scholar