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Original Article

Circulating microRNAs in patients with immune thrombocytopenia before and after treatment with thrombopoietin-receptor agonists

, , , , , ORCID Icon, , , & show all
Pages 198-205 | Received 28 Dec 2018, Accepted 17 Feb 2019, Published online: 18 Mar 2019

References

  • Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004;116:281–297.
  • Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009;136:215–233. doi:10.1016/j.cell.2009.01.002.
  • Volinia S, Calin GA, Liu CG, Ambs S, Cimmino A, Petrocca F, Visone R, Iorio M, Roldo C, Ferracin M, et al. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A 2006;103:2257–2261. doi:10.1073/pnas.0510565103.
  • Madrigal-Matute J, Rotllan N, Aranda JF, Fernandez-Hernando C. MicroRNAs and atherosclerosis. Curr Atheroscler Rep 2013;15:322. doi:10.1007/s11883-013-0322-z.
  • Liang D, Shen N. MicroRNA involvement in lupus: the beginning of a new tale. Curr Opin Rheumatol 2012;24:489–498. doi:10.1097/BOR.0b013e3283563363.
  • Teruel-Montoya R, Kong X, Abraham S, Ma L, Kunapuli SP, Holinstat M, Shaw CA, McKenzie SE, Edelstein LC, Bray PF. MicroRNA expression differences in human hematopoietic cell lineages enable regulated transgene expression. PLoS One 2014;9:e102259. doi:10.1371/journal.pone.0102259.
  • Thorsen M, Blondal T, Mouritzen P. Quantitative RT-PCR for MicroRNAs in Biofluids. Methods Mol Biol 2017;1641:379–398. doi:10.1007/978-1-4939-7172-5_21.
  • Kieffer N, Guichard J, Farcet JP, Vainchenker W, Breton-Gorius J. Biosynthesis of major platelet proteins in human blood platelets. Eur J Biochem 1987;164:189–195.
  • Newman PJ, Gorski J, White GC 2nd, Gidwitz S, Cretney CJ, Aster RH. Enzymatic amplification of platelet-specific messenger RNA using the polymerase chain reaction. J Clin Invest 1988;82:739–743. doi:10.1172/JCI113656.
  • Chen X, Ba Y, Ma L, Cai X, Yin Y, Wang K, Guo J, Zhang Y, Chen J, Guo X, et al. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res 2008;18:997–1006. doi:10.1038/cr.2008.282.
  • Weiland M, Gao XH, Zhou L, Mi QS. Small RNAs have a large impact: circulating microRNAs as biomarkers for human diseases. RNA Biol 2012;9:850–859. doi:10.4161/rna.20378.
  • Hindson CM, Chevillet JR, Briggs HA, Gallichotte EN, Ruf IK, Hindson BJ, Vessella RL, Tewari M. Absolute quantification by droplet digital PCR versus analog real-time PCR. Nat Methods 2013;10:1003–1005. doi:10.1038/nmeth.2633.
  • Campomenosi P, Gini E, Noonan DM, Poli A, D’Antona P, Rotolo N, Dominioni L, Imperatori A. A comparison between quantitative PCR and droplet digital PCR technologies for circulating microRNA quantification in human lung cancer. BMC Biotechnol 2016;16:60. doi:10.1186/s12896-016-0292-7.
  • Stasi R, Evangelista ML, Stipa E, Buccisano F, Venditti A, Amadori S. Idiopathic thrombocytopenic purpura: current concepts in pathophysiology and management. Thromb Haemost 2008;99:4–13. Epub 2008/ 01/25. doi:10.1160/TH07-08-0513.
  • Zufferey A, Kapur R, Semple JW. Pathogenesis and therapeutic mechanisms in immune thrombocytopenia (ITP). J Clin Med 2017;6(2):16.
  • McKenzie CG, Guo L, Freedman J, Semple JW. Cellular immune dysfunction in immune thrombocytopenia (ITP). Br J Haematol 2013;163:10–23. doi:10.1111/bjh.12480.
  • Ghanima W, Godeau B, Cines DB, Bussel JB. How I treat immune thrombocytopenia: the choice between splenectomy or a medical therapy as a second-line treatment. Blood 2012;120:960–969. Epub 2012/ 06/29. doi:10.1182/blood-2011-12-309153.
  • Kuter DJ, Bussel JB, Lyons RM, Pullarkat V, Gernsheimer TB, Senecal FM, Aledort LM, George JN, Kessler CM, Sanz MA, et al. Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trial. Lancet 2008;371:395–403. Epub 2008/ 02/05 doi:10.1016/S0140-6736(08)60203-2.
  • Bussel JB, Cheng G, Saleh MS, Mayer B, Vasey SV, Brainsky A. Incidence of thromboembolic events across eltrombopag clinical trials in chronic immune thrombocytopenia (ITP). Blood 2010;116.
  • Wong RSM, Saleh MN, Khelif A, Salama A, Portella MSO, Burgess P, Bussel JB. Safety and efficacy of long-term treatment of chronic/persistent ITP with eltrombopag: final results of the EXTEND study. Blood 2017;130:2527–2536. doi:10.1182/blood-2017-04-748707.
  • Zuo B, Zhai J, You L, Zhao Y, Yang J, Weng Z, Dai L, Wu Q, Ruan C, He Y. Plasma microRNAs characterising patients with immune thrombocytopenic purpura. Thromb Haemost 2017;117:1420–1431. doi:10.1160/TH-16-06-0481.
  • Bay A, Coskun E, Oztuzcu S, Ergun S, Yilmaz F, Aktekin E. Plasma microRNA profiling of pediatric patients with immune thrombocytopenic purpura. Blood Coagul Fibrinolysis 2014;25:379–383. doi:10.1097/MBC.0000000000000069.
  • Burenbatu, Borjigin M, Eerdunduleng, Huo W, Gong C, Hasengaowa, Zhang G, Longmei, Li M, Zhang X, et al. Profiling of miRNA expression in immune thrombocytopenia patients before and after Qishunbaolier (QSBLE) treatment. Biomed Pharmacother 2015;75:196–204. doi:10.1016/j.biopha.2015.07.022.
  • Hromadnikova I, Kotlabova K, Ivankova K, Vedmetskaya Y, Krofta L. Profiling of cardiovascular and cerebrovascular disease associated microRNA expression in umbilical cord blood in gestational hypertension, preeclampsia and fetal growth restriction. Int J Cardiol 2017;249:402–409. doi:10.1016/j.ijcard.2017.07.045.
  • Jernas M, Nookaew I, Wadenvik H, Olsson B. MicroRNA regulate immunological pathways in T-cells in immune thrombocytopenia (ITP). Blood 2013;121:2095–2098. doi:10.1182/blood-2012-12-471250.
  • Sui T, Ma L, Li X, Li Q, Bai X, Mu J, Zhao M. [Plasma microRNA profile in immune thrombocytopenia: screening and verification]. Zhonghua Yi Xue Za Zhi 2014;94:1083–1086.
  • Sunderland N, Skroblin P, Barwari T, Huntley RP, Lu R, Joshi A, Lovering RC, Mayr M. MicroRNA Biomarkers and Platelet Reactivity: the Clot Thickens. Circ Res 2017;120:418–435. doi:10.1161/CIRCRESAHA.116.309303.
  • Lai L, Azzam KM, Lin WC, Rai P, Lowe JM, Gabor KA, Madenspacher JH, Aloor JJ, Parks JS, Naar AM, et al. MicroRNA-33 regulates the innate immune response via ATP binding cassette transporter-mediated remodeling of membrane microdomains. J Biol Chem 2016;291:19651–19660. doi:10.1074/jbc.M116.723056.
  • Wu MH, Tsai CH, Huang YL, Fong YC, Tang CH. Visfatin promotes IL-6 and TNF-alpha production in human synovial fibroblasts by repressing miR-199a-5p through ERK, p38 and JNK signaling pathways. Int J Mol Sci 2018;19(1):190.
  • Hill QA, Newland AC. Fatigue in immune thrombocytopenia. Br J Haematol 2015;170:141–149. doi:10.1111/bjh.13385.
  • Ma X, Yao H, Yang Y, Jin L, Wang Y, Wu L, Yang S, Cheng K. miR-195 suppresses abdominal aortic aneurysm through the TNF-alpha/NF-kappaB and VEGF/PI3K/Akt pathway. Int J Mol Med 2018;41:2350–2358. doi:10.3892/ijmm.2018.3426.
  • Zeng Z, Yao J, Li Y, Xue Y, Zou Y, Shu Z, Jiao Z. Anti-apoptosis endothelial cell-secreted microRNA-195-5p promotes pulmonary arterial smooth muscle cell proliferation and migration in pulmonary arterial hypertension. J Cell Biochem 2018;119:2144–2155. doi:10.1002/jcb.26376.
  • Yoshida K, Kirito K, Yongzhen H, Ozawa K, Kaushansky K, Komatsu N. Thrombopoietin (TPO) regulates HIF-1alpha levels through generation of mitochondrial reactive oxygen species. Int J Hematol 2008;88:43–51. doi:10.1007/s12185-008-0091-6.
  • Piccoli C, D’Aprile A, Ripoli M, Scrima R, Boffoli D, Tabilio A, Capitanio N. The hypoxia-inducible factor is stabilized in circulating hematopoietic stem cells under normoxic conditions. FEBS Lett 2007;581:3111–3119. doi:10.1016/j.febslet.2007.05.077.
  • Kirito K, Fox N, Komatsu N, Kaushansky K. Thrombopoietin enhances expression of vascular endothelial growth factor (VEGF) in primitive hematopoietic cells through induction of HIF-1alpha. Blood 2005;105:4258–4263. doi:10.1182/blood-2004-07-2712.
  • Meng X, Grotsch B, Luo Y, Knaup KX, Wiesener MS, Chen XX, Jantsch J, Fillatreau S, Schett G, Bozec A. Hypoxia-inducible factor-1alpha is a critical transcription factor for IL-10-producing B cells in autoimmune disease. Nat Commun 2018;9:251. doi:10.1038/s41467-017-02683-x.
  • Qi J, You T, Pan T, Wang Q, Zhu L, Han Y. Downregulation of hypoxia-inducible factor-1alpha contributes to impaired megakaryopoiesis in immune thrombocytopenia. Thromb Haemost 2017;117:1875–1886. doi:10.1160/TH17-03-0155.
  • Serocki M, Bartoszewska S, Janaszak-Jasiecka A, Ochocka RJ, Collawn JF, Bartoszewski R. miRNAs regulate the HIF switch during hypoxia: a novel therapeutic target. Angiogenesis 2018;21:183–202. doi:10.1007/s10456-018-9600-2.
  • Bai R, Zhao AQ, Zhao ZQ, Liu WL, Jian DM. MicroRNA-195 induced apoptosis in hypoxic chondrocytes by targeting hypoxia-inducible factor 1 alpha. Eur Rev Med Pharmacol Sci 2015;19:545–551.
  • Rane S, He M, Sayed D, Vashistha H, Malhotra A, Sadoshima J, Vatner DE, Vatner SF, Abdellatif M. Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes. Circ Res 2009;104:879–886. doi:10.1161/CIRCRESAHA.108.193102.
  • Dai L, Lou W, Zhu J, Zhou X, Di W. MiR-199a inhibits the angiogenic potential of endometrial stromal cells under hypoxia by targeting HIF-1alpha/VEGF pathway. Int J Clin Exp Pathol 2015;8:4735–4744.

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