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Platelets Volume 29, 2018 - Issue 7
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Plenary Paper

Not all light transmission aggregation assays are created equal: qualitative differences between light transmission and 96-well plate aggregometry

Melissa V. ChanThe Blizard Institute, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, London, UKCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-2154-1386View further author information
ORCID Icon,
Philip D. LeadbeaterIntensive Care Unit, Western General Hospital, Edinburgh, UKView further author information
,
Steve P. WatsonInstitute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UKView further author information
&
Timothy D. WarnerThe Blizard Institute, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, London, UKView further author information
Pages 686-689 | Received 02 Mar 2018, Accepted 09 Apr 2018, Published online: 01 May 2018

References

  • Born GVR. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature. 1962;194:927–929. doi:10.1038/194927b0.
  • Cattaneo M, Cerletti C, Harrison P, Hayward CPM, Kenny D, Nugent D, et al. Recommendations for the standardization of light transmission aggregometry: a consensus of the working party from the platelet physiology subcommittee of SSC/ISTH. J Thromb Haemost. 2013;11:1183–1189. doi:10.1111/jth.12231.
  • Lordkipanidzé M, Lowe GC, Kirkby NS, Chan MV, Lundberg MH, Morgan NV, et al. Characterization of multiple platelet activation pathways in patients with bleeding as a high-throughput screening option: use of 96-well Optimul assay. Blood. 2014;123:e11–e22. doi:10.1182/blood-2013-08-520387.
  • Fratantoni JC, Poindexter BJ. Measuring platelet aggregation with microplate reader. A new technical approach to platelet aggregation studies. Am J Clin Pathol. 1990;94:613–617. doi:10.1093/ajcp/94.5.613.
  • Peace AJ, Tedesco AF, Foley DP, Dicker P, Berndt MC, Kenny D. Dual antiplatelet therapy unmasks distinct platelet reactivity in patients with coronary artery disease. J Thromb Haemost. 2008;6:2027–2034. doi:10.1111/j.1538-7836.2008.03157.x.
  • Chan MV, Armstrong PCJ, Papalia F, Kirkby NS, Warner TD. Optical multichannel (optimul) platelet aggregometry in 96-well plates as an additional method of platelet reactivity testing. Platelets. 2011;22:485–494. doi:10.3109/09537104.2011.592958.
  • Chan MV, Warner TD. Standardised optical multichannel (optimul) platelet aggregometry using high-speed shaking and fixed time point readings. Platelets. 2012;23:404–408. doi:10.3109/09537104.2011.603066.
  • Dyszkiewicz-Korpanty A, Olteanu H, Frenkel EP, Sarode R. Clopidogrel anti-platelet effect: an evaluation by optical aggregometry, impedance aggregometry, and the Platelet Function Analyzer (PFA-100TM). Platelets. 2007;18:491–496. doi:10.1080/09537100701280654.
  • Armstrong PC, Dhanji AR, Truss NJ, Zain ZN, Tucker AT, Mitchell JA, et al. Utility of 96-well plate aggregometry and measurement of thrombi adhesion to determine aspirin and clopidogrel effectiveness. Thromb Haemost. 2009;102:772–778.

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